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Patrick W. Faloon · SciRah

Researcher profile · Semantic Scholar

Patrick W. Faloon

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Patrick W. Faloon — researcher profile on SciRah

h-index: 15
Works: 63
Citations: 1,546

Most-cited papers

Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse.
M. Ema, Patrick W. Faloon, Wen-Jie Zhang, M. Hirashima +5 more
2003Genes & Development277 citations Open access
Semantic Scholar
Basic fibroblast growth factor positively regulates hematopoietic development.
Patrick W. Faloon, Elizabeth Arentson, A. Kazarov, Chu-Xia Deng +3 more
2000Development243 citations
Semantic Scholar
In vitro hematopoietic and endothelial potential of flk-1(-/-) embryonic stem cells and embryos.
A. Schuh, Patrick W. Faloon, Qingyun Hu, M. Bhimani +1 more
1999Proceedings of the National Academy of Sciences of the United States of America238 citations Open access
Semantic Scholar
Oncogenic potential of the DNA replication licensing protein CDT1
Elizabeth Arentson, Patrick W. Faloon, J. Seo, E. Moon +3 more
2002Oncogene141 citations Open access
Semantic Scholar
JUMP Cell Painting dataset: morphological impact of 136,000 chemical and genetic perturbations
Srinivas Niranj Chandrasekaran, J. Ackerman, E. Alix, D. Ando +95 more
2023bioRxiv138 citations Open access
Semantic Scholar
A βPix–Pak2a signaling pathway regulates cerebral vascular stability in zebrafish
Jing Liu, S. Fraser, Patrick W. Faloon, E. Rollins +6 more
2007Proceedings of the National Academy of Sciences of the United States of America124 citations Open access
Semantic Scholar
Identification of cancer cytotoxic modulators of PDE3A by predictive chemogenomics
L. de Waal, T. Lewis, M. Rees, Aviad Tsherniak +18 more
2015Nature Chemical Biology89 citations Open access
Semantic Scholar
Potential applications of molecular biology to the study of fish mycobacteriosis
R. Belas, Patrick W. Faloon, Amanda Hannaford
199544 citations
Semantic Scholar
Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis
D. Chou, Jeremy R. Duvall, B. Gerard, Hai-Bo Liu +6 more
2011ACS Medicinal Chemistry Letters43 citations Open access
Semantic Scholar
Mouse lysocardiolipin acyltransferase controls the development of hematopoietic and endothelial lineages during in vitro embryonic stem-cell differentiation.
Cheng-Yan Wang, Patrick W. Faloon, Zhi-Jia Tan, Ya-Xin Lv +4 more
2007Blood37 citations Open access
Semantic Scholar
Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling
D. Chou, A. Vetere, Amit Choudhary, Stephen S. Scully +22 more
2015Journal of the American Chemical Society30 citations Open access
Semantic Scholar
ASSAY DEVELOPMENT AND HIGH THROUGHPUT SCREENING FOR INHIBITORS OF KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS N-TERMINAL LANA BINDING TO NUCLEOSOMES
Chantal Beauchemin, Nathan J. Moerke, Patrick W. Faloon, K. Kaye
2014Journal of biomolecular screening30 citations Open access
Semantic Scholar
Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment.
Michel Weiwer, Qihong Xu, J. Gale, M. Lewis +23 more
2018ACS Chemical Biology29 citations
Semantic Scholar
A Small Molecule Inhibitor of the MITF Molecular Pathway
Patrick W. Faloon, Melissa Bennion, Warren S. Weiner, Robert A. Smith +16 more
201421 citations
Semantic Scholar
The identification and characterization of non-reactive inhibitor of Keap1-Nrf2 interaction through HTS using a fluorescence polarization assay
Li-Li Wang, T. Lewis, Yan-Ling Zhang, Carol Khodier +13 more
201315 citations
Semantic Scholar
Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport
C. Dockendorff, Patrick W. Faloon, Miao Yu, Willmen Youngsaye +15 more
2015ACS Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake
C. Dockendorff, Patrick W. Faloon, J. Pu, Miao Yu +10 more
2015Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake
C. Dockendorff, Patrick W. Faloon, A. Germain, Miao Yu +11 more
2015Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Identification of Small Molecule Inhibitors that Suppress Cytokine-Induced Apoptosis in Human Pancreatic Islet Cells
Patrick W. Faloon, D. Chou, E. Forbeck, D. Walpita +13 more
20116 citations
Semantic Scholar
A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake—Probe 1
Patrick W. Faloon, C. Dockendorff, Willmen Youngsaye, Yu Miao +12 more
20144 citations
Semantic Scholar
A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake—Probe 2
Patrick W. Faloon, C. Dockendorff, A. Germain, Yu Miao +12 more
20143 citations
Semantic Scholar
A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake - Probe 3
Patrick W. Faloon, C. Dockendorff, Yu Miao, Melissa Bennion +10 more
20132 citations
Semantic Scholar
Discovery of Two, Structurally Distinct Agonists of Vibrio cholerae Quorum Sensing Acting via the CqsS Membrane Receptor
Patrick W. Faloon, Willmen Youngsaye, Melissa Bennion, Wai-Leung Ng +15 more
20132 citations
Semantic Scholar
A Candidate Cell-Selective Anticancer Agent
T. Lewis, L. de Waal, Willmen Youngsaye, Lara N. Gechijian +11 more
20141 citations
Semantic Scholar
Discovery of ML370, an inhibitor of Vibrio cholerae Quorum Sensing Acting via the LuxO response regulator
Patrick W. Faloon, Ivan Jewett, Willmen Youngsaye, Melissa Bennion +12 more
20141 citations
Semantic Scholar
Abstract C136: Identification of selective cancer cytotoxic modulators of phosphodiesterase 3a by predictive chemogenomics
L. de Waal, T. Lewis, M. Rees, Aviad Tsherniak +18 more
20150 citations
Semantic Scholar
Table 6, Structural Modifications of the Core Region
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Figure 9, Possible Directions for Future SAR Investigation of ML370
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Table 8, Comparison of New & Existing Cholera QS Probes to Project Criteria
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Table 9, Probe Activation of Quorum Sensing in Vibrio cholerae Mutant Strains
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes Associated − Assay Development and High-Throughput Screening for Inhibitors of Kaposi ' s Sarcoma
Chantal Beauchemin, Nathan J. Moerke, Patrick W. Faloon, K. Kaye
20140 citations
Semantic Scholar
Table 7, Structural Modifications of the Acyl Group
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Figure 1, Reported Inhibitors of SR-BI
Patrick W. Faloon, C. Dockendorff, A. Germain, Yu Miao +12 more
20140 citations
Semantic Scholar
Figure 3, Aza-uracil-derived antagonists of LuxO ATPase activity
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Table 4, Summary of Probe Properties Computed for ML370
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Table 1, Strains of V. cholera used in assays
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Figure 4, Dose Response Curves for Initial Hit, MLS000888573
Patrick W. Faloon, C. Dockendorff, A. Germain, Yu Miao +12 more
20140 citations
Semantic Scholar
Scheme 1, Synthesis of Probe ML370
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Figure 5, Dose Response Curves for initial hit (CID 665390) and optimized probe (CID 70680248)
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Scheme 1, Synthesis of Probe (CID53377439/ML278)
Patrick W. Faloon, C. Dockendorff, Willmen Youngsaye, Yu Miao +12 more
20140 citations
Semantic Scholar
Abstract 4596: An integrated genomic characterization of the target of a small molecule identifies a novel cancer dependency
L. de Waal, T. Lewis, Lara N. Gechijian, Aviad Tsherniak +14 more
2014Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Table 3, Thiol Stability (DTT) and Plasma Stability for ML370
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Table 5, PubChem Assays Reporting Dose-Dependent Activity of CID 665390 (the hit compound)*
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Table 1, Summary of Probe Properties from PubChem*
T. Lewis, L. de Waal, Willmen Youngsaye, Lara N. Gechijian +11 more
20140 citations
Semantic Scholar
Figure 2, The V cholerae CqsS/CAI-1 Quorum Sensing Phosphorelay system
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Figure 1, The Endogenous Ligand of the Vibrio cholerae Sensor Histidine Kinase CqsS, Cholera autoinducer-1 (CAI-1)
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Figure 4, Stability of Probe ML370 in 1:1 Acetonitrile:PBS (pH 7.4, 23 °C)
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Figure 2, Recovery of Undissolved Probe (ML278) from PBS Buffer (pH 7.4, 23 °C)
Patrick W. Faloon, C. Dockendorff, A. Germain, Yu Miao +12 more
20140 citations
Semantic Scholar
Table 2, Solubility of ML370 and Analogs in PBS and LB Media
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar
Figure 8, Summary of analogs prepared to investigate the SAR profile of hit CID 665390
Patrick W. Faloon, Warren S. Weiner, D. Matharu, Benjamin Neuenswander +14 more
20140 citations
Semantic Scholar

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