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Y. Shirasaka · SciRah

Researcher profile · Semantic Scholar

Y. Shirasaka

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Y. Shirasaka — researcher profile on SciRah

h-index: 32
Works: 117
Citations: 3,047

Most-cited papers

The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans
Junko Imanaga, T. Kotegawa, Hiromitsu Imai, K. Tsutsumi +6 more
2011Pharmacogenetics & Genomics172 citations
Semantic Scholar
Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions
Y. Shirasaka, J. Sager, J. Lutz, C. Davis +1 more
2013Drug Metabolism And Disposition124 citations Open access
Semantic Scholar
Species Difference in the Effect of Grapefruit Juice on Intestinal Absorption of Talinolol between Human and Rat
Y. Shirasaka, Erika Kuraoka, H. Spahn-Langguth, T. Nakanishi +2 more
2010Journal of Pharmacology and Experimental Therapeutics121 citations
Semantic Scholar
3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents.
S. Konno, Kiyotaka Kobayashi, M. Senda, Y. Funai +17 more
2021Journal of Medicinal Chemistry110 citations
Semantic Scholar
Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption.
Toshimichi Nakamura, T. Nakanishi, Tsunemitsu Haruta, Y. Shirasaka +2 more
2010Molecular Pharmaceutics108 citations
Semantic Scholar
Model Analysis of the Concentration-Dependent Permeability of P-gp Substrates
Tatsuhiko Tachibana, S. Kitamura, Motohiro Kato, Tetsuya Mitsui +3 more
2010Pharmaceutical Research97 citations
Semantic Scholar
Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human.
Masanobu Sato, H. Mamada, N. Anzai, Y. Shirasaka +2 more
2010Biological and Pharmaceutical Bulletin89 citations Open access
Semantic Scholar
Concentration-Dependent Effect of Naringin on Intestinal Absorption of β1-Adrenoceptor Antagonist Talinolol Mediated by P-Glycoprotein and Organic Anion Transporting Polypeptide (Oatp)
Y. Shirasaka, Yan Li, Yuta Shibue, Erika Kuraoka +4 more
2009Pharmaceutical Research86 citations
Semantic Scholar
Intestinal Absorption of HMG-CoA Reductase Inhibitor Pravastatin Mediated by Organic Anion Transporting Polypeptide
Y. Shirasaka, Kensuke Suzuki, T. Nakanishi, I. Tamai
2010Pharmaceutical Research82 citations
Semantic Scholar
Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport.
Kazuhiko Kato, Y. Shirasaka, Erika Kuraoka, A. Kikuchi +5 more
2010Molecular Pharmaceutics79 citations
Semantic Scholar
Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1.
Y. Shirasaka, Kensuke Suzuki, Megumi Shichiri, T. Nakanishi +1 more
2011Drug Metabolism and Pharmacokinetics71 citations
Semantic Scholar
Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content
Y. Shirasaka, Amarjit S. Chaudhry, M. McDonald, Bhagwat Prasad +9 more
2015The Pharmacogenomics Journal70 citations Open access
Semantic Scholar
Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.
Y. Shirasaka, Megumi Shichiri, Takanori Mori, T. Nakanishi +1 more
2013Journal of Pharmacy and Science66 citations
Semantic Scholar
Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein.
Y. Shirasaka, Kensuke Suzuki, T. Nakanishi, I. Tamai
2011Journal of Pharmacy and Science64 citations Open access
Semantic Scholar
Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites.
Y. Shirasaka, Takanori Mori, Megumi Shichiri, T. Nakanishi +1 more
2012Drug Metabolism and Pharmacokinetics61 citations
Semantic Scholar
Long-Lasting Inhibitory Effect of Apple and Orange Juices, but Not Grapefruit Juice, on OATP2B1-Mediated Drug Absorption
Y. Shirasaka, Megumi Shichiri, Yukiko Murata, Takanori Mori +2 more
2013Drug Metabolism And Disposition55 citations
Semantic Scholar
Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.
Y. Shirasaka, Megumi Shichiri, Takanori Mori, T. Nakanishi +1 more
2013Journal of Pharmacy and Science55 citations
Semantic Scholar
Substrate- and Dose-Dependent Drug Interactions with Grapefruit Juice Caused by Multiple Binding Sites on OATP2B1
Y. Shirasaka, Takanori Mori, Yukiko Murata, T. Nakanishi +1 more
2014Pharmaceutical Research51 citations
Semantic Scholar
Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5
H. Arakawa, Y. Shirasaka, M. Haga, T. Nakanishi +1 more
2012Biopharmaceutics & drug disposition49 citations Open access
Semantic Scholar
Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins
Jia-Xue Yin, Haichuan Duan, Y. Shirasaka, B. Prasad +1 more
2015Drug Metabolism And Disposition48 citations Open access
Semantic Scholar
Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake.
Toshimichi Nakamura, Ryohei Fujiwara, N. Ishiguro, Masanobu Oyabu +4 more
2010Biological and Pharmaceutical Bulletin47 citations Open access
Semantic Scholar
Physiologically Based Pharmacokinetic Model of All-trans-Retinoic Acid with Application to Cancer Populations and Drug Interactions
J. Jing, C. Nelson, Jisun Paik, Y. Shirasaka +2 more
2017Journal of Pharmacology and Experimental Therapeutics43 citations Open access
Semantic Scholar
Organic Cation Transporter-Mediated Renal Secretion of Ipratropium and Tiotropium in Rats and Humans
T. Nakanishi, Tsunemitsu Haruta, Y. Shirasaka, I. Tamai
2011Drug Metabolism And Disposition38 citations
Semantic Scholar
Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats.
Masanobu Sato, T. Wakayama, H. Mamada, Y. Shirasaka +2 more
2011Biochimica et Biophysica Acta38 citations Open access
Semantic Scholar
SLC46A3 is a lysosomal proton-coupled steroid conjugate and bile acid transporter involved in transport of active catabolites of T-DM1
R. Tomabechi, Hisanao Kishimoto, Taeka Sato, Naoki Saito +5 more
2022PNAS Nexus35 citations Open access
Semantic Scholar
Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes
T. Nakanishi, Yuta Shibue, Yoko Fukuyama, K. Yoshida +3 more
2011Drug Metabolism And Disposition35 citations
Semantic Scholar
Effect of CYP3A5 Expression on the Inhibition of CYP3A-Catalyzed Drug Metabolism: Impact on Modeling CYP3A-Mediated Drug-Drug Interactions
Y. Shirasaka, Shu-Ying Chang, M. Grubb, Chi-Chi Peng +3 more
2013Drug Metabolism And Disposition32 citations Open access
Semantic Scholar
Food effects on gastrointestinal physiology and drug absorption.
A. Kambayashi, Y. Shirasaka
2022Drug Metabolism and Pharmacokinetics31 citations Open access
Semantic Scholar
Involvement of organic cation transporter 3 (Oct3/Slc22a3) in the bioavailability and pharmacokinetics of antidiabetic metformin in mice
Y. Shirasaka, Nora Lee, Wei-bin Zha, D. J. Wagner +1 more
2016Drug Metabolism and Pharmacokinetics31 citations Open access
Semantic Scholar
The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles
Amarjit S. Chaudhry, B. Prasad, Y. Shirasaka, Alison E. Fohner +8 more
2015Drug Metabolism And Disposition30 citations Open access
Semantic Scholar
Organic anion transporter OAT1 is involved in renal handling of citrulline.
Masanori Nakakariya, Yoichiro Shima, Y. Shirasaka, Keisuke Mitsuoka +2 more
2009AJP - Renal Physiology29 citations
Semantic Scholar
Multiple Transport Mechanisms Involved in the Intestinal Absorption of Metformin: Impact on the Nonlinear Absorption Kinetics: Contribution of Transporters to Metformin Absorption.
Y. Shirasaka, Maria Seki, Marie Hatakeyama, Y. Kurokawa +7 more
2022Journal of Pharmacy and Science27 citations Open access
Semantic Scholar
Osmolality of Orally Administered Solutions Influences Luminal Water Volume and Drug Absorption in Intestine.
Kazuki Ichijo, Rika Oda, Marika Ishihara, R. Okada +6 more
2017Journal of Pharmacy and Science26 citations Open access
Semantic Scholar
Mucins are Involved in the Intestinal Permeation of Lipophilic Drugs in the Proximal Region of Rat Small Intestine
Kaori Miyazaki, Hisanao Kishimoto, Miho Muratani, Hanai Kobayashi +2 more
2019Pharmaceutical Research24 citations
Semantic Scholar
Transport characteristics of L‐citrulline in renal apical membrane of proximal tubular cells
Keisuke Mitsuoka, Y. Shirasaka, A. Fukushi, Masanobu Sato +3 more
2009Biopharmaceutics & drug disposition23 citations
Semantic Scholar
Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats
Y. Funai, Y. Shirasaka, Marika Ishihara, Miyuki Takemura +3 more
2019Drug Metabolism And Disposition22 citations
Semantic Scholar
A role of prostaglandin transporter in regulating PGE₂ release from human bronchial epithelial BEAS-2B cells in response to LPS.
Y. Shirasaka, Megumi Shichiri, Taku Kasai, Y. Ohno +4 more
2013Journal of Endocrinology22 citations Open access
Semantic Scholar
Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture.
T. Nakanishi, A. Fukushi, Masanobu Sato, M. Yoshifuji +6 more
2011Molecular Pharmaceutics21 citations
Semantic Scholar
Functional characterization of monocarboxylate transporter 12 (SLC16A12/MCT12) as a facilitative creatine transporter.
Masaki Takahashi, Hisanao Kishimoto, Y. Shirasaka, Katsuhisa Inoue
2020Drug Metabolism and Pharmacokinetics18 citations
Semantic Scholar
Interspecies comparison of the functional characteristics of plasma membrane monoamine transporter (PMAT) between human, rat and mouse
Y. Shirasaka, Nora Lee, Haichuan Duan, Horace T. B. Ho +2 more
2016Journal of Chemical Neuroanatomy18 citations Open access
Semantic Scholar
MDR1 is Related to Intestinal Epithelial Injury Induced by Acetylsalicylic Acid
Munehiro Kugai, K. Uchiyama, Toshifumi Tsuji, Hiroyuki Yoriki +16 more
2013Cellular Physiology and Biochemistry16 citations Open access
Semantic Scholar
Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα.
Shinya Usui, Qiunan Zhu, Hisakazu Komori, Yui Iwamoto +3 more
2023Drug Metabolism and Pharmacokinetics14 citations Open access
Semantic Scholar
Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion
H. Arakawa, Y. Nakazono, Natsumi Matsuoka, Momoka Hayashi +3 more
2023Communications Biology14 citations Open access
Semantic Scholar
Carboxyl group-terminated polyamidoamine dendrimers bearing glucosides inhibit intestinal hexose transporter-mediated D-glucose uptake.
S. Sakuma, Y. Teraoka, T. Sagawa, Y. Masaoka +7 more
2010European journal of pharmaceutics and biopharmaceutics13 citations
Semantic Scholar
Effect of Ingested Fluid Volume and Solution Osmolality on Intestinal Drug Absorption: Impact on Drug Interaction with Beverages.
Y. Funai, Miyuki Takemura, Katsuhisa Inoue, Y. Shirasaka
2022European Journal of Pharmaceutical Sciences12 citations Open access
Semantic Scholar
The Glycosylated N-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane
Kaori Miyazaki, Hisanao Kishimoto, Hanai Kobayashi, A. Suzuki +3 more
2022Molecular Pharmacology12 citations Open access
Semantic Scholar
Functional identification of soluble uric acid as an endogenous inhibitor of CD38
Shijie Wen, H. Arakawa, S. Yokoyama, Y. Shirasaka +2 more
2024bioRxiv11 citations Open access
Semantic Scholar
Estimation of Michaelis-Menten constant of efflux transporter considering asymmetric permeability.
K. Sugano, Y. Shirasaka, S. Yamashita
2011International journal of pharmaceutics11 citations
Semantic Scholar
Absorption-Enhancing Effect of Nitric Oxide on the Absorption of Hydrophobic Drugs in Rat Duodenum.
Hisanao Kishimoto, Kaori Miyazaki, Yusuke Takizawa, Y. Shirasaka +1 more
2016Journal of Pharmacy and Science10 citations Open access
Semantic Scholar
Carnitine precursor γ-butyrobetaine is a novel substrate of the Na(+)- and Cl(-)-dependent GABA transporter Gat2.
T. Nakanishi, Yoko Fukuyama, Masaharu Fujita, Y. Shirasaka +1 more
2011Drug Metabolism and Pharmacokinetics9 citations
Semantic Scholar

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I. Tamai×30
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I. Tamai — researcher profile on SciRah
T. Nakanishi×21
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T. Nakanishi — researcher profile on SciRah
Katsuhisa Inoue×9
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Katsuhisa Inoue — researcher profile on SciRah
Hisanao Kishimoto×8
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Hisanao Kishimoto — researcher profile on SciRah

Megumi Shichiri

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Megumi Shichiri — researcher profile on SciRah

Takanori Mori×5

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Takanori Mori — researcher profile on SciRah

N. Isoherranen×4

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Y. Funai — researcher profile on SciRah

Masanobu Sato×4

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Masanobu Sato — researcher profile on SciRah

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Erika Kuraoka×3

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Toshimichi Nakamura×3

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Toshimichi Nakamura — researcher profile on SciRah