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A. C. Gorren · SciRah

Researcher profile · Semantic Scholar

A. C. Gorren

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A. C. Gorren — researcher profile on SciRah

h-index: 31
Works: 102
Citations: 3,331

Most-cited papers

Metabolic Fate of Peroxynitrite in Aqueous Solution
S. Pfeiffer, A. C. Gorren, K. Schmidt, E. R. Werner +3 more
1997Journal of Biological Chemistry297 citations Open access
Semantic Scholar
Decomposition of S-nitrosoglutathione in the presence of copper ions and glutathione.
A. C. Gorren, A. Schrammel, K. Schmidt, Bernd Mayer
1996Archives of Biochemistry and Biophysics196 citations
Semantic Scholar
Reaction of Neuronal Nitric-oxide Synthase with Oxygen at Low Temperature
N. Bec, A. C. Gorren, Christof Voelker, B. Mayer +1 more
1998Journal of Biological Chemistry154 citations Open access
Semantic Scholar
Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization.
Barbara M. List, B. Klösch, Christof Völker, A. C. Gorren +5 more
1997Biochemical Journal152 citations Open access
Semantic Scholar
Tetrahydrobiopterin and Nitric Oxide: Mechanistic and Pharmacological Aspects
E. R. Werner, A. C. Gorren, R. Heller, G. Werner-Felmayer +1 more
2003Experimental biology and medicine133 citations
Semantic Scholar
S-nitrosation of glutathione by nitric oxide, peroxynitrite, and (*)NO/O(2)(*-).
A. Schrammel, A. C. Gorren, K. Schmidt, S. Pfeiffer +1 more
2003Free Radical Biology & Medicine132 citations
Semantic Scholar
Nitric-oxide synthase: a cytochrome P450 family foster child.
A. C. Gorren, B. Mayer
2007Biochimica et Biophysica Acta125 citations
Semantic Scholar
Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites.
A. C. Gorren, Barbara M. List, A. Schrammel, Eva Pitters +4 more
1996Biochemistry124 citations
Semantic Scholar
Tetrahydrobiopterin in nitric oxide synthesis: a novel biological role for pteridines.
A. C. Gorren, Bernd Mayer
2002Current drug metabolism99 citations
Semantic Scholar
Tetrahydrobiopterin binding to macrophage inducible nitric oxide synthase: heme spin shift and dimer stabilization by the potent pterin antagonist 4-amino-tetrahydrobiopterin.
B. Mayer, Chao-Qun Wu, A. C. Gorren, S. Pfeiffer +4 more
1997Biochemistry96 citations
Semantic Scholar
Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy
P. Schmidt, R. Lange, A. C. Gorren, E. R. Werner +2 more
2001JBIC Journal of Biological Inorganic Chemistry88 citations
Semantic Scholar
Effects of pH on the structure and function of neuronal nitric oxide synthase.
A. C. Gorren, A. Schrammel, K. Schmidt, Bernd Mayer
1998Biochemical Journal71 citations Open access
Semantic Scholar
Low-temperature optical absorption spectra suggest a redox role for tetrahydrobiopterin in both steps of nitric oxide synthase catalysis.
A. C. Gorren, Nicole Bec, A. Schrammel, E. R. Werner +2 more
2000Biochemistry66 citations
Semantic Scholar
Electrochemistry of pterin cofactors and inhibitors of nitric oxide synthase.
A. C. Gorren, Andreas J. Kungl, K. Schmidt, E. R. Werner +1 more
2001Nitric oxide63 citations
Semantic Scholar
Site and mechanism of uncoupling of nitric-oxide synthase: Uncoupling by monomerization and other misconceptions.
Verena Gebhart, K. Reiss, Alexander Kollau, B. Mayer +1 more
2019Nitric oxide59 citations Open access
Semantic Scholar
The reaction of nitric oxide with copper proteins and the photodissociation of copper-NO complexes.
A. C. Gorren, E. de Boer, Ron Wever
1987Biochimica et Biophysica Acta59 citations
Semantic Scholar
Single-turnover of Nitric-oxide Synthase in the Presence of 4-Amino-tetrahydrobiopterin
M. Sørlie, A. C. Gorren, S. Marchal, T. Shimizu +3 more
2003Journal of Biological Chemistry58 citations Open access
Semantic Scholar
Functional characterization of Glu298Asp mutant human endothelial nitric oxide synthase purified from a yeast expression system.
R. Golser, A. C. Gorren, B. Mayer, K. Schmidt
2003Nitric oxide58 citations
Semantic Scholar
Interaction of Endothelial and Neuronal Nitric-oxide Synthases with the Bradykinin B2 Receptor
R. Golser, A. C. Gorren, A. Leber, Penelope J. Andrew +5 more
2000Journal of Biological Chemistry57 citations Open access
Semantic Scholar
Characterization of the East Asian Variant of Aldehyde Dehydrogenase-2
M. Beretta, A. C. Gorren, M. Wenzl, R. Weis +4 more
2009Journal of Biological Chemistry55 citations Open access
Semantic Scholar
Thiols and neuronal nitric oxide synthase: complex formation, competitive inhibition, and enzyme stabilization.
A. C. Gorren, A. Schrammel, K. Schmidt, Bernd Mayer
1997Biochemistry50 citations
Semantic Scholar
The role of tetrahydrobiopterin in the activation of oxygen by nitric-oxide synthase.
N. Bec, A. C. Gorren, B. Mayer, P. Schmidt +2 more
2000Journal of Inorganic Biochemistry49 citations
Semantic Scholar
Allosteric modulation of rat brain nitric oxide synthase by the pterin-site enzyme inhibitor 4-aminotetrahydrobiopterin.
S. Pfeiffer, A. C. Gorren, Eva Pitters, K. Schmidt +2 more
1997Biochemical Journal47 citations Open access
Semantic Scholar
Partially Irreversible Inactivation of Mitochondrial Aldehyde Dehydrogenase by Nitroglycerin
M. Beretta, Astrid Sottler, K. Schmidt, B. Mayer +1 more
2008Journal of Biological Chemistry44 citations Open access
Semantic Scholar
Efficient nitrosation of glutathione by nitric oxide
Bernd Kolesnik, Knut Palten, A. Schrammel, H. Stessel +3 more
2013Free Radical Biology & Medicine41 citations Open access
Semantic Scholar
Activation of Neuronal Nitric-oxide Synthase by the 5-Methyl Analog of Tetrahydrobiopterin
Christoph Riethmüller, A. C. Gorren, Eva Pitters, B. Hemmens +5 more
1999Journal of Biological Chemistry41 citations Open access
Semantic Scholar
The versatile and complex enzymology of nitric oxide synthase.
A. C. Gorren, Bernd Mayer
1998Biochemistry. Biokhimiia41 citations
Semantic Scholar
Vascular Bioactivation of Nitroglycerin by Aldehyde Dehydrogenase-2
Barbara S. Lang, A. C. Gorren, G. Oberdorfer, M. Wenzl +4 more
2012Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Role of the General Base Glu-268 in Nitroglycerin Bioactivation and Superoxide Formation by Aldehyde Dehydrogenase-2
M. Wenzl, M. Beretta, A. C. Gorren, A. Zeller +6 more
2009Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Haem insertion, dimerization and reactivation of haem-free rat neuronal nitric oxide synthase.
Benjamin Hemmens, A. C. Gorren, K. Schmidt, E. R. Werner +1 more
1998Biochemical Journal33 citations Open access
Semantic Scholar
Interference of the polyphenol epicatechin with the biological chemistry of nitric oxide- and peroxynitrite-mediated reactions.
R. Wippel, M. Rehn, A. C. Gorren, K. Schmidt +1 more
2004Biochemical Pharmacology32 citations
Semantic Scholar
Site-Directed Mutagenesis of Aldehyde Dehydrogenase-2 Suggests Three Distinct Pathways of Nitroglycerin Biotransformation
M. Wenzl, M. Beretta, Martina Griesberger, M. Russwurm +4 more
2011Molecular Pharmacology30 citations
Semantic Scholar
Evidence of Two Distinct Oxygen Complexes of Reduced Endothelial Nitric Oxide Synthase*
S. Marchal, A. C. Gorren, M. Sørlie, K. Andersson +2 more
2004Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Irreversible Activation and Stabilization of Soluble Guanylate Cyclase by the Protoporphyrin IX Mimetic Cinaciguat
Alexander Kollau, M. Opelt, G. Wölkart, A. C. Gorren +4 more
2017Molecular Pharmacology28 citations Open access
Semantic Scholar
Inefficient spin trapping of superoxide in the presence of nitric-oxide: implications for studies on nitric-oxide synthase uncoupling.
Marc Pignitter, A. C. Gorren, Saviana Nedeianu, K. Schmidt +1 more
2006Free Radical Biology & Medicine27 citations
Semantic Scholar
Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling
K. Schmidt, Bernd Kolesnik, A. C. Gorren, E. R. Werner +1 more
2014Biochemical Pharmacology24 citations Open access
Semantic Scholar
The role of His117 in the redox reactions of azurin from Pseudomonas aeruginosa
A. C. Gorren, T. den Blaauwen, G. Canters, D. Hopper +1 more
1996FEBS Letters23 citations Open access
Semantic Scholar
Tetrahydrobiopterin Protects Soluble Guanylate Cyclase against Oxidative Inactivation
K. Schmidt, A. Neubauer, Bernd Kolesnik, J. Stasch +3 more
2012Molecular Pharmacology22 citations Open access
Semantic Scholar
Effects of nitroglycerin/L-cysteine on soluble guanylate cyclase: evidence for an activation/inactivation equilibrium controlled by nitric oxide binding and haem oxidation.
A. C. Gorren, M. Russwurm, Alexander Kollau, D. Koesling +2 more
2005Biochemical Journal22 citations Open access
Semantic Scholar
Erratum: Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor: Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation (Journal of Biological Chemistry (2000) 275 (5291-5296))
R. Golser, A. C. Gorren, A. Leber, P. Andrew +5 more
200022 citations
Semantic Scholar
Kinetic investigations of the reactions of cytochrome c oxidase with hydrogen peroxide.
A. C. Gorren, Henk L. Dekker, Ron Wever
1986Biochimica et Biophysica Acta21 citations
Semantic Scholar
The oxidation of cytochrome c oxidase by hydrogen peroxide.
A. C. Gorren, H. Dekker, Ron Wever
1985Biochimica et Biophysica Acta21 citations
Semantic Scholar
The effects of pH and cations on the spectral and kinetic properties of methylamine dehydrogenase from Thiobacillus versutus.
A. C. Gorren, J. Duine
1994Biochemistry20 citations
Semantic Scholar
Nitric oxide-induced autoinhibition of neuronal nitric oxide synthase in the presence of the autoxidation-resistant pteridine 5-methyltetrahydrobiopterin.
A. C. Gorren, A. Schrammel, Christoph Riethmüller, K. Schmidt +3 more
2000Biochemical Journal19 citations Open access
Semantic Scholar
Dynamics of carbon monoxide binding with neuronal nitric oxide synthase.
Catherine Tetreau, Martine Tourbez, A. C. Gorren, Bernd Mayer +1 more
1999Biochemistry19 citations
Semantic Scholar
Bioactivation of Nitroglycerin by Ascorbate
Alexander Kollau, M. Beretta, A. C. Gorren, M. Russwurm +3 more
2007Molecular Pharmacology18 citations
Semantic Scholar
Pharmacological interference with dimerization of human neuronal nitric-oxide synthase expressed in adenovirus-infected DLD-1 cells.
H. Habisch, A. C. Gorren, Haiying Liang, R. Venema +3 more
2003Molecular Pharmacology18 citations
Semantic Scholar
Isoform-specific effects of salts on nitric oxide synthase activity.
A. Schrammel, A. C. Gorren, D. Stuehr, K. Schmidt +1 more
1998Biochimica et Biophysica Acta18 citations
Semantic Scholar
Selective Irreversible Inhibition of Neuronal and Inducible Nitric-oxide Synthase in the Combined Presence of Hydrogen Sulfide and Nitric Oxide
C. Heine, Renate Schmidt, Kerstin Geckl, A. Schrammel +4 more
2015Journal of Biological Chemistry17 citations Open access
Semantic Scholar
Aerobic nitric oxide-induced thiol nitrosation in the presence and absence of magnesium cations
Bernd Kolesnik, C. Heine, Renate Schmidt, K. Schmidt +2 more
2014Free Radical Biology & Medicine17 citations Open access
Semantic Scholar

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