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H. Niehues · SciRah

Researcher profile · Semantic Scholar

H. Niehues

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H. Niehues — researcher profile on SciRah

h-index: 18
Works: 51
Citations: 1,406

Most-cited papers

Microbe-host interplay in atopic dermatitis and psoriasis
N. Fyhrquist, Gareth Muirhead, Stefanie Prast-Nielsen, M. Jeanmougin +43 more
2019Nature Communications331 citations Open access
Semantic Scholar
Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal models
J. Smits, H. Niehues, G. Rikken, I. van Vlijmen-Willems +4 more
2017Scientific Reports183 citations Open access
Semantic Scholar
3D skin models for 3R research: The potential of 3D reconstructed skin models to study skin barrier function
H. Niehues, J. Bouwstra, A. El Ghalbzouri, J. Brandner +2 more
2018Experimental Dermatology168 citations Open access
Semantic Scholar
Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation
Evelyn N. Kouwenhoven, M. Oti, H. Niehues, S. J. van Heeringen +4 more
2015EMBO Reports162 citations Open access
Semantic Scholar
Psoriasis-associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity
H. Niehues, L. Tsoi, D. A. van der Krieken, P. Jansen +12 more
2017Journal of Investigative Dermatology71 citations Open access
Semantic Scholar
Epidermal equivalents of filaggrin null keratinocytes do not show impaired skin barrier function.
H. Niehues, J. Schalkwijk, I. van Vlijmen-Willems, D. Rodijk-Olthuis +5 more
2017Journal of Allergy and Clinical Immunology46 citations Open access
Semantic Scholar
The "Alarmins" HMBG1 and IL-33 Downregulate Structural Skin Barrier Proteins and Impair Epidermal Growth.
U. Nygaard, E. van den Bogaard, H. Niehues, M. Hvid +3 more
2017Acta Dermato-Venereologica44 citations Open access
Semantic Scholar
Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis
H. Niehues, G. Rikken, I. van Vlijmen-Willems, D. Rodijk-Olthuis +4 more
2021JID Innovations42 citations Open access
Semantic Scholar
Organotypic 3D Skin Models: Human Epidermal Equivalent Cultures from Primary Keratinocytes and Immortalized Keratinocyte Cell Lines.
G. Rikken, H. Niehues, E. van den Bogaard
2020Methods in molecular biology35 citations
Semantic Scholar
Late cornified envelope (LCE) proteins: distinct expression patterns of LCE2 and LCE3 members suggest nonredundant roles in human epidermis and other epithelia
H. Niehues, I. van Vlijmen-Willems, J. Bergboer, Ferry F. J. Kersten +5 more
2016British Journal of Dermatology33 citations
Semantic Scholar
Past, present and future of in vitro 3D reconstructed inflammatory skin models to study psoriasis
H. Niehues, E. H. Van den Bogaard
2018Experimental Dermatology31 citations Open access
Semantic Scholar
Novel methodologies for host-microbe interactions and microbiome-targeted therapeutics in 3D organotypic skin models
G. Rikken, L. Meesters, Patrick A. M. Jansen, D. Rodijk-Olthuis +8 more
2023Microbiome24 citations Open access
Semantic Scholar
Vesicular hand eczema transcriptome analysis provides insights into its pathophysiology
A. Voorberg, H. Niehues, J. Oosterhaven, G. L. E. Romeijn +5 more
2021Experimental Dermatology24 citations Open access
Semantic Scholar
Pharmacologic inhibition of hypoxia‐inducible factor (HIF)‐hydroxylases ameliorates allergic contact dermatitis
Mario C. Manresa, L. Smith, L. Casals-Díaz, R. R. Fagundes +11 more
2018Allergy. European Journal of Allergy and Clinical Immunology24 citations Open access
Semantic Scholar
Antibiotics in cell culture: friend or foe? Suppression of keratinocyte growth and differentiation in monolayer cultures and 3D skin models
U. Nygaard, H. Niehues, G. Rikken, D. Rodijk-Olthuis +2 more
2015Experimental Dermatology24 citations Open access
Semantic Scholar
Dissecting key contributions of Th2 and Th17 cytokines to atopic dermatitis pathophysiology.
L. Meesters, J. Roubroeks, Aranka Gerritsen, Niels Velthuijs +16 more
2025Journal of Allergy and Clinical Immunology23 citations Open access
Semantic Scholar
Investigations into the filaggrin null phenotype: showcasing the methodology for CRISPR/Cas9 editing of human keratinocytes.
J. Smits, N. V. D. van den Brink, L. Meesters, Hadia Hamdaoui +11 more
2023Journal of Investigative Dermatology22 citations Open access
Semantic Scholar
Gram-positive anaerobe cocci are underrepresented in the microbiome of filaggrin-deficient human skin.
P. Zeeuwen, T. Ederveen, D. A. van der Krieken, H. Niehues +16 more
2017Journal of Allergy and Clinical Immunology20 citations Open access
Semantic Scholar
Electrical Impedance Spectroscopy Quantifies Skin Barrier Function in Organotypic In Vitro Epidermis Models.
N. V. D. van den Brink, F. Pardow, L. Meesters, I. van Vlijmen-Willems +7 more
2024Journal of Investigative Dermatology15 citations Open access
Semantic Scholar
Keratinocyte signaling in atopic dermatitis: investigations in organotypic skin models towards clinical application.
L. Meesters, H. Niehues, L. Johnston, J. Smits +3 more
2023Journal of Allergy and Clinical Immunology15 citations Open access
Semantic Scholar
CYSRT1: an antimicrobial epidermal protein that can interact with late cornified envelope (LCE) proteins.
H. Niehues, G. Rikken, Ferry F. J. Kersten, J. Eeftens +8 more
2023Journal of Investigative Dermatology11 citations Open access
Semantic Scholar
STAT1 gain-of-function compromises skin host defense in the context of IFN-γ signaling.
H. Niehues, B. Rösler, D. A. van der Krieken, I. van Vlijmen-Willems +6 more
2019Journal of Allergy and Clinical Immunology11 citations Open access
Semantic Scholar
Ex Vivo Infection of Human Skin Models with Herpes Simplex Virus 1: Accessibility of the Receptor Nectin-1 during Formation or Impairment of Epidermal Barriers Is Restricted by Tight Junctions
Nydia C. De La Cruz, M. Möckel, H. Niehues, M. Rübsam +4 more
2023Journal of Virology10 citations Open access
Semantic Scholar
Antimicrobial late cornified envelope (LCE) proteins: the psoriasis risk factor LCE3B/C-del affects microbiota composition.
H. Niehues, D. A. van der Krieken, T. Ederveen, P. Jansen +7 more
2021Journal of Investigative Dermatology10 citations Open access
Semantic Scholar
Electrical Impedance Spectroscopy Quantifies Skin Barrier Function in Organotypic In Vitro Epidermis Models
N. V. D. van den Brink, F. Pardow, L. Meesters, I. van Vlijmen-Willems +7 more
2024bioRxiv9 citations Open access
Semantic Scholar
Keratinocyte Proliferation and Differentiation on IL-9 Stimulation: An Explorative In vitro Study.
H. Niehues, J. Smits, D. Rodijk-Olthuis, J. Schalkwijk +1 more
2017Acta Dermato-Venereologica5 citations Open access
Semantic Scholar
Fluoxetine exerts anti-proliferative effect in human epidermal keratinocytes
D. Ádám, J. Arany, K. Tóth, S. Póliska +8 more
2025Archives of Dermatological Research3 citations Open access
Semantic Scholar
Antimicrobial Late Corniﬁed Envelope Proteins: The Psoriasis Risk Factor Deletion of LCE3B/C Genes Affects Microbiota Composition
H. Niehues, D. A. van der Krieken, T. Ederveen, P. Jansen +7 more
20223 citations
Semantic Scholar
Know your enemy: Unexpected, pervasive and persistent viral and bacterial contamination of primary cell cultures
H. Niehues, P. Jansen, D. Rodijk-Olthuis, G. Rikken +4 more
2020Experimental Dermatology3 citations Open access
Semantic Scholar
Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis.
Jos G. A. Smits, J. Qu, H. Niehues, Hui-Qing Zhou
2020Journal of Visualized Experiments2 citations Open access
Semantic Scholar
Advanced methodology for bacterial colonization of 3D organotypic epidermal models: a gateway to long-term host-microbe interaction and intervention studies
G. Rikken, L. Meesters, Patrick A. M. Jansen, D. Rodijk-Olthuis +7 more
2023bioRxiv1 citations Open access
Semantic Scholar
120 Identification of keratinocyte mitogens: implications for hyperproliferation in psoriasis and atopic dermatitis
H. Niehues, G. Rikken, I. van Vlijmen-Willems, D. Rodijk-Olthuis +4 more
2021Journal of Investigative Dermatology1 citations Open access
Semantic Scholar
113 Immortalized N/TERT keratinocytes: An excellent and versatile alternative for primary keratinocytes in experimental dermatological research
J. Smits, H. Niehues, G. Rikken, I. van Vlijmen-Willems +3 more
20171 citations Open access
Semantic Scholar
107 Filaggrin deficiency impacts cutaneous microbiota
P. Zeeuwen, T. Ederveen, D. A. van der Krieken, H. Niehues +6 more
20161 citations Open access
Semantic Scholar
Validated Step-by-Step Protocols for Human Keratinocyte Isolation and the Construction of Organotypic 3D Epidermal Models.
J. Klijnhout, R. Peters, G. Rikken, D. Rodijk-Olthuis +5 more
2026Methods in molecular biology0 citations
Semantic Scholar
Future Integration of Biomarkers for Inflammatory Skin Diseases Into Daily Practice: A Survey Among a Multifaceted Group of Patients and Dermatological Care Providers
L. Godding, E. D. De Jong, S. van Beugen, A. V. van Laarhoven +9 more
2026Experimental Dermatology0 citations Open access
Semantic Scholar
Correction: Fluoxetine exerts anti-proliferative effect in human epidermal keratinocytes
D. Ádám, J. Arany, K. Tóth, S. Póliska +8 more
2025Archives of Dermatological Research0 citations Open access
Semantic Scholar
Remote monitoring in chronic immune-mediated inflammatory diseases: A systematic review of active and passive approaches
Mariona Oliver, J. Rousel, J. Schoones, H. Niehues +8 more
2025JAAD International0 citations Open access
Semantic Scholar
283 Key morphological, transcriptomic and functional AD hallmarks driven by the presence of IL-22 within a Th2 cytokine milieu are abrogated by Tapinarof
R. Peters, L. Meesters, C. Mergen, M. Hübenthal +4 more
2025Journal of Investigative Dermatology0 citations
Semantic Scholar
125 Electrical impedance spectroscopy evaluates organotypic epidermis formation and skin barrier function in vitro
N. V. D. van den Brink, F. Pardow, L. Meesters, H. Niehues +6 more
2023Journal of Investigative Dermatology0 citations Open access
Semantic Scholar
696 A data-driven approach towards mature iPSC-derived keratinocytes
L. Meesters, C. Laberthonnière, R. Simons, H. Niehues +2 more
2023Journal of Investigative Dermatology0 citations Open access
Semantic Scholar
195 Untangling the complex cytokine milieu in psoriasis and atopic dermatitis through organotypic epidermal models
L. Meesters, D. Rodijk-Olthuis, G. Rikken, I. van Vlijmen-Willems +2 more
2022Journal of Investigative Dermatology0 citations Open access
Semantic Scholar
172 CYSRT1: an antimicrobial epidermal protein that interacts with late cornified envelope (LCE) proteins
H. Niehues, G. Rikken, F. Kersten, J. Eeftens +11 more
2022Journal of Investigative Dermatology0 citations Open access
Semantic Scholar
ESDR120 - Identification of keratinocyte mitogens: implications for hyperproliferation in psoriasis and atopic dermatitis
H. Niehues
20210 citations
Semantic Scholar
136 Technical advance: bacterial colonization of 3D organotypic skin models for long-term host-microbe interactions and microbiome intervention studies
G. Rikken, L. Meesters, I. van Vlijmen-Willems, D. Rodijk-Olthuis +6 more
2021Journal of Investigative Dermatology0 citations Open access
Semantic Scholar
114 Insight into the pathogenesis of vesicular and hyperkeratotic hand eczema
L. Loman, A. Voorberg, H. Niehues, T. Ederveen +2 more
2021Journal of Investigative Dermatology0 citations Open access
Semantic Scholar
189 STAT1 gain-of-function compromises skin host defense in the context of IFN-γ signaling
H. Niehues, B. Rösler, D. A. van der Krieken, I. van Vlijmen-Willems +6 more
2019Journal of Investigative Dermatology0 citations Open access
Semantic Scholar
From sequence to function: Understanding of genetic risk factors for psoriasis and atopic dermatitis
H. Niehues
20170 citations
Semantic Scholar
Manifestations of Corporal Oppression – Embodiments of Culturalpolitical Resistance: The Representation of the Body in German Literature of the Long Nineteenth Century
H. Niehues
20170 citations
Semantic Scholar
Gram-positive anaerobe cocci ( GPAC ) are underrepresented in the 1 microbiome of filaggrin-deficient human skin 2
P. Zeeuwen, T. Ederveen, Danique A. van der, Krieken +19 more
20160 citations
Semantic Scholar

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