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R. MacLaren · SciRah

Researcher profile · Semantic Scholar

R. MacLaren

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R. MacLaren — researcher profile on SciRah

h-index: 58
Works: 498
Citations: 13K

Most-cited papers

CRISPR-Cas9 DNA Base-Editing and Prime-Editing
Ariel Kantor, M. McClements, R. MacLaren
2020International Journal of Molecular Sciences394 citations Open access
Semantic Scholar
Retinal gene therapy in X-linked retinitis pigmentosa caused by mutations in RPGR: Results at 6 months in a first in human clinical trial
Jasmina Cehajic-Kapetanovic, Kan-Min Xue, Cristina Martínez-Fernández de la Cámara, A. Nanda +19 more
2020Nature Medicine298 citations Open access
Semantic Scholar
Bioengineering strategies for restoring vision
Jasmina Cehajic-Kapetanovic, Mandeep S. Singh, E. Zrenner, R. MacLaren
2022Nature Biomedical Engineering63 citations
Semantic Scholar
Gene Therapy for Inherited Retinal Disease: Long-Term Durability of Effect
B. Leroy, M. D. Fischer, J. Flannery, R. MacLaren +6 more
2022Ophthalmic Research62 citations Open access
Semantic Scholar
Low luminance visual acuity as a clinical measure and clinical trial outcome measure: a scoping review
Laura J Wood, J. Jolly, T. M. Buckley, A. Josan +1 more
2021Ophthalmic & physiological optics59 citations Open access
Semantic Scholar
Changes in Retinal Sensitivity Associated With Cotoretigene Toliparvovec in X-Linked Retinitis Pigmentosa With RPGR Gene Variations
Lenore von Krusenstiern, Jia-Jun Liu, Eileen Liao, J. Gow +6 more
2023JAMA ophthalmology58 citations Open access
Semantic Scholar
First-In-Human Robot-Assisted Subretinal Drug Delivery Under Local Anaesthesia A Randomised Clinical Trial.
Jasmina Cehajic-Kapetanovic, Kan-Min Xue, T. L. Edwards, Thijs C. M. Meenink +4 more
2021American journal of ophthalmology-glaucoma56 citations
Semantic Scholar
Monitoring progression of retinitis pigmentosa: current recommendations and recent advances
M. Menghini, Jasmina Cehajic-Kapetanovic, R. MacLaren
2020Expert Opinion on Orphan Drugs56 citations Open access
Semantic Scholar
Therapy Approaches for Stargardt Disease
E. Piotter, M. McClements, R. MacLaren
2021Biomolecules47 citations Open access
Semantic Scholar
Functional expression of complement factor I following AAV-mediated gene delivery in the retina of mice and human cells
Anna K Dreismann, M. McClements, Alun R. Barnard, Elise Orhan +3 more
2021Gene Therapy46 citations Open access
Semantic Scholar
Cross-over to photodynamic therapy or micropulse laser after failure of primary treatment of chronic central serous chorioretinopathy.
T. V. van Rijssen, E. V. van Dijk, P. Scholz, M. Breukink +8 more
2020American journal of ophthalmology-glaucoma43 citations Open access
Semantic Scholar
Microperimetry Hill of Vision and Volumetric Measures of Retinal Sensitivity
A. Josan, T. M. Buckley, Laura J Wood, J. Jolly +2 more
2021Translational Vision Science & Technology41 citations Open access
Semantic Scholar
Insights on the Regeneration Potential of Müller Glia in the Mammalian Retina
Ahmed Salman, M. McClements, R. MacLaren
2021Cells41 citations Open access
Semantic Scholar
Impaired glutamylation of RPGRORF15 underlies the cone-dominated phenotype associated with truncating distal ORF15 variants
Jasmina Cehajic-Kapetanovic, C. Martinez-Fernandez de la Camara, J. Birtel, Salwah Rehman +4 more
2022Proceedings of the National Academy of Sciences of the United States of America40 citations Open access
Semantic Scholar
The Role of Inflammation in Age-Related Macular Degeneration—Therapeutic Landscapes in Geographic Atrophy
Grace A. Borchert, Hoda Shamsnajafabadi, Monica L. Hu, S. D. De Silva +4 more
2023Cells39 citations Open access
Semantic Scholar
Analysis of Pathogenic Variants Correctable With CRISPR Base Editing Among Patients With Recessive Inherited Retinal Degeneration.
L. Fry, M. McClements, R. MacLaren
2021JAMA ophthalmology37 citations Open access
Semantic Scholar
An Economic Evaluation of Voretigene Neparvovec for the Treatment of Biallelic RPE65-Mediated Inherited Retinal Dystrophies in the UK
D. Viriato, N. Bennett, R. Sidhu, E. Hancock +3 more
2020Advances in Therapy36 citations Open access
Semantic Scholar
Non-Viral Delivery of CRISPR/Cas Cargo to the Retina Using Nanoparticles: Current Possibilities, Challenges, and Limitations
Ahmed Salman, Ariel Kantor, M. McClements, G. Marfany +2 more
2022Pharmaceutics35 citations Open access
Semantic Scholar
Long‐term follow‐up of chronic central serous chorioretinopathy after successful treatment with photodynamic therapy or micropulse laser
T. V. van Rijssen, E. V. van Dijk, P. Scholz, M. Breukink +9 more
2021Acta ophthalmologica35 citations Open access
Semantic Scholar
Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa
H. Orlans, M. McClements, Alun R. Barnard, C. Martinez-Fernandez de la Camara +1 more
2021Nature Communications34 citations Open access
Semantic Scholar
Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids
M. McClements, H. Steward, William Atkin, E. A. Goode +3 more
2022Translational Vision Science & Technology33 citations Open access
Semantic Scholar
Retinal cadherins and the retinal cadherinopathies: Current concepts and future directions.
I. Yusuf, A. Garrett, R. MacLaren, P. Issa
2022Progress in retinal and eye research33 citations Open access
Semantic Scholar
Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retina
L. Chandler, M. McClements, I. Yusuf, C. Martinez-Fernandez de la Camara +2 more
2021Molecular Therapy: Methods & Clinical Development33 citations Open access
Semantic Scholar
Low Luminance Visual Acuity and Low Luminance Deficit in Choroideremia and RPGR-Associated Retinitis Pigmentosa
Laura J Wood, J. Jolly, A. Josan, T. M. Buckley +1 more
2021Translational Vision Science & Technology31 citations Open access
Semantic Scholar
Next generation sequencing using phenotype-based panels for genetic testing in inherited retinal diseases
Mital Shah, M. Shanks, E. Packham, Jonathan Williams +5 more
2020Ophthalmic Genetics31 citations
Semantic Scholar
Microperimetry as an Outcome Measure in RPGR-associated Retinitis Pigmentosa Clinical Trials
Laura J. Taylor, A. Josan, J. Jolly, R. MacLaren
2023Translational Vision Science & Technology29 citations Open access
Semantic Scholar
Test‐retest repeatability of microperimetry in patients with retinitis pigmentosa caused by mutations in RPGR
T. M. Buckley, J. Jolly, M. Menghini, Laura J Wood +2 more
2020Clinical and Experimental Ophthalmology27 citations Open access
Semantic Scholar
Emerging gene therapy products for RPGR-associated X-linked retinitis pigmentosa
C. Martinez-Fernandez de la Camara, Jasmina Cehajic-Kapetanovic, R. MacLaren
2022Expert Opinion on Emerging Drugs26 citations Open access
Semantic Scholar
Clinical applications of microperimetry in RPGR‐related retinitis pigmentosa: a review
T. M. Buckley, J. Jolly, A. Josan, Laura J Wood +2 more
2021Acta ophthalmologica26 citations Open access
Semantic Scholar
CRISPR Interference–Potential Application in Retinal Disease
Caroline F Peddle, L. Fry, M. McClements, R. MacLaren
2020International Journal of Molecular Sciences26 citations Open access
Semantic Scholar
Repair of Retinal Degeneration following Ex Vivo Minicircle DNA Gene Therapy and Transplantation of Corrected Photoreceptor Progenitors.
Alona Barnea-Cramer, Mandeep S. Singh, D. Fischer, S. D. De Silva +3 more
2020Molecular Therapy25 citations Open access
Semantic Scholar
Highest reported visual acuity after electronic retinal implantation
Jasmina Cehajic Kapetanovic, Nicole Troelenberg, T. L. Edwards, Kan-Min Xue +4 more
2020Acta ophthalmologica24 citations Open access
Semantic Scholar
Future Perspectives of Prime Editing for the Treatment of Inherited Retinal Diseases
Silja Hansen, M. McClements, T. Corydon, R. MacLaren
2023Cells23 citations Open access
Semantic Scholar
ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration
M. Gilhooley, Doron G. Hickey, M. Lindner, T. Palumaa +4 more
2021Experimental Eye Research23 citations Open access
Semantic Scholar
RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the Notch intracellular domain
E. Bridges, H. Sheldon, E. Kleibeuker, Evelyn Ramberger +7 more
2020Angiogenesis23 citations Open access
Semantic Scholar
Association of Clinical and Genetic Heterogeneity With BEST1 Sequence Variations.
Mital Shah, S. Broadgate, M. Shanks, P. Clouston +5 more
2020JAMA ophthalmology23 citations Open access
Semantic Scholar
Current and Future Landscape in Genetic Therapies for Leber Hereditary Optic Neuropathy
Hoda Shamsnajafabadi, R. MacLaren, Jasmina Cehajic-Kapetanovic
2023Cells22 citations Open access
Semantic Scholar
Accurate Quantification of AAV Vector Genomes by Quantitative PCR
C. Martinez-Fernandez de la Camara, M. McClements, R. MacLaren
2021Genes20 citations Open access
Semantic Scholar
Microperimetry Reliability Assessed From Fixation Performance
A. Josan, Isabella Farrance, Laura J. Taylor, Daniel Adeyoju +3 more
2023Translational Vision Science & Technology19 citations Open access
Semantic Scholar
AAV Induced Expression of Human Rod and Cone Opsin in Bipolar Cells of a Mouse Model of Retinal Degeneration
M. McClements, Federica Staurenghi, Meike Visel, J. Flannery +2 more
2021BioMed Research International19 citations Open access
Semantic Scholar
CRISPR Systems Suitable for Single AAV Vector Delivery.
M. Stevanovic, E. Piotter, M. McClements, R. MacLaren
2021Current Gene Therapy18 citations
Semantic Scholar
Early Cone Photoreceptor Outer Segment Length Shortening in RPGR X-Linked Retinitis Pigmentosa
M. Menghini, J. Jolly, A. Nanda, Laura J Wood +2 more
2020Ophthalmologica18 citations
Semantic Scholar
Programmable RNA editing with endogenous ADAR enzymes – a feasible option for the treatment of inherited retinal disease?
Julia-Sophia Bellingrath, M. McClements, M. D. Fischer, R. MacLaren
2023Frontiers in Molecular Neuroscience17 citations Open access
Semantic Scholar
Chimeric human opsins as optogenetic light sensitisers
Doron G. Hickey, W. Davies, S. Hughes, J. Rodgers +3 more
2021Journal of Experimental Biology16 citations Open access
Semantic Scholar
CRISPR genome engineering for retinal diseases.
Ariel Kantor, M. McClements, Caroline F Peddle, L. Fry +4 more
2021Progress in Molecular Biology and Translational Science16 citations
Semantic Scholar
Association of a Novel Intronic Variant in RPGR With Hypomorphic Phenotype of X-Linked Retinitis Pigmentosa.
Jasmina Cehajic-Kapetanovic, M. McClements, Jennifer Whitfield, M. Shanks +2 more
2020JAMA ophthalmology16 citations Open access
Semantic Scholar
Characterizing Visual Fields in RPGR Related Retinitis Pigmentosa Using Octopus Static-Automated Perimetry
T. M. Buckley, A. Josan, Laura J. Taylor, J. Jolly +2 more
2022Translational Vision Science & Technology15 citations Open access
Semantic Scholar
CRISPR DNA Base Editing Strategies for Treating Retinitis Pigmentosa Caused by Mutations in Rhodopsin
Maria Kaukonen, M. McClements, R. MacLaren
2022Genes14 citations Open access
Semantic Scholar
EFFICACY OF HALF-DOSE PHOTODYNAMIC THERAPY VERSUS HIGH-DENSITY SUBTHRESHOLD MICROPULSE LASER FOR TREATING PIGMENT EPITHELIAL DETACHMENTS IN CHRONIC CENTRAL SEROUS CHORIORETINOPATHY
H. M. Feenstra, Leo C. Hahn, T. V. van Rijssen, R. Tsonaka +12 more
2021Retina14 citations Open access
Semantic Scholar
Low-contrast visual acuity versus low-luminance visual acuity in choroideremia.
Laura J Wood, J. Jolly, Colm D Andrews, I. Wilson +3 more
2020Clinical and experimental optometry14 citations Open access
Semantic Scholar

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