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G. Saggu · SciRah

Researcher profile · Semantic Scholar

G. Saggu

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G. Saggu — researcher profile on SciRah

h-index: 11
Works: 28
Citations: 599

Most-cited papers

Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules
Konrad Buscher, Huiyu Wang, Xueli Zhang, Paul Striewski +7 more
2016Nature Communications89 citations Open access
Semantic Scholar
Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and C3(H2O)
G. Saggu, Claudio Cortés, H. Emch, Galia Ramírez +2 more
2012Journal of Immunology89 citations Open access
Semantic Scholar
Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement
Claudio Cortés, J. Ohtola, G. Saggu, V. Ferreira
2013Front. Immun.72 citations Open access
Semantic Scholar
ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes.
Zhen Lu, Noreen McBrearty, Jin-Yun Chen, V. Tomar +12 more
2024Cell Metabolism65 citations Open access
Semantic Scholar
Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases.
H. Nishi, K. Furuhashi, X. Cullere, G. Saggu +13 more
2017Journal of Clinical Investigation58 citations Open access
Semantic Scholar
Low-dose recombinant properdin provides substantial protection against Streptococcus pneumoniae and Neisseria meningitidis infection
Youssif M. Ali, A. Hayat, Bayad Mawlood Saeed, K. Haleem +11 more
2014Proceedings of the National Academy of Sciences of the United States of America49 citations Open access
Semantic Scholar
Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment
G. Saggu, Koshu Okubo, Yun-Feng Chen, Ravi Vattepu +11 more
2018Nature Communications44 citations Open access
Semantic Scholar
Increased lymphocyte activation and atherosclerosis in CD47-deficient mice
D. Engelbertsen, Anu Autio, R. Verwilligen, M. Depuydt +9 more
2019Scientific Reports30 citations Open access
Semantic Scholar
Properdin-mediated C5a production enhances stable binding of platelets to granulocytes in human whole blood
Adam Z. Blatt, G. Saggu, Koustubh V. Kulkarni, Claudio Cortés +5 more
2016Journal of Immunology30 citations Open access
Semantic Scholar
PKC‐δ activation in neutrophils promotes fungal clearance
Xun Li, X. Cullere, H. Nishi, G. Saggu +7 more
2016Journal of Leukocyte Biology21 citations Open access
Semantic Scholar
ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes
Zhen Lu, Noreen McBrearty, Jin-Yun Chen, Vivek S. Tomar +12 more
2022Cell Metabolism13 citations Open access
Semantic Scholar
Protection of regulatory T cells from fragility and inactivation in the tumor microenvironment
Hongru Zhang, V. Tomar, Jin-Yang Li, R J Basavaraja +12 more
2022Cancer immunology research11 citations Open access
Semantic Scholar
Factor H C-Terminal Domains Are Critical for Regulation of Platelet/Granulocyte Aggregate Formation
Adam Z. Blatt, G. Saggu, Claudio Cortés, A. Herbert +4 more
2017Frontiers in Immunology10 citations Open access
Semantic Scholar
Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling
Koshu Okubo, Michael D. Brenner, X. Cullere, G. Saggu +7 more
2021Cell Reports8 citations Open access
Semantic Scholar
The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa
Adriana Martinez, P. A. Abreu, Silvio de Arruda Vasconcellos, P. Ho +4 more
2020Frontiers in Immunology3 citations Open access
Semantic Scholar
A phase Ib/II study of modakafusp alfa alone and in combination with pembrolizumab in patients with advanced or metastatic solid tumors
D. Gill, C. Cowey, G. A. Daniels, D. Sommerhalder +18 more
2025Frontiers in Oncology2 citations
Semantic Scholar
Modakafusp Alfa Demonstrates Type I Interferon-Mediated Innate and Adaptive Immune Enhancement in a Phase 1/2 Study in Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM)
G. Saggu, Min Young Lee, F. Dunbar, Reshma Singh +9 more
2023Blood2 citations Open access
Semantic Scholar
Chapter 20 – Humoral Pathogenesis: Fcγ Receptors in Autoimmunity and End-Organ Damage
T. Ernandez, G. Saggu, T. Mayadas
20161 citations
Semantic Scholar
Role of Complement Regulatory Protein Properdin in Complement Activation on Platelets and in the Formation of Platelet-Leukocyte Aggregates
G. Saggu
20141 citations
Semantic Scholar
Modakafusp Alfa Boosts Anti-Myeloma Activity via CD38 Targeting and IFNα-Driven Immune Activation
Wassilis S. C. Bruins, R. Rentenaar, Sabrina C. Collins, James F Sampson +7 more
2026Blood Immunology & Cellular Therapy0 citations Open access
Semantic Scholar
Abstract 7446: Stratification of cell therapies in solid tumor organoids using deep learning-derived imaging metrics
Luca Lonini, M. Kannan, Geoffrey F Schau, Stanislaw Szydlo +14 more
2025Cancer Research0 citations
Semantic Scholar
Abstract CT065: Modakafusp alfa shows intratumoral immune pharmacodynamics (PD) in a subset of patients (pts) in a phase 1b study in advanced/metastatic solid tumors
G. Saggu, Janet L. Markman, Min Young Lee, F. Dunbar +3 more
2024Cancer Research0 citations
Semantic Scholar
Fcγ receptors in autoimmunity and end-organ damage
T. Ernandez, Koshu Okubo, G. Saggu, T. Mayadas
20210 citations
Semantic Scholar
This information is current as Granulocytes in Human Whole Blood Enhances Stable Binding of Platelets to Properdin-Mediated C 5 a Production
Adam Z. Blatt, G. Saggu, Koustubh V. Kulkarni, Claudio Cortés +5 more
20160 citations
Semantic Scholar
Essential regulatory role for factor H and properdin in the formation of platelet/granulocyte aggregates in human whole blood (HUM1P.301)
Adam Z. Blatt, G. Saggu, Claudio Cortés, V. Ferreira
2014Journal of Immunology0 citations
Semantic Scholar
Complement regulatory protein properdin promotes complement activation on platelets and increases platelet-leukocyte aggregate formation (P1311)
V. Ferreira, G. Saggu, S. Nauli, Claudio Cortés
2013Journal of Immunology0 citations
Semantic Scholar
LJM19, a salivary protein from the sand fly vector that transmits leishmaniasis, is a novel inhibitor of the classical pathway of complement
V. Ferreira, G. Saggu, M. H. Pereira, R. Araujo +7 more
20120 citations
Semantic Scholar
Modeling the evolution of activation marker distributions in flow cytometry data representing cell populations in patients dosed with immunomodulating agents
Dean Bottino, H. Bellout, Dina Stroopinsky, Siddha Kasar +4 more
Proceedings of the American Conference of Pharmacometrics 20240 citations Open access
Semantic Scholar

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