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C. Ohlen · SciRah

Researcher profile · Semantic Scholar

C. Ohlen

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C. Ohlen — researcher profile on SciRah

h-index: 34
Works: 87
Citations: 6,170

Most-cited papers

Empty MHC class I molecules come out in the cold
H. Ljunggren, N. Stam, C. Ohlen, J. Neefjes +7 more
1990Nature984 citations
Semantic Scholar
Association of class I major histocompatibility heavy and light chains induced by viral peptides
A. Townsend, C. Ohlen, J. Bastin, H. Ljunggren +2 more
1989Nature970 citations
Semantic Scholar
A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis
E. Huseby, D. Liggitt, T. Brabb, Bryan Schnabel +2 more
2001Journal of Experimental Medicine694 citations Open access
Semantic Scholar
Functional impairment of CD8(+) T cells by regulatory T cells during persistent retroviral infection.
U. Dittmer, Hong He, Ronald J. Messer, Simone Schimmer +10 more
2004Immunity370 citations Open access
Semantic Scholar
Recognition of beta 2-microglobulin-negative (beta 2m-) T-cell blasts by natural killer cells from normal but not from beta 2m- mice: nonresponsiveness controlled by beta 2m- bone marrow in chimeric mice.
P. Höglund, C. Ohlen, E. Carbone, L. Franksson +4 more
1991Proceedings of the National Academy of Sciences of the United States of America282 citations Open access
Semantic Scholar
Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors
R. Teague, Blythe Sather, J. Sacks, Maria Z. Huang +7 more
2006Nature Medicine252 citations
Semantic Scholar
Prevention of allogeneic bone marrow graft rejection by H-2 transgene in donor mice.
C. Ohlen, G. Kling, P. Höglund, M. Hansson +4 more
1989Science232 citations
Semantic Scholar
Allorecognition by NK cells: nonself or no self?
L. Moretta, E. Ciccone, A. Moretta, P. Höglund +2 more
1992Immunology today (Amsterdam. Regular ed.)187 citations
Semantic Scholar
Recruitment and Activation of Natural Killer (Nk) Cells in Vivo Determined by the Target Cell Phenotype
R. Glas, L. Franksson, C. Une, M. Eloranta +3 more
2000Journal of Experimental Medicine182 citations Open access
Semantic Scholar
Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death
Laurence E. Cheng, C. Ohlen, B. Nelson, P. Greenberg
2002Proceedings of the National Academy of Sciences of the United States of America141 citations Open access
Semantic Scholar
Natural resistance against lymphoma grafts conveyed by H-2Dd transgene to C57BL mice
P. Höglund, H. Ljunggren, C. Ohlen, L. ährlund-Richter +5 more
1988Journal of Experimental Medicine120 citations Open access
Semantic Scholar
CD8+ T Cell Tolerance to a Tumor-associated Antigen Is Maintained at the Level of Expansion Rather than Effector Function
C. Ohlen, M. Kalos, Laurence E. Cheng, A. Shur +7 more
2002Journal of Experimental Medicine115 citations Open access
Semantic Scholar
Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy
C. Fennessey, M. Pinkevych, T. Immonen, A. Reynaldi +15 more
2017PLoS Pathogens111 citations Open access
Semantic Scholar
The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I
R. Glas, C. Ohlen, P. Höglund, K. Kärre
1994Journal of Experimental Medicine107 citations Open access
Semantic Scholar
Multigene DNA Priming-Boosting Vaccines Protect Macaques from Acute CD4+-T-Cell Depletion after Simian-Human Immunodeficiency Virus SHIV89.6P Mucosal Challenge
N. Doria-Rose, C. Ohlen, P. Polacino, C. C. Pierce +7 more
2003Journal of Virology93 citations Open access
Semantic Scholar
Expression of a Tolerizing Tumor Antigen in Peripheral Tissue Does Not Preclude Recovery of High-Affinity CD8+ T Cells or CTL Immunotherapy of Tumors Expressing the Antigen1
C. Ohlen, M. Kalos, D. J. Hong, A. Shur +1 more
2001Journal of Immunology75 citations Open access
Semantic Scholar
Alteration of the natural killer repertoire in H-2 transgenic mice: specificity of rapid lymphoma cell clearance determined by the H-2 phenotype of the target
P. Höglund, R. Glas, C. Ohlen, H. Ljunggren +1 more
1991Journal of Experimental Medicine70 citations Open access
Semantic Scholar
Different types of allospecific CTL clones identified by their ability to recognize peptide loading‐defective target cells
F. Aosai, C. Ohlen, H. Ljunggren, P. Höglund +5 more
1991European Journal of Immunology69 citations
Semantic Scholar
Resistance to H-2-restricted but not to allo-H2-specific graft and cytotoxic T lymphocyte responses in lymphoma mutant.
C. Ohlen, J. Bastin, H. Ljunggren, L. Foster +4 more
1990Journal of Immunology68 citations Open access
Semantic Scholar
Long-lasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization
V. Patel, A. Valentin, V. Kulkarni, M. Rosati +12 more
2010Vaccine66 citations Open access
Semantic Scholar
Major histocompatibility complex class I-specific and -restricted killing of beta 2-microglobulin-deficient cells by CD8+ cytotoxic T lymphocytes.
R. Glas, Lars Franksson, C. Ohlen, P. Höglund +3 more
1992Proceedings of the National Academy of Sciences of the United States of America66 citations Open access
Semantic Scholar
Peripheral CD8+ T cell tolerance to self-proteins is regulated proximally at the T cell receptor.
R. Teague, P. Greenberg, C. Fowler, Maria Z. Huang +5 more
2008Immunity56 citations Open access
Semantic Scholar
A mutant cell in which association of class I heavy and light chains is induced by viral peptides.
Alain R. M. Townsend, C. Ohlen, L. Foster, J. Bastin +2 more
1989Cold Spring Harbor Symposia on Quantitative Biology53 citations
Semantic Scholar
The RMA‐S lymphoma mutant; consequences of a peptide loading defect on immunological recognition and graft rejection
H. Ljunggren, C. Ohlen, P. Höglund, L. Franksson +1 more
1991International journal of cancer. Supplement = Journal international du cancer. Supplement51 citations
Semantic Scholar
Afferent and efferent cellular interactions in natural resistance directed against MHC class I deficient tumor grafts.
H. Ljunggren, C. Ohlen, P. Höglund, Toshiki Yamasaki +2 more
1988Journal of Immunology44 citations
Semantic Scholar
NK sensitivity and lung clearance of MHC‐class‐I‐deficient cells within a heterogeneous fibrosarcoma
I. Algarra, C. Ohlen, Matías Pérez, H. Ljunggren +3 more
1989International Journal of Cancer43 citations
Semantic Scholar
Source of unique tumour antigens
A. Townsend, C. Ohlen, M. Rogers, J. Edwards +2 more
1994Nature42 citations
Semantic Scholar
Studies of sublines selected for loss of HLA expression from an EBV-transformed lymphoblastoid cell line. Changes in sensitivity to cytotoxic T cells activated by allostimulation and natural killer cells activated by IFN or IL-2.
C. Ohlen, M. Bejarano, A. Grönberg, S. Torsteinsdottir +5 more
1989Journal of Immunology41 citations Open access
Semantic Scholar
T-cell responses to KSHV infection: a systematic approach
Romin Roshan, Nazzarena Labo, Matthew T. Trivett, W. Miley +21 more
2017OncoTarget40 citations Open access
Semantic Scholar
In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques
Annelie Tjernlund, Jia Zhu, K. Laing, K. Diem +7 more
2010Retrovirology38 citations Open access
Semantic Scholar
Trafficking, Persistence, and Activation State of Adoptively Transferred Allogeneic and Autologous Simian Immunodeficiency Virus-Specific CD8+ T Cell Clones during Acute and Chronic Infection of Rhesus Macaques
C. Ohlen, D. O'Connor, J. Lifson, M. Roederer +7 more
200937 citations
Semantic Scholar
Inhibition of natural killer cell‐mediated bone marrow graft rejection by allogeneic major histocompatibility complex class I, but not class II molecules
C. Ohlen, P. Höglund, C. Sentman, E. Carbone +3 more
1995European Journal of Immunology37 citations
Semantic Scholar
Cutting edge: myelin basic protein-specific cytotoxic T cell tolerance is maintained in vivo by a single dominant epitope in H-2k mice.
E. Huseby, C. Ohlen, Joan M. Goverman
1999Journal of Immunology36 citations Open access
Semantic Scholar
Distribution, persistence and efficacy of adoptively transferred central and effector memory-derived autologous SIV-specific CD8+ T-cell clones in rhesus macaques during acute infection
J. Minang, Matthew T. Trivett, D. Bolton, C. M. Trubey +13 more
2009Journal of Immunology35 citations Open access
Semantic Scholar
Transduction with Human Telomerase Reverse Transcriptase Immortalizes A Rhesus Macaque CD8+ T Cell Clone with Maintenance of Surface Marker Phenotype And Function
H. Andersen, E. Barsov, Matthew T. Trivett, C. M. Trubey +4 more
2007AIDS Research and Human Retroviruses26 citations
Semantic Scholar
Induction of Tolerance in CD8+ T Cells to a Transgenic Autoantigen Expressed in the Liver Does Not Require Cross-Presentation1
J. Morimoto, Xiao-Hua Tan, R. Teague, C. Ohlen +1 more
2007Journal of Immunology25 citations Open access
Semantic Scholar
Genetic modification of T-cell clones for therapy of human viral and malignant diseases.
Philip D. Greenberg, R. J. Finch, M. Gavin, M. Kalos +9 more
1998The cancer journal from Scientific American23 citations
Semantic Scholar
Restoration of H‐2b expression and processing of endogenous antigens in the MHC class I pathway by fusion of a lymphoma mutant to L cells of the H‐2k haplotype
C. Ohlen, J. Bastin, H. Ljunggren, S. Imreh +3 more
1990European Journal of Immunology22 citations
Semantic Scholar
Nef-mediated MHC class I down-regulation unmasks clonal differences in virus suppression by SIV-specific CD8+ T cells independent of IFN-γ and CD107a responses
J. Minang, Matthew T. Trivett, L. Coren, E. Barsov +3 more
2009Virology21 citations Open access
Semantic Scholar
Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis.
M. Wölfl, S. Schwinn, Young-eun Yoo, Marie L. Reß +8 more
2013Blood20 citations Open access
Semantic Scholar
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
J. Rice, M. Dossett, C. Ohlen, Sarah L. Buchan +4 more
2008European Journal of Immunology20 citations Open access
Semantic Scholar
Dendritic cells lose ability to present protein antigen after stimulating antigen-specific T cell responses, despite upregulation of MHC class II expression.
H. Bernhard, E. Huseby, S. Hand, M. Lohmann +6 more
2000Immunobiology19 citations
Semantic Scholar
Transduction of SIV-Specific TCR Genes into Rhesus Macaque CD8+ T Cells Conveys the Ability to Suppress SIV Replication
E. Barsov, Matthew T. Trivett, J. Minang, H. Sun +2 more
2011PLoS ONE18 citations Open access
Semantic Scholar
Efficient inhibition of SIV replication in rhesus CD4+ T-cell clones by autologous immortalized SIV-specific CD8+ T-cell clones.
J. Minang, E. Barsov, Fang Yuan, Matthew T. Trivett +4 more
2008Virology18 citations Open access
Semantic Scholar
Gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with SIV or SHIV
V. Marshall, Nazzarena Labo, Xing-Pei Hao, B. Holdridge +19 more
2018PLoS Pathogens16 citations Open access
Semantic Scholar
CpG oligodeoxynucleotides allow for effective adoptive T-cell therapy in chronic retroviral infection.
Anke Kraft, F. Krux, Simone Schimmer, C. Ohlen +2 more
2007Blood16 citations
Semantic Scholar
Production of retroviral constructs for effective transfer and expression of T-cell receptor genes using Golden Gate cloning
L. Coren, Sumit P. Jain, Matthew T. Trivett, C. Ohlen +1 more
2015BioTechniques15 citations Open access
Semantic Scholar
Effect of IFN‐γ treatment and in vivo passage of murine tumor cell lines on their sensitivity to lymphokine‐activated killef (LAK) cell lysis in vitro; association with H‐2 expression on the target cells
L. Tsai, C. Ohlen, H. Ljunggren, K. Kärre +2 more
198915 citations
Semantic Scholar
Effects of dimethyl sulfoxide treatment on H-2 expression and susceptibility to NK- or cytotoxic T-lymphocyte-mediated lysis of the YAC-1 lymphoma and its beta 2-microglobulin-deficient variant.
Toshiki Yamasaki, George Klein, H. Ljunggren, P. Höglund +3 more
1988Journal of the National Cancer Institute14 citations
Semantic Scholar
Adoptive Transfer of Engineered Rhesus Simian Immunodeficiency Virus-Specific CD8+ T Cells Reduces the Number of Transmitted/Founder Viruses Established in Rhesus Macaques
V. Ayala, Matthew T. Trivett, Eugene V. Barsov, Sumit P. Jain +10 more
2016Journal of Virology13 citations Open access
Semantic Scholar

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