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A. Pellagatti · SciRah

Researcher profile · Semantic Scholar

A. Pellagatti

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A. Pellagatti — researcher profile on SciRah

h-index: 55
Works: 220
Citations: 12K

Most-cited papers

Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes
E. Bernard, Y. Nannya, R. Hasserjian, S. Devlin +76 more
2019Nature Medicine574 citations Open access
Semantic Scholar
Molecular International Prognostic Scoring System for Myelodysplastic Syndromes.
E. Bernard, H. Tuechler, P. Greenberg, R. Hasserjian +60 more
2022NEJM Evidence251 citations
Semantic Scholar
SF3B1-mutant myelodysplastic syndrome as a distinct disease subtype - A Proposal of the International Working Group for the Prognosis of Myelodysplastic Syndromes (IWG-PM).
L. Malcovati, K. Stevenson, E. Papaemmanuil, D. Neuberg +32 more
2020Blood250 citations Open access
Semantic Scholar
TP53 Mutation Status Divides Myelodysplastic Syndromes with Complex Karyotypes into Distinct Prognostic Subgroups
D. Haase, K. Stevenson, D. Neuberg, J. Maciejewski +47 more
2019Leukemia237 citations Open access
Semantic Scholar
Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes
M. Gerstung, A. Pellagatti, L. Malcovati, A. Giagounidis +12 more
2015Nature Communications227 citations Open access
Semantic Scholar
Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations.
A. Pellagatti, R. Armstrong, V. Steeples, Eshita Sharma +26 more
2018Blood221 citations Open access
Semantic Scholar
U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies
Molly A Smith, G. Choudhary, A. Pellagatti, Kwangmin Choi +16 more
2019Nature Cell Biology216 citations Open access
Semantic Scholar
Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes
H. Dolatshad, A. Pellagatti, Fabio Liberante, Miriam Llorian +14 more
2016Leukemia144 citations Open access
Semantic Scholar
Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes.
Ashwin Unnikrishnan, E. Papaemmanuil, D. Beck, N. Deshpande +36 more
2017Cell Reports113 citations Open access
Semantic Scholar
Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline
M. Hennrich, Natalie Romanov, P. Horn, S. Jaeger +15 more
2018Nature Communications90 citations Open access
Semantic Scholar
SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications
Shalini Singh, Doaa Ahmed, H. Dolatshad, Dharamveer Tatwavedi +18 more
2020Leukemia83 citations Open access
Semantic Scholar
Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells
Aditi Shastri, G. Choudhary, Margarida Teixeira, Shanisha Gordon-Mitchell +29 more
2018Journal of Clinical Investigation82 citations Open access
Semantic Scholar
SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function
Jie Sun, Xin He, Ying-Hui Zhu, Zonghui Ding +29 more
2018Cell Stem Cell80 citations Open access
Semantic Scholar
Gene expression and risk of leukemic transformation in myelodysplasia.
Y. Shiozawa, L. Malcovati, A. Gallì, A. Pellagatti +14 more
2017Blood75 citations Open access
Semantic Scholar
Epigenetically Aberrant Stroma In MDS Propagates Disease Via Wnt/β-Catenin Activation
T. Bhagat, Si Chen, M. Bartenstein, Trevor Barlowe A. +34 more
2017Cancer Research70 citations Open access
Semantic Scholar
The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes
B. Yip, V. Steeples, E. Repapi, R. Armstrong +16 more
2017Journal of Clinical Investigation69 citations Open access
Semantic Scholar
Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations
G. Choudhary, A. Pellagatti, B. Agianian, Molly A Smith +27 more
2022bioRxiv66 citations Open access
Semantic Scholar
Molecular taxonomy of myelodysplastic syndromes and its clinical implications
Elsa Bernard, R. Hasserjian, Peter L. Greenberg, J. A. Arango Ossa +53 more
2024Blood63 citations Open access
Semantic Scholar
Application of CRISPR/Cas9 genome editing to the study and treatment of disease
A. Pellagatti, H. Dolatshad, S. Valletta, J. Boultwood
2015Archives of Toxicology61 citations
Semantic Scholar
ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine
Nora E. Rahmani, N. Ramachandra, Srabani Sahu, Nadege Gitego +26 more
2021Blood Cancer Journal59 citations Open access
Semantic Scholar
Molecular and clinical presentation of UBA1-mutated myelodysplastic syndromes.
Maria Sirenko, Elsa Bernard, M. Creignou, D. Domenico +56 more
2024Blood58 citations Open access
Semantic Scholar
Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations
C. Scharenberg, Valentina Giai, A. Pellagatti, L. Saft +12 more
2016Haematologica46 citations Open access
Semantic Scholar
Pexmetinib: a novel dual inhibitor of Tie-2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia
Lohith S. Bachegowda, Kerry A. Morrone, S. Winski, Ioannis Mantzaris +32 more
2016Cancer Research43 citations Open access
Semantic Scholar
Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes
S. Sundaravel, Ryan Duggan, T. Bhagat, D. Ebenezer +20 more
2015Proceedings of the National Academy of Sciences of the United States of America35 citations Open access
Semantic Scholar
The Effects of Severe Hypoxia on Glycolytic Flux and Enzyme Activity in a Model of Solid Tumors
Hannah Smith, M. Board, A. Pellagatti, H. Turley +2 more
2016Journal of Cellular Biochemistry34 citations Open access
Semantic Scholar
Splicing factor gene mutations in the myelodysplastic syndromes: impact on disease phenotype and therapeutic applications.
A. Pellagatti, J. Boultwood
2017Advances in Biological Regulation33 citations Open access
Semantic Scholar
MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism
K. Ueda, R. Kumari, Emily Schwenger, Justin C. Wheat +19 more
2021Cancer Cell32 citations Open access
Semantic Scholar
Response of high-risk MDS to azacitdine and lenalidomide is impacted by baseline and acquired mutations in a cluster of three inositide-specific genes
M. Follo, A. Pellagatti, R. Armstrong, Stefano Ratti +16 more
2019Leukemia32 citations Open access
Semantic Scholar
Amendment history : Corrigendum ( September 2017 ) The U 2 AF 1 S 34 F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes
B. Yip, V. Steeples, E. Repapi, R. Armstrong +17 more
201830 citations
Semantic Scholar
Splicing factor mutant myelodysplastic syndromes: Recent advances.
A. Pellagatti, J. Boultwood
2019Advances in Biological Regulation25 citations
Semantic Scholar
Splicing factor mutations in the myelodysplastic syndromes: target genes and therapeutic approaches.
R. Armstrong, V. Steeples, Shalini Singh, Andrea Sanchi +2 more
2017Advances in Biological Regulation25 citations Open access
Semantic Scholar
Molecular Taxonomy of Myelodysplastic Syndromes and Its Clinical Implications
E. Bernard, R. Hasserjian, Peter L. Greenberg, J. A. Arango Ossa +49 more
2023Blood21 citations Open access
Semantic Scholar
TP53 State Dictates Genome Stability, Clinical Presentation and Outcomes in Myelodysplastic Syndromes
E. Bernard, Y. Nannya, T. Yoshizato, R. Hasserjian +71 more
2019Blood21 citations Open access
Semantic Scholar
Application of genome editing technologies to the study and treatment of hematological disease.
A. Pellagatti, H. Dolatshad, B. Yip, S. Valletta +1 more
2016Advances in Biological Regulation19 citations
Semantic Scholar
Impact of Splicing Factor Mutations on Pre-mRNA Splicing in the Myelodysplastic Syndromes.
B. Yip, H. Dolatshad, Swagata Roy, A. Pellagatti +1 more
2016Current pharmaceutical design18 citations
Semantic Scholar
Splicing factor mutations in the myelodysplastic syndromes: Role of key aberrantly spliced genes in disease pathophysiology and treatment.
A. Pellagatti, J. Boultwood
2022Advances in Biological Regulation17 citations Open access
Semantic Scholar
BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome
Petra Gorombei, F. Guidez, S. Ganesan, Mathieu Chiquet +25 more
2021International Journal of Molecular Sciences17 citations Open access
Semantic Scholar
SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML
G. Choudhary, Molly A Smith, A. Pellagatti, T. Bhagat +18 more
2019Blood17 citations Open access
Semantic Scholar
Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q
V. Adema, Laura Palomo, W. Walter, M. Mallo +16 more
2022EBioMedicine16 citations Open access
Semantic Scholar
SF3B1 mutant myelodysplastic syndrome: Recent advances.
A. Pellagatti, J. Boultwood
2020Advances in Biological Regulation16 citations
Semantic Scholar
The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes.
B. Yip, V. Steeples, E. Repapi, R. Armstrong +16 more
2017Journal of Clinical Investigation16 citations Open access
Semantic Scholar
PRR14L mutations are associated with chromosome 22 acquired uniparental disomy, age related clonal hematopoiesis and myeloid neoplasia
A. Chase, A. Pellagatti, Shalini Singh, J. Score +12 more
2018Leukemia15 citations Open access
Semantic Scholar
GFI136N as a therapeutic and prognostic marker for myelodysplastic syndrome
L. Botezatu, L. Michel, H. Makishima, T. Schroeder +26 more
2016Experimental Hematology13 citations Open access
Semantic Scholar
Non-del(5q) myelodysplastic syndromes-associated loci detected by SNP-array genome-wide association meta-analysis.
K. McGraw, Chia-Ho Cheng, Y. Chen, H. Hou +23 more
2019Blood Advances12 citations Open access
Semantic Scholar
Expression of CDKN1C in the bone marrow of patients with myelodysplastic syndrome and secondary acute myeloid leukemia is associated with poor survival after conventional chemotherapy
A. Radujkovic, S. Dietrich, M. Andrulis, A. Benner +10 more
2016International Journal of Cancer11 citations Open access
Semantic Scholar
Recent advances in MDS mutation landscape: Splicing and signalling.
M. Follo, A. Pellagatti, Stefano Ratti, G. Ramazzotti +8 more
2019Advances in Biological Regulation9 citations Open access
Semantic Scholar
Application of induced pluripotent stem cell technology for the investigation of hematological disorders.
H. Dolatshad, Dharamveer Tatwavedi, Doaa Ahmed, Jana F. Tegethoff +2 more
2019Advances in Biological Regulation9 citations
Semantic Scholar
Hyperactivation of NF-κB signaling in splicing factor mutant myelodysplastic syndromes and therapeutic approaches.
A. Pellagatti, J. Boultwood
2024Advances in Biological Regulation8 citations Open access
Semantic Scholar
L-leucine increases translation of RPS14 and LARP1 in erythroblasts from del(5q) myelodysplastic syndrome patients
E. Bello, J. Kerry, Shalini Singh, B. Yip +5 more
2018Haematologica8 citations Open access
Semantic Scholar
Phospholipase C beta1 (PI‐PLCbeta1)/Cyclin D3/protein kinase C (PKC) alpha signaling modulation during iron‐induced oxidative stress in myelodysplastic syndromes (MDS)
A. Cappellini, S. Mongiorgi, C. Finelli, Antonietta Fazio +12 more
2020The FASEB Journal7 citations Open access
Semantic Scholar

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