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A. Kanthasamy · SciRah

Researcher profile · Semantic Scholar

A. Kanthasamy

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A. Kanthasamy — researcher profile on SciRah

h-index: 63
Works: 192
Citations: 19K

Most-cited papers

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
D. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, M. Abdellatif +496 more
2021Autophagy4,016 citations Open access
Semantic Scholar
Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease
S. Sarkar, Emir Malovic, Dilshan S. Harishchandra, Shivani Ghaisas +8 more
2017npj Parkinson's Disease277 citations Open access
Semantic Scholar
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
Nikhil Panicker, S. Sarkar, D. Harischandra, Matthew L. Neal +14 more
2019Journal of Experimental Medicine226 citations Open access
Semantic Scholar
Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation
D. Harischandra, Shivani Ghaisas, Gary Zenitsky, Hua-Jun Jin +3 more
2019Frontiers in Neuroscience225 citations Open access
Semantic Scholar
Molecular Mechanisms Underlying Protective Effects of Quercetin Against Mitochondrial Dysfunction and Progressive Dopaminergic Neurodegeneration in Cell Culture and MitoPark Transgenic Mouse Models of Parkinson’s Disease
Muhammet Ay, Jie Luo, Monica R. Langley, Hua-Jun Jin +3 more
2017Journal of Neurochemistry162 citations Open access
Semantic Scholar
Manganese Activates NLRP3 Inflammasome Signaling and Propagates Exosomal Release of ASC in Microglial Cells
S. Sarkar, Dharmin Rokad, Emir Malovic, Jie Luo +7 more
2019Science Signaling154 citations Open access
Semantic Scholar
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein
D. Harischandra, Dharmin Rokad, Matthew L. Neal, Shivani Ghaisas +10 more
2019Science Signaling154 citations Open access
Semantic Scholar
Blinded RT-QuIC Analysis of α-Synuclein Biomarker in Skin Tissue from Parkinson’s Disease Patients
Sireesha Manne, N. Kondru, Hua-Jun Jin, G. Serrano +5 more
2020Movement Disorders136 citations Open access
Semantic Scholar
Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes
S. Sarkar, Emir Malovic, D. Harischandra, H. A. Ngwa +8 more
2017Neurotoxicology132 citations Open access
Semantic Scholar
Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice
Monica R. Langley, A. Ghosh, Adhithiya Charli, S. Sarkar +14 more
2017Antioxidants and Redox Signaling126 citations Open access
Semantic Scholar
Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes
Matthew L. Neal, Dan Luo, D. Harischandra, R. Gordon +6 more
2018Glia123 citations Open access
Semantic Scholar
α-Synuclein RT-QuIC in the Submandibular Glands of Parkinson’s Disease Patients
Sireesha Manne, N. Kondru, Hua-Jun Jin, V. Anantharam +3 more
2019Movement Disorders121 citations Open access
Semantic Scholar
Organophosphate Pesticide Chlorpyrifos Impairs STAT1 Signaling to Induce Dopaminergic Neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events
Neeraj Singh, Vivek Lawana, Jie Luo, P. Phong +8 more
2018Neurobiology of Disease109 citations Open access
Semantic Scholar
Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson’s Disease
A. Ghosh, Monica R. Langley, D. Harischandra, Matthew L. Neal +8 more
2016Journal of Neuroimmune Pharmacology103 citations Open access
Semantic Scholar
α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease.
D. Harischandra, Hua-Jun Jin, V. Anantharam, A. Kanthasamy +1 more
2015Toxicological Sciences100 citations Open access
Semantic Scholar
Environmental Neurotoxicant Manganese Regulates Exosome-mediated Extracellular miRNAs in Cell Culture Model of Parkinson’s Disease: Relevance to α-Synuclein Misfolding in Metal Neurotoxicity
D. Harischandra, Shivani Ghaisas, Dharmin Rokad, M. Zamanian +5 more
2017Neurotoxicology98 citations Open access
Semantic Scholar
Protein Kinase Cδ Upregulation in Microglia Drives Neuroinflammatory Responses and Dopaminergic Neurodegeneration in Experimental Models of Parkinson's Disease
R. Gordon, Neeraj Singh, Vivek Lawana, A. Ghosh +9 more
2016Neurobiology of Disease95 citations Open access
Semantic Scholar
Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders
Sireesha Manne, N. Kondru, Monica Hepker, Hua-Jun Jin +5 more
2019Journal of Neuroimmune Pharmacology90 citations Open access
Semantic Scholar
Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration
R. Gordon, Matthew L. Neal, Jie Luo, Monica R. Langley +9 more
2016Nature Communications86 citations Open access
Semantic Scholar
Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson’s Disease
Minhong Huang, Alejandra Bargues-Carot, Zainab Riaz, H. Wickham +5 more
2022International Journal of Molecular Sciences84 citations Open access
Semantic Scholar
Alterations in mitochondrial dynamics induced by tebufenpyrad and pyridaben in a dopaminergic neuronal cell culture model
Adhithiya Charli, Hua-Jun Jin, V. Anantharam, A. Kanthasamy +1 more
2015Neurotoxicology82 citations Open access
Semantic Scholar
Involvement of c-Abl kinase in microglial activation of NLRP3 inflammasome and impairment in autolysosomal system
Vivek Lawana, Neeraj Singh, S. Sarkar, Adhithiya Charli +4 more
2017Journal of Neuroimmune Pharmacology70 citations Open access
Semantic Scholar
Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders
Piyush Padhi, C. Worth, Gary Zenitsky, Hua-Jun Jin +4 more
2022Frontiers in Neuroscience67 citations Open access
Semantic Scholar
Microglial immune regulation by epigenetic reprogramming through histone H3K27 acetylation in neuroinflammation
Minhong Huang, Emir Malovic, Alyssa Ealy, Hua-Jun Jin +3 more
2023Frontiers in Immunology66 citations Open access
Semantic Scholar
Role of Neurotoxicants and Traumatic Brain Injury in α-Synuclein Protein Misfolding and Aggregation
Dharmin Rokad, Shivani Ghaisas, D. Harischandra, Hua-Jun Jin +3 more
2016Brain Research Bulletin59 citations Open access
Semantic Scholar
Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson's disease: Relevance to gene and environment interactions in metal neurotoxicity
Monica R. Langley, Shivani Ghaisas, Muhammet Ay, Jie Luo +5 more
2017Neurotoxicology57 citations Open access
Semantic Scholar
Environmental neurotoxicant-induced dopaminergic neurodegeneration: a potential link to impaired neuroinflammatory mechanisms
A. Kanthasamy, Hua-Jun Jin, Adhithiya Charli, Anantharam Vellareddy +1 more
2019Pharmacology and Therapeutics44 citations Open access
Semantic Scholar
Mechanistic Interplay Between Autophagy and Apoptotic Signaling in Endosulfan-Induced Dopaminergic Neurotoxicity: Relevance to the Adverse Outcome Pathway in Pesticide Neurotoxicity.
Chun-Juan Song, Adhithiya Charli, Jie Luo, Zainab Riaz +4 more
2019Toxicological Sciences43 citations Open access
Semantic Scholar
MitoPark Transgenic Mouse Model Recapitulates the Gastrointestinal Dysfunction and Gut-Microbiome Changes of Parkinson’s Disease
Shivani Ghaisas, Monica R. Langley, B. Palanisamy, Somak Dutta +8 more
2019Neurotoxicology43 citations Open access
Semantic Scholar
PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway
Manikandan Samidurai, B. Palanisamy, Alejandra Bargues-Carot, Monica Hepker +7 more
2021Frontiers in Aging Neuroscience41 citations Open access
Semantic Scholar
Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults
S. Sarkar, Emir Malovic, Deeksha Sarda, Vivek Lawana +5 more
2018Neurotoxicology39 citations Open access
Semantic Scholar
Enhanced Differentiation of Human Dopaminergic Neuronal Cell Model for Preclinical Translational Research in Parkinson’s Disease
D. Harischandra, Dharmin Rokad, Shivani Ghaisas, Saurabh Verma +5 more
2019Biochimica et Biophysica Acta - Molecular Basis of Disease37 citations Open access
Semantic Scholar
Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Discovery in Protein Misfolding Diseases
N. Kondru, Sireesha Manne, J. Greenlee, Heather West Greenlee +4 more
2017Scientific Reports36 citations Open access
Semantic Scholar
Characterizing a mouse model for evaluation of countermeasures against hydrogen sulfide–induced neurotoxicity and neurological sequelae
P. Anantharam, Elizabeth M. Whitley, Belinda Mahama, Dongsuk Kim +5 more
2017Annals of the New York Academy of Sciences36 citations Open access
Semantic Scholar
Exosomes as Mediators of Chemical-induced Toxicity
Dharmin Rokad, Hua-Jun Jin, V. Anantharam, A. Kanthasamy +1 more
2019Current Environmental Health Reports35 citations Open access
Semantic Scholar
Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology
Emir Malovic, Alyssa Ealy, A. Kanthasamy, A. Kanthasamy
2021Toxicological Sciences32 citations Open access
Semantic Scholar
Protein Kinase D1 (PKD1) Phosphorylation Promotes Dopaminergic Neuronal Survival during 6-OHDA-Induced Oxidative Stress
A. Asaithambi, Muhammet Ay, Hua-Jun Jin, A. Gosh +3 more
2014PLoS ONE31 citations Open access
Semantic Scholar
Mitochondrial dysfunction–induced H3K27 hyperacetylation perturbs enhancers in Parkinson’s disease
Minhong Huang, D. Lou, Adhithiya Charli, De-Hui Kong +6 more
2021JCI Insight30 citations Open access
Semantic Scholar
Characterization of Nonmotor Behavioral Impairments and their Neurochemical Mechanisms in the MitoPark Mouse Model of Progressive Neurodegeneration in Parkinson’s Disease
Monica R. Langley, Shivani Ghaisas, B. Palanisamy, Muhammet Ay +4 more
2021Experimental Neurology29 citations Open access
Semantic Scholar
Neurotoxicity of Vanadium.
H. A. Ngwa, Muhammet Ay, Hua-Jun Jin, V. Anantharam +2 more
2017Advances in neurobiology26 citations
Semantic Scholar
Molecular Cloning, Epigenetic Regulation and Functional Characterization of Prkd1 Gene Promoter in Dopaminergic Cell Culture Models of Parkinson’s Disease
Muhammet Ay, Hua-Jun Jin, D. Harischandra, A. Asaithambi +3 more
2015Journal of Neurochemistry26 citations Open access
Semantic Scholar
Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia
Cameron Miller, Alyssa Ealy, A. Gregory, C. Janarthanam +7 more
2025Cell Reports24 citations Open access
Semantic Scholar
Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Enhances Activation of STAT3/NLRC4 Inflammasome Signaling Axis through PKCδ in Astrocytes: Implications for Parkinson’s Disease
Manikandan Samidurai, Prashant Tarale, C. Janarthanam, Crystal Gomez Estrada +6 more
2020Cells24 citations Open access
Semantic Scholar
Cobinamide is effective for treatment of hydrogen sulfide–induced neurological sequelae in a mouse model
P. Anantharam, Elizabeth M. Whitley, Belinda Mahama, Dongsuk Kim +7 more
2017Annals of the New York Academy of Sciences23 citations Open access
Semantic Scholar
Environmental Neurotoxic Pesticide Exposure Induces Gut Inflammation and Enteric Neuronal Degeneration by Impairing Enteric Glial Mitochondrial Function in Pesticide Models of Parkinson’s Disease: Potential Relevance to Gut-Brain Axis Inflammation in Disease Pathogenesis
B. Palanisamy, S. Sarkar, Emir Malovic, Manikandan Samidurai +6 more
2022International Journal of Biochemistry and Cell Biology22 citations Open access
Semantic Scholar
Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: relevance to translational research
Hariharan Saminathan, Adhithiya Charli, Jie Luo, Nikhil Panicker +6 more
2020European Journal of Pharmacology21 citations Open access
Semantic Scholar
Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study
Shivani Ghaisas, D. Harischandra, B. Palanisamy, A. Proctor +9 more
2021Environmental Health Perspectives20 citations Open access
Semantic Scholar
p73 gene in Dopaminergic Neurons is Highly Susceptible to Manganese Neurotoxicity
Dongsuk Kim, Hua-Jun Jin, V. Anantharam, R. Gordon +2 more
2016Neurotoxicology20 citations Open access
Semantic Scholar
Nuclear pore and nucleocytoplasmic transport impairment in oxidative stress-induced neurodegeneration: relevance to molecular mechanisms in Pathogenesis of Parkinson’s and other related neurodegenerative diseases
Zainab Riaz, Gabriel S. Richardson, Hua-Jun Jin, Gary Zenitsky +3 more
2024Molecular Neurodegeneration19 citations Open access
Semantic Scholar
Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility.
S. Sarkar, Emir Malovic, B. Plante, Gary Zenitsky +4 more
2017Journal of Visualized Experiments19 citations Open access
Semantic Scholar

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Emir Malovic — researcher profile on SciRah