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T. Dafforn · SciRah

Researcher profile · Semantic Scholar

T. Dafforn

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T. Dafforn — researcher profile on SciRah

h-index: 51
Works: 185
Citations: 8,547

Most-cited papers

Membrane proteins solubilized intact in lipid containing nanoparticles bounded by styrene maleic acid copolymer.
Timothy J. Knowles, Rachael Finka, Corinne S. Smith, Yu-pin Lin +2 more
2009Journal of the American Chemical Society519 citations
Semantic Scholar
A method for detergent-free isolation of membrane proteins in their local lipid environment
Sarah C. Lee, Timothy J. Knowles, V. Postis, Mohammed Jamshad +7 more
2016Nature Protocols339 citations
Semantic Scholar
Detergent-free isolation, characterization, and functional reconstitution of a tetrameric K+ channel: The power of native nanodiscs
J. M. Dörr, M. Koorengevel, Marre Schäfer, A. Prokofyev +5 more
2014Proceedings of the National Academy of Sciences of the United States of America306 citations Open access
Semantic Scholar
Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum
Tomas Laursen, J. Borch, Camilla Knudsen, Krutika Bavishi +11 more
2016Science254 citations Open access
Semantic Scholar
Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins
Mohammed Jamshad, Vinciane Grimard, Ilaria Idini, Timothy J. Knowles +13 more
2014Nano Reseach189 citations Open access
Semantic Scholar
Linear Dichroism and Circular Dichroism
B. Nordén, A. Rodger, T. Dafforn
2010189 citations
Semantic Scholar
Detergent-free purification of ABC (ATP-binding-cassette) transporters.
S. Gulati, Mohammed Jamshad, Timothy J. Knowles, K. A. Morrison +9 more
2014Biochemical Journal177 citations Open access
Semantic Scholar
G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent
Mohammed Jamshad, J. Charlton, Yu-pin Lin, S. Routledge +8 more
2015Bioscience Reports171 citations Open access
Semantic Scholar
The use of SMALPs as a novel membrane protein scaffold for structure study by negative stain electron microscopy
V. Postis, S. Rawson, Jennifer K. Mitchell, Sarah C. Lee +4 more
2015Biochimica et Biophysica Acta169 citations Open access
Semantic Scholar
Using a SMALP platform to determine a sub-nm single particle cryo-EM membrane protein structure
Mayuriben Parmar, S. Rawson, C. Scarff, A. Goldman +3 more
2018Biochimica et Biophysica Acta - Biomembranes118 citations Open access
Semantic Scholar
Surfactant-free purification of membrane proteins with intact native membrane environment.
Mohammed Jamshad, Yu-pin Lin, Timothy J. Knowles, R. A. Parslow +7 more
2011Biochemical Society Transactions112 citations
Semantic Scholar
University of Birmingham Membrane protein extraction and purification using styrene–maleic acid (SMA) copolymer: effect of variations in polymer structure
K. A. Morrison, Aneel Akram, A. Mathews, Zoeya A. Khan +13 more
201684 citations
Semantic Scholar
Characterizing the assembly of the Sup35 yeast prion fragment, GNNQQNY: structural changes accompany a fiber-to-crystal switch.
K. Marshall, M. Hicks, T. Williams, S. Hoffmann +3 more
2010Biophysical Journal82 citations Open access
Semantic Scholar
Analysis of SMALP co-extracted phospholipids shows distinct membrane environments for three classes of bacterial membrane protein
A. Teo, Sarah C. Lee, Naomi L. Pollock, Zoe Stroud +6 more
2019Scientific Reports81 citations Open access
Semantic Scholar
Ultrarapid detection of SARS-CoV-2 RNA using a reverse transcription–free exponential amplification reaction, RTF-EXPAR
Jake G. Carter, Lorea Orueta Iturbe, Jean-Louis H. A. Duprey, I. Carter +8 more
2021Proceedings of the National Academy of Sciences of the United States of America78 citations Open access
Semantic Scholar
Membrane protein insertion and assembly by the bacterial holo-translocon SecYEG–SecDF–YajC–YidC
Joanna Komar, Sara Alvira, Ryan J. Schulze, Remy Martin +7 more
2016Biochemical Journal69 citations Open access
Semantic Scholar
De Novo Design of Ln(III) Coiled Coils for Imaging Applications
Matthew R. Berwick, D. J. Lewis, Andrew W. Jones, R. A. Parslow +6 more
2014Journal of the American Chemical Society65 citations Open access
Semantic Scholar
Purification of membrane proteins free from conventional detergents: SMA, new polymers, new opportunities and new insights.
Zoe Stroud, Stephen C. L. Hall, T. Dafforn
2018Methods62 citations Open access
Semantic Scholar
Surfactant-free purification of membrane protein complexes from bacteria: application to the staphylococcal penicillin-binding protein complex PBP2/PBP2a
Sarah Paulin, Mohammed Jamshad, T. Dafforn, J. García-Lara +5 more
2014Nanotechnology62 citations Open access
Semantic Scholar
High-resolution, three-dimensional modeling of human leukocyte antigen class I structure and surface electrostatic potential reveals the molecular basis for alloantibody binding epitopes.
V. Kosmoliaptsis, T. Dafforn, A. Chaudhry, D. Halsall +2 more
2011Human Immunology61 citations
Semantic Scholar
α-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease.
N. Sinden, M. Baker, D. Smith, Jan-Ulrich Kreft +2 more
2015American Journal of Physiology - Lung cellular and Molecular Physiology58 citations Open access
Semantic Scholar
Tetramerization of ZapA is required for FtsZ bundling.
R. Pacheco-Gómez, Xi Cheng, M. Hicks, Corinne J. Smith +4 more
2013Biochemical Journal57 citations
Semantic Scholar
Assembly pathway of a designed alpha-helical protein fiber.
E. H. Bromley, K. Channon, P. J. S. King, Zahra N. Mahmoud +8 more
2010Biophysical Journal57 citations Open access
Semantic Scholar
Nbr1 Is a Novel Inhibitor of Ligand-Mediated Receptor Tyrosine Kinase Degradation
F. Mardakheh, Giulio Auciello, T. Dafforn, J. Rappoport +1 more
2010Molecular and Cellular Biology57 citations Open access
Semantic Scholar
Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition
S. Nicholls, K. Piper, F. Mohammed, T. Dafforn +10 more
2009Proceedings of the National Academy of Sciences of the United States of America45 citations Open access
Semantic Scholar
GPCR-styrene maleic acid lipid particles (GPCR-SMALPs): their nature and potential.
M. Wheatley, J. Charlton, Mohammed Jamshad, S. Routledge +7 more
2016Biochemical Society Transactions43 citations Open access
Semantic Scholar
A simple and convenient method for the hydrolysis of styrene-maleic anhydride copolymers to styrene-maleic acid copolymers.
Adrian H. Kopf, M. Koorengevel, C. A. van Walree, T. Dafforn +1 more
2019Chemistry and Physics of Lipids37 citations Open access
Semantic Scholar
Ligand-induced conformational changes in a SMALP-encapsulated GPCR.
S. Routledge, Mohammed Jamshad, Haydn A Little, Yu-pin Lin +7 more
2020Biochimica et Biophysica Acta - Biomembranes35 citations Open access
Semantic Scholar
Detection of pathogenic bacteria using a homogeneous immunoassay based on shear alignment of virus particles and linear dichroism.
R. Pacheco-Gómez, J. Kraemer, S. Stokoe, Hannah J. England +6 more
2012Analytical Chemistry33 citations
Semantic Scholar
The pH Dependence of Polymerization and Bundling by the Essential Bacterial Cytoskeltal Protein FtsZ
R. Pacheco-Gómez, D. Roper, T. Dafforn, A. Rodger
2011PLoS ONE33 citations Open access
Semantic Scholar
Encapsulated membrane proteins: A simplified system for molecular simulation.
Sarah C. Lee, S. Khalid, Naomi L. Pollock, Timothy J. Knowles +4 more
2016Biochimica et Biophysica Acta31 citations Open access
Semantic Scholar
The mechanics of FtsZ fibers.
D. Turner, Ian Portman, T. Dafforn, A. Rodger +3 more
2012Biophysical Journal29 citations Open access
Semantic Scholar
Examining the stability of membrane proteins within SMALPs
A. Gulamhussein, Danyall Meah, Damian D. Soja, S. Fenner +15 more
2019European Polymer Journal28 citations Open access
Semantic Scholar
Membrane protein extraction and purification using styrene-maleic acid (SMA) copolymer: effect of variations in polymer structure.
K. A. Morrison, Aneel Akram, A. Mathews, Zoeya A. Khan +11 more
2016Biochemical Journal26 citations Open access
Semantic Scholar
Membrane protein extraction and purification using partially-esterified SMA polymers
Olivia P. Hawkins, C. P. T. Jahromi, A. Gulamhussein, Stephanie A. Nestorow +33 more
2021Biochimica et Biophysica Acta - Biomembranes25 citations Open access
Semantic Scholar
Influence of DIBMA Polymer Length on Lipid Nanodisc Formation and Membrane Protein Extraction.
Lauren E. Ball, L. Riley, W. Hadasha, Rueben Pfukwa +3 more
2020Biomacromolecules25 citations Open access
Semantic Scholar
Improvements in the production of purified M13 bacteriophage bio-nanoparticle
Paolo Passaretti, Inam Khan, T. Dafforn, Pola Goldberg Oppenheimer
2020Scientific Reports25 citations Open access
Semantic Scholar
Automated High-Throughput Capillary Circular Dichroism and Intrinsic Fluorescence Spectroscopy for Rapid Determination of Protein Structure
Charles Moore-Kelly, J. Welsh, A. Rodger, T. Dafforn +1 more
2019Analytical Chemistry25 citations Open access
Semantic Scholar
Identification and characterization of trimethylamine N-oxide (TMAO) demethylase and TMAO permease in Methylocella silvestris BL2.
Yi-Jun Zhu, E. Jameson, R. A. Parslow, I. Lidbury +4 more
2014Environmental Microbiology23 citations
Semantic Scholar
Nano-encapsulated Escherichia coli Divisome Anchor ZipA, and in Complex with FtsZ
Sarah C. Lee, R. Collins, Yu-pin Lin, Mohammed Jamshad +12 more
2019Scientific Reports22 citations Open access
Semantic Scholar
University of Birmingham Kinetic study of the thermal denaturation of a hyperthermostable extracellular -amylase from Pyrococcus furiosus
T. Dafforn, P. Fryer, P. W. Cox
201422 citations
Semantic Scholar
Differences in SMA-like polymer architecture dictate the conformational changes exhibited by the membrane protein rhodopsin encapsulated in lipid nano-particles
Rachael L. Grime, Richard T. Logan, Stephanie A. Nestorow, Pooja Sridhar +7 more
2021Nanoscale21 citations Open access
Semantic Scholar
Determination and characterisation of the surface charge properties of the bacteriophage M13 to assist bio-nanoengineering
Paolo Passaretti, Yi-Wei Sun, T. Dafforn, P. Oppenheimer
2020RSC Advances21 citations Open access
Semantic Scholar
Förster Resonance Energy Transfer Nanoplatform Based on Recognition-Induced Fusion/Fission of DNA Mixed Micelles for Nucleic Acid Sensing
Setareh Vafaei, Francia Allabush, S. R. Tabaei, L. Male +3 more
2021ACS Nano20 citations Open access
Semantic Scholar
Detergent free purification of ABC transporters
S. Gulati, Mohammed Jamshad, Timothy J. Knowles, K. A. Morrison +9 more
201517 citations
Semantic Scholar
Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2
Huan-Yu Z. Li, A. Pike, Irina Lotsaris, G. Chi +15 more
2023bioRxiv15 citations Open access
Semantic Scholar
Production, Purification and Characterization of Recombinant, Full-Length Human Claudin-1
N. Bonander, Mohammed Jamshad, D. Oberthür, Michelle Clare +10 more
2013PLoS ONE13 citations Open access
Semantic Scholar
Rapid injection linear dichroism for studying the kinetics of biological processes.
M. Hicks, A. Rodger, Yu-pin Lin, N. Jones +2 more
2012Analytical Chemistry13 citations Open access
Semantic Scholar
Effect of Anionic Lipids on Mammalian Plasma Cell Membrane Properties
Alexandra L Martin, Philip N Jemmett, Thomas Howitt, Mary H. Wood +13 more
2023Langmuir12 citations Open access
Semantic Scholar
Multifunctional graphene oxide-bacteriophage based porous three-dimensional micro-nanocomposites.
Paolo Passaretti, Yi-Wei Sun, Inam Khan, Kieran Chan +4 more
2019Nanoscale12 citations Open access
Semantic Scholar

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Mohammed Jamshad×11
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A. Rodger×10
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Timothy J. Knowles×8
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Sarah C. Lee×7

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R. A. Parslow×6

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