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C. Keenan · SciRah

Researcher profile · Semantic Scholar

C. Keenan

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C. Keenan — researcher profile on SciRah

h-index: 26
Works: 65
Citations: 2,459

Most-cited papers

Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia
F. Vicentini, C. Keenan, L. Wallace, Crystal Woods +6 more
2020Microbiome287 citations Open access
Semantic Scholar
Intestinal fungi are causally implicated in microbiome assembly and immune development in mice
E. van Tilburg Bernardes, Veronika Kuchařová Pettersen, M. Gutierrez, I. Laforest-Lapointe +12 more
2020Nature Communications219 citations Open access
Semantic Scholar
Activation of the Cannabinoid 2 Receptor (CB2) Protects Against Experimental Colitis
M. Storr, C. Keenan, Hong Zhang, K. Patel +2 more
2009Inflammatory Bowel Diseases184 citations Open access
Semantic Scholar
Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors
M. Storr, C. Keenan, D. Emmerdinger, Hong Zhang +9 more
2008Journal of molecular medicine180 citations
Semantic Scholar
Cannabinoid CB2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats.
M. Duncan, A. Mouihate, K. Mackie, C. Keenan +5 more
2008American Journal of Physiology - Gastrointestinal and Liver Physiology144 citations Open access
Semantic Scholar
Role of enteric glia in intestinal physiology: effects of the gliotoxin fluorocitrate on motor and secretory function.
Y. Nasser, E. Fernández, C. Keenan, W. Ho +6 more
2006American Journal of Physiology - Gastrointestinal and Liver Physiology135 citations
Semantic Scholar
Protective Actions of Epithelial 5-hydroxytryptamine 4 Receptors in Normal and Inflamed Colon
Stephanie N. Spohn, F. Bianco, R. Scott, C. Keenan +10 more
2016Gastroenterology117 citations Open access
Semantic Scholar
Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with Δ9-Tetrahydrocannabinol
N. Cluny, C. Keenan, R. Reimer, B. Le Foll +1 more
2015PLoS ONE113 citations Open access
Semantic Scholar
A monocyte–leptin–angiogenesis pathway critical for repair post-infection
Rachel M. Kratofil, Hanjoo B Shim, Raymond Shim, Woo-Yong Lee +11 more
2022Nature97 citations
Semantic Scholar
Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves.
W. MacNaughton, Marja D. Van Sickle, C. Keenan, Kelly C. Cushing +2 more
2004American Journal of Physiology - Gastrointestinal and Liver Physiology69 citations
Semantic Scholar
Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet‐induced obese rats
N. Cluny, Lindsay K. Eller, C. Keenan, Raylene A. Reimer +1 more
2015Obesity66 citations Open access
Semantic Scholar
Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice with Colitis
S. MacEachern, B. Patel, C. Keenan, M. Dicay +6 more
2015Gastroenterology65 citations Open access
Semantic Scholar
Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation.
P. Beck, Yan Li, J. Wong, Changjiang Chen +3 more
2007Gastroenterology64 citations Open access
Semantic Scholar
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a Peripherally Restricted Cannabinoid CB1/CB2 Receptor Agonist, Inhibits Gastrointestinal Motility but Has No Effect on Experimental Colitis in Mice
N. Cluny, C. Keenan, M. Duncan, Alyson J. Fox +2 more
2010Journal of Pharmacology and Experimental Therapeutics60 citations
Semantic Scholar
Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy
P. Vaananen, C. Keenan, M. Grisham, J. Wallace
1992Inflammation48 citations
Semantic Scholar
On the suppression of food intake in experimental models of colitis in the rat.
Kevin McHugh, Harvey P. Weingarten, C. Keenan, John L. Wallace +1 more
1993American Journal of Physiology47 citations
Semantic Scholar
Expression of a functional metabotropic glutamate receptor 5 on enteric glia is altered in states of inflammation
Y. Nasser, C. Keenan, Adrienne C. Ma, D. McCafferty +1 more
2007Glia45 citations
Semantic Scholar
Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes
M. A. Windsor, D. Hermanson, Philip J. Kingsley, Shu Xu +6 more
2012ACS Medicinal Chemistry Letters38 citations Open access
Semantic Scholar
Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro.
M. Buresi, N. Vergnolle, K. Sharkey, C. Keenan +5 more
2005American Journal of Physiology - Gastrointestinal and Liver Physiology38 citations
Semantic Scholar
Alterations in melatonin and 5‐HT signalling in the colonic mucosa of mice with dextran‐sodium sulfate‐induced colitis
S. MacEachern, C. Keenan, Evangelia Papakonstantinou, K. Sharkey +1 more
2018British Journal of Pharmacology33 citations Open access
Semantic Scholar
AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner
C. Keenan, M. Storr, G. Thakur, J. Wood +9 more
2015British Journal of Pharmacology32 citations Open access
Semantic Scholar
Immediate-Early Gene Expression in the Inferior Mesenteric Ganglion and Colonic Myenteric Plexus of the Guinea Pig
K. Sharkey, E. J. Parr, C. Keenan
1999Journal of Neuroscience31 citations Open access
Semantic Scholar
Endogenous prion protein attenuates experimentally induced colitis.
G. Martin, C. Keenan, K. Sharkey, F. Jirik
2011American Journal of Pathology29 citations Open access
Semantic Scholar
The expression and role of Fas ligand in intestinal inflammation
F. Sayani, C. Keenan, M. D. Van Sickle, K. Amundson +5 more
2004Neurogastroenterology and Motility29 citations
Semantic Scholar
Endocannabinoid regulation of homeostatic feeding and stress‐induced alterations in food intake in male rats
Martin A Sticht, David Lau, C. Keenan, Jean-Baptiste Cavin +6 more
2018British Journal of Pharmacology27 citations Open access
Semantic Scholar
Prostaglandin E2 activation of VIP secretomotor neurons in the guinea pig ileum.
J. Dekkers, A. Kroese, C. Keenan, W. MacNaughton +1 more
1997Journal of the Autonomic Nervous System26 citations Open access
Semantic Scholar
Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase
Haley A. Vecchiarelli, M. Morena, C. Keenan, Vincent Chiang +7 more
2021Neuropsychopharmacology25 citations Open access
Semantic Scholar
The expression levels of cellular prion protein affect copper isotopic shifts in the organs of mice
K. Miller, C. Keenan, G. Martin, F. Jirik +2 more
201623 citations
Semantic Scholar
Differential adipokine response in genetically predisposed lean and obese rats during inflammation: a role in modulating experimental colitis?
N. Hyland, A. P. Chambers, C. Keenan, Q. Pittman +1 more
2009American Journal of Physiology - Gastrointestinal and Liver Physiology23 citations
Semantic Scholar
Eicosanoid interactions in the canine proximal colon.
C. Keenan, P. K. Rangachari
1989American Journal of Physiology22 citations
Semantic Scholar
Contrasting effects of PGE2 and PGD2: ion transport in the canine proximal colon.
C. Keenan, P. K. Rangachari
1991American Journal of Physiology19 citations
Semantic Scholar
The Modulation of Gastric Mucosal Integrity by Endothelin‐1 and Prostacyclin
W. MacNaughton, C. Keenan, G. Mcknight, J. Wallace
1989Journal of Cardiovascular Pharmacology17 citations Open access
Semantic Scholar
Role of CB1 receptors in the acute regulation of small intestinal permeability: Effects of high-fat diet.
Hailey Cuddihey, Jean-Baptiste Cavin, C. Keenan, L. Wallace +4 more
2022American Journal of Physiology - Gastrointestinal and Liver Physiology16 citations Open access
Semantic Scholar
Leukotriene B4 potentiates colonic ulceration in the rat
J. Wallace, C. Keenan
1990Digestive Diseases and Sciences15 citations
Semantic Scholar
Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists.
Shan Jiang, Christos Iliopoulos-Tsoutsouvas, Fei Tong, Christina A. Brust +14 more
2021Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
Mechanisms underlying the protective effects of interleukin-1 in experimental NSAID-gastropathy.
J. Wallace, C. Keenan, M. Cucala, K. Mugridge +1 more
199214 citations
Semantic Scholar
T cells regulate intestinal motility and shape enteric neuronal responses to intestinal microbiota
Patricia Rodrigues Marques de Souza, C. Keenan, Laurie E. Wallace, Y. Habibyan +5 more
2024bioRxiv12 citations Open access
Semantic Scholar
Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse.
Crystal Woods, A. Flockton, L. Wallace, C. Keenan +3 more
2022American Journal of Physiology - Gastrointestinal and Liver Physiology8 citations
Semantic Scholar
Genetic Variants of Fatty Acid Amide Hydrolase Modulate Acute Inflammatory Responses to Colitis in Adult Male Mice
Haley A. Vecchiarelli, Robert J. Aukema, C. Hume, Vincent Chiang +7 more
2021Frontiers in Cellular Neuroscience6 citations Open access
Semantic Scholar
Microbial dysbiosis alters serotonin signaling in a post-inflammatory murine model of visceral pain
T. Roth, L. Russo-Savage, Yasaman Bahojb Habibyan, C. Keenan +5 more
2025American Journal of Physiology - Gastrointestinal and Liver Physiology3 citations Open access
Semantic Scholar
Interleukin-1B (IL-1B) stimulates fos expression in specific subsets of enteric neurons through a cyclooxygenase-dependent pathway
Joe M P Bradley, E. Tjwa, C. Keenan, A. Kroese +1 more
20003 citations
Semantic Scholar
Responses of the colonic epithelium to auranofin: evidence for involvement of enteric nerves.
A. de Beaux, C. Keenan, K. Tytgat, P. K. Rangachari
1990Journal of Rheumatology3 citations
Semantic Scholar
The gut microbiota is a determinant of sexual dimorphism in ALS-linked TDP43 mice
Evandro J. Beraldi, Sukyoung Lee, Yu-Lan Jiang, Isabel M. Rea +11 more
2024bioRxiv2 citations Open access
Semantic Scholar
Alterations in melatonin and serotonin signalling in the colonic mucosa of mice with dextran-sodium sulfate-induced colitis
S. MacEachern, C. Keenan, Evangelia Papakonstantinou, A. Keith +3 more
20182 citations
Semantic Scholar
Cannabinoid CB1 receptor distribution and function in neurally mediated chloride secretion in the guinea pig ileum
W. MacNaughton, Kelly C. Cushing, Marja D. Van Sickle, C. Keenan +2 more
20032 citations Open access
Semantic Scholar
Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia 1 2
F. Vicentini, C. Keenan, Laurie E. Wallace, Crystal Woods +4 more
20201 citations
Semantic Scholar
Contribution of fungal microbiome to intestinal physiology, early-life immune development and mucosal inflammation in mice
E. van Tilburg Bernardes, Veronika Kuchařová Pettersen, M. Gutierrez, I. Laforest-Lapointe +12 more
2019bioRxiv1 citations Open access
Semantic Scholar
N-Acylphosphatidylethanolamines as Novel Regulators of Gastrointestinal Motility in the Mouse
M. Bashashati, Huang-Ming Hu, C. Keenan, B. Cravatt +1 more
20111 citations
Semantic Scholar
W1697 Regional Specificity of Fatty Acid Amide Hydrolase (FAAH) Inhibition On Contractility in the Mouse Intestine: Endotoxin Upregulation of Faah Sensitivity in the Ileum
M. Storr, M. Bashashati, K. Vemuri, Shakiru O. Alapafuja +6 more
20091 citations
Semantic Scholar
A58 ALTERATIONS IN INTESTINAL MOTILITY AND BARRIER FUNCTION AFTER ANTIBIOTIC TREATMENT IN MALE AND FEMALE MICE: THE ROLE OF ENTERIC GLIA
F. Vicentini, S. Paul, C. Keenan, S. Hirota +1 more
2019Journal of the Canadian Association of Gastroenterology0 citations Open access
Semantic Scholar

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