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H. Heijnen · SciRah

Researcher profile · Semantic Scholar

H. Heijnen

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H. Heijnen — researcher profile on SciRah

h-index: 39
Works: 86
Citations: 9,196

Most-cited papers

Exosome: from internal vesicle of the multivesicular body to intercellular signaling device.
K. Denzer, M. Kleijmeer, H. Heijnen, W. Stoorvogel +1 more
2000Journal of Cell Science1,089 citations
Semantic Scholar
Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules.
H. Heijnen, Anja Schiel, R. Fijnheer, H. Geuze +1 more
1999Blood1,059 citations
Semantic Scholar
Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules
H. Heijnen, A. Schiel, R. Fijnheer, H. Geuze +1 more
1999708 citations
Semantic Scholar
PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time.
S. Kooijmans, L. A. L. Fliervoet, R. van der Meel, M. Fens +4 more
2016Journal of Controlled Release577 citations Open access
Semantic Scholar
Recycling Compartments and the Internal Vesicles of Multivesicular Bodies Harbor Most of the Cholesterol Found in the Endocytic Pathway
Wiebke Möbius, E. V. van Donselaar, Y. Ohno-Iwashita, Y. Shimada +3 more
2003Traffic : the International Journal of Intracellular Transport463 citations
Semantic Scholar
Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress.
A. Reininger, H. Heijnen, H. Schumann, H. Specht +2 more
2006Blood358 citations Open access
Semantic Scholar
Immunoelectron Microscopic Localization of Cholesterol Using Biotinylated and Non-cytolytic Perfringolysin O
Wiebke Möbius, Y. Ohno-Iwashita, E. V. van Donselaar, V. Oorschot +5 more
2002Journal of Histochemistry and Cytochemistry296 citations Open access
Semantic Scholar
Proteomic analysis of platelet α‐granules using mass spectrometry
D. Maynard, H. Heijnen, M. K. Horne, James G. White +1 more
2007284 citations Open access
Semantic Scholar
Identification of S-nitrosylation motifs by site-specific mapping of the S-nitrosocysteine proteome in human vascular smooth muscle cells.
T. Greco, R. Hodara, I. Parastatidis, H. Heijnen +3 more
2006Proceedings of the National Academy of Sciences of the United States of America257 citations
Semantic Scholar
Lysosome-related organelles: Unusual compartments become mainstream
M. Marks, H. Heijnen, G. Raposo
2013Current Opinion in Cell Biology256 citations Open access
Semantic Scholar
Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin).
E. U. M. Saelman, H. Nieuwenhuis, K. M. Hese, P. D. de Groot +6 more
1994Blood256 citations
Semantic Scholar
Selective binding of perfringolysin O derivative to cholesterol-rich membrane microdomains (rafts)
A. Waheed, Y. Shimada, H. Heijnen, Megumi Nakamura +5 more
2001Proceedings of the National Academy of Sciences of the United States of America229 citations Open access
Semantic Scholar
Platelet secretory behaviour: as diverse as the granules … or not?
H. Heijnen, P. van der Sluijs
2015Journal of Thrombosis and Haemostasis226 citations Open access
Semantic Scholar
Multivesicular Bodies Are an Intermediate Stage in the Formation of Platelet α-Granules
H. Heijnen, N. Debili, W. Vainchencker, J. Breton-Gorius +2 more
1998213 citations Open access
Semantic Scholar
Increased platelet deposition on atherosclerotic coronary arteries.
G. H. van Zanten, S. de Graaf, Pieter J. Slootweg, H. Heijnen +3 more
1994Journal of Clinical Investigation193 citations Open access
Semantic Scholar
The platelet interior revisited: electron tomography reveals tubular alpha-granule subtypes.
H. E. van Nispen Tot Pannerden, F. De Haas, W. Geerts, G. Posthuma +2 more
2010Blood174 citations Open access
Semantic Scholar
Multivesicular bodies are an intermediate stage in the formation of platelet alpha-granules.
H. Heijnen, N. Debili, W. Vainchencker, J. Breton-Gorius +2 more
1998Blood163 citations
Semantic Scholar
Proteomic analysis of platelet alpha-granules using mass spectrometry.
D. Maynard, H. Heijnen, M. Horne, J. White +1 more
2007Journal of Thrombosis and Haemostasis160 citations
Semantic Scholar
Extracellular superoxide dismutase and oxidant damage in osteoarthritis.
E. Regan, J. Flannelly, R. Bowler, K. Tran +6 more
2005Arthritis & Rheumatism158 citations Open access
Semantic Scholar
Biogenesis of the demarcation membrane system (DMS) in megakaryocytes.
A. Eckly, H. Heijnen, Fabien Pertuy, W. Geerts +5 more
2014Blood143 citations Open access
Semantic Scholar
Polyphosphate nanoparticles on the platelet surface trigger contact system activation.
J. Verhoef, A. Barendrecht, Katrin F. Nickel, Kim Dijkxhoorn +11 more
2017Blood139 citations Open access
Semantic Scholar
Fibrinogen-coated albumin microcapsules reduce bleeding in severely thrombocytopenic rabbits
M. Levi, P. Friederich, S. Middleton, P. D. de Groot +6 more
1999Nature Medicine124 citations
Semantic Scholar
Plasminogen activator inhibitor-1 released from activated platelets plays a key role in thrombolysis resistance. Studies with thrombi generated in the Chandler loop.
H. A. Stringer, P. V. Van Swieten, H. Heijnen, J. Sixma +1 more
1994Arteriosclerosis and Thrombosis A Journal of Vascular Biology98 citations Open access
Semantic Scholar
Fibrinogen β-Chain Tyrosine Nitration Is a Prothrombotic Risk Factor*
I. Parastatidis, L. Thomson, A. Burke, I. N. Chernysh +9 more
2008Journal of Biological Chemistry92 citations Open access
Semantic Scholar
Thrombin Stimulates Glucose Transport in Human Platelets via the Translocation of the Glucose Transporter GLUT-3 from α-Granules to the Cell Surface
H. Heijnen, V. Oorschot, J. Sixma, J. Slot +1 more
1997Journal of Cell Biology91 citations Open access
Semantic Scholar
The Alpha Granule Proteome: Novel Proteins in Normal and Ghost Granules in Gray Platelet Syndrome
D. Maynard, H. Heijnen, William A. Gahl, M. Gunay-Aygun
2010Journal of Thrombosis and Haemostasis88 citations Open access
Semantic Scholar
Subcellular localization of tyrosine-nitrated proteins is dictated by reactive oxygen species generating enzymes and by proximity to nitric oxide synthase.
H. Heijnen, E. V. van Donselaar, J. Slot, D. Fries +9 more
2006Free Radical Biology & Medicine88 citations
Semantic Scholar
Recombinant factor VIIa restores aggregation of αIIbβ3-deficient platelets via tissue factor–independent fibrin generation
T. Lisman, J. Adelmeijer, H. Heijnen, P. D. de Groot
200476 citations Open access
Semantic Scholar
Platelet adhesion to fibronectin in flow: the importance of von Willebrand factor and glycoprotein Ib.
S. Beumer, H. Heijnen, M. Ijsseldijk, E. Orlando +2 more
1995Blood76 citations
Semantic Scholar
Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway
H. Heijnen, R. van Wijk, Tamara C. Pereboom, Yvonne J. Goos +11 more
2014PLoS Genetics74 citations Open access
Semantic Scholar
Morphology of the hemostatic plug in human skin wounds: transformation of the plug.
J. Wester, J. Sixma, J. Geuze, H. Heijnen
1979Laboratory investigation; a journal of technical methods and pathology72 citations
Semantic Scholar
Concentration of rafts in platelet filopodia correlates with recruitment of c‐Src and CD63 to these domains
H. Heijnen, M. van Lier, S. Waaijenborg, Y. Ohno-Iwashita +6 more
2003Journal of Thrombosis and Haemostasis66 citations Open access
Semantic Scholar
SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models.
Ronghua Meng, Yuhuan Wang, Yu Yao, Zhe Zhang +8 more
2012Blood61 citations Open access
Semantic Scholar
Increased Protein Nitration Burden in the Atherosclerotic Lesions and Plasma of Apolipoprotein A-I–Deficient Mice
I. Parastatidis, L. Thomson, D. Fries, Ryan E. Moore +8 more
2007Circulation Research56 citations Open access
Semantic Scholar
FLow-Induced PRotrusions (FLIPRs): A Platelet-Derived Platform for the Retrieval of Microparticles by Monocytes and Neutrophils
C. Tersteeg, H. Heijnen, A. Eckly, G. Pasterkamp +8 more
2014Circulation Research52 citations Open access
Semantic Scholar
Colocalization of eNOS and the Catalytic Subunit of PKA in Endothelial Cell Junctions: A Clue for Regulated NO Production
H. Heijnen, S. Waaijenborg, J. Crapo, R. Bowler +2 more
2004Journal of Histochemistry and Cytochemistry49 citations Open access
Semantic Scholar
Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy
C. Baaten, F. Moenen, Y. Henskens, F. Swieringa +8 more
2018Haematologica48 citations Open access
Semantic Scholar
Expression of Inducible Nitric-oxide Synthase and Intracellular Protein Tyrosine Nitration in Vascular Smooth Muscle Cells
D. Fries, E. Paxinou, Marios Themistocleous, E. Swanberg +6 more
2003Journal of Biological Chemistry47 citations Open access
Semantic Scholar
A fifty percent reduction of platelet surface glycoprotein Ib does not affect platelet adhesion under flow conditions.
G. H. van Zanten, H. Heijnen, Ya-Ping Wu, Karin M. Schut-Hese +4 more
1998Blood44 citations Open access
Semantic Scholar
Lipid Rafts Facilitate the Interaction of PECAM-1 with the Glycoprotein VI-FcR γ-Chain Complex in Human Platelets*
F. Lee, M. van Lier, I. Relou, Loraine J. Foley +3 more
2006Journal of Biological Chemistry32 citations Open access
Semantic Scholar
Biochemical and immunohistochemical characteristics of CD62 and CD63 monoclonal antibodies
M. Metzelaar, H. Schuurman, H. Heijnen, J. Sixma +1 more
1992Virchows Archiv B Cell Pathology Including Molecular Pathology32 citations
Semantic Scholar
Identification of a 33-Kd protein associated with the alpha-granule membrane (GMP-33) that is expressed on the surface of activated platelets.
M. J. Metzelaar, H. Heijnen, J. Sixma, H. K. Nieuwenhuis
1992Blood31 citations
Semantic Scholar
Platelet protein disulfide isomerase is localized in the dense tubular system and does not become surface expressed after activation.
H. E. van Nispen Tot Pannerden, Suzanne van Dijk, Vivian X. Du, H. Heijnen
2009Blood30 citations
Semantic Scholar
Recombinant factor VIIa restores aggregation of alphaIIbbeta3-deficient platelets via tissue factor-independent fibrin generation.
T. Lisman, J. Adelmeijer, H. Heijnen, P. D. de Groot
2004Blood30 citations
Semantic Scholar
Platelet Adhesion to Collagen Types I Through VI 11 Under Conditions of Stasis and Flow Is Mediated by GPIa / IIa ( a 2 Bl-Integrin )
Edwin, Saelman, H., Karel H. Nieuwenhuis +11 more
200230 citations
Semantic Scholar
Endosome-mediated autophagy
V. Kondylis, H. E. van Nispen Tot Pannerden, Suzanne van Dijk, T. ten Broeke +5 more
2013Autophagy25 citations Open access
Semantic Scholar
Flow cytometric mepacrine fluorescence can be used for the exclusion of platelet dense granule deficiency
I. van Asten, Maaike W Blaauwgeers, L. Granneman, H. Heijnen +11 more
2019Journal of Thrombosis and Haemostasis24 citations Open access
Semantic Scholar
Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP)
Martín Hugo, Alejandra Martinez, M. Trujillo, D. Estrada +9 more
2017Proceedings of the National Academy of Sciences of the United States of America22 citations Open access
Semantic Scholar
Spatial organization of the transforming MHC class II compartment
Hezder E. Nispen Pannerden, W. Geerts, Monique J. Kleijmeer, H. Heijnen
2010Biology of the Cell22 citations Open access
Semantic Scholar
Platelet Morphology and Ultrastructure
H. Heijnen, S. Korporaal
201721 citations Open access
Semantic Scholar

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