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M. Stark · SciRah

Researcher profile · Semantic Scholar

M. Stark

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M. Stark — researcher profile on SciRah

h-index: 20
Works: 42
Citations: 1,377

Most-cited papers

Arabinogalactan-folic acid-drug conjugate for targeted delivery and target-activated release of anticancer drugs to folate receptor-overexpressing cells.
Roy I Pinhassi, Y. Assaraf, S. Farber, M. Stark +4 more
2010Biomacromolecules130 citations
Semantic Scholar
Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity
B. Zhitomirsky, Anna Yunaev, Roman Kreiserman, Ariel Kaplan +2 more
2018Cell Death and Disease117 citations Open access
Semantic Scholar
Chemotherapeutic drug-induced ABCG2 promoter demethylation as a novel mechanism of acquired multidrug resistance.
Eran Bram, M. Stark, S. Raz, Y. Assaraf
2009Neoplasia117 citations Open access
Semantic Scholar
Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers
Y. Adar, M. Stark, EE Bram, P. Nowak-Sliwinska +6 more
2012Cell Death and Disease101 citations Open access
Semantic Scholar
Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.
M. Stark, C. Wichman, I. Avivi, Y. Assaraf
2009Blood86 citations Open access
Semantic Scholar
Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer.
S. Raz, M. Stark, Y. Assaraf
2016Drug resistance updates77 citations
Semantic Scholar
Loss of Multidrug Resistance Protein 1 Expression and Folate Efflux Activity Results in a Highly Concentrative Folate Transport in Human Leukemia Cells*
Y. Assaraf, L. Rothem, J. H. Hooijberg, M. Stark +5 more
2003Journal of Biological Chemistry76 citations Open access
Semantic Scholar
Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest
S. Raz, D. Sheban, N. Gonen, M. Stark +2 more
2014Cell Death and Disease67 citations Open access
Semantic Scholar
Reduced Folate Carrier Gene Silencing in Multiple Antifolate-resistant Tumor Cell Lines Is Due to a Simultaneous Loss of Function of Multiple Transcription Factors but Not Promoter Methylation*
L. Rothem, M. Stark, Yotam Kaufman, L. Mayo +1 more
2004Journal of Biological Chemistry55 citations Open access
Semantic Scholar
Heterogeneous Nuclear Ribonucleoprotein H1/H2-dependent Unsplicing of Thymidine Phosphorylase Results in Anticancer Drug Resistance
M. Stark, Eran Bram, Martin Akerman, Yael Mandel-Gutfreund +1 more
2010Journal of Biological Chemistry53 citations Open access
Semantic Scholar
The Lysosomotropic Activity of Hydrophobic Weak Base Drugs is Mediated via Their Intercalation into the Lysosomal Membrane
M. Stark, Tomás F. D. Silva, Guy Levin, M. Machuqueiro +1 more
2020Cells52 citations Open access
Semantic Scholar
Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance
A. Wojtuszkiewicz, S. Raz, M. Stark, Y. Assaraf +5 more
2016International Journal of Cancer44 citations Open access
Semantic Scholar
Antifolate resistance associated with loss of MRP1 expression and function in Chinese hamster ovary cells with markedly impaired export of folate and cholate.
M. Stark, L. Rothem, G. Jansen, G. Scheffer +2 more
2003Molecular Pharmacology44 citations
Semantic Scholar
Surmounting Cytarabine-resistance in acute myeloblastic leukemia cells and specimens with a synergistic combination of hydroxyurea and azidothymidine
M. Levin, M. Stark, B. Berman, Y. Assaraf
2019Cell Death and Disease43 citations Open access
Semantic Scholar
Deciphering molecular mechanisms underlying chemoresistance in relapsed AML patients: towards precision medicine overcoming drug resistance
M. Levin, M. Stark, Y. Ofran, Y. Assaraf
2021Cancer Cell International37 citations Open access
Semantic Scholar
Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma: clinical evidence and new pharmacological tools
E. Giovannetti, P. Zucali, Y. Assaraf, N. Funel +10 more
2017Annals of Oncology30 citations Open access
Semantic Scholar
The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity
M. Levin, M. Stark, Y. Assaraf
2018OncoTarget29 citations Open access
Semantic Scholar
Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy.
K. Fotoohi, G. Jansen, Y. Assaraf, L. Rothem +5 more
2004Blood28 citations
Semantic Scholar
Functional elements in the minimal promoter of the human proton-coupled folate transporter.
M. Stark, N. Gonen, Y. Assaraf
2009Biochemical and Biophysical Research Communications - BBRC22 citations
Semantic Scholar
Impaired CREB-1 Phosphorylation in Antifolate-Resistant Cell Lines with Down-Regulation of the Reduced Folate Carrier Gene
L. Rothem, M. Stark, Y. Assaraf
2004Molecular Pharmacology22 citations
Semantic Scholar
Loss of Sp1 function via inhibitory phosphorylation in antifolate-resistant human leukemia cells with down-regulation of the reduced folate carrier.
M. Stark, Y. Assaraf
2006Blood17 citations Open access
Semantic Scholar
Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma: clinical evidence and new pharmacological tools.
E. Giovannetti, P. Zucali, Y. Assaraf, N. Funel +10 more
201716 citations Open access
Semantic Scholar
Doubly Stimulated Corrole for Organelle-Selective Antitumor Cytotoxicity.
V. Sharma, M. Stark, N. Fridman, Y. Assaraf +1 more
2022Journal of Medicinal Chemistry15 citations
Semantic Scholar
Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia
S. Raz, M. Stark, Y. Assaraf
2014OncoTarget14 citations Open access
Semantic Scholar
Multiple MAPK Cascades Regulate the Transcription of IME1, the Master Transcriptional Activator of Meiosis in Saccharomyces cerevisiae
S. Kahana-Edwin, M. Stark, Y. Kassir
2013PLoS ONE14 citations Open access
Semantic Scholar
Targeting an extracellular epitope of the human multidrug resistance protein 1 (MRP1) in malignant cells with a novel recombinant single chain Fv antibody
L. Binyamin, Y. Assaraf, Maya Haus‐Cohen, M. Stark +1 more
2004International Journal of Cancer13 citations Open access
Semantic Scholar
The Roles of the Catalytic and Noncatalytic Activities of Rpd3L and Rpd3S in the Regulation of Gene Transcription in Yeast
Daniella Yeheskely‐Hayon, Anat Kotler, M. Stark, T. Hashimshony +2 more
2013PLoS ONE12 citations Open access
Semantic Scholar
The Reduced Folate Carrier Gene Is a Novel Selectable Marker for Recombinant Protein Overexpression
L. Rothem, B. Berman, M. Stark, G. Jansen +1 more
2005Molecular Pharmacology10 citations
Semantic Scholar
Folylpoly-ɣ-glutamate synthetase association to the cytoskeleton: Implications to folate metabolon compartmentalization.
M. Stark, S. Raz, Y. Assaraf
2021Journal of Proteomics9 citations
Semantic Scholar
Folylpolyglutamate synthetase mRNA G-quadruplexes regulate its cell protrusion localization and enhance a cancer cell invasive phenotype upon folate repletion
M. Stark, M. Levin, I. Ulitsky, Y. Assaraf
2023BMC Biology8 citations Open access
Semantic Scholar
Structural recognition of tubulysin B derivatives by multidrug resistance efflux transporters in human cancer cells
M. Stark, Y. Assaraf
2017OncoTarget8 citations Open access
Semantic Scholar
Targeting Lysosomes for Enhanced Anti-Cancer Therapeutics and Immune Response
M. Stark, Y. Assaraf
2026International Journal on Biological Sciences6 citations Open access
Semantic Scholar
Abstract 4335: Role of proton-coupled folate transporter expression in resistance of mesothelioma patients treated with pemetrexed
E. Giovannetti, P. Zucali, Y. Assaraf, N. Funel +7 more
20153 citations
Semantic Scholar
Inactivation oftheProtein Phosphatase 2ARegulatory Subunit A Results inMorphological andTranscriptional Defects inSaccharomyces cerevisiae
M. Stark, A. Sentenac
19922 citations
Semantic Scholar
Targeting Folate Receptors for the Detection and Selective Treatment of Cancer: Advanced Precision Oncology in Practice
M. Stark, Y. Assaraf
2026International Journal on Biological Sciences0 citations Open access
Semantic Scholar
KAT6A-Mutant iPSC-Derived Cortical Neurons Display Precocious Maturation, Dysregulated Electrophysiology, and Altered Morphology
Naama Wiesel-Motiuk, Ashwani Choudhary, Yara Hussein, Utkarsh Tripathi +11 more
2026International Journal on Biological Sciences0 citations Open access
Semantic Scholar
but Not Promoter Methylation Function of Multiple Transcription Factors Lines Is Due to a Simultaneous Loss of Multiple Antifolate-resistant Tumor Cell Reduced Folate Carrier Gene Silencing in Recombination:
L. Mayo, Y. Assaraf, L. Rothem, M. Stark +1 more
20140 citations
Semantic Scholar
The intricate role of Smads in the regulation of FPGS gene expression
S. Raz, M. Stark, Y. Assaraf
20140 citations
Semantic Scholar
cells: implications for efficacy of methotrexate therapy methotrexate and its metabolite 7-hydroxymethotrexate in leukemia Disparate mechanisms of antifolate resistance provoked by
J. Gregorczyk, G. Peters, G. Jansen, Y. Assaraf +3 more
20130 citations
Semantic Scholar
Abstract 4628: Alterations in FPGS splicing as a plausible underlying mechanism of MTX resistance in ALL.
A. Wojtuszkiewicz, Y. Assaraf, S. Raz, M. Stark +5 more
20130 citations
Semantic Scholar
reduced folate carrier antifolate-resistant human leukemia cells with down-regulation of the Loss of Sp1 function via inhibitory phosphorylation in
M. Stark, Y. Assaraf
20130 citations
Semantic Scholar
HNRNP H1/H2-DEPENDENT UNSPLICING OF THYMIDINE PHOSPHORYLASE RESULTS IN ANTICANCER DRUG RESISTANCE
M. Stark, Eran Bram, Martin Akerman, Yael Mandel-Gutfreund +1 more
20100 citations
Semantic Scholar

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