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R. Nagaraj · SciRah

Researcher profile · Semantic Scholar

R. Nagaraj

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R. Nagaraj — researcher profile on SciRah

h-index: 38
Works: 183
Citations: 5,121

Most-cited papers

Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in non diabetics)
T. Uchiki, Karen A Weikel, W. Jiao, F. Shang +6 more
2011Aging Cell200 citations Open access
Semantic Scholar
The pathogenic role of Maillard reaction in the aging eye
R. Nagaraj, M. Linetsky, Alan W. Stitt
2010Amino Acids148 citations
Semantic Scholar
Indoleamine 2,3-dioxygenase and 3OH-kynurenine Modifications are found in the Neuropathology of Alzheimer Disease
D. Bonda, Maneesh Mailankot, Jeremy G. Stone, Matthew R. Garrett +8 more
2010Redox Report108 citations Open access
Semantic Scholar
Candesartan Attenuates Diabetic Retinal Vascular Pathology by Restoring Glyoxalase-I Function
A. Miller, G. Tan, K. Binger, R. Pickering +4 more
2010Diabetes105 citations Open access
Semantic Scholar
Chaperone Peptides of α-Crystallin Inhibit Epithelial Cell Apoptosis, Protein Insolubilization, and Opacification in Experimental Cataracts*
R. Nahomi, Ben-Lian Wang, Cibin T. Raghavan, O. Voss +3 more
2013Journal of Biological Chemistry87 citations Open access
Semantic Scholar
Comprehensive Analysis of Maillard Protein Modifications in Human Lenses: Effect of Age and Cataract
M. Smuda, C. Henning, Cibin T. Raghavan, K. Johar +3 more
2015Biochemistry79 citations Open access
Semantic Scholar
Acetylation of αA-crystallin in the human lens: Effects on structure and chaperone function
R. Nagaraj, R. Nahomi, S. Shanthakumar, M. Linetsky +6 more
2011Biochimica et Biophysica Acta70 citations Open access
Semantic Scholar
AGEs in human lens capsule promote the TGFβ2‐mediated EMT of lens epithelial cells: implications for age‐associated fibrosis
Cibin T. Raghavan, M. Smuda, A. J. O. Smith, S. Howell +6 more
2016Aging Cell69 citations Open access
Semantic Scholar
Plasma Protein Pentosidine and Carboxymethyllysine, Biomarkers for Age-related Macular Degeneration
Jiaqian Ni, Xianglin Yuan, J. Gu, X. Yue +3 more
2009Molecular & Cellular Proteomics68 citations Open access
Semantic Scholar
UVA Light-excited Kynurenines Oxidize Ascorbate and Modify Lens Proteins through the Formation of Advanced Glycation End Products
M. Linetsky, Cibin T. Raghavan, K. Johar, Xingjun Fan +3 more
2014Journal of Biological Chemistry65 citations Open access
Semantic Scholar
Glycation-mediated inter-protein cross-linking is promoted by chaperone–client complexes of α-crystallin: Implications for lens aging and presbyopia
Sandip K. Nandi, R. Nahomi, Johanna M. Rankenberg, M. Glomb +1 more
2020Journal of Biological Chemistry49 citations Open access
Semantic Scholar
Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human lens epithelial cells: Apoptosis through the formation of 3-hydroxykynurenine
Maneesh Mailankot, R. Nagaraj
2010International Journal of Biochemistry and Cell Biology47 citations Open access
Semantic Scholar
Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells
R. Nahomi, Allison Palmer, Katelyn E. Roth, P. Fort +1 more
2013Biochimica et Biophysica Acta45 citations Open access
Semantic Scholar
Hydroimidazolone Modification of the Conserved Arg12 in Small Heat Shock Proteins: Studies on the Structure and Chaperone Function Using Mutant Mimics
R. Nagaraj, A. K. Panda, S. Shanthakumar, P. Santhoshkumar +3 more
2012PLoS ONE41 citations Open access
Semantic Scholar
Differential role of arginine mutations on the structure and functions of α-crystallin
A. K. Panda, Sandip K. Nandi, Ayon Chakraborty, R. Nagaraj +1 more
2015Biochimica et Biophysica Acta38 citations Open access
Semantic Scholar
Acetylation of Lysine92 Improves the Chaperone and Anti-apoptotic Activities of Human αB-Crystallin
R. Nahomi, Rong Huang, Sandip K. Nandi, Ben-Lian Wang +5 more
2013Biochemistry38 citations Open access
Semantic Scholar
Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities
R. Nahomi, M. Dimauro, Ben-Lian Wang, R. Nagaraj
2015Biochemical Journal36 citations Open access
Semantic Scholar
Hydroimidazolone Modification of Human αA-Crystallin: Effect on the Chaperone Function and Protein Refolding Ability
M. Gangadhariah, Ben-Lian Wang, M. Linetsky, C. Henning +3 more
2010Biochimica et Biophysica Acta36 citations Open access
Semantic Scholar
The Combined Effect of Acetylation and Glycation on the Chaperone and Anti-apoptotic Functions of Human α-Crystallin
R. Nahomi, T. Oya-Ito, R. Nagaraj
2012Biochimica et Biophysica Acta35 citations Open access
Semantic Scholar
Antibody-mediated retinal pericyte injury: implications for diabetic retinopathy.
Yan Li, Dawn Smith, Qing Li, N. Sheibani +4 more
2012Investigative Ophthalmology and Visual Science33 citations Open access
Semantic Scholar
Acetylation of Gly1 and Lys2 Promotes Aggregation of Human γD-Crystallin
M. Dimauro, Sandip K. Nandi, Cibin T. Raghavan, R. Kar +4 more
2014Biochemistry32 citations Open access
Semantic Scholar
Indoleamine 2,3-dioxygenase overexpression causes kynurenine-modification of proteins, fiber cell apoptosis and cataract formation in the mouse lens
Maneesh Mailankot, M. Staniszewska, H. Butler, M. Caprara +5 more
2009Laboratory Investigation31 citations Open access
Semantic Scholar
The Role of the Cysteine Residue in the Chaperone and Anti-Apoptotic Functions of Human Hsp27
Nagarekha Pasupuleti, M. Gangadhariah, Smitha Padmanabha, P. Santhoshkumar +1 more
2010Journal of Cellular Biochemistry30 citations Open access
Semantic Scholar
AGE-RAGE interaction in the TGFβ2-mediated epithelial to mesenchymal transition of human lens epithelial cells
Cibin T. Raghavan, R. Nagaraj
2016Glycoconjugate Journal27 citations Open access
Semantic Scholar
Glyoxalase I activity and immunoreactivity in the aging human lens
Maneesh Mailankot, Smitha Padmanabha, Nagarekha Pasupuleti, Denice L. Major +2 more
2009Biogerontology (Dordrecht)27 citations Open access
Semantic Scholar
Effect of methylglyoxal modification on stress-induced aggregation of client proteins and their chaperoning by human alphaA-crystallin.
Ashis Biswas, Ben-Lian Wang, M. Miyagi, R. Nagaraj
2008Biochemical Journal27 citations
Semantic Scholar
Advanced glycation end products in human diabetic lens capsules
Johanna M. Rankenberg, S. Rakete, Brandie D. Wagner, J. Patnaik +4 more
2021Experimental Eye Research24 citations Open access
Semantic Scholar
αB-crystallin is essential for the TGF-β2-mediated epithelial to mesenchymal transition of lens epithelial cells
R. Nahomi, M. Pantcheva, R. Nagaraj
2016Biochemical Journal22 citations Open access
Semantic Scholar
Succinylation Is a Gain-of-Function Modification in Human Lens αB-Crystallin
Sandip K. Nandi, S. Rakete, R. Nahomi, Cole R. Michel +3 more
2019Biochemistry21 citations Open access
Semantic Scholar
The role of HIF-1α in the TGF-β2-mediated epithelial-to-mesenchymal transition of human lens epithelial cells
R. Nahomi, R. Nagaraj
2018Journal of Cellular Biochemistry21 citations Open access
Semantic Scholar
Kynurenic Acid Protects Against Ischemia/Reperfusion-Induced Retinal Ganglion Cell Death in Mice
R. Nahomi, Mi-hyun Nam, Johanna M. Rankenberg, S. Rakete +6 more
2020International Journal of Molecular Sciences20 citations Open access
Semantic Scholar
Lysine malonylation and propionylation are prevalent in human lens proteins
R. Nahomi, Sandip K. Nandi, S. Rakete, Cole R. Michel +2 more
2019Experimental Eye Research19 citations Open access
Semantic Scholar
Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma
Dorota L. Stankowska, Mi-hyun Nam, R. Nahomi, Renuka M. Chaphalkar +4 more
2019Cell Death Discovery18 citations Open access
Semantic Scholar
Aggrelyte‐2 promotes protein solubility and decreases lens stiffness through lysine acetylation and disulfide reduction: Implications for treating presbyopia
Sudipta Panja, R. Nahomi, Johanna M. Rankenberg, Cole R. Michel +3 more
2023Aging Cell17 citations Open access
Semantic Scholar
Peptains block retinal ganglion cell death in animal models of ocular hypertension: implications for neuroprotection in glaucoma
M-H Nam, Dorota L. Stankowska, Gretchen A Johnson, R. Nahomi +2 more
2022Cell Death and Disease15 citations Open access
Semantic Scholar
Transforming growth factor-β2-mediated mesenchymal transition in lens epithelial cells is repressed in the absence of RAGE.
M-H Nam, M. Pantcheva, Johanna M. Rankenberg, R. Nagaraj
2021Biochemical Journal15 citations
Semantic Scholar
The Absence of SIRT3 and SIRT5 Promotes the Acetylation of Lens Proteins and Improves the Chaperone Activity of α-Crystallin in Mouse Lenses
Sandip K. Nandi, R. Nahomi, Peter S. Harris, Cole R. Michel +2 more
2019Experimental Eye Research15 citations Open access
Semantic Scholar
Transient elevation of temperature promotes cross-linking of α-crystallin-client proteins through formation of advanced glycation endproducts: A potential role in presbyopia and cataracts
Sandip K. Nandi, Johanna M. Rankenberg, M. Glomb, R. Nagaraj
2020Biochemical and Biophysical Research Communications - BBRC13 citations Open access
Semantic Scholar
Promotion of Protein Solubility and Reduction in Stiffness in Human Lenses by Aggrelyte-1: Implications for Reversing Presbyopia
Sudipta Panja, Hanmant K. Gaikwad, Johanna M. Rankenberg, Mi-hyun Nam +1 more
2023International Journal of Molecular Sciences12 citations Open access
Semantic Scholar
Glycation-mediated protein crosslinking and stiffening in mouse lenses are inhibited by carboxitin in vitro
Sandip K. Nandi, Johanna M. Rankenberg, S. Rakete, R. Nahomi +3 more
2020Glycoconjugate Journal12 citations Open access
Semantic Scholar
Matrix-bound AGEs enhance TGFβ2-mediated mesenchymal transition of lens epithelial cells via the noncanonical pathway: implications for secondary cataract formation
Mi-hyun Nam, R. Nagaraj
2018Biochemical Journal10 citations Open access
Semantic Scholar
Inhibition of Methylglyoxal-Mediated Protein Modification in Glyoxalase I Overexpressing Mouse Lenses
M. Gangadhariah, Maneesh Mailankot, L. Reneker, R. Nagaraj
2010Journal of Ophthalmology9 citations Open access
Semantic Scholar
Identification of Kynoxazine, a Novel Fluorescent Product of the Reaction between 3-Hydroxykynurenine and Erythrulose in the Human Lens, and Its Role in Protein Modification*
S. Rakete, R. Nagaraj
2016Journal of Biological Chemistry8 citations Open access
Semantic Scholar
Effects of photobleaching on selected advanced glycation end products in the human lens
T. Holm, Cibin T. Raghavan, R. Nahomi, R. Nagaraj +1 more
2015BMC Research Notes8 citations Open access
Semantic Scholar
Role of cysteine residues in the enhancement of chaperone function in methylglyoxal-modified human αA-crystallin
S. R. Kanade, Nagarekha Pasupuleti, R. Nagaraj
2008Molecular and Cellular Biochemistry8 citations Open access
Semantic Scholar
Modulation of Advanced Glycation Endproduct Synthesis by Kynurenines in Human Lens Proteins
R. Nagaraj, Smitha Padmanabha, Maneesh Mailankot, Magdalena Staniszewska +3 more
2009Biochimica et Biophysica Acta7 citations Open access
Semantic Scholar
DAF in diabetic patients is subject to glycation/inactivation at its active site residues
R. Flückiger, E. Cocuzzi, R. Nagaraj, M. Shoham +2 more
2017Molecular Immunology6 citations Open access
Semantic Scholar
The Other Side of the Maillard Reaction
R. Nagaraj, Dr. Ashis Biswas, A. Miller, T. Oya-Ito +1 more
2008Annals of the New York Academy of Sciences6 citations
Semantic Scholar
AAV2-Mediated Expression of HspB1 in RGCs Prevents Somal Damage and Axonal Transport Deficits in a Mouse Model of Ocular Hypertension
M-H Nam, R. Nahomi, M. Pantcheva, Armaan Dhillon +3 more
2022Translational Vision Science & Technology4 citations Open access
Semantic Scholar
Small Heat Shock Proteins in Retinal Diseases
Vivian Rajeswaren, Jeffrey O. Wong, D. Yabroudi, R. Nahomi +3 more
2022Frontiers in Molecular Biosciences4 citations Open access
Semantic Scholar

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