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Deepthi Bhupathi · SciRah

Researcher profile · Semantic Scholar

Deepthi Bhupathi

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Deepthi Bhupathi — researcher profile on SciRah

h-index: 9
Works: 27
Citations: 389

Most-cited papers

Molecular and Cellular Pharmacology of the Hypoxia-Activated Prodrug TH-302
F. Meng, James W. Evans, Deepthi Bhupathi, Monica Banica +13 more
2011Molecular Cancer Therapeutics192 citations Open access
Semantic Scholar
Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer
Jessica D. Sun, Qian Liu, Dharmendra Ahluwalia, Wenwu Li +5 more
2015Cancer Biology & Therapy54 citations Open access
Semantic Scholar
Combination treatment with hypoxia-activated prodrug evofosfamide (TH-302) and mTOR inhibitors results in enhanced antitumor efficacy in preclinical renal cell carcinoma models.
Jessica D. Sun, Dharmendra Ahluwalia, Qian Liu, Wenwu Li +5 more
2015American Journal of Cancer Research25 citations
Semantic Scholar
Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition
F. Meng, Deepthi Bhupathi, Jessica D. Sun, Qian Liu +4 more
2015BMC Cancer23 citations Open access
Semantic Scholar
Hypoxia-Targeting Drug Evofosfamide (TH-302) Enhances Sunitinib Activity in Neuroblastoma Xenograft Models1
Sushil Kumar, Jessica D. Sun, Libo Zhang, R. B. Mokhtari +8 more
2018Translational Oncology19 citations Open access
Semantic Scholar
14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment.
Jianxin Duan, Xiao-Hong Cai, F. Meng, Jessica D. Sun +10 more
2011Journal of Medicinal Chemistry18 citations
Semantic Scholar
Discovery of a Series of Potent, Selective, and Orally Bioavailable Nucleoside Inhibitors of CD73 That Demonstrates In Vivo Antitumor Activity.
Jim Li, Lijing Chen, R. Billedeau, Timothy F. Stanton +25 more
2022Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Abstract 6093: IDE161, a potential first-in-class clinical candidate PARG inhibitor, selectively targets homologous-recombination-deficient and PARP inhibitor resistant breast and ovarian tumors
Mona Abed, D. Muñoz, Vidya Seshadri, Stephen Federowicz +9 more
2023Cancer Research12 citations
Semantic Scholar
Deletion mutational analysis of BMRP, a pro-apoptotic protein that binds to Bcl-2
S. Malladi, Kishore V. L. Parsa, Deepthi Bhupathi, M. A. Rodríguez-González +6 more
2011Molecular and Cellular Biochemistry10 citations
Semantic Scholar
705 Anti-tumor activity of CB-668, a potent, selective and orally bioavailable small-molecule inhibitor of the immuno-suppressive enzyme Interleukin 4 (IL-4)-Induced Gene 1 (IL4I1)
A. Mackinnon, Deepthi Bhupathi, Jason J. Chen, Tony T. Huang +6 more
20209 citations Open access
Semantic Scholar
Abstract 4134: Reversal of adenosine-mediated immune suppression by CB-708, an orally bioavailable and potent small molecule inhibitor of CD73
Clarissa C. Lee, Deepthi Bhupathi, Roland J. Billedeau, Jason J. Chen +17 more
2019Immunology3 citations
Semantic Scholar
Abstract 5497: An efficient clonogenic assay for cytotoxic drug screening
F. Meng, Deepthi Bhupathi, C. Hart
20103 citations
Semantic Scholar
Abstract 5054: Hypoxia-activated prodrug TH-302 enhances antitumor activity of antiangiogenics in preclinical models
Jessica D. Sun, Dharmendra Ahluwalia, Qian Liu, Yan Wang +5 more
20112 citations
Semantic Scholar
Abstract 3867: DNA repair processes involved with the hypoxia-activated prodrug TH-302: comparison to cisplatin and temozolomide
F. Meng, Deepthi Bhupathi, C. Hart
20151 citations
Semantic Scholar
Abstract 2424: Association between Chk1 inhibitor AZD7762-mediated modulation of pharmacodynamic biomarkers and potentiation of hypoxia-activated prodrug TH-302 antitumor efficacy in a human tumor xenograft model
Jessica D. Sun, F. Meng, Qian Liu, Dharmendra Ahluwalia +4 more
20151 citations
Semantic Scholar
Evaluation of the Luting Cement Space for Provisional Restoration by using Various Coats of Die Spacer Materials-An Invitro Study.
Sandeep Chiramana, Krishna Chaitanya Siddineni, Ravi Rakesh Dev Jyothula, Phani Krishna Gade +4 more
2014Journal of clinical and diagnostic research : JCDR1 citations Open access
Semantic Scholar
Abstract 2648: Pharmacological modulation of TH-302-mediatedin vitrocytotoxicity
F. Meng, Deepthi Bhupathi, M. Matteucci, C. Hart
20111 citations
Semantic Scholar
Abstract A22: Hypoxia-dependent antitumor activity of TH-302, a hypoxia-activated prodrug, in preclinical pancreatic xenograft models
Jessica D. Sun, Qian Liu, Dharmendra Ahluwalia, Yan Wang +5 more
20101 citations
Semantic Scholar
Abstract 2263: NADPH-cytochrome P450 reductase reduction of TH-302, a hypoxia-activated prodrug
F. Meng, Jackson V. Matteucci, Deepthi Bhupathi, Heli Huang +3 more
20101 citations
Semantic Scholar
Abstract 2803: Distinct roles of intracellular ROS in cisplatin and evofosfamide cytotoxicity
F. Meng, Deepthi Bhupathi, G. Chan, C. Hart
20160 citations
Semantic Scholar
DNA repair processes involved with the hypoxia-activated prodrug evofosfamide (TH-302): comparison to cisplatin and temozolomide
F. Meng, Deepthi Bhupathi, C. Hart
20150 citations
Semantic Scholar
Abstract 3289: Mechanistic studies of the potentiation of hypoxia-targeted drug TH-302 by co-administration of checkpoint kinase1 (Chk1) inhibitors.
F. Meng, Deepthi Bhupathi, C. Hart
20130 citations
Semantic Scholar
Enhancement of Hypoxia-Activated Prodrug TH-302 Activity by Chk1 Inhibition
Fan-Ying Meng, Deepthi Bhupathi, Jessica D. Sun, Qian Liu +3 more
20120 citations
Semantic Scholar
Abstract 1784: Enhancement of hypoxia-activated prodrug TH-302 activity by Chk1 inhibition
F. Meng, Deepthi Bhupathi, M. Matteucci, C. Hart
20120 citations
Semantic Scholar
Abstract 535: Hypoxia-dependent in vivo activity of the hypoxia-activated prodrug (HAP) TH-302
Jessica D. Sun, Qian Liu, Dharmendra Ahluwalia, Yan Wang +5 more
20110 citations
Semantic Scholar
Abstract A42: Antiangiogenic-induced increase in tumor hypoxia in RCC and NSCLC human tumor xenografts and its selective targeting by the hypoxia-activated prodrug TH-302: A model for clinical exploration?
C. Hart, Dharmendra Ahluwalia, Qian Liu, F. Meng +3 more
20100 citations
Semantic Scholar
Abstract 762: 14-Aminocamptothecin: Synthesis, preclinical activity, and potential use for cancer treatment
Jianxin Duan, Xiao-Hong Cai, Jessica D. Sun, F. Meng +7 more
20100 citations
Semantic Scholar

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