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J. Bear · SciRah

Researcher profile · Semantic Scholar

J. Bear

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J. Bear — researcher profile on SciRah

h-index: 50
Works: 140
Citations: 12K

Most-cited papers

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins
Gurkan Guntas, R. Hallett, S. Zimmerman, T. Williams +3 more
2014Proceedings of the National Academy of Sciences of the United States of America605 citations Open access
Semantic Scholar
PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics
Jillian L. Perry, K. Reuter, Marc P. Kai, Kevin P. Herlihy +5 more
2012Nano letters (Print)581 citations Open access
Semantic Scholar
The principles of directed cell migration
Shuvasree SenGupta, C. Parent, J. Bear
2021Nature reviews. Molecular cell biology576 citations Open access
Semantic Scholar
Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles
T. Merkel, Stephen W. Jones, Kevin P. Herlihy, Farrell R. Kersey +8 more
2011Proceedings of the National Academy of Sciences of the United States of America522 citations Open access
Semantic Scholar
Arp2/3 complex is critical for lamellipodia and organization of cell-matrix adhesion but dispensable for fibroblast chemotaxis
Cong-Ying Wu, Sreeja B. Asokan, Matthew E. Berginski, Elizabeth M. Haynes +4 more
2012Cell488 citations Open access
Semantic Scholar
New insights into the regulation and cellular functions of the ARP2/3 complex
Jeremy D. Rotty, Cong-Ying Wu, J. Bear
2012Nature reviews. Molecular cell biology486 citations
Semantic Scholar
Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and –independent pathways
Jeremy D. Rotty, Cong-Ying Wu, Elizabeth M. Haynes, C. Suarez +5 more
2014Developmental Cell264 citations Open access
Semantic Scholar
Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation.
Qi Yang, Stephen W. Jones, Christina L. Parker, W. Zamboni +2 more
2014Molecular Pharmaceutics248 citations
Semantic Scholar
Tumor cell-driven extracellular matrix remodeling drives haptotaxis during metastatic progression
Madeleine J. Oudin, O. Jonas, Tatsiana Kosciuk, Liliane C. Broye +15 more
2016Cancer Discovery181 citations Open access
Semantic Scholar
Unraveling the enigma: Progress towards understanding the Coronin family of actin regulators
K. Chan, S. Creed, J. Bear
2011Trends in Cell Biology179 citations Open access
Semantic Scholar
Nanoparticle clearance is governed by Th1/Th2 immunity and strain background.
Stephen W. Jones, Reid A. Roberts, G. Robbins, Jillian L. Perry +7 more
2013Journal of Clinical Investigation177 citations Open access
Semantic Scholar
Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet
J. Bear, Jason M. Haugh
2014Current Opinion in Cell Biology173 citations Open access
Semantic Scholar
LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma
Wen-Jin Liu, Kimberly B. Monahan, A. Pfefferle, T. Shimamura +11 more
2012Cancer Cell133 citations Open access
Semantic Scholar
Arp2/3 complex is required for macrophage integrin functions but is dispensable for FcR phagocytosis and in vivo motility
Jeremy D. Rotty, Hailey E. Brighton, Stephanie Craig, Sreeja B. Asokan +3 more
2017Developmental Cell120 citations Open access
Semantic Scholar
Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1
A. Freemerman, Liyang Zhao, A. Pingili, B. Teng +19 more
2019Journal of Immunology118 citations Open access
Semantic Scholar
Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction
David M Graham, T. Andersen, Lisa Sharek, G. Uzer +6 more
2018Journal of Cell Biology113 citations Open access
Semantic Scholar
Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation
Hayretin Yumerefendi, D. Dickinson, Hui Wang, S. Zimmerman +4 more
2015PLoS ONE103 citations Open access
Semantic Scholar
F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling
Heath E. Johnson, S. King, Sreeja B. Asokan, Jeremy D. Rotty +2 more
2015Journal of Cell Biology98 citations Open access
Semantic Scholar
Light-induced nuclear export reveals rapid dynamics of epigenetic modifications
Hayretin Yumerefendi, Andrew M Lerner, S. Zimmerman, K. Hahn +3 more
2016Nature Chemical Biology93 citations Open access
Semantic Scholar
Correlating in vitro and in vivo Activities of Light Inducible Dimers: a Cellular Optogenetics Guide
R. Hallett, S. Zimmerman, Hayretin Yumerefendi, J. Bear +1 more
2015ACS Synthetic Biology87 citations Open access
Semantic Scholar
β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion
S. Creed, C. P. Le, M. Hassan, C. Pon +10 more
2015Breast Cancer Research82 citations Open access
Semantic Scholar
Self-sorting of nonmuscle myosins IIA and IIB polarizes the cytoskeleton and modulates cell motility
M. Shutova, Sreeja B. Asokan, Shefali Talwar, R. Assoian +2 more
2017Journal of Cell Biology77 citations Open access
Semantic Scholar
Lamellipodia are crucial for haptotactic sensing and response
S. King, Sreeja B. Asokan, Elizabeth M. Haynes, S. Zimmerman +12 more
2016Journal of Cell Science77 citations Open access
Semantic Scholar
Tuning the Binding Affinities and Reversion Kinetics of a Light Inducible Dimer Allows Control of Transmembrane Protein Localization
S. Zimmerman, R. Hallett, Ashley M. Bourke, J. Bear +2 more
2016Biochemistry73 citations Open access
Semantic Scholar
Mesenchymal chemotaxis requires selective inactivation of Myosin II at the leading edge via a non-canonical PLCγ/PKCα pathway
Sreeja B. Asokan, Heath E. Johnson, Anisur Rahman, S. King +4 more
2014Developmental Cell71 citations Open access
Semantic Scholar
New mechanisms of resistance to MEK inhibitors in melanoma revealed by intravital imaging
Hailey E. Brighton, Steven P. Angus, T. Bo, J. Roques +8 more
2017Cancer Research61 citations Open access
Semantic Scholar
Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance
Marc P. Kai, Hailey E. Brighton, C. Fromen, Tammy W. Shen +8 more
2015ACS Nano58 citations Open access
Semantic Scholar
LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues
K. Chan, Sreeja B. Asokan, S. King, T. Bo +8 more
2014Journal of Cell Biology50 citations Open access
Semantic Scholar
Competition and collaboration between different actin assembly pathways allows for homeostatic control of the actin cytoskeleton
Jeremy D. Rotty, J. Bear
2015BioArchitecture49 citations Open access
Semantic Scholar
Tropomyosin Promotes Lamellipodial Persistence by Collaborating with Arp2/3 at the Leading Edge
Simon Brayford, Nicole S. Bryce, G. Schevzov, Elizabeth M. Haynes +3 more
2016Current Biology48 citations Open access
Semantic Scholar
Plexin-B2 Negatively Regulates Macrophage Motility, Rac, and Cdc42 Activation
Kelly E. Roney, B. O'Connor, Haitao Wen, E. Holl +8 more
2011PLoS ONE46 citations Open access
Semantic Scholar
Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice
David S. Paul, C. Casari, Cong-Ying Wu, Raymond Piatt +12 more
2017Blood Advances45 citations Open access
Semantic Scholar
Loss of Arp2/3 induces an NF-κB–dependent, nonautonomous effect on chemotactic signaling
Cong-Ying Wu, Elizabeth M. Haynes, Sreeja B. Asokan, Jeremy M. Simon +5 more
2013Journal of Cell Biology44 citations Open access
Semantic Scholar
Tortuous Microvessels Contribute to Wound Healing via Sprouting Angiogenesis
Diana C. Chong, Zhi-Xian Yu, Hailey E. Brighton, J. Bear +1 more
2017Arteriosclerosis, Thrombosis and Vascular Biology43 citations Open access
Semantic Scholar
Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin
K. Chan, D. W. Roadcap, Nicholas Holoweckyj, J. Bear
2012Biochemical Journal43 citations Open access
Semantic Scholar
Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function
Alessia Castagnino, Antonio Castro-Castro, M. Irondelle, A. Guichard +15 more
2018Oncogene42 citations Open access
Semantic Scholar
GMFβ controls branched actin content and lamellipodial retraction in fibroblasts
Elizabeth M. Haynes, Sreeja B. Asokan, Samantha King, Heath E. Johnson +2 more
2015Journal of Cell Biology41 citations Open access
Semantic Scholar
Metastasis in an Orthotopic Murine Model of Melanoma is Independent of RAS/RAF Mutation
G. Rozenberg, Kimberly B. Monahan, C. Torrice, J. Bear +1 more
2010Melanoma research39 citations Open access
Semantic Scholar
Megakaryocytes use in vivo podosome‐like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids
A. Eckly, Cyril Scandola, Antoine Oprescu, D. Michel +13 more
2020Journal of Thrombosis and Haemostasis38 citations Open access
Semantic Scholar
Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes
Fang-Fei Qu, Damaris N. Lorenzo, S. King, Rebecca Brooks +2 more
2016eLife38 citations Open access
Semantic Scholar
N-glycosylation controls the function of junctional adhesion molecule-A
D. Scott, Caitlin E. Tolbert, David M Graham, Erika S Wittchen +2 more
2015Molecular Biology of the Cell34 citations Open access
Semantic Scholar
Simultaneous Multi-Species Tracking in Live Cells with Quantum Dot Conjugates
M. Clausen, E. C. Arnspang, B. Ballou, J. Bear +1 more
2014PLoS ONE32 citations Open access
Semantic Scholar
Subtumoral analysis of PRINT nanoparticle distribution reveals targeting variation based on cellular and particle properties
Luke E. Roode, Hailey E. Brighton, T. Bo, Jillian L. Perry +6 more
2016Nanomedicine: Nanotechnology, Biology and Medicine31 citations Open access
Semantic Scholar
Intravital imaging of donor allogeneic effector and regulatory T cells with host dendritic cells during GVHD.
K. Lin, Leshara M Fulton, Matthew E. Berginski, Michelle L. West +6 more
2014Blood30 citations Open access
Semantic Scholar
Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation.
S. Tessier, Alexandra C. Doolittle, Kimheak Sao, Jeremy D. Rotty +6 more
2020JCI Insight29 citations Open access
Semantic Scholar
Cells lay their own tracks – optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration
S. Zimmerman, Sreeja B. Asokan, B. Kuhlman, J. Bear
2017Journal of Cell Science28 citations Open access
Semantic Scholar
Coro1B and Coro1C regulate lamellipodia dynamics and cell motility by tuning branched actin turnover
Zayna T King, Mitchell T. Butler, Max A. Hockenberry, Bhagawat C. Subramanian +4 more
2022Journal of Cell Biology27 citations Open access
Semantic Scholar
A circle RNA regulatory axis promotes lung squamous metastasis via CDR1-mediated regulation of Golgi trafficking
E. B. Harrison, A. Porrello, Brittany M. Bowman, A. Belanger +19 more
2020Cancer Research27 citations Open access
Semantic Scholar
Role of Coronin 1B in PDGF-induced Migration of Vascular Smooth Muscle Cells
H. Williams, Alejandra San Martín, C. Adamo, B. Seidel-Rogol +5 more
2012Circulation Research24 citations Open access
Semantic Scholar
The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility
N. Mitin, K. Rossman, R. Currin, S. Anne +4 more
2013PLoS ONE23 citations Open access
Semantic Scholar

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