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J. Radolf · SciRah

Researcher profile · Semantic Scholar

J. Radolf

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J. Radolf — researcher profile on SciRah

h-index: 85
Works: 305
Citations: 24K

Most-cited papers

Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes
J. Radolf, M. Caimano, Brian Stevenson, Linden T. Hu
2012Nature Reviews Microbiology733 citations Open access
Semantic Scholar
Genomic insights into the Ixodes scapularis tick vector of Lyme disease
Monika Gulia-Nuss, Andrew B. Nuss, Jason M. Meyer, D. Sonenshine +89 more
2016Nature Communications486 citations Open access
Semantic Scholar
Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen
J. Radolf, R. Deka, A. Anand, D. Šmajs +2 more
2016Nature Reviews Microbiology271 citations Open access
Semantic Scholar
Lyme Disease in Humans
J. Radolf, K. Strle, J. Lemieux, F. Strle
2020Current Issues in Molecular Biology146 citations Open access
Semantic Scholar
A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy
Arlene C. Seña, Xiao-Hui Zhang, T. Li, He-Ping Zheng +7 more
2015BMC Infectious Diseases141 citations Open access
Semantic Scholar
Stage-Specific Global Alterations in the Transcriptomes of Lyme Disease Spirochetes During Tick Feeding and Following Mammalian Host-Adaptation
R. Iyer, M. Caimano, A. Luthra, David R. Axline +4 more
2014Molecular Microbiology139 citations Open access
Semantic Scholar
Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-β
J. Cervantes, Star M. Dunham-Ems, Carson J. La Vake, Mary M. Petzke +4 more
2011Proceedings of the National Academy of Sciences of the United States of America136 citations Open access
Semantic Scholar
Immune Evasion and Recognition of the Syphilis Spirochete in Blood and Skin of Secondary Syphilis Patients: Two Immunologically Distinct Compartments
A. Cruz, L. Ramírez, Ana V. Zuluaga, A. Pillay +9 more
2012PLoS Neglected Tropical Diseases124 citations Open access
Semantic Scholar
The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue
Michael W. Harman, Star M. Dunham-Ems, M. Caimano, A. Belperron +4 more
2012Proceedings of the National Academy of Sciences of the United States of America114 citations Open access
Semantic Scholar
Borrelia burgdorferi Requires the Alternative Sigma Factor RpoS for Dissemination within the Vector during Tick-to-Mammal Transmission
Star M. Dunham-Ems, M. Caimano, C. H. Eggers, J. Radolf
2012PLoS Pathogens108 citations Open access
Semantic Scholar
The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity
M. Caimano, Ashley M. Groshong, A. Belperron, Jialing Mao +8 more
2019Frontiers in Microbiology91 citations Open access
Semantic Scholar
The Treponema pallidum Outer Membrane
J. Radolf, Sanjiv Kumar
2017Current Topics in Microbiology and Immunology76 citations Open access
Semantic Scholar
Cyclic di-GMP Modulates Gene Expression in Lyme Disease Spirochetes at the Tick-Mammal Interface To Promote Spirochete Survival during the Blood Meal and Tick-to-Mammal Transmission
M. Caimano, Star M. Dunham-Ems, Anna M. Allard, M. Cassera +2 more
2015Infection and Immunity76 citations Open access
Semantic Scholar
CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi
K. Hawley, C. Olson, J. M. Iglesias-Pedraz, N. Navasa +8 more
2012Proceedings of the National Academy of Sciences of the United States of America76 citations Open access
Semantic Scholar
IFNγ Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages
K. Hawley, A. Cruz, Sarah J. Benjamin, Carson J. La Vake +8 more
2017Frontiers in Immunology55 citations Open access
Semantic Scholar
TprC/D (Tp0117/131), a Trimeric, Pore-Forming Rare Outer Membrane Protein of Treponema pallidum, Has a Bipartite Domain Structure
A. Anand, A. Luthra, Star M. Dunham-Ems, M. Caimano +5 more
2012Journal of Bacteriology52 citations Open access
Semantic Scholar
Structural Modeling of the Treponema pallidum Outer Membrane Protein Repertoire: a Road Map for Deconvolution of Syphilis Pathogenesis and Development of a Syphilis Vaccine
K. Hawley, J. M. Montezuma-Rusca, K. Delgado, Navreet Singh +4 more
2021Journal of Bacteriology48 citations Open access
Semantic Scholar
Peptide Uptake Is Essential for Borrelia burgdorferi Viability and Involves Structural and Regulatory Complexity of its Oligopeptide Transporter
Ashley M. Groshong, A. Dey, I. Bezsonova, M. Caimano +1 more
2017mBio46 citations Open access
Semantic Scholar
A suite of PCR-LwCas13a assays for detection and genotyping of Treponema pallidum in clinical samples
Wen-Tao Chen, Hao Luo, Lihong Zeng, Yu-Ying Pan +10 more
2022Nature Communications45 citations Open access
Semantic Scholar
Xenodiagnosis for posttreatment Lyme disease syndrome: resolving the conundrum or adding to it?
L. Bockenstedt, J. Radolf
2014Clinical Infectious Diseases45 citations Open access
Semantic Scholar
Viscous dynamics of Lyme disease and syphilis spirochetes reveal flagellar torque and drag.
Michael W. Harman, Dhruv K. Vig, J. Radolf, C. Wolgemuth
2013Biophysical Journal41 citations Open access
Semantic Scholar
Sequence Variation of Rare Outer Membrane Protein β-Barrel Domains in Clinical Strains Provides Insights into the Evolution of Treponema pallidum subsp. pallidum, the Syphilis Spirochete
Sanjiv Kumar, M. Caimano, A. Anand, A. Dey +10 more
2018mBio39 citations Open access
Semantic Scholar
A Homology Model Reveals Novel Structural Features and an Immunodominant Surface Loop/Opsonic Target in the Treponema pallidum BamA Ortholog TP_0326
A. Luthra, A. Anand, K. Hawley, Morgan LeDoyt +5 more
2015Journal of Bacteriology39 citations Open access
Semantic Scholar
Structural Modeling and Physicochemical Characterization Provide Evidence that P66 Forms a β-Barrel in the Borrelia burgdorferi Outer Membrane
Melisha R. Kenedy, A. Luthra, A. Anand, J. P. Dunn +2 more
2013Journal of Bacteriology38 citations Open access
Semantic Scholar
Syphilis
R. Peeling, D. Mabey, M. Kamb, Xiang-Sheng Chen +2 more
2017Nature Reviews Disease Primers36 citations Open access
Semantic Scholar
Bipartite Topology of Treponema pallidum Repeat Proteins C/D and I
A. Anand, Morgan LeDoyt, Carson Karanian, A. Luthra +5 more
2015Journal of Biological Chemistry34 citations Open access
Semantic Scholar
Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity
N. Ledala, M. Malik, K. Rezaul, S. Paveglio +17 more
2022mBio33 citations Open access
Semantic Scholar
The Major Outer Sheath Protein (Msp) of Treponema denticola Has a Bipartite Domain Architecture and Exists as Periplasmic and Outer Membrane-Spanning Conformers
A. Anand, A. Luthra, Maxwell E. Edmond, Morgan LeDoyt +2 more
2013Journal of Bacteriology33 citations Open access
Semantic Scholar
Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by Borrelia burgdorferi, the Lyme Disease Spirochete
Arianna P. Grove, D. Liveris, R. Iyer, Mary M. Petzke +4 more
2017mBio30 citations Open access
Semantic Scholar
HrpA, an RNA Helicase Involved in RNA Processing, Is Required for Mouse Infectivity and Tick Transmission of the Lyme Disease Spirochete
Aydan Salman-Dilgimen, Pierre-Olivier Hardy, J. Radolf, M. Caimano +1 more
2013PLoS Pathogens30 citations Open access
Semantic Scholar
BosR and PlzA reciprocally regulate RpoS function to sustain Borrelia burgdorferi in ticks and mammals
A. Grassmann, R. Tokarz, Caroline Golino, Melissa A McLain +3 more
2023Journal of Clinical Investigation29 citations Open access
Semantic Scholar
Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis
A. Luthra, J. M. Montezuma-Rusca, Carson J. La Vake, Morgan LeDoyt +6 more
2020PLoS Pathogens25 citations Open access
Semantic Scholar
Analysis of Treponema pallidum strains from China using improved methods for whole-genome sequencing from primary syphilis chancres
Wen-Tao Chen, D. Šmajs, Yong-Fei Hu, Wu-Jian Ke +10 more
2020bioRxiv24 citations Open access
Semantic Scholar
Extracellular Loops of the Treponema pallidum FadL Orthologs TP0856 and TP0858 Elicit IgG Antibodies and IgG+-Specific B-Cells in the Rabbit Model of Experimental Syphilis
K. Delgado, J. M. Montezuma-Rusca, Isabel C. Orbe, M. Caimano +11 more
2022mBio23 citations Open access
Semantic Scholar
The Transition from Closed to Open Conformation of Treponema pallidum Outer Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices*
A. Luthra, Guang-Yu Zhu, Daniel C. Desrosiers, C. H. Eggers +8 more
2011Journal of Biological Chemistry22 citations Open access
Semantic Scholar
Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of Treponema pallidum BamA (TP0326)
Mary R Ferguson, K. Delgado, Shannon McBride, Isabel C. Orbe +9 more
2023bioRxiv20 citations Open access
Semantic Scholar
An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms
Thomas M. Hart, Nicole D. Sonnert, Xiao-Tian Tang, R. Chaurasia +31 more
2024Cell19 citations Open access
Semantic Scholar
Consensus computational network analysis for identifying candidate outer membrane proteins from Borrelia spirochetes
Melisha R. Kenedy, Edgar J. Ii Scott, Binu Shrestha, A. Anand +4 more
2016BMC Microbiology19 citations Open access
Semantic Scholar
Structural characterization and modeling of the Borrelia burgdorferi hybrid histidine kinase Hk1 periplasmic sensor: a system for sensing small molecules associated with tick feeding
William J. Bauer, A. Luthra, Guang-Yu Zhu, J. Radolf +2 more
2015Journal of Structural Biology19 citations Open access
Semantic Scholar
Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation
Sarah J. Benjamin, K. Hawley, P. Vera-Licona, Carson J. La Vake +7 more
2019bioRxiv18 citations Open access
Semantic Scholar
MyD88 Deficiency Markedly Worsens Tissue Inflammation and Bacterial Clearance in Mice Infected with Treponema pallidum, the Agent of Syphilis
Adam C. Silver, Dana W. Dunne, C. Zeiss, L. Bockenstedt +3 more
2013PLoS ONE18 citations Open access
Semantic Scholar
Clinical and genomic diversity of Treponema pallidum subspecies pallidum to inform vaccine research: an international, molecular epidemiology study
Arlene C. Seña, Mitch M Matoga, Li-Gang Yang, E. López-Medina +23 more
2024The Lancet Microbe16 citations Open access
Semantic Scholar
PlzA is a bifunctional c-di-GMP biosensor that promotes tick and mammalian host-adaptation of Borrelia burgdorferi
Ashley M. Groshong, A. Grassmann, A. Luthra, Melissa A McLain +3 more
2021PLoS Pathogens16 citations Open access
Semantic Scholar
Evaluation of the Borrelia burgdorferi BBA64 Protein as a Protective Immunogen in Mice
K. Brandt, Toni G. Patton, A. Allard, M. Caimano +2 more
2014Clinical and Vaccine Immunology16 citations Open access
Semantic Scholar
New Pathways in Syphilis Vaccine Development
Andy Liu, L. Giacani, K. Hawley, Caroline E. Cameron +4 more
2024Sexually Transmitted Diseases15 citations Open access
Semantic Scholar
The major outer sheath protein forms distinct conformers and multimeric complexes in the outer membrane and periplasm of Treponema denticola
Robbins Puthenveetil, Sanjiv Kumar, M. Caimano, A. Dey +3 more
2017Scientific Reports15 citations Open access
Semantic Scholar
Treponema pallidum in Gel Microdroplets: A Method for Topological Analysis of BamA (TP0326) and Localization of Rare Outer Membrane Proteins.
A. Luthra, A. Anand, J. Radolf
2015Methods in molecular biology11 citations
Semantic Scholar
Development and utilization of Treponema pallidum expressing green fluorescent protein to study spirochete-host interactions and antibody-mediated clearance: expanding the toolbox for syphilis research
K. Delgado, Crystal F. Vicente, C. Hennelly, Farhang Aghakhanian +5 more
2024bioRxiv10 citations Open access
Semantic Scholar
High-throughput nanopore sequencing of Treponema pallidum tandem repeat genes arp and tp0470 reveals clade-specific patterns and recapitulates global whole genome phylogeny
N. Lieberman, Thaddeus D Armstrong, B. Chung, Daniel Pfalmer +36 more
2022bioRxiv9 citations Open access
Semantic Scholar
Host-specific functional compartmentalization within the oligopeptide transporter during the Borrelia burgdorferi enzootic cycle
Ashley M. Groshong, Melissa A McLain, J. Radolf
2021PLoS Pathogens9 citations Open access
Semantic Scholar

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M. Caimano×31
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M. Caimano — researcher profile on SciRah
K. Hawley×16
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K. Hawley — researcher profile on SciRah
A. Luthra×14
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A. Luthra — researcher profile on SciRah
J. Salazar×12
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J. Salazar — researcher profile on SciRah

×11

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A. Anand — researcher profile on SciRah

Carson J. La Vake×7

Morgan LeDoyt×7

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Morgan LeDoyt — researcher profile on SciRah

Star M. Dunham-Ems×6

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Star M. Dunham-Ems — researcher profile on SciRah

Arlene C. Seña×5

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Arlene C. Seña — researcher profile on SciRah

J. Cervantes×5

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J. Cervantes — researcher profile on SciRah

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A. Cruz — researcher profile on SciRah

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L. Ramírez — researcher profile on SciRah