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A. K. Dubé · SciRah

Researcher profile · Semantic Scholar

A. K. Dubé

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A. K. Dubé — researcher profile on SciRah

h-index: 18
Works: 68
Citations: 976

Most-cited papers

Exploring the northern limit of the distribution of Saccharomyces cerevisiae and Saccharomyces paradoxus in North America.
G. Charron, Jean-Baptiste Leducq, Chloé Bertin, A. K. Dubé +1 more
2014FEMS Yeast Research76 citations Open access
Semantic Scholar
Local climatic adaptation in a widespread microorganism
Jean-Baptiste Leducq, G. Charron, P. Samani, A. K. Dubé +7 more
2014Proceedings of the Royal Society of London. Biological Sciences76 citations Open access
Semantic Scholar
Perturbing proteomes at single residue resolution using base editing
Philippe C. Després, A. K. Dubé, M. Seki, Nozomu Yachie +1 more
2020Nature Communications58 citations Open access
Semantic Scholar
Evolutionary rescue by compensatory mutations is constrained by genomic and environmental backgrounds
Marie Filteau, Véronique Hamel, Marie-Christine Pouliot, Isabelle Gagnon-Arsenault +2 more
2015Molecular Systems Biology57 citations Open access
Semantic Scholar
Protein context shapes the specificity of SH3 domain-mediated interactions in vivo
Ugo Dionne, Émilie Bourgault, A. K. Dubé, David Bradley +11 more
2021Nature Communications50 citations Open access
Semantic Scholar
Most azole resistance mutations in the Candida albicans drug target confer cross-resistance without intrinsic fitness cost
Camille Bédard, Isabelle Gagnon-Arsenault, Jonathan Boisvert, Samuel Plante +7 more
2024Nature Microbiology48 citations
Semantic Scholar
Systematic identification of signal integration by protein kinase A
Marie Filteau, G. Diss, Francisco Torres-Quiroz, A. K. Dubé +10 more
2015Proceedings of the National Academy of Sciences of the United States of America48 citations Open access
Semantic Scholar
Evidence for the Robustness of Protein Complexes to Inter-Species Hybridization
Jean-Baptiste Leducq, G. Charron, G. Diss, Isabelle Gagnon-Arsenault +2 more
2012PLoS Genetics47 citations Open access
Semantic Scholar
The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs
A. Marchant, Angel F. Cisneros, A. K. Dubé, Isabelle Gagnon-Arsenault +7 more
2019bioRxiv44 citations Open access
Semantic Scholar
Turnover of ribosome-associated transcripts from de novo ORFs produces gene-like characteristics available for de novo gene emergence in wild yeast populations
E. Durand, Isabelle Gagnon-Arsenault, J. Hallin, I. Hatin +4 more
2019Genome Research41 citations Open access
Semantic Scholar
qPCA: a scalable assay to measure the perturbation of protein-protein interactions in living cells.
L. Freschi, Francisco Torres-Quiroz, A. K. Dubé, C. Landry
2013Molecular Biosystems40 citations
Semantic Scholar
Expression attenuation as a mechanism of robustness against gene duplication
Diana Ascencio, G. Diss, Isabelle Gagnon-Arsenault, A. K. Dubé +2 more
2021Proceedings of the National Academy of Sciences of the United States of America39 citations Open access
Semantic Scholar
A systematic approach for the genetic dissection of protein complexes in living cells.
G. Diss, A. K. Dubé, Joël Boutin, Isabelle Gagnon-Arsenault +1 more
2013Cell Reports37 citations Open access
Semantic Scholar
Transcriptional divergence plays a role in the rewiring of protein interaction networks after gene duplication.
Isabelle Gagnon-Arsenault, François-Christophe Marois Blanchet, Samuel Rochette, G. Diss +2 more
2013Journal of Proteomics30 citations
Semantic Scholar
Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
Samuel Rochette, G. Diss, Marie Filteau, Jean-Baptiste Leducq +2 more
2015Journal of Visualized Experiments28 citations Open access
Semantic Scholar
Asymmetrical dose responses shape the evolutionary trade-off between antifungal resistance and nutrient use
Philippe C. Després, Angel F. Cisneros, E. Alexander, Ria Sonigara +3 more
2022Nature Ecology & Evolution27 citations Open access
Semantic Scholar
Epistasis between promoter activity and coding mutations shapes gene evolvability
Angel F. Cisneros, Isabelle Gagnon-Arsenault, A. K. Dubé, Philippe C. Després +4 more
2022bioRxiv26 citations Open access
Semantic Scholar
Double Selection Enhances the Efficiency of Target-AID and Cas9-Based Genome Editing in Yeast
Philippe C. Després, A. K. Dubé, Lou Nielly-Thibault, Nozomu Yachie +1 more
2018G3: Genes, Genomes, Genetics22 citations Open access
Semantic Scholar
Compensatory mutations potentiate constructive neutral evolution by gene duplication
Philippe C. Després, A. K. Dubé, Marie-Ève Picard, Jordan Grenier +2 more
2024Science17 citations Open access
Semantic Scholar
Evolutionary Trajectories are Contingent on Mitonuclear Interactions
Damien Biot-Pelletier, S. Bettinazzi, Isabelle Gagnon-Arsenault, A. K. Dubé +5 more
2023bioRxiv17 citations Open access
Semantic Scholar
Deep mutational scanning of Pneumocystis jirovecii dihydrofolate reductase reveals allosteric mechanism of resistance to an antifolate
François D. Rouleau, A. K. Dubé, Isabelle Gagnon-Arsenault, Soham Dibyachintan +4 more
2024bioRxiv13 citations Open access
Semantic Scholar
The Rapid Evolution of an Ohnolog Contributes to the Ecological Specialization of Incipient Yeast Species
Chris Eberlein, Lou Nielly-Thibault, H. Maaroufi, A. K. Dubé +3 more
2017Molecular biology and evolution13 citations Open access
Semantic Scholar
A collection of barcoded natural isolates of Saccharomyces paradoxus to study microbial evolutionary ecology
Clara Bleuven, A. K. Dubé, Guillaume Q Nguyen, Isabelle Gagnon-Arsenault +2 more
2018MicrobiologyOpen11 citations Open access
Semantic Scholar
N-terminal entrance loop of yeast Yps1 and O-glycosylation of substrates are determinant factors controlling the shedding activity of this GPI-anchored endopeptidase
A. K. Dubé, M. Bélanger, Isabelle Gagnon-Arsenault, Y. Bourbonnais
2015BMC Microbiology10 citations Open access
Semantic Scholar
Cross-feeding affects the target of resistance evolution to an antifungal drug
Romain Durand, Jordan Jalbert-Ross, A. Fijarczyk, A. K. Dubé +1 more
2023bioRxiv9 citations Open access
Semantic Scholar
Extended linkers improve the detection of protein-protein interactions (PPIs) by dihydrofolate reductase protein-fragment complementation assay (DHFR PCA) in living cells
Andrée-Ève Chrétien, Isabelle Gagnon-Arsenault, A. K. Dubé, X. Barbeau +5 more
2018Molecular & Cellular Proteomics9 citations Open access
Semantic Scholar
Mutational landscape and molecular bases of echinocandin resistance in Saccharomyces cerevisiae
Romain Durand, Alexandre G. Torbey, Mathieu Giguère, Alicia Pageau +3 more
2026bioRxiv8 citations Open access
Semantic Scholar
Dissection of the role of a Src homology 3 domain in the evolution of binding preference of paralogous proteins
Pascale Lemieux, David Bradley, A. K. Dubé, Ugo Dionne +1 more
2023Genetics8 citations Open access
Semantic Scholar
Barcode fusion genetics-protein-fragment complementation assay (BFG-PCA): tools and resources that expand the potential for binary protein interaction discovery
Daniel Evans-Yamamoto, François D. Rouleau, P. Nanda, K. Makanae +8 more
2021bioRxiv7 citations Open access
Semantic Scholar
The high turnover of ribosome-associated transcripts from de novo ORFs produces gene-like characteristics available for de novo gene emergence in wild yeast populations
E. Durand, Isabelle Gagnon-Arsenault, J. Hallin, I. Hatin +4 more
20187 citations Open access
Semantic Scholar
The fitness cost of spurious phosphorylation
David Bradley, Alexander Hogrebe, Rohan Dandage, A. K. Dubé +5 more
2024EMBO Journal6 citations Open access
Semantic Scholar
Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network
Soham Dibyachintan, A. K. Dubé, David Bradley, Pascale Lemieux +2 more
2025Nature Communications5 citations Open access
Semantic Scholar
The fitness cost of spurious phosphorylation
David Bradley, Alexander Hogrebe, Rohan Dandage, A. K. Dubé +5 more
2023bioRxiv5 citations Open access
Semantic Scholar
Parallel Nonfunctionalization of CK1δ/ε Kinase Ohnologs Following a Whole-Genome Duplication Event
Daniel Evans-Yamamoto, A. K. Dubé, Gourav Saha, Samuel Plante +3 more
2023bioRxiv5 citations Open access
Semantic Scholar
Extended Linkers Improve the Detection of Protein-protein Interactions (PPIs) by Dihydrofolate Reductase Protein-fragment Complementation Assay (DHFR PCA) in Living Cells*
Andrée-Ève Chrétien, Isabelle Gagnon-Arsenault, A. K. Dubé, X. Barbeau +5 more
2017Molecular & Cellular Proteomics5 citations Open access
Semantic Scholar
Making deep mutational scanning accessible: a cost-efficient approach to construct barcoded libraries for genes of any length
J. Jann, Isabelle Gagnon-Arsenault, Alicia Pageau, A. K. Dubé +3 more
2025bioRxiv4 citations Open access
Semantic Scholar
Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network
Soham Dibyachintan, A. K. Dubé, David Bradley, Pascale Lemieux +2 more
2024bioRxiv4 citations Open access
Semantic Scholar
Asymmetrical dose-responses shape the evolutionary trade-off between antifungal resistance and nutrient use
Philippe C. Després, Angel F. Cisneros, E. Alexander, Ria Sonigara +3 more
2022bioRxiv4 citations Open access
Semantic Scholar
Most azole antifungal resistance mutations in the drug target provide cross-resistance and carry no intrinsic fitness cost
Camille Bédard, Isabelle Gagnon-Arsenault, Jonathan Boisvert, Samuel Plante +7 more
2024bioRxiv3 citations Open access
Semantic Scholar
Dissection of the role of a SH3 domain in the evolution of binding preference of paralogous proteins
Pascale Lemieux, David Bradley, A. K. Dubé, Ugo Dionne +1 more
2023bioRxiv3 citations Open access
Semantic Scholar
Deep Mutational Scanning of Protein-Protein Interactions Between Partners Expressed from Their Endogenous Loci In Vivo.
A. K. Dubé, Rohan Dandage, Soham Dibyachintan, Ugo Dionne +2 more
2022Methods in molecular biology3 citations
Semantic Scholar
Extended Linkers Improve the Detection of Protein-protein Interactions (PPIs) by Dihydrofolate Reductase Protein-fragment Complementation Assay (DHFR PCA) in Living Cells.
Andrée-Ève Chrétien, Isabelle Gagnon-Arsenault, A. K. Dubé, X. Barbeau +5 more
2018Molecular & Cellular Proteomics3 citations Open access
Semantic Scholar
Extended linkers improve the detection of PPIs by DHFR PCA in living cells
Andrée-Ève Chrétien, Isabelle Gagnon-Arsenault, A. K. Dubé, X. Barbeau +5 more
20173 citations Open access
Semantic Scholar
Paralog interference contributes to the preservation of genetic redundancy
Angel F. Cisneros, Florian Mattenberger, Isabelle Gagnon-Arsenault, Yacine Seffal +5 more
2025bioRxiv2 citations Open access
Semantic Scholar
A protein-fragment complementation assay to quantify synthetic protein scaffold efficiency
Pascale Lemieux, A. K. Dubé, Christian R. Landry
2025bioRxiv1 citations Open access
Semantic Scholar
Compensatory mutations potentiate constructive neutral evolution by gene duplication
Philippe C. Després, A. K. Dubé, Jordan Grenier, Marie-Ève Picard +2 more
2024bioRxiv1 citations Open access
Semantic Scholar
Rewiring the Three-Carbon Metabolism Abrogates Multiple MAPK-Induced Cellular Dysfunctions During Metabolic Disorder
A. K. Dubé, Nicolas Malenfant, Florence Ladonne, A. Piano +6 more
2021bioRxiv1 citations Open access
Semantic Scholar
Adaptive gene duplication can exceed optimal dosage
F. Bédard, A. K. Dubé, Isabelle Gagnon-Arsenault, Christian R. Landry
2026bioRxiv0 citations Open access
Semantic Scholar
The shape of fitness functions and the distribution of mutational effect sizes jointly limit adaptation by regulatory mutations
Simon Aubé, A. K. Dubé, Christian R. Landry
2026bioRxiv0 citations Open access
Semantic Scholar
A cost-effective and scalable barcoded library construction method for deep mutational scanning studies
J. Jann, Isabelle Gagnon-Arsenault, Alicia Pageau, A. K. Dubé +3 more
2026PLoS Biology0 citations Open access
Semantic Scholar

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Philippe C. Després×15
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Christian R. Landry×8

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Jean-Baptiste Leducq×5

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