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John E. Dominy · SciRah

Researcher profile · Semantic Scholar

John E. Dominy

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John E. Dominy — researcher profile on SciRah

h-index: 22
Works: 30
Citations: 3,632

Most-cited papers

Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism.
M. Stipanuk, John E. Dominy, Jeong‐In Lee, R. Coloso
2006Journal of NutriLife488 citations Open access
Semantic Scholar
The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD+
Zachary Gerhart-Hines, John E. Dominy, Sharon M. Blättler, Mark P. Jedrychowski +5 more
2011Molecules and Cells318 citations Open access
Semantic Scholar
The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis
John E. Dominy, Yoonjin Lee, Mark P. Jedrychowski, H. Chim +12 more
2012Molecules and Cells293 citations Open access
Semantic Scholar
Mitochondrial biogenesis through activation of nuclear signaling proteins.
John E. Dominy, P. Puigserver
2013Cold Spring Harbor Perspectives in Biology240 citations Open access
Semantic Scholar
Cyclin D1-CDK4 Controls Glucose Metabolism Independently of Cell Cycle Progression
Yoonjin Lee, John E. Dominy, Y. Choi, M. Jurczak +10 more
2014Nature237 citations Open access
Semantic Scholar
The sirtuin family's role in aging and age-associated pathologies.
J. A. Hall, John E. Dominy, Yoonjin Lee, P. Puigserver
2013Journal of Clinical Investigation231 citations Open access
Semantic Scholar
Nutrient-dependent Regulation of PGC-1α’s Acetylation State and Metabolic Function Through the Enzymatic Activities of Sirt1/GCN5
John E. Dominy, Yoonjin Lee, Zachary Gerhart-Hines, P. Puigserver
2009Biochimica et Biophysica Acta213 citations Open access
Semantic Scholar
Oleic Acid Stimulates Complete Oxidation of Fatty Acids through Protein Kinase A-dependent Activation of SIRT1-PGC1α Complex*
Ji-Hong Lim, Zachary Gerhart-Hines, John E. Dominy, Yoonjin Lee +4 more
2013Journal of Biological Chemistry197 citations Open access
Semantic Scholar
Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes
K. Sharabi, Hua Lin, Clint D. J. Tavares, John E. Dominy +19 more
2017Cell192 citations Open access
Semantic Scholar
Discovery and Characterization of a Second Mammalian Thiol Dioxygenase, Cysteamine Dioxygenase*
John E. Dominy, C. Simmons, L. L. Hirschberger, Jesse Hwang +2 more
2007Journal of Biological Chemistry156 citations Open access
Semantic Scholar
Thiol Dioxygenases: Unique Families of Cupin Proteins
M. Stipanuk, Chad R. Simmons, P. Karplus, John E. Dominy
2010Amino Acids122 citations Open access
Semantic Scholar
HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway.
Jeong‐In Lee, John E. Dominy, A. Sikalidis, L. L. Hirschberger +2 more
2008Physiological Genomics110 citations
Semantic Scholar
Synthesis of Amino Acid Cofactor in Cysteine Dioxygenase Is Regulated by Substrate and Represents a Novel Post-translational Regulation of Activity*
John E. Dominy, Jesse Hwang, Stephanie Guo, L. L. Hirschberger +2 more
2008Journal of Biological Chemistry108 citations Open access
Semantic Scholar
Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation
Jenny D. Y. Chow, R. T. Lawrence, Marin E. Healy, John E. Dominy +15 more
2014Molecular Metabolism106 citations Open access
Semantic Scholar
New roles for cysteine and transsulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant.
John E. Dominy, M. Stipanuk
2004Nutrition reviews100 citations
Semantic Scholar
Identification and Characterization of Bacterial Cysteine Dioxygenases: a New Route of Cysteine Degradation for Eubacteria
John E. Dominy, Chad R. Simmons, P. Karplus, A. M. Gehring +1 more
2006Journal of Bacteriology97 citations
Semantic Scholar
A Putative Fe2+-bound Persulfenate Intermediate in Cysteine Dioxygenase
Chad R. Simmons, K. Krishnamoorthy, Spencer L. Granett, D. Schuller +4 more
2008Biochemistry89 citations Open access
Semantic Scholar
Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin-26 S proteasome system in the living rat.
John E. Dominy, L. L. Hirschberger, R. Coloso, M. Stipanuk
2006Biochemical Journal86 citations
Semantic Scholar
Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells.
John E. Dominy, Jesse Hwang, M. Stipanuk
2007American Journal of Physiology. Endocrinology and Metabolism71 citations
Semantic Scholar
Cysteamine dioxygenase: evidence for the physiological conversion of cysteamine to hypotaurine in rat and mouse tissues.
R. Coloso, L. L. Hirschberger, John E. Dominy, Jeong‐In Lee +1 more
2006Advances in Experimental Medicine and Biology56 citations
Semantic Scholar
The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator*
Clint D. J. Tavares, K. Sharabi, John E. Dominy, Yoonjin Lee +7 more
2016Journal of Biological Chemistry37 citations Open access
Semantic Scholar
Measurement of Cysteine Dioxygenase Activity and Protein Abundance
M. Stipanuk, John E. Dominy, I. Ueki, L. L. Hirschberger
2008Current Protocols in Toxicology24 citations Open access
Semantic Scholar
Nutrient-dependent acetylation controls basic regulatory metabolic switches and cellular reprogramming.
John E. Dominy, Zachary Gerhart-Hines, P. Puigserver
2011Cold Spring Harbor Symposia on Quantitative Biology16 citations Open access
Semantic Scholar
Surprising insights that aren’t so surprising in the modeling of sulfur amino acid metabolism
M. Stipanuk, John E. Dominy
2006Amino Acids15 citations
Semantic Scholar
Nuclear FoxO1 inflames insulin resistance
John E. Dominy, P. Puigserver
2010EMBO Journal14 citations Open access
Semantic Scholar
In vivo regulation of cysteine dioxygenase via the ubiquitin-26S proteasome system.
John E. Dominy, L. L. Hirschberger, R. Coloso, M. Stipanuk
2006Advances in Experimental Medicine and Biology13 citations
Semantic Scholar
Glycine decarboxylase cleaves a "malignant" metabolic path to promote tumor initiation.
John E. Dominy, F. Vazquez, P. Puigserver
2012Cancer Cell6 citations Open access
Semantic Scholar
In vivo measurement of the acetylation state of sirtuin substrates as a proxy for sirtuin activity.
John E. Dominy, P. Puigserver, C. Cantó
2013Methods in molecular biology3 citations
Semantic Scholar
Evolution and Disease Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in
D. Wallace, Dimitra Chalkia, Tom Bender, J. Martinou +5 more
20140 citations
Semantic Scholar
Dietary cysteine and ubiquitination regulate cysteine dioxygenase levels
John E. Dominy, L. L. Hirschberger, Relicardo M. Coloso, M. Stipanuk
20060 citations
Semantic Scholar

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