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J. Harmatz · SciRah

Researcher profile · Semantic Scholar

J. Harmatz

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J. Harmatz — researcher profile on SciRah

h-index: 81
Works: 314
Citations: 18K

Most-cited papers

Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram.
L. von Moltke, D. Greenblatt, Gina M. Giancarlo, B. W. Granda +2 more
2001Drug Metabolism And Disposition228 citations
Semantic Scholar
Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice
D. Greenblatt, L. von Moltke, J. Harmatz, Geng-Sheng Chen +5 more
2003Clinical pharmacology and therapy197 citations
Semantic Scholar
Inhibition of human cytochromes P450 by components of Ginkgo biloba
L. von Moltke, James L. Weemhoff, E. Bedi̇r, I. Khan +3 more
2004The Journal of pharmacy and pharmacology156 citations
Semantic Scholar
Clinical Pharmacokinetics of Anxiolytics and Hypnotics in the Elderly
D. Greenblatt, J. Harmatz, R. Shader
2012Clinical Pharmacokinetics155 citations
Semantic Scholar
Comparative kinetics and response to the benzodiazepine agonists triazolam and zolpidem: evaluation of sex-dependent differences.
D. Greenblatt, J. Harmatz, L. von Moltke, C. Wright +3 more
2000Journal of Pharmacology and Experimental Therapeutics133 citations
Semantic Scholar
Inhibition of Human Cytochrome P450 Isoforms by Nonnucleoside Reverse Transcriptase Inhibitors
L. von Moltke, D. Greenblatt, B. W. Granda, Gina M. Giancarlo +4 more
2001Journal of clinical pharmacology124 citations
Semantic Scholar
Alprazolam‐ritonavir interaction: Implications for product labeling
D. Greenblatt, L. von Moltke, J. Harmatz, Anna Liza B. Durol +5 more
2000Clinical pharmacology and therapy124 citations
Semantic Scholar
Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men.
J. Olubodun, H. Ochs, L. von Moltke, R. Roubenoff +4 more
2003British Journal of Clinical Pharmacology115 citations Open access
Semantic Scholar
Mechanism of cytochrome P450‐3A inhibition by ketoconazole
D. Greenblatt, Yan-Li Zhao, K. Venkatakrishnan, Su X. Duan +4 more
2011The Journal of pharmacy and pharmacology113 citations Open access
Semantic Scholar
In Vitro, Pharmacokinetic, and Pharmacodynamic Interactions of Ketoconazole and Midazolam in the Rat
T. Kotegawa, B. Laurijssens, L. von Moltke, M. Cotreau +6 more
2002Journal of Pharmacology and Experimental Therapeutics112 citations
Semantic Scholar
Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450-3A in drug-drug interaction studies.
D. Greenblatt, J. Harmatz
2015British Journal of Clinical Pharmacology103 citations Open access
Semantic Scholar
Gender differences in pharmacokinetics and pharmacodynamics of zolpidem following sublingual administration
D. Greenblatt, J. Harmatz, Nikhilesh Singh, F. Steinberg +4 more
2014Journal of clinical pharmacology103 citations
Semantic Scholar
Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: In vitro and clinical studies
D. Greenblatt, L. von Moltke, Elke Störmer Perloff, Yan Luo +2 more
2006Clinical pharmacology and therapy101 citations
Semantic Scholar
Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers
Laurie P. Volak, M. Hanley, G. Masse, Suwagmani Hazarika +5 more
2013British Journal of Clinical Pharmacology97 citations Open access
Semantic Scholar
Differential Impairment of Triazolam and Zolpidem Clearance by Ritonavir
D. Greenblatt, L. von Moltke, J. Harmatz, A. Durol +5 more
2000Journal of Acquired Immune Deficiency Syndromes95 citations
Semantic Scholar
Effect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: Comparison with ritonavir
Kerry E. Culm-Merdek, L. von Moltke, Lu Gan, Kelly A. Horan +4 more
2006Clinical pharmacology and therapy94 citations
Semantic Scholar
Pomegranate Juice Does Not Impair Clearance of Oral or Intravenous Midazolam, a Probe for Cytochrome P450‐3A Activity: Comparison With Grapefruit Juice
D. Farkas, Lauren E. Oleson, Yan-Li Zhao, J. Harmatz +3 more
2007Journal of clinical pharmacology93 citations
Semantic Scholar
Comparison of Duloxetine, Escitalopram, and Sertraline Effects on Cytochrome P450 2D6 Function in Healthy Volunteers
S. Preskorn, D. Greenblatt, D. Flockhart, Yan Luo +6 more
2007Journal of Clinical Psychopharmacology91 citations
Semantic Scholar
Effect of lipophilicity on drug distribution and elimination: Influence of obesity
Christopher Donald Bruno, J. Harmatz, Su X. Duan, Qingchen Zhang +2 more
2021British Journal of Clinical Pharmacology86 citations
Semantic Scholar
Microsomal protein concentration modifies the apparent inhibitory potency of CYP3A inhibitors.
T. Tran, L. von Moltke, K. Venkatakrishnan, B. W. Granda +4 more
2002Drug Metabolism And Disposition83 citations
Semantic Scholar
Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion.
Xi He, Leah M. Hesse, Suwagmani Hazarika, G. Masse +3 more
2009British Journal of Clinical Pharmacology74 citations Open access
Semantic Scholar
Pharmacokinetic and Pharmacodynamic Interactions Between Zolpidem and Caffeine
Roberta M. Cysneiros, D. Farkas, J. Harmatz, L. von Moltke +1 more
2007Clinical pharmacology and therapy70 citations
Semantic Scholar
Short‐Term Exposure to Low‐Dose Ritonavir Impairs Clearance and Enhances Adverse Effects of Trazodone
D. Greenblatt, L. von Moltke, J. Harmatz, Steven M. Fogelman +8 more
2003Journal of clinical pharmacology68 citations
Semantic Scholar
Dynamics and Kinetics of a Modified‐Release Formulation of Zolpidem: Comparison With Immediate‐Release Standard Zolpidem and Placebo
D. Greenblatt, E. Legangneux, J. Harmatz, E. Weinling +3 more
2006Journal of clinical pharmacology64 citations
Semantic Scholar
Age and Gender Effects on the Pharmacokinetics and Pharmacodynamics of Ramelteon, a Hypnotic Agent Acting via Melatonin Receptors MT1 and MT2
D. Greenblatt, J. Harmatz, A. Karim
2007Journal of clinical pharmacology63 citations
Semantic Scholar
Relative Contribution of CYP3A to Amitriptyline Clearance in Humans: In Vitro and In Vivo Studies
K. Venkatakrishnan, J. Schmider, J. Harmatz, B. Ehrenberg +7 more
2001Journal of clinical pharmacology63 citations
Semantic Scholar
Zolpidem and Gender: Are Women Really At Risk?
D. Greenblatt, J. Harmatz, T. Roth
2019Journal of Clinical Psychopharmacology61 citations
Semantic Scholar
Ginkgo biloba Does Not Alter Clearance of Flurbiprofen, a Cytochrome P450‐2C9 Substrate
D. Greenblatt, L. von Moltke, Yan Luo, Elke S. Perloff +7 more
2006Journal of clinical pharmacology60 citations
Semantic Scholar
Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics.
K. Culm-Merdek, L. von Moltke, J. Harmatz, D. Greenblatt
2005British Journal of Clinical Pharmacology60 citations Open access
Semantic Scholar
Inhibition of oral midazolam clearance by boosting doses of ritonavir, and by 4,4-dimethyl-benziso-(2H)-selenazine (ALT-2074), an experimental catalytic mimic of glutathione oxidase.
D. Greenblatt, D. Peters, Lauren E. Oleson, J. Harmatz +4 more
2009British Journal of Clinical Pharmacology59 citations Open access
Semantic Scholar
Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers
M. Court, Zhao-Hui Zhu, G. Masse, Su X. Duan +3 more
2017Journal of Pharmacology and Experimental Therapeutics58 citations Open access
Semantic Scholar
Fentanyl Clearance and Volume of Distribution Are Increased in Patients With Major Burns
T. Han, J. Harmatz, D. Greenblatt, J. J. Jeevendra Martyn
2007Journal of clinical pharmacology53 citations
Semantic Scholar
The Absence of an Interaction Between Warfarin and Cranberry Juice: A Randomized, Double‐Blind Trial
J. Ansell, Maryellen McDonough, Yan-Li Zhao, J. Harmatz +1 more
2009Journal of clinical pharmacology52 citations
Semantic Scholar
Enzyme kinetic modelling as a tool to analyse the behaviour of cytochrome P450 catalysed reactions: application to amitriptyline N-demethylation.
J. Schmider, D. Greenblatt, J. Harmatz, R. Shader
2003British Journal of Clinical Pharmacology51 citations Open access
Semantic Scholar
Inhibition of cytochrome P450 by nefazodone in vitro: studies of dextromethorphan O- and N-demethylation.
J. Schmider, D. Greenblatt, L. von Moltke, J. Harmatz +1 more
2003British Journal of Clinical Pharmacology46 citations Open access
Semantic Scholar
Impaired Rivaroxaban Clearance in Mild Renal Insufficiency With Verapamil Coadministration: Potential Implications for Bleeding Risk and Dose Selection
D. Greenblatt, Maulik M. Patel, J. Harmatz, W. Nicholson +2 more
2018Journal of clinical pharmacology45 citations
Semantic Scholar
Comparison of pharmacokinetic profiles of zolpidem buffered sublingual tablet and zolpidem oral immediate-release tablet: results from a single-center, single-dose, randomized, open-label crossover study in healthy adults.
D. Greenblatt, J. Harmatz, T. Roth, Nikhilesh Singh +3 more
2013Clinical Therapeutics43 citations
Semantic Scholar
Serum concentrations and clinical effects of atorvastatin in patients taking grapefruit juice daily.
P. Reddy, David Ellington, Yi-Liang Zhu, Immo Zdrojewski +5 more
2011British Journal of Clinical Pharmacology43 citations Open access
Semantic Scholar
Role of NADPH-cytochrome P450 reductase and cytochrome b5 / NADH b5 reductase in variability of CYP3A activity in human liver microsomes
Lu Gan, L. von Moltke, L. Trepanier, J. Harmatz +2 more
2008Drug Metabolism And Disposition43 citations Open access
Semantic Scholar
Psychotropic drug prescribing in the United States: extent, costs, and expenditures.
D. Greenblatt, J. Harmatz, R. Shader
2011Journal of Clinical Psychopharmacology38 citations Open access
Semantic Scholar
Sources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro
D. Greenblatt, K. Venkatakrishnan, J. Harmatz, Sarah J. Parent +1 more
2010Xenobiotica; the fate of foreign compounds in biological systems37 citations
Semantic Scholar
Update on Psychotropic Drug Prescribing in the United States: 2014-2015.
D. Greenblatt, J. Harmatz, R. Shader
2017Journal of Clinical Psychopharmacology36 citations
Semantic Scholar
Pharmocokinetics and pharmacodynamics of single-dose triazolam: electroencephalography compared with the Digit-Symbol Substitution Test.
D. Greenblatt, Lu Gan, J. Harmatz, R. Shader
2005British Journal of Clinical Pharmacology36 citations Open access
Semantic Scholar
Kinetics and Dynamics of Intravenous Adinazolam, N‐Desmethyl Adinazolam, and Alprazolam in Healthy Volunteers
K. Venkatakrishnan, Kerry E. Culm, B. Ehrenberg, J. Harmatz +3 more
2005Journal of clinical pharmacology36 citations
Semantic Scholar
Effect of zolpidem on human Cytochrome P450 activity, and on transport mediated by P‐glycoprotein
L. von Moltke, James L. Weemhoff, M. Perloff, Leah M. Hesse +3 more
2002Biopharmaceutics & drug disposition36 citations
Semantic Scholar
Effect of Age on in Vitro Triazolam Biotransformation in Male Human Liver Microsomes
K. Patki, L. von Moltke, J. Harmatz, Leah M. Hesse +2 more
2004Journal of Pharmacology and Experimental Therapeutics34 citations
Semantic Scholar
Apparent mechanism‐based inhibition of human CYP3A in‐vitro by lopinavir
James L. Weemhoff, L. von Moltke, C. Richert, Leah M. Hesse +2 more
2003The Journal of pharmacy and pharmacology34 citations Open access
Semantic Scholar
Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen
Yan-Li Zhao, J. Harmatz, Carol Epstein, Y. Nakagawa +6 more
2015British Journal of Clinical Pharmacology31 citations Open access
Semantic Scholar
Pomegranate juice and pomegranate extract do not impair oral clearance of flurbiprofen in human volunteers: Divergence from in vitro results
M. Hanley, G. Masse, J. Harmatz, M. Court +1 more
2012Clinical pharmacology and therapy30 citations Open access
Semantic Scholar
Short‐Term Clarithromycin Administration Impairs Clearance and Enhances Pharmacodynamic Effects of Trazodone but Not of Zolpidem
D. Farkas, Laurie P. Volak, J. Harmatz, L. von Moltke +2 more
2009Clinical pharmacology and therapy30 citations
Semantic Scholar

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D. Greenblatt×50
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L. von Moltke×25
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L. von Moltke — researcher profile on SciRah
R. Shader×14
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R. Shader — researcher profile on SciRah
M. Court×7
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M. Court — researcher profile on SciRah

K. Venkatakrishnan

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B. W. Granda×5

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Leah M. Hesse×5

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Leah M. Hesse — researcher profile on SciRah

Michael H. Court×5

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Michael H. Court — researcher profile on SciRah

James L. Weemhoff×4

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James L. Weemhoff — researcher profile on SciRah

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