J. Mannick

Most-cited papers

Fas-induced caspase denitrosylation.
J. Mannick, A. Hausladen, Limin Liu, D. Hess +5 more
1999Science749 citations
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mTOR inhibition improves immune function in the elderly
J. Mannick, G. Del Giudice, M. Lattanzi, N. Valiante +8 more
2014Science Translational Medicine748 citations
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Biomarkers of Aging for the Identification and Evaluation of Longevity Interventions
M. Moqri, Chiara M. S. Herzog, J. Poganik, J. Justice +23 more
2023Cell587 citations Open access
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Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation.
J. Mannick, K. Asano, K. Izumi, E. Kieff +1 more
1994Cell526 citations
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Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation.
J. Cohen, Fred Wang, J. Mannick, E. Kieff
1989Proceedings of the National Academy of Sciences of the United States of America523 citations Open access
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TORC1 inhibition enhances immune function and reduces infections in the elderly
J. Mannick, M. Morris, H. Hockey, G. Roma +8 more
2018Science Translational Medicine445 citations Open access
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S-Nitrosylation of mitochondrial caspases
J. Mannick, Christopher M. Schonhoff, N. Papeta, P. Ghafourifar +3 more
2001Journal of Cell Biology383 citations Open access
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Targeting the biology of aging with mTOR inhibitors
J. Mannick, Dudley Lamming
2023Nature Aging333 citations Open access
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Nitric Oxide Inhibits Fas-induced Apoptosis*
J. Mannick, Qiang Miao, J. Stamler
1997Journal of Biological Chemistry315 citations Open access
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The Epstein-Barr virus nuclear protein encoded by the leader of the EBNA RNAs is important in B-lymphocyte transformation
J. Mannick, Jeffrey I. Cohen, M. Birkenbach, A. Marchini +1 more
1991Journal of Virology261 citations Open access
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S-Nitrosothiol measurements in biological systems.
A. Gow, Allan Doctor, J. Mannick, B. Gaston
2007Journal of chromatography. B, Analytical technologies in the biomedical and life sciences116 citations Open access
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Nitrosylation of Cytochrome c during Apoptosis*
Christopher M. Schonhoff, B. Gaston, J. Mannick
2003Journal of Biological Chemistry116 citations Open access
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Nitrosylation: the next phosphorylation?
J. Mannick, Christopher M. Schonhoff
2002Archives of Biochemistry and Biophysics115 citations
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Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials
J. Mannick, G. Teo, Patti Bernardo, Dean Quinn +4 more
2021The Lancet Healthy Longevity111 citations Open access
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S-nitrosothiol depletion in amyotrophic lateral sclerosis
Christopher M. Schonhoff, M. Matsuoka, H. Tummala, Michael A. Johnson +9 more
2006Proceedings of the National Academy of Sciences of the United States of America106 citations
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Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells
L. C. Godoy, C. Muñoz-Pinedo, Laura Castro, S. Cardaci +16 more
2009Proceedings of the National Academy of Sciences of the United States of America101 citations Open access
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Regulation of apoptosis by protein S-nitrosylation
J. Mannick
2006Amino Acids83 citations
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Antibody targeting of TGF-β in cancer patients.
S. Lonning, J. Mannick, J. McPherson
2011Current Pharmaceutical Biotechnology82 citations
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Challenges in developing Geroscience trials
Y. Rolland, F. Sierra, L. Ferrucci, N. Barzilai +46 more
2023Nature Communications79 citations Open access
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The antiviral role of nitric oxide.
J. Mannick
1995Research in Immunology75 citations
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Tackling immunosenescence to improve COVID-19 outcomes and vaccine response in older adults
L. Cox, I. Bellantuono, J. Lord, Elizabeth Sapey +5 more
2020The Lancet Healthy Longevity68 citations Open access
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Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology
T. Shavlakadze, Jiang Zhu, Sharon X. Wang, Weihua Zhou +10 more
2018The journals of gerontology. Series A, Biological sciences and medical sciences58 citations Open access
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Accelerated S-Nitrosothiol Breakdown by Amyotrophic Lateral Sclerosis Mutant Copper,Zinc-Superoxide Dismutase*
Michael A. Johnson, T. Macdonald, J. Mannick, M. Conaway +1 more
2001Journal of Biological Chemistry55 citations Open access
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The Epstein-Barr virus nuclear antigen leader protein associates with hsp72/hsc73
J. Mannick, Xiao Tong, A. Hemnes, E. Kieff
1995Journal of Virology55 citations Open access
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ReviewNO Means No and Yes: Regulation of Cell Signaling by Protein Nitrosylation
J. Mannick, Christopher M. Schonhoff
2004Free radical research54 citations
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Immunoregulatory and antimicrobial effects of nitrogen oxides.
J. Mannick
2006Proceedings of the American Thoracic Society53 citations Open access
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Extending human health span and longevity—a symposium report
Loren M Devito, N. Barzilai, Ana Maria Cuervo, Laura J. Niedernhofer +11 more
2021Annals of the New York Academy of Sciences50 citations Open access
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Nitric oxide modulates HIV-1 replication.
J. Mannick, Jonathan S. Stamler, E. Teng, N. Simpson +3 more
1999Journal of Acquired Immune Deficiency Syndromes50 citations Open access
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Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity
Yu-Xuan Lyu, Q. Fu, Dominika Wilczok, K. Ying +122 more
2024Aging45 citations Open access
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Fisetin for COVID-19 in Skilled Nursing Facilities (COVID-FIS): Senolytic Trials in the COVID Era
B. Verdoorn, Tamara K. Evans, G. J. Hanson, Yi Zhu +23 more
2021Journal of The American Geriatrics Society44 citations Open access
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Biomarkers of aging for the identiﬁcation and evaluation of longevity interventions
M. Moqri, Chiara Herzog, J. Poganik, D. Belsky +22 more
41 citations
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Translational strategies in aging and age-related disease
M. Armanios, R. de Cabo, J. Mannick, L. Partridge +2 more
2015Nature Medicine32 citations Open access
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Measurement of protein S-nitrosylation during cell signaling.
J. Mannick, Christopher M. Schonhoff
2008Methods in Enzymology25 citations
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Assessment of S-nitrosothiols on diaminofluorescein gels.
Michael King, O. Gildemeister, B. Gaston, J. Mannick
2005Analytical Biochemistry24 citations
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Analysis of Protein S‐Nitrosylation
J. Mannick, Christopher M. Schonhoff
2004Current Protocols in Protein Science20 citations
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Defining a longevity biotechnology company
Nicola Boekstein, N. Barzilai, André Bertram, Joe Betts-Lacroix +14 more
2023Nature Biotechnology14 citations
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Control of tissue oxygenation by S-nitrosohemoglobin in human subjects
J. Reynolds, K. Posina, Lin Zhu, Trevor Jenkins +9 more
2023Proceedings of the National Academy of Sciences of the United States of America12 citations Open access
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Skin longevity: A paradigm shift in aesthetics
Saranya P. Wyles, R. Mehta, J. Mannick, Doris Day
2024Journal of Cosmetic Dermatology11 citations Open access
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Immune aging biomarkers for clinical trials
Andrea Cipriano, Jamie N. Justice, J. Poganik, M. Moqri +19 more
2026Nature Medicine3 citations
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Research and resource needs for understanding host immune responses to SARS-CoV-2 and COVID-19 vaccines during aging
M. Prabhudas, R. Fuldner, Donna Farber, G. Kuchel +4 more
2021Nature Aging3 citations Open access
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Selecting Appropriate Clinical Trial Endpoints for Geroscience Trials: A Path Towards Consensus
Stephen Kritchevsky, Ezequiel Zamora, S. Bhasin, Alan A. Cohen +28 more
2025Research Square2 citations
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LB2. TORC1 Inhibition with RTB101 as a Potential Pan-Antiviral Immunotherapy to Decrease the Incidence of Respiratory Tract Infections Due to Multiple Respiratory Viruses in Older Adults
J. Mannick, Amelia Tomlinson, S. Shergill, G. Teo +1 more
2019Open Forum Infectious Diseases2 citations Open access
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TORC1 inhibition as an immunotherapy to reduce infections in the elderly
J. Mannick, M. Morris, H. Hockey, G. Roma +8 more
2017bioRxiv1 citations Open access
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Translocation of cytochrome C to the cytoplasm and nucleus in non-apoptotic cells
L. C. Godoy, C. Pinedo, Laura Castro, S. Cardaci +16 more
20071 citations
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O39. The role of NO and Fe-Met80 bond rupture in regulating the release of cytochrome c from mitochondria and subsequent subcellular localization
L. C. Godoy, J. Mannick
20061 citations
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Regulation of Cell Signaling by Protein Nitrosylation/Denitrosylation
J. Mannick
20051 citations
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Oral TORC1 Inhibitor Dactolisib Enhances Immune Function and Reduces the Incidence of Respiratory Tract Infections in Elderly Subjects with Asthma
J. Mannick, S. Shergill, G. Teo
2019B15. IMMUNOTHERAPY FOR LUNG DISEASE0 citations
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People
Sunil Agarwal, Rupert Vessey, Patrick J. Balthrop, Eric H. Bjerkholt +8 more
2017Nature Biotechnology0 citations
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Traitement du cancer à l'aide du récepteur antigénique chimérique anti-cd33
Jennifer Brogdon, Hilmar Ebersbach, Saar Gill, David Glass +11 more
20150 citations
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Nucleic acid encoding a humanized anti-BCMA chimeric antigen receptor
J. Brogdon, Eugene Choi, Hilmar Ebersbach, D. Glass +11 more
20150 citations
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