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S. Singleton · SciRah

Researcher profile · Semantic Scholar

S. Singleton

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S. Singleton — researcher profile on SciRah

h-index: 20
Works: 44
Citations: 1,349

Most-cited papers

Thermodynamic characterization of the stability and the melting behavior of a DNA triplex: a spectroscopic and calorimetric study.
G. Plum, Y. W. Park, S. Singleton, P. Dervan +1 more
1990Proceedings of the National Academy of Sciences of the United States of America181 citations Open access
Semantic Scholar
A perspective on biological catalysis
W. Cannon, S. Singleton, S. Benkovic
1996Nature Structural Biology124 citations
Semantic Scholar
Nucleic acid hybridization: triplex stability and energetics.
G. Plum, D. S. Pilch, S. Singleton, K. Breslauer
1995Annual Review of Biophysics and Biomolecular Structure111 citations
Semantic Scholar
Evidence for dynamics in proteins as a mechanism for ligand dissociation
M. Carroll, Randall V. Mauldin, A. Gromova, S. Singleton +2 more
2012Nature Chemical Biology86 citations Open access
Semantic Scholar
Synthesis and application of a chain-terminating dinucleotide mRNA cap analog.
Zheng-Hong Peng, V. Sharma, S. Singleton, P. Gershon
2002Organic Letters79 citations
Semantic Scholar
Inhibitors of RecA Activity Discovered by High-Throughput Screening: Cell-Permeable Small Molecules Attenuate the SOS Response in Escherichia coli
T. Wigle, J. Sexton, A. Gromova, M. Hadimani +4 more
2009Journal of biomolecular screening68 citations Open access
Semantic Scholar
Directed molecular screening for RecA ATPase inhibitors.
T. Wigle, S. Singleton
2007Bioorganic & Medicinal Chemistry Letters63 citations Open access
Semantic Scholar
Novel Inhibitors of E. coli RecA ATPase Activity
J. Sexton, T. Wigle, Qingping He, Mark A. Hughes +4 more
2010Current Chemical Genomics62 citations Open access
Semantic Scholar
A molecular target for suppression of the evolution of antibiotic resistance: inhibition of the Escherichia coli RecA protein by N(6)-(1-naphthyl)-ADP.
A. M. Lee, Christian T Ross, Bu-Bing Zeng, S. Singleton
2005Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
Thermodynamics of oligodeoxyribonucleotide-directed triple helix formation: an analysis using quantitative affinity cleavage titration
S. Singleton, P. Dervan
199246 citations
Semantic Scholar
High-Throughput Screening for RecA Inhibitors Using a Transcreener Adenosine 5′-O-Diphosphate Assay
Eliza J. R. Peterson, W. Janzen, D. Kireev, S. Singleton
2012Assay and drug development technologies40 citations Open access
Semantic Scholar
Inhibition of the Escherichia coli RecA protein: zinc(II), copper(II) and mercury(II) trap RecA as inactive aggregates.
A. M. Lee, S. Singleton
2004Journal of Inorganic Biochemistry40 citations
Semantic Scholar
Direct Evaluation of a Kinetic Model for RecA‐Mediated DNA‐strand exchange: The Importance of Nucleic Acid Dynamics and Entropy During Homologous Genetic Recombination
Jie Xiao, A. M. Lee, S. Singleton
2006ChemBioChem32 citations
Semantic Scholar
Elucidating a key intermediate in homologous DNA strand exchange: structural characterization of the RecA-triple-stranded DNA complex using fluorescence resonance energy transfer.
Jie Xiao, S. Singleton
2002Journal of Molecular Biology31 citations
Semantic Scholar
Intein-mediated affinity-fusion purification of the Escherichia coli RecA protein.
S. Singleton, R. Simonette, N. Sharma, A. Roca
2002Protein Expression and Purification28 citations
Semantic Scholar
Facile synthesis of a fluorescent deoxycytidine analogue suitable for probing the RecA nucleoprotein filament.
S. Singleton, Shan Feng, M. Kanan, C. M. McIntosh +3 more
2001Organic Letters28 citations
Semantic Scholar
Rapid metabolic and newborn screening of thyroxine (T4) from dried blood spots by MS/MS.
D. Chace, S. Singleton, J. DiPerna, Mauro Aiello +1 more
2009Clinica chimica acta; international journal of clinical chemistry25 citations
Semantic Scholar
Inhibition of Escherichia coli RecA by rationally redesigned N-terminal helix.
D. J. Cline, Shannon L Holt, S. Singleton
2007Organic and biomolecular chemistry23 citations
Semantic Scholar
Conformationally selective binding of nucleotide analogues to Escherichia coli RecA: a ligand-based analysis of the RecA ATP binding site.
T. Wigle, A. M. Lee, S. Singleton
2006Biochemistry23 citations
Semantic Scholar
Origins of sequence selectivity in homologous genetic recombination: insights from rapid kinetic probing of RecA-mediated DNA strand exchange.
A. M. Lee, Jie Xiao, S. Singleton
2006Journal of Molecular Biology22 citations
Semantic Scholar
Probing the structure of RecA-DNA filaments. Advantages of a fluorescent guanine analog.
S. Singleton, A. Roca, A. M. Lee, Jie Xiao
2007Tetrahedron20 citations Open access
Semantic Scholar
A complementary pair of rapid molecular screening assays for RecA activities.
A. M. Lee, T. Wigle, S. Singleton
2007Analytical Biochemistry20 citations Open access
Semantic Scholar
Temperature Dependence of the Energetics of Oligonucleotide-Directed Triple-Helix Formation at a Single DNA Site
S. Singleton, P. Dervan
199420 citations
Semantic Scholar
Construction and evaluation of a kinetic scheme for RecA‐mediated DNA strand exchange
Jie Xiao, A. M. Lee, S. Singleton
2006Biopolymers18 citations
Semantic Scholar
Direct detection of structurally resolved dynamics in a multi-conformation receptor-ligand complex
M. Carroll, A. Gromova, K. Miller, Hao Tang +5 more
2011Journal of the American Chemical Society17 citations Open access
Semantic Scholar
Inhibitors of Streptococcus pneumoniae Surface Endonuclease EndA Discovered by High-Throughput Screening Using a PicoGreen Fluorescence Assay
Eliza J. R. Peterson, D. Kireev, A. F. Moon, M. Midon +4 more
2012Journal of biomolecular screening16 citations Open access
Semantic Scholar
The stretched DNA geometry of recombination and repair nucleoprotein filaments.
S. Singleton, Jie Xiao
2001Biopolymers14 citations
Semantic Scholar
Direct evaluation of a mechanism for activation of the RecA nucleoprotein filament.
A. Roca, S. Singleton
2003Journal of the American Chemical Society13 citations
Semantic Scholar
Design and evaluation of a tryptophanless RecA protein with wild type activity.
M. D. Berger, A. M. Lee, Rebecca A. Simonette, B. Jackson +2 more
2001Biochemical and Biophysical Research Communications - BBRC9 citations
Semantic Scholar
State-to-state collisional energy transfer in electronically excited silicon monochloride radicals
S. Singleton, K. McKendrick
19938 citations
Semantic Scholar
An Analysis of the Electronic States of Aceanthrylene
B. Plummer, S. Singleton
19908 citations
Semantic Scholar
The photodimerization of aceanthrylene
B. Plummer, S. Singleton
19878 citations
Semantic Scholar
Intersubunit electrostatic complementarity in the RecA nucleoprotein filament regulates nucleotide substrate specificity and conformational activation.
A. M. Lee, S. Singleton
2006Biochemistry6 citations
Semantic Scholar
Vibrational transition probabilities in the B-X and B'-X systems of the chlorosilylidyne radical
S. Singleton, K. McKendrick, R. Copeland, J. Jeffries
19926 citations
Semantic Scholar
Triplets, biradicals, radical ions, and the heavy-atom effect in the photodimerization of aceanthrylene
B. Plummer, S. Singleton
19896 citations
Semantic Scholar
Cover Picture: Direct Evaluation of a Kinetic Model for RecA‐Mediated DNA‐strand exchange: The Importance of Nucleic Acid Dynamics and Entropy During Homologous Genetic Recombination (ChemBioChem 8/2006)
Jie Xiao, A. M. Lee, S. Singleton
20061 citations
Semantic Scholar
Synthesis and Application of a Chain-Terminating Dinucleotide mRNA Cap Analogue.
Zheng-Hong Peng, V. Sharma, S. Singleton, P. Gershon
20021 citations
Semantic Scholar
Sensitivity of receptor internal motions to ligand binding affinity and kinetic off-rate
E. Collins, Andrew L. Lee, M. Carroll, Randall V. Mauldin +2 more
20120 citations
Semantic Scholar
Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR
E. J. Collins, A. L. Lee, M. Carroll, A. Gromova +2 more
20100 citations
Semantic Scholar
Development of mutant RecA proteins with unique fluorescent residues
S. Singleton, M. Berger, R. Simonette, A. M. Lee
20000 citations
Semantic Scholar
Adventures in trying to understand enzymic catalysis
S. Benkovic, J. Huang, S. Singleton, A. Nixon +1 more
19960 citations
Semantic Scholar
The thermodynamics of oligonucleotide-directed triple helix formation at single DNA sites
S. Singleton
19950 citations
Semantic Scholar
Stability and Energetics
G. Plum, D. S. Pilch, S. Singleton
19950 citations
Semantic Scholar
The Photodimerization of Aceanthrylene (I).
B. Plummer, S. Singleton
19880 citations
Semantic Scholar

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