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I. Kostakis · SciRah

Researcher profile · Semantic Scholar

I. Kostakis

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I. Kostakis — researcher profile on SciRah

h-index: 19
Works: 76
Citations: 909

Most-cited papers

In vitro assessment of antioxidant activity of tyrosol, resveratrol and their acetylated derivatives.
Ioanna C Vlachogianni, E. Fragopoulou, I. Kostakis, Smaragdi Antonopoulou
2015Food Chemistry74 citations
Semantic Scholar
Revisiting Histone Deacetylases in Human Tumorigenesis: The Paradigm of Urothelial Bladder Cancer
Aikaterini F. Giannopoulou, Athanassios D. Velentzas, Eumorphia G. Konstantakou, M. Avgeris +11 more
2019International Journal of Molecular Sciences54 citations Open access
Semantic Scholar
Design, synthesis, and antiproliferative activity of some new pyrazole-fused amino derivatives of the pyranoxanthenone, pyranothioxanthenone, and pyranoacridone ring systems: a new class of cytotoxic agents.
I. Kostakis, P. Magiatis, Nicole Pouli, P. Marakos +4 more
2002Journal of Medicinal Chemistry53 citations
Semantic Scholar
Synthesis and free radical scavenging activity of some new spiropyranocoumarins.
Vassiliki Panteleon, I. Kostakis, P. Marakos, Nicole Pouli +1 more
2008Bioorganic & Medicinal Chemistry Letters44 citations Open access
Semantic Scholar
Rapid synthesis of 2,3-disubstituted-quinazolin-4-ones enhanced by microwave-assisted decomposition of formamide
I. Kostakis, A. Elomri, Elisabeth Seguin, M. Iannelli +1 more
200744 citations
Semantic Scholar
Decomposition of formamide assisted by microwaves, a tool for synthesis of nitrogen-containing heterocycles
Ines Nouira, I. Kostakis, Carole Dubouilh, E. Chosson +2 more
200842 citations
Semantic Scholar
Urolithin Α modulates inter-organellar communication via calcium-dependent mitophagy to promote healthy ageing
Antonis Roussos, Katerina Kitopoulou, Fivos Borbolis, Christina Ploumi +10 more
2025Autophagy31 citations Open access
Semantic Scholar
Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions.
Ioanna C Vlachogianni, E. Fragopoulou, G. Stamatakis, I. Kostakis +1 more
2015Prostaglandins & other lipid mediators31 citations
Semantic Scholar
Synthesis and cytotoxic activity of some new azapyranoxanthenone aminoderivatives.
G. Kolokythas, I. Kostakis, Nicole Pouli, P. Marakos +2 more
2003Bioorganic & Medicinal Chemistry31 citations
Semantic Scholar
Biomimetic Synthesis of Oleocanthal, Oleacein, and Their Analogues Starting from Oleuropein, A Major Compound of Olive Leaves.
Georgia Sarikaki, N. Christoforidou, N. Gaboriaud-Kolar, Amos B. Smith +2 more
2020Journal of Natural Products30 citations Open access
Semantic Scholar
Novel pyrazolopyridine derivatives as potential angiogenesis inhibitors: Synthesis, biological evaluation and transcriptome-based mechanistic analysis.
M. Michailidou, Vassiliki Giannouli, V. Kotsikoris, O. Papadodima +8 more
2016European journal of medicinal chemistry29 citations
Semantic Scholar
Hydroxytyrosol (HT) Analogs Act as Potent Antifungals by Direct Disruption of the Fungal Cell Membrane
G. Diallinas, Nausica Rafailidou, Ioanna Kalpaktsi, Aikaterini Christina Komianou +5 more
2018Frontiers in Microbiology26 citations Open access
Semantic Scholar
Design and synthesis of some new pyranoxanthenone aminoderivatives with cytotoxic activity.
G. Kolokythas, I. Kostakis, Nicole Pouli, P. Marakos +2 more
2002Bioorganic & Medicinal Chemistry Letters24 citations
Semantic Scholar
Synthesis, cytotoxic activity, NMR study and stereochemical effects of some new pyrano[3,2-b]thioxanthen-6-ones and pyrano[2,3-c]thioxanthen-7-ones.
I. Kostakis, Nicole Pouli, P. Marakos, E. Mikros +4 more
2001Bioorganic & Medicinal Chemistry24 citations
Semantic Scholar
New bioactive 5-arylcarboximidamidopyrazolo[3,4-c]pyridines: Synthesis, cytotoxic activity, mechanistic investigation and structure-activity relationships.
Athanasios Papastathopoulos, N. Lougiakis, I. Kostakis, P. Marakos +3 more
2021European journal of medicinal chemistry22 citations
Semantic Scholar
Design, synthesis, and evaluation of the antiproliferative activity of a series of novel fused xanthenone aminoderivatives in human breast cancer cells.
V. Giannouli, I. Kostakis, Nicole Pouli, P. Marakos +3 more
2007Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol
Amalia D. Kalampaliki, Vassiliki Giannouli, A. Skaltsounis, I. Kostakis
2019Molecules21 citations Open access
Semantic Scholar
Synthesis and Biological Evaluation of Resveratrol Methoxy Derivatives
E. Fragopoulou, Katerina Gkotsi, Filio Petsini, K. Gioti +4 more
2023Molecules20 citations Open access
Semantic Scholar
Antiproliferative and proapoptotic activities of pyranoxanthenones, pyranothioxanthenones and their pyrazole-fused derivatives in HL-60 cells.
E. Perchellet, M. M. Ward, A. Skaltsounis, I. Kostakis +3 more
2006Anticancer Research20 citations
Semantic Scholar
Design and synthesis of new pyranoxanthenones bearing a nitro group or an aminosubstituted side chain on the pyran ring. Evaluation of their growth inhibitory activity in breast cancer cells.
G. Kolokythas, I. Kostakis, Nicole Pouli, P. Marakos +3 more
2007European journal of medicinal chemistry19 citations
Semantic Scholar
Design, synthesis, and antiproliferative activity of some novel aminosubstituted xanthenones, able to overcome multidrug resistance toward MES-SA/Dx5 cells.
I. Kostakis, R. Tenta, Nicole Pouli, P. Marakos +3 more
2005Bioorganic & Medicinal Chemistry Letters18 citations
Semantic Scholar
Synthesis and cytotoxic activity of 2-dialkylaminoethylamino substituted xanthenone and thioxanthenone derivatives.
I. Kostakis, K. Ghirtis, Nicole Pouli, P. Marakos +4 more
2000Il Farmaco16 citations
Semantic Scholar
The discovery of new cytotoxic pyrazolopyridine derivatives.
Vassiliki Giannouli, N. Lougiakis, I. Kostakis, Nicole Pouli +8 more
2016Bioorganic & Medicinal Chemistry Letters13 citations
Semantic Scholar
Next-generation sequencing reveals altered gene expression and enriched pathways in triple-negative breast cancer cells treated with oleuropein and oleocanthal
P. Karousi, C. Kontos, Panagiota Papakotsi, I. Kostakis +2 more
2023Functional & Integrative Genomics12 citations Open access
Semantic Scholar
Decomposition of Formamide Assisted by Microwaves, a Tool for Synthesis of Nitrogen-Containing Heterocycles.
Ines Nouira, I. Kostakis, Carole Dubouilh, E. Chosson +2 more
200912 citations
Semantic Scholar
Design and synthesis of novel amino-substituted xanthenones and benzo[b]xanthenones: Evaluation of their antiproliferative activity and their ability to overcome multidrug resistance toward MES-SA/D × 5 cells
I. Kostakis, Nicole Pouli, P. Marakos, A. Skaltsounis +2 more
200612 citations
Semantic Scholar
Xanthone synthetic derivatives with high anticandidal activity and positive mycostatic selectivity index values
K. Rząd, Rachel Ioannidi, P. Marakos, Nicole Pouli +3 more
2023Scientific Reports11 citations Open access
Semantic Scholar
Synthesis and Tautomerism of Substituted Pyrazolo[4,3‐c]pyrazoles
S. Kadam, Lukas Maier, I. Kostakis, Nicole Pouli +4 more
201311 citations Open access
Semantic Scholar
Design, synthesis and cell growth inhibitory activity of a series of novel aminosubstituted xantheno[1,2-d]imidazoles in breast cancer cells.
I. Kostakis, Nicole Pouli, P. Marakos, O. C. Kousidou +3 more
2008Bioorganic & Medicinal Chemistry11 citations
Semantic Scholar
Molecular investigation of artificial and natural sweeteners as potential anti-inflammatory agents
E. Chontzopoulou, Christina D. Papaemmanouil, M. Chatziathanasiadou, D. Kolokouris +10 more
2021Journal of Biomolecular Structure and Dynamics10 citations Open access
Semantic Scholar
Design and Synthesis of New Substituted Pyrazolopyridines with Potent Antiproliferative Activity
Vassiliki Giannouli, N. Lougiakis, I. Kostakis, Nicole Pouli +6 more
2020Medicinal chemistry9 citations Open access
Semantic Scholar
Anti-Inflammatory Activity of the Major Triterpenic Acids of Chios Mastic Gum and Their Semi-Synthetic Analogues
P. Stamou, D. Gianniou, I. Trougakos, S. Mitakou +3 more
2024Biomolecules7 citations Open access
Semantic Scholar
Exploring 4,7-Disubstituted Pyrimido[4,5-d]pyrimidines as Antiviral and Anticancer Agents
Eleftheria A. Georgiou, K. Paraskevas, Christina Koutra, L. Persoons +3 more
2024Molecules7 citations Open access
Semantic Scholar
Mitochondria-Targeted Triphenylphosphonium-Hydroxytyrosol Prevents Lipotoxicity-Induced Endothelial Injury by Enhancing Mitochondrial Function and Redox Balance via Promoting FoxO1 and Nrf2 Nuclear Translocation and Suppressing Inflammation via Inhibiting p38/NF-кB Pathway
Xu-Yun Liu, Jing Gao, Yizhen Yan, Eleftheria A. Georgiou +7 more
2023Antioxidants7 citations Open access
Semantic Scholar
Design, synthesis and antiproliferative activity of novel aminosubstituted benzothiopyranoisoindoles.
A. Christodoulou, I. Kostakis, Vassilios N. Kourafalos, Nicole Pouli +3 more
2011Bioorganic & Medicinal Chemistry Letters7 citations
Semantic Scholar
Synthesis and antiproliferative activity of substituted benzopyranoisoindoles: a new class of cytotoxic compounds.
Christiana Hadjipavlou, I. Kostakis, Nicole Pouli, P. Marakos +2 more
2006Bioorganic & Medicinal Chemistry Letters7 citations
Semantic Scholar
Exploring the Effect of Resveratrol, Tyrosol, and Their Derivatives on Platelet-Activating Factor Biosynthesis in U937 Cells
Filio Petsini, M. Detopoulou, M. Choleva, I. Kostakis +2 more
2024Molecules6 citations
Semantic Scholar
Chemometrically Assisted Optimization of Pregabalin Fluorescent Derivatization Reaction with a Novel Xanthone Analogue and Validation of the Method for the Determination of Pregabalin in Bulk via a Plate Reader
N. Kritikos, Aikaterini Iliou, Amalia D. Kalampaliki, E. Gikas +3 more
2022Molecules6 citations Open access
Semantic Scholar
Synthesis of some new spiropyranoquinolines and evaluation of their free radical scavenging activity.
Vassiliki Panteleon, I. Kostakis, P. Marakos, Nicole Pouli +1 more
2009Chemical and pharmaceutical bulletin6 citations Open access
Semantic Scholar
1-Ethyl-1H-3-nitrobenzopyrano[4,3,2-cd]isoindole: a novel heterocyclic ring system bearing an unusually labile deuterium-exchangeable aromatic proton
Christiana Hadjipavlou, I. Kostakis, Nicole Pouli, P. Marakos +1 more
20066 citations
Semantic Scholar
Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors
Chiara Bosetti, Dionisis Kampasis, Albert Galera-Prat, S. A. Brinch +6 more
2024bioRxiv5 citations Open access
Semantic Scholar
Copper-Catalyzed C–H Arylation of Fused-Pyrimidinone Derivatives Using Diaryliodonium Salts
Alexandra Pacheco-Benichou, Eugénie Ivendengani, I. Kostakis, T. Besson +1 more
2020Catalysts5 citations Open access
Semantic Scholar
Synthesis, Biological Evaluation and Stability Studies of Some Novel Aza-Acridine Aminoderivatives
Maria Karelou, V. Kourafalos, Athanasia Tragomalou, P. Marakos +4 more
2020Molecules5 citations Open access
Semantic Scholar
Exploring the Interaction of New Pyridoquinazoline Derivatives with G-Quadruplex in the c-MYC Promoter Region
S. Princiotto, Maria Karelou, Rachel Ioannidi, G. Beretta +5 more
2023International Journal of Molecular Sciences4 citations Open access
Semantic Scholar
Synthesis of novel xanthone and acridone carboxamides with potent antiproliferative activities
A. Georgakopoulos, Amalia D. Kalampaliki, K. Gioti, Sami Hamdoun +7 more
20204 citations Open access
Semantic Scholar
Discovery of New Aminosubstituted Pyrrolopyrimidines with Antiproliferative Activity Against Breast Cancer Cells and Investigation of their Effect Towards the PI3Kα Enzyme.
Konstantinos Daniilides, N. Lougiakis, T. Evangelidis, I. Kostakis +13 more
2017Anti-Cancer Agents in Medicinal Chemistry4 citations
Semantic Scholar
Synthesis, Stability, and Biological Evaluation of Novel Aminoderivatives Incorporating the Aza-Acridine Scaffold
Maria Karelou, A. Panara, Eleftheria Chatziorfanou, Aikaterini F. Giannopoulou +3 more
2025Molecules3 citations Open access
Semantic Scholar
Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3H)-Ones with Antiproliferative Activities
Maria Karelou, Dionysis Kampasis, Amalia D. Kalampaliki, L. Persoons +5 more
2023Molecules3 citations Open access
Semantic Scholar
Synthesis, spectroscopic and computational evaluation of a xanthene-based fluorogenic derivatization reagent for the determination of primary amines
Amalia D. Kalampaliki, Steve Vincent, Sumana Mallick, Hoang-Ngoan Le +7 more
2021Dyes and pigments3 citations Open access
Semantic Scholar
Synthesis and antiproliferative activity of some novel benzo-fused imidazo[1,8]naphthyridinones.
Vassiliki Giannouli, I. Kostakis, Nicole Pouli, P. Marakos +2 more
2015Bioorganic & Medicinal Chemistry Letters3 citations
Semantic Scholar

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Nicole Pouli — researcher profile on SciRah
P. Marakos×26
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A. Skaltsounis×14
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Amalia D. Kalampaliki×6

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Vassiliki Giannouli×5

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Vassiliki Giannouli — researcher profile on SciRah

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R. Tenta — researcher profile on SciRah

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