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V. Sauzeau · SciRah

Researcher profile · Semantic Scholar

V. Sauzeau

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V. Sauzeau — researcher profile on SciRah

h-index: 32
Works: 70
Citations: 4,377

Most-cited papers

GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo
X. Bustelo, V. Sauzeau, Inmaculada M. Berenjeno
2007Bioessays666 citations Open access
Semantic Scholar
Cyclic GMP-dependent Protein Kinase Signaling Pathway Inhibits RhoA-induced Ca2+ Sensitization of Contraction in Vascular Smooth Muscle*
V. Sauzeau, Hélène le Jeune, C. Cario-Toumaniantz, A. Smolenski +5 more
2000Journal of Biological Chemistry612 citations Open access
Semantic Scholar
Human Urotensin II–Induced Contraction and Arterial Smooth Muscle Cell Proliferation Are Mediated by RhoA and Rho-Kinase
V. Sauzeau, Erik Le Mellionnec, J. Bertoglio, E. Scalbert +2 more
2001Circulation Research277 citations Open access
Semantic Scholar
Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis.
J. Segain, D. Raingeard de la Blétière, V. Sauzeau, A. Bourreille +5 more
2003Gastroenterology198 citations Open access
Semantic Scholar
RhoA Expression Is Controlled by Nitric Oxide through cGMP-dependent Protein Kinase Activation*
V. Sauzeau, M. Rolli-Derkinderen, Céline Marionneau, G. Loirand +1 more
2003Journal of Biological Chemistry183 citations Open access
Semantic Scholar
Rho-Associated Protein Kinase Contributes to Early Atherosclerotic Lesion Formation in Mice
Z. Mallat, A. Gojová, V. Sauzeau, V. Brun +6 more
2003Circulation Research171 citations
Semantic Scholar
Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension
C. Guilluy, V. Sauzeau, M. Rolli-Derkinderen, P. Guérin +3 more
2005British Journal of Pharmacology162 citations Open access
Semantic Scholar
Phosphorylation of Serine 188 Protects RhoA from Ubiquitin/Proteasome-Mediated Degradation in Vascular Smooth Muscle Cells
M. Rolli-Derkinderen, V. Sauzeau, L. Boyer, E. Lemichez +4 more
2005Circulation Research153 citations Open access
Semantic Scholar
Mesenchymal Stem Cells Induce Suppressive Macrophages Through Phagocytosis in a Mouse Model of Asthma
F. Braza, S. Dirou, V. Forest, V. Sauzeau +6 more
2016Stem Cells151 citations Open access
Semantic Scholar
Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction
V. Sauzeau, M. Sevilla, Juan V. Rivas-Elena, E. de Álava +3 more
2006Nature Medicine125 citations Open access
Semantic Scholar
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition.
A. J. Schuhmacher, C. Guerra, V. Sauzeau, M. Cañamero +2 more
2008Journal of Clinical Investigation113 citations Open access
Semantic Scholar
P2Y(1), P2Y(2), P2Y(4), and P2Y(6) receptors are coupled to Rho and Rho kinase activation in vascular myocytes.
V. Sauzeau, Hélène le Jeune, C. Cario-Toumaniantz, N. Vaillant +6 more
2000American Journal of Physiology. Heart and Circulatory Physiology110 citations
Semantic Scholar
Small G proteins in the cardiovascular system: physiological and pathological aspects.
G. Loirand, V. Sauzeau, P. Pacaud
2013Physiological Reviews96 citations
Semantic Scholar
Coronin 1A promotes a cytoskeletal‐based feedback loop that facilitates Rac1 translocation and activation
Antonio Castro-Castro, Virginia Ojeda, M. Barreira, V. Sauzeau +6 more
2011EMBO Journal87 citations Open access
Semantic Scholar
Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1.
J. Barrera-Chimal, G. André-Grégoire, Aurélie Nguyen Dinh Cat, S. Lechner +7 more
2017Journal of the American Society of Nephrology83 citations Open access
Semantic Scholar
The dioxin receptor regulates the constitutive expression of the vav3 proto-oncogene and modulates cell shape and adhesion.
J. Carvajal-González, Sonia Mulero-Navarro, Angel-Carlos Román, V. Sauzeau +3 more
2009Molecular Biology of the Cell81 citations Open access
Semantic Scholar
Sildenafil Prevents Change in RhoA Expression Induced by Chronic Hypoxia in Rat Pulmonary Artery
V. Sauzeau, M. Rolli-Derkinderen, S. Lehoux, G. Loirand +1 more
2003Circulation Research76 citations Open access
Semantic Scholar
Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice.
V. Sauzeau, M. Jerkic, J. López-Novoa, X. Bustelo
2007Molecular Biology of the Cell71 citations Open access
Semantic Scholar
Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome
Jelena Urosevic, V. Sauzeau, M. L. Soto-Montenegro, S. Reig +7 more
2011Proceedings of the National Academy of Sciences of the United States of America68 citations Open access
Semantic Scholar
Prime role of IL-17A in neutrophilia and airway smooth muscle contraction in a house dust mite-induced allergic asthma model.
J. Chesné, F. Braza, G. Chadeuf, G. Mahay +6 more
2015Journal of Allergy and Clinical Immunology64 citations Open access
Semantic Scholar
Transcriptional Factor Aryl Hydrocarbon Receptor (Ahr) Controls Cardiovascular and Respiratory Functions by Regulating the Expression of the Vav3 Proto-oncogene*
V. Sauzeau, J. Carvajal-González, A. Riolobos, M. Sevilla +6 more
2010Journal of Biological Chemistry61 citations Open access
Semantic Scholar
The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.
V. Sauzeau, M. Sevilla, M. Montero, X. Bustelo
2009Journal of Clinical Investigation61 citations Open access
Semantic Scholar
Gi‐dependent and ‐independent mechanisms downstream of the P2Y12 ADP‐receptor
Carine Soulet, V. Sauzeau, M. Plantavid, J. Herbert +3 more
2004Journal of Thrombosis and Haemostasis56 citations Open access
Semantic Scholar
Modulation of RhoA—Rho kinase‐mediated Ca2+ sensitization of rabbit myometrium during pregnancy — role of Rnd3
C. Cario-Toumaniantz, G. Reillaudoux, V. Sauzeau, F. Heutte +5 more
2003Journal of Physiology50 citations Open access
Semantic Scholar
RRAD mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome.
Nadjet Belbachir, V. Portero, Z. Al Sayed, J. Gourraud +29 more
2019European Heart Journal47 citations Open access
Semantic Scholar
Vav3-deficient Mice Exhibit a Transient Delay in Cerebellar Development
C. Quevedo, V. Sauzeau, M. Menacho-Márquez, Antonio Castro-Castro +1 more
2010Molecular Biology of the Cell46 citations Open access
Semantic Scholar
Rac1 as a therapeutic anticancer target: promises and limitations.
C. Bailly, J. Beignet, G. Loirand, V. Sauzeau
2022Biochemical Pharmacology44 citations
Semantic Scholar
Rac-ing to the plasma membrane
X. Bustelo, Virginia Ojeda, M. Barreira, V. Sauzeau +1 more
2012Small GTPases41 citations Open access
Semantic Scholar
Vav3 Is Involved in GABAergic Axon Guidance Events Important for the Proper Function of Brainstem Neurons Controlling Cardiovascular, Respiratory, and Renal Parameters
V. Sauzeau, J. A. C. Horta-Júnior, A. Riolobos, G. Fernández +5 more
2010Molecular Biology of the Cell36 citations Open access
Semantic Scholar
Smooth Muscle Specific Rac1 Deficiency Induces Hypertension by Preventing p116RIP3‐Dependent RhoA Inhibition
G. André, J. Sandoval, Kevin Retailleau, L. Loufrani +5 more
2014Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease35 citations Open access
Semantic Scholar
Chronic sympathoexcitation through loss of Vav3, a Rac1 activator, results in divergent effects on metabolic syndrome and obesity depending on diet.
M. Menacho-Márquez, R. Nogueiras, Salvatore Fabbiano, V. Sauzeau +3 more
2013Cell Metabolism34 citations Open access
Semantic Scholar
Overexpressed or hyperactivated Rac1 as a target to treat hepatocellular carcinoma.
V. Sauzeau, J. Beignet, G. Vergoten, C. Bailly
2022Pharmacological Research33 citations Open access
Semantic Scholar
A TRANSCRIPTIONAL CROSS–TALK BETWEEN RhoA AND c–Myc INHIBITS THE RhoA/Rock–DEPENDENT CYTOSKELETON
V. Sauzeau, Inma M. Berenjeno, C. Citterio, X. Bustelo
2010Oncogene32 citations Open access
Semantic Scholar
Targeting of Rac1 prevents bronchoconstriction and airway hyperresponsiveness
G. André-Grégoire, F. Dilasser, J. Chesné, F. Braza +3 more
2017Journal of Allergy and Clinical Immunology31 citations Open access
Semantic Scholar
Valvular dystrophy associated filamin A mutations reveal a new role of its first repeats in small-GTPase regulation
D. Duval, A. Lardeux, T. Letourneau, R. Norris +7 more
2013Biochimica et Biophysica Acta31 citations Open access
Semantic Scholar
Stent Implantation Activates RhoA in Human Arteries: Inhibitory Effect of Rapamycin
P. Guérin, V. Sauzeau, M. Rolli-Derkinderen, Oussama Al Habbash +4 more
2005Journal of Vascular Research26 citations
Semantic Scholar
Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling
F. Dilasser, L. Rose, D. Hassoun, M. Klein +12 more
2021Thorax21 citations Open access
Semantic Scholar
Rho proteins and vascular diseases.
P. Pacaud, V. Sauzeau, G. Loirand
2005Archives des maladies du coeur et des vaisseaux21 citations
Semantic Scholar
Rac1 as a Target to Treat Dysfunctions and Cancer of the Bladder
V. Sauzeau, J. Beignet, C. Bailly
2022Biomedicines20 citations Open access
Semantic Scholar
New Functions of Vav Family Proteins in Cardiovascular Biology, Skeletal Muscle, and the Nervous System
S. Rodríguez-Fdez, L. F. Lorenzo-Martín, Salvatore Fabbiano, M. Menacho-Márquez +3 more
2021Biology17 citations Open access
Semantic Scholar
Bronchial smooth muscle cell in asthma: where does it fit?
D. Hassoun, L. Rose, F. Blanc, A. Magnan +2 more
2022BMJ Open Respiratory Research15 citations Open access
Semantic Scholar
Expression of VAV1 in the tumour microenvironment of glioblastoma multiforme
J. García, J. Couceiro, J. Gómez-Moreta, J. M. Gonzalez Valero +8 more
2012Journal of Neuro-Oncology15 citations Open access
Semantic Scholar
Der p 2.1 Peptide Abrogates House Dust Mites-Induced Asthma Features in Mice and Humanized Mice by Inhibiting DC-Mediated T Cell Polarization
M. Klein, L. Colas, M. Cheminant, C. Brosseau +3 more
2020Frontiers in Immunology14 citations Open access
Semantic Scholar
Smooth muscle Rac1 contributes to pulmonary hypertension
F. Dilasser, M. Rio, L. Rose, A. Tesse +3 more
2019British Journal of Pharmacology10 citations Open access
Semantic Scholar
Allergic Sensitization Driving Immune Phenotyping and Disease Severity in a Mouse Model of Asthma
E. Dijoux, M. Klein, Barbara Misme-Aucouturier, M. Cheminant +9 more
2023Allergy Asthma and Immunology Research8 citations Open access
Semantic Scholar
The Endothelial Dysfunction Could Be a Cause of Heart Failure with Preserved Ejection Fraction Development in a Rat Model
T. Dupas, T. Pelé, J. Dhot, M. Burban +12 more
2022Oxidative Medicine and Cellular Longevity8 citations Open access
Semantic Scholar
Increased β2-adrenergic vasorelaxation at the early phase of endotoxemic shock in rats.
D. Roul, B. Rozec, G. André, N. Merlet +7 more
2015Vascular pharmacology7 citations
Semantic Scholar
Synthesis and biological evaluation of 3-amino-, 3-alkoxy- and 3-aryloxy-6-(hetero)arylpyridazines as potent antitumor agents.
S. Sengmany, Mathilde Sitter, Eric Léonel, E. Le Gall +9 more
2019Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
[New protagonists in asthma pathophysiology].
M. Klein, E. Dijoux, F. Dilasser, D. Hassoun +6 more
2019Presse medicale2 citations Open access
Semantic Scholar
Essential role of smooth muscle Rac1 in airway hyperresponsiveness and airway remodelling associated to severe asthma
F. Dilasser, M. Klein, A. Magnan, G. Loirand +1 more
20181 citations
Semantic Scholar

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G. Loirand×27
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X. Bustelo×16
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P. Pacaud×13
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M. Rolli-Derkinderen×6

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