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I. Frew · SciRah

Researcher profile · Semantic Scholar

I. Frew

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I. Frew — researcher profile on SciRah

h-index: 31
Works: 68
Citations: 3,652

Most-cited papers

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia.
K. Nakayama, I. Frew, M. Hagensen, M. Skals +8 more
2004Cell427 citations Open access
Semantic Scholar
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice
Rouven Hoefflin, Sabine Harlander, Silvia Schäfer, Patrick Metzger +21 more
2020Nature Communications258 citations Open access
Semantic Scholar
pVHL and GSK3β are components of a primary cilium-maintenance signalling network
C. Thoma, I. Frew, Christian R. Hoerner, M. Montani +2 more
2007Nature Cell Biology253 citations
Semantic Scholar
A clearer view of the molecular complexity of clear cell renal cell carcinoma.
I. Frew, H. Moch
2015Annual Review of Pathology212 citations Open access
Semantic Scholar
VHL loss causes spindle misorientation and chromosome instability
C. Thoma, A. Toso, Katrin L. Gutbrodt, Sabina P. Reggi +6 more
2009Nature Cell Biology174 citations Open access
Semantic Scholar
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation
I. Frew, C. Thoma, Strahil Georgiev, A. Minola +4 more
2008EMBO Journal157 citations Open access
Semantic Scholar
Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice
J. Albers, Michal Rajski, Désirée Schönenberger, Sabine Harlander +7 more
2013EMBO Molecular Medicine149 citations Open access
Semantic Scholar
A binding motif for Siah ubiquitin ligase
C. House, I. Frew, Huei-Luen Huang, G. Wiche +4 more
2003Proceedings of the National Academy of Sciences of the United States of America148 citations Open access
Semantic Scholar
Stress‐induced decrease in TRAF2 stability is mediated by Siah2
H. Habelhah, I. Frew, Aaron Laine, P. W. Janes +4 more
2002EMBO Journal133 citations Open access
Semantic Scholar
Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia
P. Schraml, I. Frew, C. Thoma, G. Boysen +3 more
2009Modern Pathology129 citations Open access
Semantic Scholar
The Ubiquitin Ligase Component Siah1a Is Required for Completion of Meiosis I in Male Mice
R. Dickins, I. Frew, C. House, M. O'Bryan +5 more
2002Molecular and Cellular Biology109 citations Open access
Semantic Scholar
Hedgehog Pathway Inhibitors Promote Adaptive Immune Responses in Basal Cell Carcinoma
A. Otsuka, J. Dreier, P. Cheng, M. Nägeli +6 more
2015Clinical Cancer Research102 citations Open access
Semantic Scholar
pVHL: A Multipurpose Adaptor Protein
I. Frew, W. Krek
2008Science Signaling94 citations
Semantic Scholar
Combined Vhl, Trp53 and Rb1 mutation causes clear cell renal cell carcinoma in mice
Sabine Harlander, Désirée Schönenberger, N. Toussaint, Michael Prummer +5 more
2017Nature Medicine91 citations Open access
Semantic Scholar
Glucagon like peptide-2 for Intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans.
J. Norona, Petya Apostolova, Dominik Schmidt, Rebekka Ihlemann +23 more
2020Blood88 citations Open access
Semantic Scholar
Induction of long noncoding RNA MALAT1 in hypoxic mice
Aurélia Lelli, K. Nolan, S. Santambrogio, A. F. Gonçalves +6 more
2015Hypoxia79 citations Open access
Semantic Scholar
Generation and Analysis of Siah2 Mutant Mice
I. Frew, V. Hammond, R. Dickins, J. Quinn +11 more
2003Molecular and Cellular Biology79 citations Open access
Semantic Scholar
Multitasking by pVHL in tumour suppression.
I. Frew, W. Krek
2007Current Opinion in Cell Biology77 citations
Semantic Scholar
A versatile modular vector system for rapid combinatorial mammalian genetics.
J. Albers, Claudia Danzer, M. Rechsteiner, H. Lehmann +10 more
2015Journal of Clinical Investigation69 citations Open access
Semantic Scholar
Tumor necrosis factor stimulates fibroblast growth factor 23 levels in chronic kidney disease and non-renal inflammation.
Daniela Egli-Spichtig, P. H. Imenez Silva, Bob Glaudemans, N. Gehring +24 more
2019Kidney International63 citations Open access
Semantic Scholar
The VHL Tumor Suppressor: Riding Tandem with GSK3β in Primary Cilium Maintenance
C. Thoma, I. Frew, W. Krek
2007Cell Cycle60 citations Open access
Semantic Scholar
Abstract 3293: p53 suppresses type II endometrial carcinomas in mice and governs endometrial tumour aggressiveness in humans
P. Wild, K. Ikenberg, T. Fuchs, Strahil Georgiev +8 more
201254 citations
Semantic Scholar
Formation of Renal Cysts and Tumors in Vhl/Trp53-Deficient Mice Requires HIF1α and HIF2α.
Désirée Schönenberger, Sabine Harlander, Michal Rajski, R. Jacobs +6 more
2016Cancer Research50 citations Open access
Semantic Scholar
Combined Vhlh and Pten Mutation Causes Genital Tract Cystadenoma and Squamous Metaplasia
I. Frew, A. Minola, Strahil Georgiev, M. Hitz +4 more
2008Molecular and Cellular Biology46 citations Open access
Semantic Scholar
Betahistine hydrochloride in Méniére's disease.
I. Frew, G. Menon
1976Postgraduate medical journal46 citations Open access
Semantic Scholar
Normal p53 Function in Primary Cells Deficient for Siah Genes
I. Frew, R. Dickins, A. Cuddihy, M. del Rosario +3 more
2002Molecular and Cellular Biology41 citations Open access
Semantic Scholar
IL‐8 and CXCR1 expression is associated with cancer stem cell‐like properties of clear cell renal cancer
Claudia Corrò, M. E. Healy, S. Engler, B. Bodenmiller +6 more
2019Journal of Pathology39 citations Open access
Semantic Scholar
A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours
Madhuri Kalathur, A. Toso, Jing-Jing Chen, Ajinkya Revandkar +22 more
2015Nature Communications38 citations Open access
Semantic Scholar
VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma
A. Ganner, Christina Gehrke, Marinella Klein, Lena Thegtmeier +10 more
2021Scientific Reports33 citations Open access
Semantic Scholar
Detecting circulating tumor DNA in renal cancer: An open challenge.
Claudia Corrò, Tomáš Hejhal, C. Poyet, T. Sulser +7 more
2017Experimental and molecular pathology (Print)33 citations Open access
Semantic Scholar
KPNA2 is overexpressed in human and mouse endometrial cancers and promotes cellular proliferation
K. Ikenberg, N. Valtcheva, S. Brandt, Qing Zhong +13 more
2014Journal of Pathology32 citations Open access
Semantic Scholar
Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions
A. Guinot, H. Lehmann, P. Wild, I. Frew
2016Journal of Pathology27 citations Open access
Semantic Scholar
Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation.
H. Lehmann, D. Vicari, P. Wild, I. Frew
2015Journal of the American Society of Nephrology24 citations Open access
Semantic Scholar
Therapeutic significance of ARID1A mutation in bladder cancer
Marina Conde, I. Frew
2022Neoplasia22 citations Open access
Semantic Scholar
Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells
A. F. Gonçalves, Mojca Adlesic, S. Brandt, Tomáš Hejhal +5 more
2017Nature Communications20 citations Open access
Semantic Scholar
Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis
Désirée Schönenberger, Michal Rajski, Sabine Harlander, I. Frew
2016OncoTarget18 citations Open access
Semantic Scholar
Nitric oxide donors selectively potentiate thrombin-stimulated p70(S6k) activity and morphological changes in Swiss 3T3 cells.
Leise A. Berven, I. Frew, Michael F. Crouch
1999Biochemical and Biophysical Research Communications - BBRC18 citations
Semantic Scholar
Activation of the Hypoxia-Inducible Factor Pathway Inhibits Epithelial Sodium Channel–Mediated Sodium Transport in Collecting Duct Principal Cells
Eva Dizin, Valérie Olivier, I. Roth, A. Sassi +9 more
2021Journal of the American Society of Nephrology17 citations Open access
Semantic Scholar
Genetic deletion of the long isoform of the von Hippel-Lindau tumour suppressor gene product alters microtubule dynamics.
I. Frew, Zlatko Smole, C. Thoma, W. Krek
2013European Journal of Cancer17 citations
Semantic Scholar
Osteopenia in Siah1a Mutant Mice*
I. Frew, N. Sims, J. Quinn, Carl R Walkley +3 more
2004Journal of Biological Chemistry16 citations Open access
Semantic Scholar
ATR represents a therapeutic vulnerability in clear cell renal cell carcinoma
Philipp Seidel, Anne Rubarth, Kyra Zodel, Asin Peighambari +17 more
2022JCI Insight15 citations Open access
Semantic Scholar
The familial association of neurofibromatosis, peroneal muscular atrophy, congenital deafness, partial albinism, and Axenfeld's defect.
W. Bradley, J. Richardson, I. Frew
1974Brain : a journal of neurology14 citations
Semantic Scholar
Integrated Metabolomic and Transcriptomic Analysis of Modified Nucleosides for Biomarker Discovery in Clear Cell Renal Cell Carcinoma
Daniel A. Mohl, S. Lagies, Kyra Zodel, M. Zumkeller +7 more
2023Cells12 citations Open access
Semantic Scholar
Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma
Rouven Hoefflin, Sabine Harlander, B. A. Abhari, Asin Peighambari +13 more
2021Cancers11 citations Open access
Semantic Scholar
p53 suppresses type II endometrial carcinomas in mice and governs endometrial tumour aggressiveness in humans
Peter J Wild, Kristian Ikenberg, T. Fuchs, M. Rechsteiner +10 more
2012EMBO Molecular Medicine11 citations Open access
Semantic Scholar
Mouse genetic background influences whether HrasG12V expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma
Laura P. Brandt, J. Albers, Tomáš Hejhal, Svende Pfundstein +4 more
2018OncoTarget9 citations Open access
Semantic Scholar
SCD5 Regulation by VHL Affects Cell Proliferation and Lipid Homeostasis in ccRCC
A. Ganner, A. Philipp, S. Lagies, Laura Wingendorf +10 more
2023Cells8 citations Open access
Semantic Scholar
The Familial Association of Neurofibromatosis, Peroneal Muscular Atrophy, Congenital Deafness, Partial Albinism, and Axenfeld's Defect
W. Bradley, J. Richardson, I. Frew
19748 citations
Semantic Scholar
Sensitivity and Resistance of Oncogenic RAS-Driven Tumors to Dual MEK and ERK Inhibition
A. Catalano, Mojca Adlesic, Thorsten Kaltenbacher, R. Klar +13 more
2021Cancers7 citations Open access
Semantic Scholar
Versatile roles of annexin A4 in clear cell renal cell carcinoma: Impact on membrane repair, transcriptional signatures, and composition of the tumor microenvironment
Maximilian Wess, M. Rogg, Constance Gueib-Picard, Annika Merz +8 more
2025iScience4 citations Open access
Semantic Scholar

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