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Bas Brouwers · SciRah

Researcher profile · Semantic Scholar

Bas Brouwers

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Bas Brouwers — researcher profile on SciRah

h-index: 13
Works: 27
Citations: 854

Most-cited papers

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity
L. Lotta, J. Mokrosiński, Edson Mendes de Oliveira, Chen Li +15 more
2019Cell255 citations Open access
Semantic Scholar
Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression
Bas Brouwers, G. de Faudeur, Anna B. Osipovich, L. Goyvaerts +17 more
2014Cell Metabolism148 citations Open access
Semantic Scholar
Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone
J. Declercq, Bas Brouwers, V. Pruniau, P. Stijnen +7 more
2015PLoS ONE70 citations Open access
Semantic Scholar
Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
Bas Brouwers, E. D. de Oliveira, M. Marti-Solano, Fabiola B. F. Monteiro +14 more
2021Cell Reports66 citations Open access
Semantic Scholar
Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities
T. Sonoyama, L. Stadler, Mingyan Zhu, J. Keogh +13 more
2020Scientific Reports55 citations Open access
Semantic Scholar
Phlorizin Pretreatment Reduces Acute Renal Toxicity in a Mouse Model for Diabetic Nephropathy*
Bas Brouwers, V. Pruniau, Elisa J. G. Cauwelier, F. Schuit +4 more
2013Journal of Biological Chemistry52 citations Open access
Semantic Scholar
Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior
Yang He, Bas Brouwers, He-Song Liu, Hai-Lan Liu +29 more
2022Nature Medicine44 citations Open access
Semantic Scholar
Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis
P. Kirwan, Richard G. Kay, Bas Brouwers, V. Herranz-Pérez +11 more
2018Molecular Metabolism28 citations Open access
Semantic Scholar
Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans
He-Song Liu, Yang He, Hai-Lan Liu, Bas Brouwers +22 more
2024Science Advances27 citations Open access
Semantic Scholar
Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth
J. Declercq, Bas Brouwers, V. Pruniau, P. Stijnen +6 more
2015BioMed Research International22 citations Open access
Semantic Scholar
Endoplasmic reticulum-associated degradation of the mouse PC1/3-N222D hypomorph and human PCSK1 mutations contributes to obesity
P. Stijnen, Bas Brouwers, E. Dirkx, B. Ramos-Molina +5 more
2016International Journal of Obesity20 citations Open access
Semantic Scholar
Loss of Furin in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction
Ada Admin, Bas Brouwers, I. Coppola, K. Vints +12 more
2020Diabetes19 citations Open access
Semantic Scholar
The AlfpCre mouse revisited: Evidence for liver steatosis related to growth hormone deficiency
Vincent P. E. G. Pruniau, Els Louagie, Bas Brouwers, J. Declercq +1 more
2013Hepatology16 citations Open access
Semantic Scholar
Endosome to trans-Golgi network transport of Proprotein Convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteines.
J. Declercq, B. Ramos-Molina, Ragna Sannerud, Bas Brouwers +5 more
2017European Journal of Cell Biology11 citations Open access
Semantic Scholar
Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic β Cells of Mice
I. Coppola, Bas Brouwers, S. Meulemans, B. Ramos-Molina +1 more
2021International Journal of Molecular Sciences10 citations Open access
Semantic Scholar
Transgenic Artifacts Caused by Passenger Human Growth Hormone.
G. de Faudeur, Bas Brouwers, F. Schuit, J. Creemers +1 more
2018Trends in endocrinology and metabolism6 citations
Semantic Scholar
Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice
I. Coppola, Bas Brouwers, Leanne Walker, Ceyhun Alar +4 more
2022Molecular Metabolism4 citations Open access
Semantic Scholar
Furin controls β cell function via mTORC1 signaling
Bas Brouwers, I. Coppola, K. Vints, B. Dislich +10 more
2020bioRxiv2 citations Open access
Semantic Scholar
Human Growth Hormone in Transgenesis: A Growing Problem?
Bas Brouwers, J. Creemers
2015Diabetes2 citations Open access
Semantic Scholar
Human POMC processing in vitro and in vivo revealed by quantitative peptidomics
P. Kirwan, Richard G. Kay, Bas Brouwers, V. Herranz-Pérez +10 more
2018bioRxiv0 citations Open access
Semantic Scholar
Hypothalamic hGH expression increases STAT5 phosphorylation, induces Cish expression and leads to a reduction in the expression of Ghrh.
J. Declercq, Bas Brouwers, V. Pruniau, P. Stijnen +7 more
20150 citations Open access
Semantic Scholar
GHD in Nestin-Cre mice leads to a decrease in STAT5 phosphorylation, lower expression of Igf1 and an increase in the expression of CD36 and Vldlr in the liver.
J. Declercq, Bas Brouwers, V. Pruniau, P. Stijnen +7 more
20150 citations Open access
Semantic Scholar
Primer sequences used for transcript detection.
J. Declercq, Bas Brouwers, V. Pruniau, P. Stijnen +7 more
20150 citations Open access
Semantic Scholar
The total body weight of Nestin-Cre mice is reduced.
J. Declercq, Bas Brouwers, V. Pruniau, P. Stijnen +7 more
20150 citations Open access
Semantic Scholar
Commonly used pancreatic Cre-driver lines secrete human growth hormone which profoundly alters islet phenotype
Bas Brouwers, A. Schraenen, G. de Faudeur, Anna B. Osipovich +16 more
20140 citations
Semantic Scholar
Loss of furin in beta cells leads to activation of ER stress pathways and impaired glucose homeostasis in vivo
Bas Brouwers, P. Stijnen, Elisa J. G. Cauwelier, Bastian Dieslich +4 more
20140 citations
Semantic Scholar
Inhibition of Sglt2-mediated streptozotocin uptake reduces direct renal toxicity in a mouse model for diabetic nephropathy
Bas Brouwers, V. Pruniau, F. Schuit, E. Lerut +3 more
20130 citations
Semantic Scholar

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J. Declercq×16
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