Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

David A. Brow · SciRah

Researcher profile · Semantic Scholar

David A. Brow

Share profile

David A. Brow — researcher profile on SciRah

h-index: 34
Works: 71
Citations: 4,223

Most-cited papers

RNA-binding protein Nrd1 directs poly(A)-independent 3′-end formation of RNA polymerase II transcripts
E. Steinmetz, Nicholas K. Conrad, David A. Brow, J. Corden
2001Nature400 citations
Semantic Scholar
Allosteric cascade of spliceosome activation.
David A. Brow
2002Annual Review of Genetics379 citations
Semantic Scholar
Spliceosomal RNA U6 is remarkably conserved from yeast to mammals
David A. Brow, C. Guthrie
1988Nature353 citations
Semantic Scholar
Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase.
E. Steinmetz, Christopher L. Warren, Jason N. Kuehner, Bahman Panbehi +2 more
2006Molecules and Cells350 citations Open access
Semantic Scholar
A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II.
Nicholas K. Conrad, Scott M. Wilson, E. Steinmetz, M. Patturajan +3 more
2000Genetics157 citations
Semantic Scholar
Repression of gene expression by an exogenous sequence element acting in concert with a heterogeneous nuclear ribonucleoprotein-like protein, Nrd1, and the putative helicase Sen1
E. Steinmetz, David A. Brow
1996Molecular and Cellular Biology146 citations Open access
Semantic Scholar
Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure
A. Huppler, L. J. Nikstad, A. Allmann, David A. Brow +1 more
2002Nature Structural Biology145 citations
Semantic Scholar
Transcription of a yeast U6 snRNA gene requires a polymerase III promoter element in a novel position.
David A. Brow, C. Guthrie
1990Genes & Development129 citations Open access
Semantic Scholar
Ssu72 Protein Mediates Both Poly(A)-Coupled and Poly(A)-Independent Termination of RNA Polymerase II Transcription
E. Steinmetz, David A. Brow
2003Molecular and Cellular Biology128 citations Open access
Semantic Scholar
The life of U6 small nuclear RNA, from cradle to grave
A. Didychuk, S. Butcher, David A. Brow
2018RNA: A publication of the RNA Society120 citations Open access
Semantic Scholar
Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome.
Andreas N. Kuhn, Zairong Li, David A. Brow
1999Molecules and Cells117 citations Open access
Semantic Scholar
Control of pre-mRNA accumulation by the essential yeast protein Nrd1 requires high-affinity transcript binding and a domain implicated in RNA polymerase II association.
E. Steinmetz, David A. Brow
1998Proceedings of the National Academy of Sciences of the United States of America110 citations Open access
Semantic Scholar
A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing.
David M. Fortner, Raymond G. Troy, David A. Brow
1994Genes & Development108 citations Open access
Semantic Scholar
Regulation of a eukaryotic gene by GTP-dependent start site selection and transcription attenuation.
Jason N. Kuehner, David A. Brow
2008Molecules and Cells93 citations Open access
Semantic Scholar
Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation
A. Kuhn, Elizabeth M. Reichl, David A. Brow
2002Proceedings of the National Academy of Sciences of the United States of America91 citations Open access
Semantic Scholar
Quantitative Analysis of in Vivo Initiator Selection by Yeast RNA Polymerase II Supports a Scanning Model*
Jason N. Kuehner, David A. Brow
2006Journal of Biological Chemistry89 citations Open access
Semantic Scholar
Architecture of a yeast U6 RNA gene promoter.
J. B. Eschenlauer, M. Kaiser, Valerie L. Gerlach, David A. Brow
1993Molecular and Cellular Biology89 citations Open access
Semantic Scholar
cis- and trans-Acting Determinants of Transcription Termination by Yeast RNA Polymerase II
E. Steinmetz, Sarah B. H. Ng, Joseph P. Cloute, David A. Brow
2006Molecular and Cellular Biology86 citations Open access
Semantic Scholar
Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation.
Andreas N. Kuhn, David A. Brow
2000Genetics81 citations
Semantic Scholar
Splicing a spliceosomal RNA
David A. Brow, C. Guthrie
1989Nature73 citations Open access
Semantic Scholar
An essential snRNA from S. cerevisiae has properties predicted for U4, including interaction with a U6-like snRNA.
P. G. Siliciano, David A. Brow, H. Roiha, C. Guthrie
1987Cell72 citations
Semantic Scholar
Towards understanding the catalytic core structure of the spliceosome.
S. Butcher, David A. Brow
2005Biochemical Society Transactions62 citations
Semantic Scholar
Core structure of the U6 snRNP at 1.7 Å resolution
E. Montemayor, E. Curran, Hong-Hong Liao, K. Andrews +3 more
2014Nature Structural &Molecular Biology61 citations Open access
Semantic Scholar
Saccharomyces cerevisiae Sen1 Helicase Domain Exhibits 5′- to 3′-Helicase Activity with a Preference for Translocation on DNA Rather than RNA*♦
S. Martin-Tumasz, David A. Brow
2015Journal of Biological Chemistry56 citations Open access
Semantic Scholar
Structure and interactions of the first three RNA recognition motifs of splicing factor prp24.
E. Bae, N. J. Reiter, C. Bingman, Sharon S. Kwan +4 more
2007Journal of Molecular Biology44 citations Open access
Semantic Scholar
A rapid assay for quantitative detection of specific RNAs.
Zairong Li, David A. Brow
1993Nucleic Acids Research44 citations Open access
Semantic Scholar
A spontaneous duplication in U6 spliceosomal RNA uncouples the early and late functions of the ACAGA element in vivo.
Z. Li, David A. Brow
1996RNA: A publication of the RNA Society43 citations
Semantic Scholar
Human spliceosomal snRNA sequence variants generate variant spliceosomes
Justin W. Mabin, P. Lewis, David A. Brow, H. Dvinge
2021RNA: A publication of the RNA Society42 citations Open access
Semantic Scholar
A novel occluded RNA recognition motif in Prp24 unwinds the U6 RNA internal stem loop
S. Martin-Tumasz, A. Richie, Lawrence J. Clos, David A. Brow +1 more
2011Nucleic Acids Research42 citations Open access
Semantic Scholar
Multiple functions of Saccharomyces cerevisiae splicing protein Prp24 in U6 RNA structural rearrangements.
R. Vidaver, David M. Fortner, Liana S. Loos-Austin, David A. Brow
1999Genetics41 citations
Semantic Scholar
An element in human U6 RNA destabilizes the U4/U6 spliceosomal RNA complex.
David A. Brow, R. Vidaver
1995RNA: A publication of the RNA Society40 citations
Semantic Scholar
Molecular basis for the distinct cellular functions of the Lsm1–7 and Lsm2–8 complexes
E. Montemayor, Johanna M. Virta, Samuel M. Hayes, Y. Nomura +2 more
2020bioRxiv39 citations Open access
Semantic Scholar
Saccharomyces cerevisiae Sen1 as a Model for the Study of Mutations in Human Senataxin That Elicit Cerebellar Ataxia
Xin Chen, Ulrika Müller, Kaitlin E. Sundling, David A. Brow
2014Genetics35 citations Open access
Semantic Scholar
A Novel Upstream RNA Polymerase III Promoter Element Becomes Essential When the Chromatin Structure of the Yeast U6 RNA Gene Is Altered
Michael P. Martin, V. Gerlach, David A. Brow
2001Molecular and Cellular Biology34 citations Open access
Semantic Scholar
Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities
A. Didychuk, E. Montemayor, Tucker J. Carrocci, Andrew T DeLaitsch +5 more
2017Nature Communications32 citations Open access
Semantic Scholar
Structure and functional implications of a complex containing a segment of U6 RNA bound by a domain of Prp24.
S. Martin-Tumasz, N. J. Reiter, David A. Brow, S. Butcher
2010RNA: A publication of the RNA Society29 citations Open access
Semantic Scholar
A dynamic bulge in the U6 RNA internal stem-loop functions in spliceosome assembly and activation.
C. J. McManus, Matthew L. Schwartz, S. Butcher, David A. Brow
2007RNA: A publication of the RNA Society28 citations Open access
Semantic Scholar
Structural requirements for protein-catalyzed annealing of U4 and U6 RNAs during di-snRNP assembly
A. Didychuk, E. Montemayor, David A. Brow, S. Butcher
2015Nucleic Acids Research26 citations Open access
Semantic Scholar
The N- and C-terminal RNA recognition motifs of splicing factor Prp24 have distinct functions in U6 RNA binding.
Sharon S. Kwan, David A. Brow
2005RNA: A publication of the RNA Society26 citations Open access
Semantic Scholar
Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA
E. Montemayor, A. Didychuk, Allyson D. Yake, Gurnimrat K. Sidhu +2 more
2018Nature Communications24 citations Open access
Semantic Scholar
Regulation of a Eukaryotic Gene by GTP-Dependent Start Site Selection and Transcription Attenuation.
Jason N. Kuehner, David A. Brow
2019Molecules and Cells22 citations Open access
Semantic Scholar
Small nuclear RNAs from budding yeasts: phylogenetic comparisons reveal extensive size variation.
H. Roiha, E. O. Shuster, David A. Brow, C. Guthrie
1989Gene22 citations
Semantic Scholar
An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8
Argenta M Price, Janina Görnemann, C. Guthrie, David A. Brow
2014RNA: A publication of the RNA Society20 citations Open access
Semantic Scholar
Transcriptomes of six mutants in the Sen1 pathway reveal combinatorial control of transcription termination across the Saccharomyces cerevisiae genome
Xin Chen, Kunal Poorey, Melissa N. Carver, Ulrika Müller +3 more
2017PLoS Genetics18 citations Open access
Semantic Scholar
In vitro transcripts of a yeast variant 5 S rRNA gene exhibit alterations in 3'-end processing and protein binding.
D. Brow
1987Journal of Biological Chemistry15 citations Open access
Semantic Scholar
A multi-step model for facilitated unwinding of the yeast U4/U6 RNA duplex
Margaret L. Rodgers, A. Didychuk, Samuel E. Butcher, David A. Brow +1 more
2016Nucleic Acids Research13 citations Open access
Semantic Scholar
Spliceosome assembly in the absence of stable U4/U6 RNA pairing
J. Burke, S. Butcher, David A. Brow
2015RNA: A publication of the RNA Society11 citations Open access
Semantic Scholar
Sen-sing RNA terminators
David A. Brow
2011Molecules and Cells8 citations Open access
Semantic Scholar
An Allosteric Network for Spliceosome Activation Revealed by High-Throughput Suppressor Analysis in Saccharomyces cerevisiae
David A. Brow
2019Genetics7 citations Open access
Semantic Scholar
Position-dependent function of a B block promoter element implies a specialized chromatin structure on the S.cerevisiae U6 RNA gene, SNR6.
M. Kaiser, Jing Chi, David A. Brow
2004Nucleic Acids Research7 citations Open access
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

S. Butcher×13
Invite
S. Butcher — researcher profile on SciRah
E. Steinmetz×7
Invite
E. Steinmetz — researcher profile on SciRah
C. Guthrie×6
Invite
C. Guthrie — researcher profile on SciRah
A. Didychuk×5
Invite
A. Didychuk — researcher profile on SciRah

×5

Invite

E. Montemayor — researcher profile on SciRah

Jason N. Kuehner×4

Invite

Jason N. Kuehner — researcher profile on SciRah

S. Martin-Tumasz×3

Invite

S. Martin-Tumasz — researcher profile on SciRah

Nicholas K. Conrad×2

Invite

Nicholas K. Conrad — researcher profile on SciRah

Invite

J. Corden — researcher profile on SciRah

Andreas N. Kuhn×2

Invite

Andreas N. Kuhn — researcher profile on SciRah

Invite

Zairong Li — researcher profile on SciRah

David M. Fortner×2

Invite

David M. Fortner — researcher profile on SciRah