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E. Theisen · SciRah

Researcher profile · Semantic Scholar

E. Theisen

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E. Theisen — researcher profile on SciRah

h-index: 11
Works: 36
Citations: 774

Most-cited papers

High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors.
Venkataswamy Sorna, E. Theisen, B. Stephens, S. Warner +3 more
2013Journal of Medicinal Chemistry185 citations Open access
Semantic Scholar
Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth
S. Sankar, E. Theisen, Jared J. Bearss, Timothy S. Mulvihill +5 more
2014Clinical Cancer Research153 citations Open access
Semantic Scholar
Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting
E. Theisen, K. Pishas, Ranajeet S. Saund, S. Lessnick
2016OncoTarget79 citations Open access
Semantic Scholar
Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growth
Kirsten M. Johnson, Nathan R Mahler, Ranajeet S. Saund, E. Theisen +5 more
2017Proceedings of the National Academy of Sciences of the United States of America69 citations Open access
Semantic Scholar
Therapeutic targeting of KDM1A/LSD1 in Ewing sarcoma with SP-2509 engages the endoplasmic reticulum stress response
K. Pishas, C. Drenberg, C. Taslim, E. Theisen +12 more
2018Molecular Cancer Therapeutics52 citations Open access
Semantic Scholar
Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma
E. Theisen, Snehal Gajiwala, Jared J. Bearss, Venkataswamy Sorna +2 more
2014BMC Cancer52 citations Open access
Semantic Scholar
EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma
Iftekhar A. Showpnil, Julia Selich-Anderson, C. Taslim, Megann A. Boone +3 more
2021bioRxiv42 citations Open access
Semantic Scholar
The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma
Megann A. Boone, C. Taslim, Jesse C. Crow, Julia Selich-Anderson +7 more
2020bioRxiv26 citations Open access
Semantic Scholar
Chromatin profiling reveals relocalization of lysine-specific demethylase 1 by an oncogenic fusion protein
E. Theisen, Julia Selich-Anderson, K. R. Miller, J. Tanner +4 more
2020Epigenetics25 citations Open access
Semantic Scholar
Empowering people to change occupational behaviours to address critical global issues
M. Ikiugu, Madeline A Westerfield, Jamie M Lien, E. Theisen +2 more
2015Canadian journal of occupational therapy. Revue canadienne d'ergotherapie18 citations
Semantic Scholar
Transcriptomic analysis functionally maps the intrinsically disordered domain of EWS/FLI and reveals novel transcriptional dependencies for oncogenesis
E. Theisen, K. R. Miller, Iftekhar A. Showpnil, C. Taslim +2 more
2019Genes & cancer16 citations Open access
Semantic Scholar
Mitochondrial Dysfunction is a Driver of SP-2509 Drug Resistance in Ewing Sarcoma
E. J. Tokarsky, Jesse C. Crow, Lillian M. Guenther, John W. Sherman +9 more
2022Molecular Cancer Research11 citations Open access
Semantic Scholar
Lysine specific demethylase 1 is a molecular driver and therapeutic target in sarcoma
R. Dreher, E. Theisen
2023Frontiers in Oncology8 citations Open access
Semantic Scholar
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
Iftekhar A. Showpnil, K. R. Miller, C. Taslim, K. Pishas +2 more
2020Journal of Visualized Experiments8 citations Open access
Semantic Scholar
RNA-SeqEZPZ: A Point-and-Click Pipeline for Comprehensive Transcriptomics Analysis with Interactive Visualizations
C. Taslim, Yuan Zhang, Genevieve C. Kendall, E. Theisen
2024bioRxiv5 citations
Semantic Scholar
The DBD-α4 helix of EWS::FLI is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma
Ariunaa Bayanjargal, C. Taslim, Iftekhar A. Showpnil, Julia Selich-Anderson +4 more
2024bioRxiv5 citations Open access
Semantic Scholar
Cancer Therapy : Preclinical Reversible LSD 1 Inhibition Interferes with Global EWS / ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth
S. Sankar, E. Theisen, Jared J. Bearss, Timothy S. Mulvihill +5 more
20144 citations
Semantic Scholar
Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma
E. Theisen, Snehal Gajiwala, Jared J. Bearss, Venkataswamy Sorna +2 more
2014BMC Cancer4 citations Open access
Semantic Scholar
Investigating the role of LSD2 as an epigenetic regulator in Ewing sarcoma
Priyal O. Patel, K. Pishas, C. Taslim, Julia Selich-Anderson +2 more
2019OncoTarget3 citations Open access
Semantic Scholar
Seclidemstat blocks the transcriptional function of multiple FET-fusion oncoproteins
G. Rask, C. Taslim, Ariunaa Bayanjargal, Matthew V. Cannon +4 more
2024bioRxiv2 citations Open access
Semantic Scholar
Abstract 3: Targeted inhibition of LSD1 in castration-resistant prostate cancer.
E. Theisen, Jared J. Bearss, Venkataswamy Sorna, D. Bearss +1 more
20132 citations
Semantic Scholar
Abstract 1045: Activity of the LSD1 inhibitor HCI-2509 in ER-negative breast cancer cells
B. Stephens, E. Theisen, S. Warner, Sunil Sharma +1 more
20122 citations
Semantic Scholar
Abstract P087: Targeting LSD1 protein scaffolding function in FET-rearranged sarcomas with SP-2577
G. Rask, E. Theisen, Aundrietta D. Duncan, D. Santiesteban
2021Poster Presentations - Proffered Abstracts1 citations
Semantic Scholar
Chromatin profiling reveals reorganization of lysine specific demethylase 1 by an oncogenic fusion protein
E. Theisen, Julia Selich-Anderson, K. R. Miller, J. Tanner +4 more
2020bioRxiv1 citations Open access
Semantic Scholar
HOTAIR primes the Ewing sarcoma family of tumors for tumorigenesis via epigenetic dysregulation involving LSD1
Hasan Siddiqui, Julia Selich-Anderson, Joshua Felgenhauer, James R. Fitch +9 more
2018bioRxiv1 citations Open access
Semantic Scholar
Reversible inhibition of lysine-specific demethylase 1 is a novel therapeutic strategy for solid tumors
E. Theisen
20151 citations
Semantic Scholar
GFI1 Snag Domain Methylation Directs LSD1 Recruitment to Control Transcription and Cell Fate Determination in Hematopoiesis
Matt Velinder, Jason Singer, Jessica A. Meznarich, E. Theisen +5 more
20151 citations
Semantic Scholar
N’-(1-phenylethylidene)-benzohydrazide cytotoxicity is LSD1 independent and linked to Fe-S cluster disruption in Ewing sarcoma
John W. Sherman, G. Rask, Bingcong Xiong, E. J. Tokarsky +3 more
2025bioRxiv0 citations Open access
Semantic Scholar
13P Transcriptional profiling of FET-rearranged sarcomas in response to SP-2577
G. Rask, E. Theisen, A. Duncan, D. Santiesteban
2022Annals of Oncology0 citations Open access
Semantic Scholar
Abstract PO-041: Genome-wide CRISPR/Cas9 screen reveals mitochondrial gene mutation as a driver for drug resistance in Ewing sarcoma
Jack P. Tokarsky, Jesse C. Crow, Lillian M. Guenther, E. Theisen +2 more
2020Poster Presentations - Proffered Abstracts0 citations
Semantic Scholar
Abstract 1305: Structure-function mapping reveal FLI1 contributes more than the DNA-binding properties to drive Ewing sarcoma biology
Megann A. Boone, Jesse C. Crow, Julia Selich-Anderson, C. Taslim +2 more
2020Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar
Abstract B15: Different structural features of EWS are required for distinct modes of EWS/FLI-mediated oncogenic gene regulation
E. Theisen, K. R. Miller, S. Lessnick
2018Poster Presentations - Proffered Abstracts0 citations
Semantic Scholar
Abstract 3679: Inhibition of LSD1 disrupts global EWS/ETS transcriptional function in Ewing sarcoma
E. Theisen, S. Sankar, Jared J. Bearss, Timothy S. Mulvihill +3 more
20140 citations
Semantic Scholar
Abstract B19: Lysine specific demethylase-1 inhibition as a therapeutic strategy that leverages the requirement for growth factor independence-1 in Notch-driven T-ALL
Jason Singer, Daniel Andrade, Diana Bareyan, David McClellan +8 more
20140 citations
Semantic Scholar
Notch Alters Sumoylation To Govern GFI1 Protein Stability and Support Its Transcriptional Repression Function
Jason Singer, Daniel Andrade, Diana Bareyan, Helena Lucente +6 more
20130 citations
Semantic Scholar
Abstract B84: HCI-2528 is a potent inhibitor of LSD1 with improved druglike characteristics.
B. Stephens, Venkataswamy Sorna, E. Theisen, H. Vankayalapati +3 more
20110 citations
Semantic Scholar

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S. Lessnick×18
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Sunil Sharma×11
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Julia Selich-Anderson×9
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Venkataswamy Sorna

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Jared J. Bearss×6

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Iftekhar A. Showpnil×5

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