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Laychiluh Mekonnen · SciRah

Researcher profile · Semantic Scholar

Laychiluh Mekonnen

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Laychiluh Mekonnen — researcher profile on SciRah

h-index: 11
Works: 22
Citations: 480

Most-cited papers

Knowledge, Attitude, and Utilization of Traditional Medicine among the Communities of Merawi Town, Northwest Ethiopia: A Cross-Sectional Study
Samuel Masresha Wassie, Leul Lisanework Aragie, B. Taye, Laychiluh Mekonnen
2015Evidence-Based Complementary and Alternative Medicine91 citations Open access
Semantic Scholar
Global burden of lower respiratory infections and aetiologies, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
Sarah Brooke Sirota, Rose G. Bender, R. Dominguez, Amanda Movo +496 more
2025Lancet. Infectious Diseases (Print)67 citations Open access
Semantic Scholar
In vivo antimalarial activity of the crude root and fruit extracts of Croton macrostachyus (Euphorbiaceae) against Plasmodium berghei in mice
Laychiluh Mekonnen
2015Journal of Traditional and Complementary Medicine66 citations Open access
Semantic Scholar
Highly Potent, Selective, and Orally Bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine Cyclin-Dependent Kinases 4 and 6 Inhibitors as Anticancer Drug Candidates: Design, Synthesis, and Evaluation.
S. Tadesse, Ming-Feng Yu, Laychiluh Mekonnen, F. Lam +9 more
2017Journal of Medicinal Chemistry61 citations Open access
Semantic Scholar
Targeting CDK9: a promising therapeutic opportunity in prostate cancer.
M. Rahaman, M. Kumarasiri, Laychiluh Mekonnen, Ming-Feng Yu +4 more
2016Endocrine-Related Cancer54 citations Open access
Semantic Scholar
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019
Cecilia Anza-Ramírez, J. Miranda, B. Armocida, J. Correia +496 more
2025Nature Communications31 citations Open access
Semantic Scholar
Discovery of CDK5 Inhibitors through Structure-Guided Approach.
N. Khair, J. Lenjisa, Solomon Tulu Tadesse, M. Kumarasiri +8 more
2019ACS Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
2-Anilino-4-(1-methyl-1H-pyrazol-4-yl)pyrimidine-derived CDK2 inhibitors as anticancer agents: Design, synthesis & evaluation.
B. Fanta, Laychiluh Mekonnen, Sunita K. C. Basnet, Theodosia Teo +7 more
2023Bioorganic & Medicinal Chemistry18 citations Open access
Semantic Scholar
Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation.
Ming-Feng Yu, Theodosia Teo, Yuchao Yang, Manjun Li +12 more
2021European journal of medicinal chemistry15 citations Open access
Semantic Scholar
A novel series of N-(pyridin-2-yl)-4-(thiazol-5-yl)pyrimidin-2-amines as highly potent CDK4/6 inhibitors.
S. Tadesse, Ge Zhu, Laychiluh Mekonnen, J. Lenjisa +3 more
2017Future Medicinal Chemistry14 citations
Semantic Scholar
Discovery of N,4-Di(1H-pyrazol-4-yl)pyrimidin-2-amine-Derived CDK2 Inhibitors as Potential Anticancer Agents: Design, Synthesis, and Evaluation
B. Fanta, J. Lenjisa, Theodosia Teo, Lianmeng Kou +7 more
2023Molecules11 citations Open access
Semantic Scholar
A brain-penetrant CDK4/6 inhibitor - AU3-14 shows robust anti-tumor efficacy against glioblastoma.
Laychiluh Mekonnen, Theodosia Teo, Benjamin Noll, M. Rahaman +14 more
2025Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie7 citations Open access
Semantic Scholar
Discovery of N-phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine derivatives as potent Mnk2 inhibitors: design, synthesis, SAR analysis, and evaluation of in vitro anti-leukaemic activity.
A. Abdelaziz, Sarah Diab, Saiful Islam, Sunita K. C. Basnet +9 more
2019Medicinal chemistry6 citations
Semantic Scholar
A novel CDK4 inhibitor for myeloid protection in chemotherapy-treated triple-negative breast Cancer
A. Safaroghli-azar, Laychiluh Mekonnen, Ramin Hassankhani, J. Lenjisa +4 more
2025Investigational new drugs4 citations Open access
Semantic Scholar
Cancer Burden Attributable to Potentially Modifiable Risk Factors in Australia
T. Tiruye, B. Duko, Laychiluh Mekonnen, P. Ward +4 more
2025Cancers4 citations Open access
Semantic Scholar
Kinase inhibitors: Opportunities for small molecule anticancer immunotherapies.
A. Safaroghli-azar, F. Emadi, J. Lenjisa, Laychiluh Mekonnen +1 more
2023Drug Discovery Today4 citations
Semantic Scholar
Discovery of Potent Inhibitors of Cyclin‐Dependent Kinases 7 and 9: Design, Synthesis, Structure‐Activity Relationship Analysis and Biological Evaluation
Ren-Hong Chen, Ramin Hassankhani, Yi Long, Sunita K. C. Basnet +5 more
2022ChemMedChem4 citations
Semantic Scholar
The evolving landscape of CDK2 inhibition in cancer: Therapeutic potential, clinical progress, and future directions.
J. Lenjisa, S. Kasirzadeh, A. Safaroghli-azar, Laychiluh Mekonnen
2026Critical reviews in oncology/hematology3 citations
Semantic Scholar
Cell-cycle targeted cancer therapy: clinical advances, biological gaps, and the emergence of selective CDK4 inhibitors
A. Safaroghli-azar, Laychiluh Mekonnen, J. Lenjisa, Robert Milne +1 more
2026Journal of Hematology & Oncology2 citations Open access
Semantic Scholar
CDK4-selective inhibitor AU2-94 for the treatment of advanced and therapy-resistant prostate cancer
A. Safaroghli-azar, T. Croft, Laychiluh Mekonnen, J. Lenjisa +9 more
2026Journal of experimental & clinical cancer research : CR0 citations Open access
Semantic Scholar
Burden of non-communicable diseases and their attributable risk factors in Africa from 1990 to 2023: a systematic analysis for the Global Burden of Disease Study 2023.
A. Awedew, Mihretu Jegnie, K. Abate, Y. Abate +496 more
2026Lancet Global Health0 citations Open access
Semantic Scholar
Abstract 1524: A first-in-class CDK4 inhibitor shows excellent in vitro and in vivo efficacy against ovarian cancer
Laychiluh Mekonnen, Solomon Zeleke, J. Lenjisa, Ming-Feng Yu +6 more
2018Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar

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Shu-Dong Wang×15
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Shu-Dong Wang — researcher profile on SciRah
J. Lenjisa×11
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J. Lenjisa — researcher profile on SciRah
Ming-Feng Yu×9
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Ming-Feng Yu — researcher profile on SciRah
Sunita K. C. Basnet×9
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Sunita K. C. Basnet — researcher profile on SciRah

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Theodosia Teo — researcher profile on SciRah

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R. Milne — researcher profile on SciRah

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M. Rahaman — researcher profile on SciRah

Benjamin Noll×5

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Benjamin Noll — researcher profile on SciRah

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H. Albrecht — researcher profile on SciRah

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Sarah Diab — researcher profile on SciRah

Ramin Hassankhani×4

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Ramin Hassankhani — researcher profile on SciRah

A. Safaroghli-azar×4

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A. Safaroghli-azar — researcher profile on SciRah