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C. Xing · SciRah

Researcher profile · Semantic Scholar

C. Xing

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C. Xing — researcher profile on SciRah

h-index: 35
Works: 124
Citations: 4,693

Most-cited papers

Chalcone: A Privileged Structure in Medicinal Chemistry
Chunlin Zhuang, Wen Zhang, Chun-Quan Sheng, Wannian Zhang +2 more
2017Chemical Reviews1,230 citations Open access
Semantic Scholar
Diverse Molecular Targets for Chalcones with Varied Bioactivities
Bo Zhou, C. Xing
2015Medicinal chemistry165 citations Open access
Semantic Scholar
Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search.
Chunlin Zhuang, S. Narayanapillai, Wannian Zhang, Y. Sham +1 more
2014Journal of Medicinal Chemistry148 citations Open access
Semantic Scholar
A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy
Wei-Yang He, Qiong Wang, Balasubramanian Srinivasan, Jennings Xu +8 more
2013Oncogene124 citations Open access
Semantic Scholar
Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives.
Hui Cong, Lijuan Xu, You-hua Wu, Zhuo Qu +4 more
2019Journal of Medicinal Chemistry101 citations Open access
Semantic Scholar
Anti-cancer and other bioactivities of Korean Angelica gigas Nakai (AGN) and its major pyranocoumarin compounds.
Jin-Hui Zhang, Li Li, Cheng Jiang, C. Xing +2 more
2012Anti-Cancer Agents in Medicinal Chemistry86 citations
Semantic Scholar
Kava as a Clinical Nutrient: Promises and Challenges
Tengfei Bian, Pedro Corral, Yu-Zhi Wang, Jordy F. Botello +8 more
2020Nutrients76 citations Open access
Semantic Scholar
Nanomagnetic competition assay for low-abundance protein biomarker quantification in unprocessed human sera.
Yuan-Peng Li, Balasubramanian Srinivasan, Ying Jing, X. Yao +3 more
2010Journal of the American Chemical Society73 citations
Semantic Scholar
After Embedding in Membranes Antiapoptotic Bcl-XL Protein Binds Both Bcl-2 Homology Region 3 and Helix 1 of Proapoptotic Bax Protein to Inhibit Apoptotic Mitochondrial Permeabilization*
Jingzhen Ding, B. Mooers, Zhi Zhang, Justin Kale +7 more
2014Journal of Biological Chemistry71 citations Open access
Semantic Scholar
Small molecules inhibiting Keap1-Nrf2 protein-protein interactions: a novel approach to activate Nrf2 function.
Chunlin Zhuang, Zhongli Wu, C. Xing, Z. Miao
2017MedChemComm70 citations Open access
Semantic Scholar
Direct inhibition of Keap1-Nrf2 Protein-Protein interaction as a potential therapeutic strategy for Alzheimer's disease.
Yi Sun, Jiaxuan Huang, Yufei Chen, Hao Shang +5 more
2020Bioorganic chemistry (Print)58 citations Open access
Semantic Scholar
Structure-activity relationship and molecular mechanisms of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and its analogues.
S. Das, Balasubramanian Srinivasan, D. Hermanson, N. Bleeker +4 more
2011Journal of Medicinal Chemistry50 citations
Semantic Scholar
Double-edged swords as cancer therapeutics: novel, orally active, small molecules simultaneously inhibit p53-MDM2 interaction and the NF-κB pathway.
Chunlin Zhuang, Z. Miao, Yue-Lin Wu, Zi-Zhao Guo +5 more
2014Journal of Medicinal Chemistry48 citations
Semantic Scholar
A three-layer competition-based giant magnetoresistive assay for direct quantification of endoglin from human urine.
Balasubramanian Srinivasan, Yuan-Peng Li, Ying Jing, C. Xing +2 more
2011Analytical Chemistry47 citations
Semantic Scholar
Flavokawains A and B in Kava, Not Dihydromethysticin, Potentiate Acetaminophen-Induced Hepatotoxicity in C57BL/6 Mice
S. Narayanapillai, P. Leitzman, M. O'Sullivan, C. Xing
2014Chemical Research in Toxicology46 citations Open access
Semantic Scholar
Characterization of the Fluorescence Properties of 4‐Dialkylaminochalcones and Investigation of the Cytotoxic Mechanism of Chalcones
Bo Zhou, Peixin Jiang, Jun-Xuan Lu, C. Xing
2016Archiv der Pharmazie42 citations
Semantic Scholar
Measuring the Chemical and Cytotoxic Variability of Commercially Available Kava (Piper methysticum G. Forster)
Amanda C. Martin, E. Johnston, C. Xing, A. Hegeman
2014PLoS ONE42 citations Open access
Semantic Scholar
Overexpression of Mcl-1 Confers Multidrug Resistance, Whereas Topoisomerase IIβ Downregulation Introduces Mitoxantrone-Specific Drug Resistance in Acute Myeloid Leukemia
D. Hermanson, S. Das, Yunfang Li, C. Xing
2013Molecular Pharmacology42 citations Open access
Semantic Scholar
Structure-Activity Relationship (SAR) Study of Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and the Potential of the Lead against Multidrug Resistance in Cancer Treatment
G. Aridoss, Bo Zhou, D. Hermanson, N. Bleeker +1 more
2012Journal of Medicinal Chemistry41 citations Open access
Semantic Scholar
An indole-chalcone inhibits multidrug-resistant cancer cell growth by targeting microtubules
Hui Cong, Xinghua Zhao, B. Castle, Emily J. Pomeroy +11 more
2018Molecular Pharmaceutics38 citations Open access
Semantic Scholar
Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice.
S. Narayanapillai, S. Balbo, P. Leitzman, A. Grill +8 more
2014Carcinogenesis38 citations Open access
Semantic Scholar
4H-Chromene-based anticancer agents towards multi-drug resistant HL60/MX2 human leukemia: SAR at the 4th and 6th positions
Manohar Puppala, Xinghua Zhao, D. Casemore, Bo Zhou +3 more
2016Bioorganic & Medicinal Chemistry35 citations Open access
Semantic Scholar
Kava for the treatment of generalised anxiety disorder (K-GAD): study protocol for a randomised controlled trial
K. Savage, C. Stough, G. Byrne, A. Scholey +9 more
2015Trials35 citations Open access
Semantic Scholar
Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.
Le Zhang, Lijuan Xu, Haihu Chen, Wannian Zhang +4 more
2021European journal of medicinal chemistry33 citations Open access
Semantic Scholar
Kava Blocks 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced Lung Tumorigenesis in Association with Reducing O6-methylguanine DNA Adduct in A/J Mice
P. Leitzman, S. Narayanapillai, S. Balbo, Bo Zhou +6 more
2014Cancer Prevention Research31 citations Open access
Semantic Scholar
A Novel SERCA Inhibitor Demonstrates Synergy with Classic SERCA Inhibitors and Targets Multidrug-Resistant AML
N. Bleeker, Răzvan L. Cornea, David D. Thomas, C. Xing
2013Molecular Pharmaceutics31 citations Open access
Semantic Scholar
Single Oral Dose Pharmacokinetics of Decursin and Decursinol Angelate in Healthy Adult Men and Women
Jin-Hui Zhang, Li Li, T. Hale, W. Chee +3 more
2015PLoS ONE30 citations Open access
Semantic Scholar
Crystallography-Guided Optimizations of the Keap1-Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides.
Guodong Liu, Rui-Zhen Hou, Lijuan Xu, Xinqi Zhang +4 more
2022Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis
Shao-Qing Shi, Qiong Wang, Jennings Xu, Jun-Ho Jang +5 more
2015OncoTarget29 citations Open access
Semantic Scholar
Inhibition of mitogen activated protein kinases increases the sensitivity of A549 lung cancer cells to the cytotoxicity induced by a kava chalcone analog
Janel K. Warmka, Eric L Solberg, N. Zeliadt, Balasubramanian Srinivasan +3 more
2012Biochemical and Biophysical Research Communications - BBRC29 citations Open access
Semantic Scholar
Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice.
T. E. Johnson, D. Hermanson, Lei Wang, F. Kassie +5 more
2011The American Journal of Chinese Medicine28 citations
Semantic Scholar
A new chalcone derivative (E)-3-(4-methoxyphenyl)-2-methyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one suppresses prostate cancer involving p53-mediated cell cycle arrests and apoptosis.
Yong Zhang, Balasubramanian Srinivasan, C. Xing, Jun-Xuan Lu
2012Anticancer Research26 citations
Semantic Scholar
A stable isotope dilution tandem mass spectrometry method of major kavalactones and its applications
Yi Wang, S. Eans, Heather M. Stacy, S. Narayanapillai +6 more
2018PLoS ONE25 citations Open access
Semantic Scholar
Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) – a novel scaffold that re-sensitizes multidrug resistant leukemia cells to chemotherapy
S. Das, D. Hermanson, N. Bleeker, X. Lowman +3 more
2012ACS Chemical Biology25 citations Open access
Semantic Scholar
Autophagy-mediated degradation of IAPs and c-FLIPL potentiates apoptosis induced by combination of TRAIL and Chal-24
Jennings Xu, Xiuling Xu, Shao-Qing Shi, Qiong Wang +9 more
2015Journal of Cellular Biochemistry24 citations Open access
Semantic Scholar
Chalcone-based inhibitors against hypoxia-inducible factor 1 – Structure activity relationship studies
Balasubramanian Srinivasan, T. E. Johnson, C. Xing
2010Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Clinical pharmacokinetics of kavalactones after oral dosing of standardized kava extract in healthy volunteers
Siva Rama Raju Kanumuri, Jessica Mamallapalli, Robyn Nelson, C. McCurdy +3 more
2022Journal of Ethnopharmacology22 citations Open access
Semantic Scholar
Quantitative profiling of cortisol metabolites in human urine by high-resolution accurate-mass MS.
Yi Wang, N. Fujioka, C. Xing
2018Bioanalysis22 citations Open access
Semantic Scholar
Reduction in Colon Cancer Risk by Consumption of Kava or Kava Fractions in Carcinogen-Treated Rats
J. Triolet, A. Shaik, D. Gallaher, M. O'Sullivan +1 more
2012Nutrition and Cancer21 citations
Semantic Scholar
Chemopreventive effect of Korean Angelica root extract on TRAMP carcinogenesis and integrative “omic” profiling of affected neuroendocrine carcinomas
Jin-Hui Zhang, Lei Wang, Yong Zhang, Li Li +5 more
2014Molecular Carcinogenesis20 citations Open access
Semantic Scholar
Single Oral Dose Pharmacokinetics of Decursin, Decursinol Angelate, and Decursinol in Rats
Li Li, Jin-Hui Zhang, C. Xing, Sung-Hoon Kim +1 more
2013Planta Medica20 citations
Semantic Scholar
Quantitative determination of decursin, decursinol angelate, and decursinol in mouse plasma and tumor tissue using liquid-liquid extraction and HPLC.
Li Li, Jin-Hui Zhang, A. Shaik, Yong Zhang +4 more
2012Planta Medica19 citations
Semantic Scholar
Pilot in vivo structure-activity relationship of dihydromethysticin in blocking 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced O6-methylguanine and lung tumor in A/J mice
Manohar Puppala, S. Narayanapillai, P. Leitzman, Hai-Feng Sun +4 more
2017Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O6-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice
S. Narayanapillai, Shang Lin, P. Leitzman, P. Upadhyaya +2 more
2016Chemical Research in Toxicology18 citations Open access
Semantic Scholar
Cancer Chemoprevention with Korean Angelica: Active Compounds, Pharmacokinetics, and Human Translational Considerations
Jun-Xuan Lu, Jin-Hui Zhang, Li Li, Cheng Jiang +1 more
2015Current Pharmacology Reports18 citations Open access
Semantic Scholar
Chemopreventive effects of Korean Angelica vs. its major pyranocoumarins on two lineages of transgenic adenocarcinoma of mouse prostate carcinogenesis
Suni Tang, Jin-Hui Zhang, Wei Wu, Peixin Jiang +6 more
2015Cancer Prevention Research18 citations Open access
Semantic Scholar
Angelica gigas: Signature Compounds, In Vivo Anticancer, Analgesic, Neuroprotective and Other Activities, and the Clinical Translation Challenges.
Jun-Xuan Lu, Cheng Jiang, T. Schell, M. Joshi +2 more
2022The American Journal of Chinese Medicine17 citations Open access
Semantic Scholar
The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers
Yi Wang, S. Narayanapillai, Katelyn M. Tessier, L. Strayer +9 more
2020Cancer Prevention Research17 citations Open access
Semantic Scholar
Prostate Cancer Xenograft Inhibitory Activity and Pharmacokinetics of Decursinol, a Metabolite of Angelica Gigas Pyranocoumarins, in Mouse Models
Wei Wu, Suni Tang, Yong Zhang, Manohar Puppala +4 more
2017The American Journal of Chinese Medicine17 citations Open access
Semantic Scholar
A synthetic decursin analog with increased in vivo stability suppresses androgen receptor signaling in vitro and in vivo
Yong Zhang, A. Shaik, C. Xing, Yu-Bo Chai +6 more
2012Investigational new drugs17 citations
Semantic Scholar

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Jun-Xuan Lu×17
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Jun-Xuan Lu — researcher profile on SciRah
Chunlin Zhuang×9
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Chunlin Zhuang — researcher profile on SciRah
S. Narayanapillai×9
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S. Narayanapillai — researcher profile on SciRah
Jin-Hui Zhang×8
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Cheng Jiang — researcher profile on SciRah

Wannian Zhang×7

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Bo Zhou — researcher profile on SciRah

Balasubramanian Srinivasan×7

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Li Li — researcher profile on SciRah

Sung-Hoon Kim×6

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