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G. Downey · SciRah

Researcher profile · Semantic Scholar

G. Downey

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G. Downey — researcher profile on SciRah

h-index: 72
Works: 272
Citations: 18K

Most-cited papers

Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis
F. McCormack, Y. Inoue, J. Moss, L. Singer +21 more
2011New England Journal of Medicine555 citations Open access
Semantic Scholar
The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance
E. Burnham, W. Janssen, D. Riches, M. Moss +1 more
2013European Respiratory Journal339 citations Open access
Semantic Scholar
Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management.
F. McCormack, N. Gupta, G. Finlay, L. Young +28 more
2016American Journal of Respiratory and Critical Care Medicine271 citations Open access
Semantic Scholar
Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report
H. Kulkarni, Janet S. Lee, J. Bastarache, W. Kuebler +46 more
2022American Journal of Respiratory Cell and Molecular Biology224 citations Open access
Semantic Scholar
Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis.
E. Redente, Kristen M. Jacobsen, J. Solomon, Abigail R. Lara +5 more
2011American Journal of Physiology - Lung cellular and Molecular Physiology197 citations Open access
Semantic Scholar
Lymphangioleiomyomatosis Diagnosis and Management: High‐Resolution Chest Computed Tomography, Transbronchial Lung Biopsy, and Pleural Disease Management. An Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guideline
N. Gupta, G. A. Finlay, R. Kotloff, C. Strange +17 more
2017American Journal of Respiratory and Critical Care Medicine193 citations Open access
Semantic Scholar
Neutrophil transmigration triggers repair of the lung epithelium via β-catenin signaling
R. Zemans, N. Briones, Megan N Campbell, J. McClendon +10 more
2011Proceedings of the National Academy of Sciences of the United States of America193 citations Open access
Semantic Scholar
Transforming Growth Factor-β: Master Regulator of the Respiratory System in Health and Disease.
Y. Aschner, G. Downey
2016American Journal of Respiratory Cell and Molecular Biology188 citations Open access
Semantic Scholar
Serum VEGF-D concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial
L. Young, Hye-Seung Lee, Y. Inoue, J. Moss +16 more
2013The Lancet Respiratory Medicine177 citations Open access
Semantic Scholar
Tumor necrosis factor-α accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages.
E. Redente, R. Keith, W. Janssen, P. Henson +4 more
2014American Journal of Respiratory Cell and Molecular Biology165 citations Open access
Semantic Scholar
The basis of a more contagious 501Y.V1 variant of SARS-CoV-2
Hao-Lin Liu, Qian-Qian Zhang, Pengcheng Wei, Zhongzhou Chen +11 more
2021Cell Research158 citations Open access
Semantic Scholar
Cardiovascular , Pulmonary , and Renal Pathology Matrix Metalloproteinase 3 Is a Mediator of Pulmonary Fibrosis
C. Yamashita, L. Dolgonos, R. Zemans, S. Young +11 more
2011134 citations
Semantic Scholar
Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression
M. Stallings-Mann, J. Waldmann, Ying Zhang, Erin Miller +6 more
2012Science Translational Medicine114 citations Open access
Semantic Scholar
Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis.
F. Ahangari, Christine Becker, D. Foster, M. Chioccioli +30 more
2022American Journal of Respiratory and Critical Care Medicine86 citations
Semantic Scholar
501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to Bamlanivimab in vitro
Hao-Lin Liu, Pengcheng Wei, Qian-Qian Zhang, Zhongzhou Chen +9 more
2021bioRxiv80 citations Open access
Semantic Scholar
Respiratory Health after Military Service in Southwest Asia and Afghanistan. An Official American Thoracic Society Workshop Report
E. Garshick, Joseph H. Abraham, Coleen P Baird, P. Ciminera +21 more
2019Annals of the American Thoracic Society76 citations Open access
Semantic Scholar
Matrix metalloproteinases and protein tyrosine kinases: potential novel targets in acute lung injury and ARDS.
Y. Aschner, R. Zemans, C. Yamashita, G. Downey
2014Chest69 citations Open access
Semantic Scholar
Human epidermal growth factor receptor signaling in acute lung injury.
J. Finigan, G. Downey, J. Kern
2012American Journal of Respiratory Cell and Molecular Biology62 citations Open access
Semantic Scholar
Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury.
R. Zemans, J. McClendon, Y. Aschner, N. Briones +4 more
2013American Journal of Physiology - Lung cellular and Molecular Physiology53 citations Open access
Semantic Scholar
Analysis of the MILES cohort reveals determinants of disease progression and treatment response in lymphangioleiomyomatosis
N. Gupta, Hye-Seung Lee, L. Young, C. Strange +17 more
2019European Respiratory Journal51 citations Open access
Semantic Scholar
Adhesion Molecules: Master Controllers of the Circulatory System
E. Schmidt, W. Kuebler, Warren L. Lee, G. Downey
2016Comprehensive Physiology49 citations
Semantic Scholar
Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells
K. Schweitzer, Taylor Crue, Jordan M. Nall, D. Foster +10 more
2021European Respiratory Journal48 citations Open access
Semantic Scholar
Divergent functions of Toll-like receptors during bacterial lung infections.
Pankaj Baral, S. Batra, R. Zemans, G. Downey +1 more
2014American Journal of Respiratory and Critical Care Medicine48 citations Open access
Semantic Scholar
Neutrophil Intercellular Communication in Acute Lung Injury: Emerging Roles of Microparticles and Gap Junctions.
Viola Dengler, G. Downey, R. Tuder, H. Eltzschig +1 more
2013American Journal of Respiratory Cell and Molecular Biology45 citations Open access
Semantic Scholar
Investigating the role of nucleotide-binding oligomerization domain-like receptors in bacterial lung infection.
Mary K. Leissinger, Ritwij Kulkarni, R. Zemans, G. Downey +1 more
2014American Journal of Respiratory and Critical Care Medicine44 citations Open access
Semantic Scholar
501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to bamlanivimab in vitro
Hao-Lin Liu, Pengcheng Wei, Qian-Qian Zhang, Zhongzhou Chen +9 more
2021mAbs42 citations Open access
Semantic Scholar
Emerging Roles of Inflammasomes in Acute Pneumonia
S. Kumar, Sagar Paudel, Laxman Ghimire, Scott R. Bergeron +4 more
2018American Journal of Respiratory and Critical Care Medicine42 citations Open access
Semantic Scholar
Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition
M. Raeeszadeh-Sarmazdeh, K. Greene, B. Sankaran, G. Downey +2 more
2019Journal of Biological Chemistry41 citations Open access
Semantic Scholar
The Lambda variant of SARS-CoV-2 has a better chance than the Delta variant to escape vaccines
Hao-Lin Liu, Pengcheng Wei, Qian-Qian Zhang, K. Aviszus +11 more
2021bioRxiv35 citations Open access
Semantic Scholar
Isolated Cystic Lung Disease: An Algorithmic Approach to Distinguishing Birt-Hogg-Dubé Syndrome, Lymphangioleiomyomatosis, and Lymphocytic Interstitial Pneumonia.
J. Escalon, J. Richards, Tilman L. Koelsch, G. Downey +1 more
2019AJR. American journal of roentgenology34 citations
Semantic Scholar
Protein tyrosine phosphatase α mediates profibrotic signaling in lung fibroblasts through TGF-β responsiveness.
Y. Aschner, A. P. Khalifah, N. Briones, C. Yamashita +13 more
2014American Journal of Pathology32 citations Open access
Semantic Scholar
Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10
M. Raeeszadeh-Sarmazdeh, Matt Coban, S. Mahajan, Alexandra Hockla +4 more
2022Journal of Biological Chemistry31 citations Open access
Semantic Scholar
IL‐1β enhances cell adhesion to degraded fibronectin
D. Rajshankar, G. Downey, C. McCulloch
2012The FASEB Journal30 citations Open access
Semantic Scholar
Neutrophil intercellular communication in acute lung injury. Emerging roles of microparticles and gap junctions.
Viola Dengler, G. Downey, R. Tuder, H. Eltzschig +1 more
2013American Journal of Respiratory Cell and Molecular Biology20 citations Open access
Semantic Scholar
Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression.
Qin Wang, K. Siminovitch, G. Downey, C. McCulloch
2013Biochemical Journal20 citations Open access
Semantic Scholar
The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation
Qin Wang, Karambir Notay, G. Downey, C. McCulloch
2020Cell Reports19 citations Open access
Semantic Scholar
The importance of matrix metalloproteinase-3 in respiratory disorders
C. Yamashita, D. Radisky, Y. Aschner, G. Downey
2014Expert Review of Respiratory Medicine19 citations
Semantic Scholar
The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not
Y. Aschner, G. Downey
2018American Journal of Respiratory Cell and Molecular Biology15 citations Open access
Semantic Scholar
Interactions of the Protein-tyrosine Phosphatase-α with the Focal Adhesion Targeting Domain of Focal Adhesion Kinase Are Involved in Interleukin-1 Signaling in Fibroblasts*
Qin Wang, Yongqiang Wang, Dominik K. Fritz, D. Rajshankar +2 more
2014Journal of Biological Chemistry15 citations Open access
Semantic Scholar
Afghanistan Particulate Matter Enhances Pro-Inflammatory Responses in IL-13-Exposed Human Airway Epithelium via TLR2 Signaling
Reena Berman, G. Downey, A. Dakhama, B. Day +1 more
2018Toxicological Sciences14 citations Open access
Semantic Scholar
Role of Particulate Matter from Afghanistan and Iraq in Deployment-Related Lung Disease.
Reena Berman, C. Rose, G. Downey, B. Day +1 more
2021Chemical Research in Toxicology12 citations
Semantic Scholar
Protein Tyrosine Phosphatase-α Amplifies TGF-β-Dependent Pro-Fibrotic Signaling in Lung Fibroblasts.
Y. Aschner, M. Nelson, Matthew L. Brenner, H. Roybal +17 more
2020American Journal of Physiology - Lung cellular and Molecular Physiology12 citations Open access
Semantic Scholar
IL-33/ST2 signaling modulates Afghanistan particulate matter induced airway hyperresponsiveness in mice.
Reena Berman, K. Kopf, E. Min, Jie Huang +4 more
2020Toxicology and Applied Pharmacology12 citations Open access
Semantic Scholar
Regulation of IL‐1 signaling through control of focal adhesion assembly
Qin Wang, Julie Delcorde, Tracy T. Tang, G. Downey +1 more
2018The FASEB Journal12 citations Open access
Semantic Scholar
A ternary complex comprising FAK, PTPα and IP3 receptor 1 functionally engages focal adhesions and the endoplasmic reticulum to mediate IL-1-induced Ca2+ signalling in fibroblasts.
Qin Wang, Yongqiang Wang, G. Downey, Sergey Plotnikov +1 more
2016Biochemical Journal12 citations
Semantic Scholar
Single Cell RNA Sequencing Reveals a Unique Monocyte Population in Bronchoalveolar Lavage Cells of Mice Challenged with Afghanistan Particulate Matter and Allergen.
Reena Berman, E. Min, Jie Huang, K. Kopf +7 more
2021Toxicological Sciences11 citations Open access
Semantic Scholar
Update in Cystic Fibrosis 2018.
B. Ramsey, G. Downey, C. Goss
2019American Journal of Respiratory and Critical Care Medicine11 citations Open access
Semantic Scholar
The yin and yang of cystic fibrosis transmembrane conductance regulator function: implications for chronic lung disease.
N. Vij, G. Downey
2013American Journal of Respiratory and Critical Care Medicine11 citations Open access
Semantic Scholar
Lymphangioleiomyomatosis and other Cystic Lung Diseases
M. Koslow, D. Lynch, Carlyne D. Cool, S. Groshong +1 more
2023Immunology and allergy clinics of North America10 citations Open access
Semantic Scholar
Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians.
Ryan McGinn, D. Fergusson, D. Stewart, A. Kristof +23 more
2020Critical Care Medicine10 citations
Semantic Scholar

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D. Riches×6
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J. Moss — researcher profile on SciRah

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