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B. Shook · SciRah

Researcher profile · Semantic Scholar

B. Shook

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B. Shook — researcher profile on SciRah

h-index: 19
Works: 40
Citations: 2,141

Most-cited papers

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore
F. Fleming, L. Yao, P. Ravikumar, L. Funk +1 more
2010Journal of Medicinal Chemistry1,402 citations Open access
Semantic Scholar
Nitrile Anion Cyclizations
F. Fleming, B. Shook
200299 citations
Semantic Scholar
Adenosine A(2A) Receptor Antagonists and Parkinson's Disease.
B. Shook, P. Jackson
2011ACS Chemical Neuroscience84 citations Open access
Semantic Scholar
In vivo characterization of a dual adenosine A2A/A1 receptor antagonist in animal models of Parkinson's disease.
B. Shook, S. Rassnick, M. Osborne, Scott Davis +21 more
2010Journal of Medicinal Chemistry51 citations Open access
Semantic Scholar
A practical enantioselective total synthesis of the bengamides B, E, and Z.
R. K. Boeckman, T. Clark, B. Shook
2002Organic Letters42 citations Open access
Semantic Scholar
EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model
Michael H. J. Rhodin, Nicole McAllister, J. Castillo, S. Noton +9 more
2021PLoS Pathogens41 citations Open access
Semantic Scholar
JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease.
J. Atack, B. Shook, S. Rassnick, P. Jackson +13 more
2014ACS Chemical Neuroscience36 citations
Semantic Scholar
Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies
Joshua S. Alford, J. Lampe, Dorothy Brach, R. Chesworth +10 more
2022ACS Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
Design and characterization of optimized adenosine A₂A/A₁ receptor antagonists for the treatment of Parkinson's disease.
B. Shook, S. Rassnick, N. Wallace, J. Crooke +21 more
2012Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate.
H. Lim, Jie Chen, C. Sensenhauser, Kevin L. Cook +10 more
2011Chemical Research in Toxicology29 citations
Semantic Scholar
Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.
B. Shook, S. Rassnick, Daniel A. Hall, K. Rupert +20 more
2010Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Unsaturated nitriles: stereoselective MgO eliminations.
F. Fleming, B. Shook
2002Journal of Organic Chemistry24 citations
Semantic Scholar
Recent Advances in Developing Antiviral Therapies for Respiratory Syncytial Virus
B. Shook, Kai Lin
2017Topics in current chemistry23 citations
Semantic Scholar
Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine
K. A. Haanes, Alejandro Labastida-Ramírez, K. Chan, R. de Vries +7 more
2018The Journal of Headache and Pain22 citations Open access
Semantic Scholar
Microwave-assisted Sonogashira-type cross couplings of various heterocyclic methylthioethers
B. Shook, Chakravarty Devraj, P. Jackson
200922 citations
Semantic Scholar
The Development of a Convergent and Efficient Enantioselective Synthesis of the Bengamides via a Common Polyol Intermediate
R. K. Boeckman, T. Clark, B. Shook
200221 citations
Semantic Scholar
Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists.
B. Shook, D. Chakravarty, J. Barbay, Ai-Hua Wang +13 more
2013Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
beta-Siloxy unsaturated nitriles: stereoselective cyclizations to cis- and trans-decalins.
F. Fleming, B. Shook, T. Jiang, O. W. Steward
1999Organic Letters20 citations
Semantic Scholar
Metalated nitriles: chelation-controlled cyclizations to cis and trans hydrindanes and decalins.
F. Fleming, V. A. Vu, B. Shook, Moshfiqur Rahman +1 more
2007Journal of Organic Chemistry19 citations
Semantic Scholar
Nitrile anions: solvent-dependent cyclizations.
F. Fleming, B. Shook
2002Journal of Organic Chemistry17 citations
Semantic Scholar
Vinyl-Flanked Diketopyrrolopyrrole Polymer/MoS2 Hybrid for Donor–Acceptor Semiconductor Photodetection
Ranganath Wahalathantrige Don, Priyanka Das, Zi-Yuan Ma, Udara M. Kuruppu +6 more
2023Chemistry of Materials16 citations
Semantic Scholar
Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists.
Feng-Bin Song, Guo-Zhang Xu, M. Gaul, Bao-Ping Zhao +10 more
2019Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Optimization of arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.
B. Shook, S. Rassnick, D. Chakravarty, N. Wallace +25 more
2010Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Glucagon Receptor Antagonist–Stimulated α-Cell Proliferation Is Severely Restricted With Advanced Age
Carol J. Lam, Matthew M. Rankin, Kourtney B. King, Melinda C Wang +2 more
2019Diabetes9 citations Open access
Semantic Scholar
Aminomethyl substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists
B. Shook, Devraj Charavarty, J. Barbay, Ai-Hua Wang +14 more
20119 citations
Semantic Scholar
β-Siloxy unsaturated nitriles: stereodivergent cyclizations to cis- and trans-decalins
F. Fleming, B. Shook, T. Jiang, O. W. Steward
20038 citations
Semantic Scholar
α,β-Unsaturated nitriles: preparative MgO elimination
F. Fleming, B. Shook
20006 citations
Semantic Scholar
Adenosine A 2A Receptor Antagonists
B. Shook
20144 citations
Semantic Scholar
Tetrazole‐Based Angiotensin II Type 1 (AT1) Antagonists for the Treatment of Heart Failure and Congestive Hypertension
E. Lawson, B. Shook, J. Lanter
20132 citations
Semantic Scholar
1-Oxo-2-cyclohexenyl-2-carbonitrile: (1-cyclohexene-1-acetonitrile, 6-oxo-)
F. Fleming, B. Shook, Anne F. Vergne, Marvin J. Miller
20022 citations
Semantic Scholar
Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes.
Guo-Zhang Xu, M. Gaul, Feng-Bin Song, F. Du +8 more
2019Bioorganic & Medicinal Chemistry Letters1 citations Open access
Semantic Scholar
HETEROARYLDIAZEPINE DERIVATIVES AS RSV INHIBITORS
I. Kim, B. Shook, Thomas P Blaisdell, Jianming Yu +2 more
20180 citations
Semantic Scholar
Unsaturated Nitriles: Stereoselective MgO Eliminations.
F. Fleming, B. Shook
20100 citations
Semantic Scholar
Microwave‐Assisted Sonogashira‐Type Cross Couplings of Various Heterocyclic Methylthioethers.
B. Shook, Chakravarty Devraj, P. Jackson
20090 citations
Semantic Scholar
Strategies for Enhancing Oral Bioavailability and Brain Penetration
B. Shook, P. Jackson
20080 citations
Semantic Scholar
(4S,5S)‐4‐(2,2‐Dimethyl‐4‐phenyl‐1,3‐dioxan‐5‐yl)‐1‐phenyl‐4H‐1,2,4‐triazol‐1‐ium Perchlorate
B. Shook
20060 citations
Semantic Scholar
1‐Oxo‐2‐Cyclohexenyl‐2‐Carbonitrile
F. Fleming, B. Shook
20030 citations
Semantic Scholar
α,β-Unsaturated Nitriles: Preparative MgO Elimination.
F. Fleming, B. Shook
20010 citations
Semantic Scholar
β‐Siloxy Unsaturated Nitriles: Stereoselective Cyclizations to cis‐ and trans‐Decalins.
F. Fleming, B. Shook, T. Jiang, O. W. Steward
20000 citations
Semantic Scholar
Unsaturated nitriles : Elimination of β-hydroxy nitriles
F. Fleming, B. Shook, B. Ashead
19990 citations
Semantic Scholar

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