Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

Hideyuki Takeshima · SciRah

Researcher profile · Semantic Scholar

Hideyuki Takeshima

Share profile

Hideyuki Takeshima — researcher profile on SciRah

h-index: 29
Works: 85
Citations: 3,019

Most-cited papers

DNMT3L Stimulates the DNA Methylation Activity of Dnmt3a and Dnmt3b through a Direct Interaction*
I. Suetake, Fuminori Shinozaki, Junichi Miyagawa, Hideyuki Takeshima +1 more
2004Journal of Biological Chemistry509 citations Open access
Semantic Scholar
Accumulation of genetic and epigenetic alterations in normal cells and cancer risk
Hideyuki Takeshima, T. Ushijima
2019npj Precision Oncology244 citations Open access
Semantic Scholar
Hippocampal epigenetic modification at the brain‐derived neurotrophic factor gene induced by an enriched environment
Naoko Kuzumaki, D. Ikegami, Rie Tamura, Nana Hareyama +11 more
2011Hippocampus194 citations Open access
Semantic Scholar
Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain.
S. Imai, D. Ikegami, Akira Yamashita, Toshikazu Shimizu +19 more
2013Brain : a journal of neurology152 citations Open access
Semantic Scholar
Abstract 176: The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands
Hideyuki Takeshima, S. Yamashita, T. Shimazu, T. Niwa +1 more
2010134 citations
Semantic Scholar
Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer
Y. Yoda, Hideyuki Takeshima, T. Niwa, Jeong Goo Kim +6 more
2014Gastric Cancer115 citations Open access
Semantic Scholar
Enhanced IL‐1β production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice
Naoko Kuzumaki, D. Ikegami, S. Imai, Michiko Narita +10 more
2010Synapse107 citations
Semantic Scholar
Genetic and epigenetic alterations in normal tissues have differential impacts on cancer risk among tissues
S. Yamashita, Takayoshi Kishino, Takamasa Takahashi, T. Shimazu +13 more
2018Proceedings of the National Academy of Sciences of the United States of America93 citations Open access
Semantic Scholar
Distinct DNA methylation activity of Dnmt3a and Dnmt3b towards naked and nucleosomal DNA.
Hideyuki Takeshima, I. Suetake, H. Shimahara, K. Ura +2 more
2006Journal of Biochemistry (Tokyo)86 citations
Semantic Scholar
Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3
Masahiro Maeda, Hideyuki Takeshima, N. Iida, Naoko Hattori +12 more
2019Gut83 citations
Semantic Scholar
Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction
M. Katsurano, T. Niwa, Y. Yasui, Y. Shigematsu +6 more
2012Oncogene82 citations Open access
Semantic Scholar
Distinct enzymatic properties of recombinant mouse DNA methyltransferases Dnmt3a and Dnmt3b.
I. Suetake, J. Miyazaki, Chikako Murakami, Hideyuki Takeshima +1 more
2003Journal of Biochemistry (Tokyo)80 citations
Semantic Scholar
Identification of coexistence of DNA methylation and H3K27me3 specifically in cancer cells as a promising target for epigenetic therapy.
Hideyuki Takeshima, M. Wakabayashi, Naoko Hattori, S. Yamashita +1 more
2015Carcinogenesis75 citations
Semantic Scholar
TET repression and increased DNMT activity synergistically induce aberrant DNA methylation.
Hideyuki Takeshima, T. Niwa, S. Yamashita, T. Takamura-Enya +7 more
2020Journal of Clinical Investigation71 citations Open access
Semantic Scholar
Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers.
Jeong Goo Kim, Hideyuki Takeshima, T. Niwa, E. Rehnberg +11 more
2013Cancer Letters62 citations Open access
Semantic Scholar
Frequent involvement of chromatin remodeler alterations in gastric field cancerization.
Hideyuki Takeshima, T. Niwa, Takamasa Takahashi, M. Wakabayashi +8 more
2015Cancer Letters59 citations
Semantic Scholar
Mouse Dnmt3a preferentially methylates linker DNA and is inhibited by histone H1.
Hideyuki Takeshima, I. Suetake, S. Tajima
2008Journal of Molecular Biology52 citations
Semantic Scholar
Novel epigenetic markers for gastric cancer risk stratification in individuals after Helicobacter pylori eradication
Masahiro Maeda, S. Yamashita, T. Shimazu, N. Iida +12 more
2018Gastric Cancer46 citations Open access
Semantic Scholar
Precancerous nature of intestinal metaplasia with increased chance of conversion and accelerated DNA methylation
C. Takeuchi, S. Yamashita, Yu-Yu Liu, Hideyuki Takeshima +11 more
2023Gut41 citations
Semantic Scholar
Novel prodrugs of decitabine with greater metabolic stability and less toxicity
Naoko Hattori, M. Sako, Kana Kimura, N. Iida +4 more
2019Clinical Epigenetics41 citations Open access
Semantic Scholar
Hippocampal epigenetic modification at the doublecortin gene is involved in the impairment of neurogenesis with aging
Naoko Kuzumaki, D. Ikegami, Rie Tamura, T. Sasaki +11 more
2010Synapse41 citations
Semantic Scholar
Characterization of DNA-binding activity in the N-terminal domain of the DNA methyltransferase Dnmt3a.
I. Suetake, Yuichi Mishima, Hironobu Kimura, Young-Ho Lee +4 more
2011Biochemical Journal40 citations
Semantic Scholar
Development of a Novel Output Value for Quantitative Assessment in Methylated DNA Immunoprecipitation-CpG Island Microarray Analysis
S. Yamashita, Kosuke Hosoya, Ken Gyobu, Hideyuki Takeshima +1 more
2009DNA Research39 citations Open access
Semantic Scholar
Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation.
M. Kikuyama, Hideyuki Takeshima, T. Kinoshita, E. Okochi‐Takada +5 more
2012Cancer Letters36 citations
Semantic Scholar
Induction of aberrant trimethylation of histone H3 lysine 27 by inflammation in mouse colonic epithelial cells.
Hideyuki Takeshima, D. Ikegami, M. Wakabayashi, T. Niwa +2 more
2012Carcinogenesis32 citations
Semantic Scholar
SAA1 is upregulated in gastric cancer-associated fibroblasts possibly by its enhancer activation.
Yoshimi Yasukawa, Naoko Hattori, N. Iida, Hideyuki Takeshima +5 more
2020Carcinogenesis31 citations Open access
Semantic Scholar
Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer
L. Zong, Naoko Hattori, Y. Yoda, S. Yamashita +8 more
2016Gastric Cancer30 citations Open access
Semantic Scholar
PRECLINICAL STUDY: BRIEF REPORT: Epigenetic modulation at the CCR2 gene correlates with the maintenance of behavioral sensitization to methamphetamine
D. Ikegami, M. Narita, S. Imai, Kazuhiko Miyashita +11 more
2010Addiction Biology30 citations
Semantic Scholar
Epigenetic reprogramming underlies efficacy of DNA demethylation therapy in osteosarcomas
N. Asano, Hideyuki Takeshima, S. Yamashita, Hironori Takamatsu +11 more
2019Scientific Reports29 citations Open access
Semantic Scholar
Chronic treatment of non-small-cell lung cancer cells with gefitinib leads to an epigenetic loss of epithelial properties associated with reductions in microRNA-155 and -200c
Michiko Narita, Eri Shimura, Atsumi Nagasawa, Toshiki Aiuchi +12 more
2017PLoS ONE29 citations Open access
Semantic Scholar
Distinct DNA methylation targets by aging and chronic inflammation: a pilot study using gastric mucosa infected with Helicobacter pylori
S. Yamashita, S. Nanjo, E. Rehnberg, N. Iida +5 more
2019Clinical Epigenetics28 citations Open access
Semantic Scholar
MACON: a web tool for computing DNA methylation data obtained by the Illumina Infinium Human DNA methylation BeadArray.
N. Iida, Y. Okuda, O. Ogasawara, S. Yamashita +2 more
2018Epigenomics26 citations
Semantic Scholar
ARID1A loss-of-function induces CpG island methylator phenotype.
Harumi Yamada, Hideyuki Takeshima, Ryoji Fujiki, S. Yamashita +9 more
2022Cancer Letters24 citations Open access
Semantic Scholar
Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease.
Naoko Kuzumaki, Yukari Suda, Chizuru Iwasawa, Michiko Narita +13 more
2019Brain : a journal of neurology22 citations Open access
Semantic Scholar
Early-Stage Induction of SWI/SNF Mutations during Esophageal Squamous Cell Carcinogenesis
Hidetsugu Nakazato, Hideyuki Takeshima, Takayoshi Kishino, E. Kubo +7 more
2016PLoS ONE22 citations Open access
Semantic Scholar
Close Associations of Gum Bleeding with Systemic Diseases in Late Adolescence
M. Abe, A. Mitani, A. Yao, Hideyuki Takeshima +3 more
2020International Journal of Environmental Research and Public Health21 citations Open access
Semantic Scholar
Enhanced processivity of Dnmt1 by monoubiquitinated histone H3
Yuichi Mishima, Laura Brueckner, Saori Takahashi, T. Kawakami +14 more
2019Genes to Cells20 citations Open access
Semantic Scholar
Methylation destiny: Moira takes account of histones and RNA polymerase II
Hideyuki Takeshima, T. Ushijima
2010Epigenetics20 citations Open access
Semantic Scholar
Low-dose DNA demethylating therapy induces reprogramming of diverse cancer-related pathways at the single-cell level
Hideyuki Takeshima, Y. Yoda, M. Wakabayashi, Naoko Hattori +2 more
2020Clinical Epigenetics19 citations Open access
Semantic Scholar
FGF5 methylation is a sensitivity marker of esophageal squamous cell carcinoma to definitive chemoradiotherapy
Jun Iwabu, S. Yamashita, Hideyuki Takeshima, Takayoshi Kishino +11 more
2019Scientific Reports18 citations Open access
Semantic Scholar
Effects of genome architecture and epigenetic factors on susceptibility of promoter CpG islands to aberrant DNA methylation induction.
Hideyuki Takeshima, S. Yamashita, T. Shimazu, T. Ushijima
2011Genomics16 citations Open access
Semantic Scholar
A quantification method of somatic mutations in normal tissues and their accumulation in pediatric patients with chemotherapy
S. Ueda, S. Yamashita, Miho Nakajima, T. Kumamoto +12 more
2022Proceedings of the National Academy of Sciences of the United States of America15 citations Open access
Semantic Scholar
Histone modification of pain-related gene expression in spinal cord neurons under a persistent postsurgical pain-like state by electrocautery
Yosuke Katsuda, Kenichi Tanaka, T. Mori, Michiko Narita +12 more
2021Molecular Brain13 citations Open access
Semantic Scholar
Degree of methylation burden is determined by the exposure period to carcinogenic factors
Hideyuki Takeshima, T. Niwa, T. Toyoda, M. Wakabayashi +2 more
2017Cancer Science13 citations Open access
Semantic Scholar
BRAF inhibitor: a novel therapy for ameloblastoma in mandible
M. Abe, L. Zong, Takahiro Abe, Hideyuki Takeshima +3 more
2018Chinese journal of cancer research = Chung-kuo yen cheng yen chiu10 citations Open access
Semantic Scholar
Severe induction of aberrant DNA methylation by nodular gastritis in adults
Akiko Sasaki, Hideyuki Takeshima, S. Yamashita, Chikamasa Ichita +15 more
2024Journal of gastroenterology8 citations
Semantic Scholar
DNA methylation marker to estimate ovarian cancer cell fraction
T. Ebata, S. Yamashita, Hideyuki Takeshima, Hiroshi Yoshida +7 more
2021Medical Oncology8 citations Open access
Semantic Scholar
Combination of a synthetic retinoid and a DNA demethylating agent induced differentiation of neuroblastoma through retinoic acid signal reprogramming
Naoko Hattori, K. Asada, Nozomu Miyajima, A. Mori +7 more
2021British Journal of Cancer8 citations Open access
Semantic Scholar
Depletion of R270C Mutant p53 in Osteosarcoma Attenuates Cell Growth but Does Not Prevent Invasion and Metastasis In Vivo
T. Shimizu, E. Sugihara, Hideyuki Takeshima, Hiroyuki Nobusue +6 more
2022Cells7 citations Open access
Semantic Scholar
Prediction of tissue origin of adenocarcinomas in the esophagogastric junction by DNA methylation
Chun-Dong Zhang, Hideyuki Takeshima, S. Sekine, S. Yamashita +12 more
2021Gastric Cancer7 citations Open access
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

T. Ushijima×42
Invite
T. Ushijima — researcher profile on SciRah
S. Yamashita×25
Invite
S. Yamashita — researcher profile on SciRah
Naoko Hattori×13
Invite
Naoko Hattori — researcher profile on SciRah
N. Iida×9
Invite
N. Iida — researcher profile on SciRah

×9

Invite

M. Wakabayashi — researcher profile on SciRah

Naoko Kuzumaki×8

Invite

Naoko Kuzumaki — researcher profile on SciRah

Michiko Narita×8

Invite

Michiko Narita — researcher profile on SciRah

Invite

T. Niwa — researcher profile on SciRah

Invite

D. Ikegami — researcher profile on SciRah

Invite

T. Ando — researcher profile on SciRah

Invite

H. Katai — researcher profile on SciRah

Invite

I. Suetake — researcher profile on SciRah