S. Margolin

Most-cited papers

Dietary intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters.
S. Iyer, J. Wild, M. Schiedt, D. Hyde +2 more
1995Journal of Laboratory and Clinical Medicine223 citations
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Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin‐diabetic rats
Goran Miric, C. Dallemagne, Z. Endre, S. Margolin +2 more
2001British Journal of Pharmacology219 citations Open access
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Pirfenidone effectively reverses experimental liver fibrosis.
L. Garcia, I. Hernández, A. Sandoval, A. Salazar +6 more
2002Journal of Hepatology170 citations
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Pirfenidone improves renal function and fibrosis in the post-obstructed kidney.
Toshikatsu Shimizu, T. Kuroda, S. Hata, M. Fukagawa +2 more
1998Kidney International167 citations Open access
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Attenuation of cardiac fibrosis by pirfenidone and amiloride in DOCA‐salt hypertensive rats
S. Mirkovic, Anne-Marie L. Seymour, A. Fenning, Anna J. Strachan +3 more
2002British Journal of Pharmacology130 citations Open access
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Lung fibrosis is ameliorated by pirfenidone fed in diet after the second dose in a three-dose bleomycin-hamster model.
S. Iyer, S. Margolin, D. Hyde, S. N. Giri
1998Experimental Lung Research112 citations
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Pirfenidone reduces in vitro rat renal fibroblast activation and mitogenesis.
T. Hewitson, K. J. Kelynack, M. G. Tait, M. Martić +3 more
2001JN. Journal of Nephrology (Milano. 1992)97 citations
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Effects of three anti-TNF-alpha drugs: etanercept, infliximab and pirfenidone on release of TNF-alpha in medium and TNF-alpha associated with the cell in vitro.
K. Grattendick, J. Nakashima, L. Feng, S. Giri +1 more
2008International Immunopharmacology91 citations
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Effects of pirfenidone on the generation of reactive oxygen species in vitro.
S. Giri, S. Leonard, X. Shi, S. Margolin +1 more
1999Journal of Environmental Pathology And Toxicology81 citations
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Inhibition of tumor necrosis factor and subsequent endotoxin shock by pirfenidone.
W. Cain, R. Stuart, D. Lefkowitz, J. Starnes +2 more
1998International Journal of Immunopharmacology80 citations
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Pirfenidone induces intercellular adhesion molecule‐1 (ICAM‐1) down‐regulation on cultured human synovial fibroblasts
M. Kaneko, H. Inoue, R. Nakazawa, N. Azuma +5 more
1998Clinical and Experimental Immunology78 citations Open access
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Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity.
J. Card, W. J. Racz, J. Brien, S. Margolin +1 more
2003Toxicological Sciences67 citations
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Amelioration of doxorubicin-induced cardiac and renal toxicity by pirfenidone in rats
S. Giri, M. Al-Bayati, Xiaogu Du, E. Schelegle +2 more
2004Cancer Chemotherapy and Pharmacology65 citations
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Pirfenidone Blocks the In Vitro and In Vivo Effects of Staphylococcal Enterotoxin B
M. Hale, S. Margolin, T. Krakauer, C. Roy +1 more
2002Infection and Immunity57 citations Open access
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A double-blind, randomized, controlled study of oral pirfenidone for treatment of secondary progressive multiple sclerosis
Jonathan E. Walker, S. Giri, S. Margolin
2005Multiple Sclerosis48 citations
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Pharmacokinetics and metabolism of a novel antifibrotic drug pirfenidone, in mice following intravenous administration
S. Giri, Qing-Jian Wang, Yan Xie, J. Langó +3 more
2002Biopharmaceutics & drug disposition46 citations
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Pirfenidone inhibits obliterative airway disease in mouse tracheal allografts.
Hailan Zhou, C. Latham, D. Zander, S. Margolin +1 more
2005The Journal of Heart and Lung Transplantation41 citations
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THE HISTORY, CHEMISTRY, AND PHARMACOLOGY OF CARISOPRODOL
F. M. Berger, M. Kletzkin, B. J. Ludwig, S. Margolin
1960Annals of the New York Academy of Sciences40 citations
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Pirfenidone for chronic progressive multiple sclerosis
Jonathan E. Walker, S. Margolin
2001Multiple Sclerosis36 citations
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Involution of keloid implants in athymic mice treated with pirfenidone or with triamcinolone.
M. Shetlar, D. Shetlar, Robert F. Bloom, C. L. Shetlar +1 more
1998Journal of Laboratory and Clinical Medicine33 citations
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Pirfenidone inhibits obliterative airway disease in a murine heterotopic tracheal transplant model1
Brice W. McKane, F. Fernández, K. Narayanan, Shawn Marshbank +3 more
2004Transplantation30 citations Open access
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Pirfenidone attenuates ischaemia–reperfusion injury in the rat small intestine
T. Arumugam, I. Shiels, S. Margolin, S. Taylor +1 more
2002Clinical and Experimental Pharmacology and Physiology28 citations
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Pharmacokinetics of an antifibrotic agent, pirfenidone, in haemodialysis patients
M. Taniyama, S. Ohbayashi, M. Narita, R. Nakazawa +6 more
1997European Journal of Clinical Pharmacology28 citations
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Open-label study of pirfenidone in patients with progressive forms of multiple sclerosis
J. Bowen, K. Maravilla, S. Margolin
2003Multiple Sclerosis27 citations
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Effects of intravenous administration of pirfenidone on horses with experimentally induced endotoxemia.
Amy E. Poulin Braim, M. H. Macdonald, M. Bruss, K. Grattendick +2 more
2009American Journal of Veterinary Research25 citations
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Pirfenidone and candesartan ameliorate morphological damage in mild chronic anti-GBM nephritis in rats.
S. Leh, Øyvind Vaagnes, S. Margolin, B. Iversen +1 more
2005Nephrology, Dialysis and Transplantation24 citations Open access
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Pharmacokinetics of orally administered pirfenidone in male and female beagles.
M. Bruss, S. Margolin, S. Giri
2004Journal of Veterinary Pharmacology and Therapeutics23 citations
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Unusual muscle relaxant and analgesic properties of N-isopropyl-2-propyl-1,3-propanediol dicarbamate (carisoprodol).
F. M. Berger, M. Kletzkin, B. J. Ludwig, S. Margolin +1 more
1959Journal of Pharmacology and Experimental Therapeutics21 citations
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Pharmacokinetics and metabolism of intravenous pirfenidone in sheep
M. Bruss, S. Stanley, S. Margolin, S. Giri
2008Biopharmaceutics & drug disposition19 citations
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Effects of three anti-TNF-α drugs : Etanercept , infliximab and pirfenidone on release of TNF-α in medium and TNF-α associated with the cell in vitro
K. Grattendick, J. Nakashima, L. Feng, S. Giri +1 more
200819 citations
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Centrally Mediated Inhibition of Gastrointestinal Propulsive Motility By Morphine over a Non-Neural Pathway
S. Margolin
1963Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine19 citations
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Variations in the electrocardiographic form of experimental ventricular ectopic beats induced in the monkey and dog
D. I. Abramson, L. Katz, S. Margolin, R. Lourie
193714 citations
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The pharmacological properties of 2-methyl-2-sec-butyl-1,3-propanediol dicarbamate (Mebutamate, W-583), a new centrally acting blood pressure lowering agent.
F. M. Berger, J. Douglas, M. Kletzkin, B. J. Ludwig +1 more
1961Journal of Pharmacology and Experimental Therapeutics13 citations
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Pirfenidone inhibits early myointimal proliferation but has no effect on late lesion size in rats.
J. Waller, G. J. Murphy, G. Bicknell, R. Sandford +2 more
2002European Journal of Vascular and Endovascular Surgery12 citations Open access
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Mercury in marine seafood: the scientific medical margin of safety as a guide to the potential risk to public health.
S. Margolin
1980World Review of Nutrition and Dietetics12 citations
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PHARMACOLOGIC PROPERTIES OF A NEW TRANQUILIZING AGENT, 2-METHYL-2-PROPYLTRIMETHYLENE BUTYLCARBAMATE CARBAMATE (TYBAMATE).
F. M. Berger, M. Kletzkin, S. Margolin
1964Medicina Experimentalis12 citations
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Pharmacological Properties of a New Parasympathetic Blocking Agent, N,N Dimethyl 4-Piperidylidene 1,1 Diphenylmethane Methyl Sulfate (Prantal)
S. Margolin, M. Doyle, J. Giblin, A. Makovsky +5 more
1951Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine12 citations
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Endotoxin-Induced Inhibition of Renal Function in the Mouse
H. M. Bates, S. Margolin
1968Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine11 citations
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Influence of pirfenidone on airway hyperresponsiveness and inflammation in a Brown-Norway rat model of asthma.
J. Mansoor, K. Decile, S. Giri, K. Pinkerton +5 more
2007Pulmonary Pharmacology & Therapeutics10 citations
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THE EFFECT OF N-γ-PHENYLPROPYL-N-BENZYLOXY ACETA- MIDE (W-1372) ON EXPERIMENTAL ATHEROSCLEROSIS AND HYPERCHOLESTEREMIA
F. M. Berger, J. Douglas, B. J. Ludwig, S. Margolin
1969Journal of Pharmacology and Experimental Therapeutics10 citations
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Postnatal Behavioural Effects of Meprobamate injected into the Gravid Rat
M. Kletzkin, H. Wojciechowski, S. Margolin
1964Nature10 citations
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Pharmacologic Demonstration in Man of Increased Thresholds to Tooth Pain Following Carisoprodol and other Analgesics
S. Margolin
1960Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine10 citations
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Antirheumatic effect of pirfenidone in a double blind clinical pilot trial in humans.
E. Pesce, E. Struma, S. Giri, S. Margolin
2004Research Communications in Molecular Pathology and Pharmacology9 citations
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Selective Suppression of Penicillin Hypersensitivity by Certain Phenoxy Propanediols
F. M. Berger, G. Fukui, B. J. Ludwig, S. Margolin
1967Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine9 citations
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Experimental oral cholecystography with a new contrast medium, teridax (triiodoethionic acid)
S. Margolin, I. Stephens, M. T. Spoerlein, A. Makovsky +1 more
1953Journal of the American Pharmaceutical Association. American Pharmaceutical Association9 citations Open access
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Effects of pirfenidone on vascular smooth muscle cell proliferation and intimal hyperplasia following arterial balloon injury.
J. Waller, G. Murphy, M. Metcalfe, G. Bicknell +3 more
2001Transplantation Proceedings7 citations
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A NEUROHUMORAL SUBSTANCE DISCHARGED INTO BLOOD PERFUSATE FROM ISOLATED RABBIT HEADS BY INTRACEREBRAL MORPHINE.
S. Margolin, O. J. Plekss
1965Medicina et Pharmacologia Experimentalis6 citations
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Tudies on the mechanism of the hypocholesterolemic ction of benzyl N-benzyl carbethoxyhydroxamate (W-398)
J. Douglas, B. J. Ludwig, S. Margolin, F. M. Berger
19665 citations
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Effect of Benzyl N-Benzyl Carbethoxyhydroxamate (W-398) on Experimental Atherosclerosis and Hypercholesteremia
F. M. Berger, J. Douglas, B. J. Ludwig, S. Margolin
1963Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine5 citations
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Selective inhibition of dog spinal vasoconstrictor tracts by mebutamate.
S. Margolin, O. J. Plekss, E. Fedor
1963Journal of Pharmacology and Experimental Therapeutics5 citations
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