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M. Hrdinka · SciRah

Researcher profile · Semantic Scholar

M. Hrdinka

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M. Hrdinka — researcher profile on SciRah

h-index: 19
Works: 49
Citations: 1,409

Most-cited papers

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling
P. Elliott, Derek M Leske, M. Hrdinka, Katrin Bagola +9 more
2016Molecules and Cells156 citations Open access
Semantic Scholar
CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling
M. Hrdinka, Berthe Katrine Fiil, M. Zucca, Derek M Leske +7 more
2016Cell Reports144 citations Open access
Semantic Scholar
The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation.
M. Hrdinka, M. Gyrd-Hansen
2017Molecules and Cells118 citations Open access
Semantic Scholar
Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors
P. Canning, Quin Ruan, T. Schwerd, M. Hrdinka +10 more
2015Chemistry and Biology118 citations Open access
Semantic Scholar
Venetoclax: A new wave in hematooncology.
J. Mihályová, T. Jelínek, K. Growková, M. Hrdinka +2 more
2018Experimental Hematology95 citations Open access
Semantic Scholar
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling
M. Hrdinka, L. Schlicher, Bing Dai, D. Pinkas +12 more
2018EMBO Journal70 citations Open access
Semantic Scholar
More Than 2% of Circulating Tumor Plasma Cells Defines Plasma Cell Leukemia–Like Multiple Myeloma
T. Jelínek, R. Bezděková, D. Žihala, T. Ševčíková +26 more
2022Journal of Clinical Oncology65 citations Open access
Semantic Scholar
SCIMP, a Transmembrane Adaptor Protein Involved in Major Histocompatibility Complex Class II Signaling
Peter Draber, Ivana Vonkova, Ondřej Štěpánek, M. Hrdinka +8 more
2011Molecular and Cellular Biology65 citations Open access
Semantic Scholar
Inhibitor of apoptosis proteins in human health and disease
M. Hrdinka, M. Yabal
2019Genes and Immunity61 citations
Semantic Scholar
Membrane microdomains in immunoreceptor signaling
V. Hořejší, M. Hrdinka
2014FEBS Letters54 citations
Semantic Scholar
Intercellular Mitochondrial Transfer in the Tumor Microenvironment
H. Sahinbegovic, T. Jelínek, M. Hrdinka, J. Bago +5 more
2020Cancers51 citations Open access
Semantic Scholar
Beyond the marrow: insights from comprehensive next-generation sequencing of extramedullary multiple myeloma tumors
T. Jelínek, D. Žihala, T. Ševčíková, A. Anilkumar Sithara +18 more
2024Leukemia48 citations Open access
Semantic Scholar
A New Type of Membrane Raft-Like Microdomains and Their Possible Involvement in TCR Signaling
P. Otáhal, P. Angelisová, M. Hrdinka, Tomáš Brdička +3 more
2010Journal of Immunology42 citations
Semantic Scholar
Synaptonuclear messenger PRR7 inhibits c‐Jun ubiquitination and regulates NMDA‐mediated excitotoxicity
Dana O Kravchick, Anna Karpova, M. Hrdinka, J. Lopez-Rojas +5 more
2016EMBO Journal39 citations Open access
Semantic Scholar
Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility
P. Celichowski, M. Turi, Sandra Charvátová, Dhwani Radhakrishnan +7 more
2023Journal of Translational Medicine38 citations Open access
Semantic Scholar
Systematic analysis of the IL‐17 receptor signalosome reveals a robust regulatory feedback loop
Helena Dráberová, Sarka Janusova, Daniela Knizkova, Tereza Semberova +11 more
2020EMBO Journal34 citations Open access
Semantic Scholar
May 2006 update in porphobilinogen deaminase gene polymorphisms and mutations causing acute intermittent porphyria: comparison with the situation in Slavic population.
M. Hrdinka, H. Puy, Pavel Martásek
2006Physiological Research32 citations Open access
Semantic Scholar
The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma
A. Vdovin, T. Jelínek, D. Žihala, T. Ševčíková +11 more
2022Nature Communications22 citations Open access
Semantic Scholar
LST1/A Is a Myeloid Leukocyte-specific Transmembrane Adaptor Protein Recruiting Protein Tyrosine Phosphatases SHP-1 and SHP-2 to the Plasma Membrane*
Peter Draber, Ondřej Štěpánek, M. Hrdinka, A. Drobek +6 more
2012Journal of Biological Chemistry22 citations Open access
Semantic Scholar
Insight into the mechanism of CD34+ cell mobilisation impairment in multiple myeloma patients treated with anti‐CD38 therapy
O. Venglar, V. Kapustová, Anjana Anilkumar Sithara, D. Žihala +15 more
2023British Journal of Haematology19 citations Open access
Semantic Scholar
Acute intermittent porphyria – impact of mutations found in the hydroxymethylbilane synthase gene on biochemical and enzymatic protein properties
D. Ulbrichová, M. Hrdinka, V. Saudek, P. Martásek
2009The FEBS Journal19 citations Open access
Semantic Scholar
Transcriptome Analysis of Diffuse Large B-Cell Lymphoma Cells Inducibly Expressing MyD88 L265P Mutation Identifies Upregulated CD44, LGALS3, NFKBIZ, and BATF as Downstream Targets of Oncogenic NF-κB Signaling
M. Turi, Anjana Anilkumar Sithara, L. Hofmanová, D. Žihala +11 more
2023International Journal of Molecular Sciences15 citations Open access
Semantic Scholar
Selection, Expansion, and Unique Pretreatment of Allogeneic Human Natural Killer Cells with Anti-CD38 Monoclonal Antibody for Efficient Multiple Myeloma Treatment
Benjamin Motais, Sandra Charvátová, Zuzana Walek, M. Hrdinka +11 more
2021Cells14 citations Open access
Semantic Scholar
A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers
Benjamin Motais, Sandra Charvátová, M. Hrdinka, M. Šimíček +5 more
2020Cancers13 citations Open access
Semantic Scholar
PRR7 Is a Transmembrane Adaptor Protein Expressed in Activated T Cells Involved in Regulation of T Cell Receptor Signaling and Apoptosis*
M. Hrdinka, Peter Draber, Ondřej Štěpánek, Tereza Ormsby +6 more
2011Journal of Biological Chemistry13 citations Open access
Semantic Scholar
Novel immunotargets in multiple myeloma: biological relevance and therapeutic potential
Jana Kotulová, Klára Baďurová, Z. Chyra, S. Ševčíková +4 more
2025Biomarker Research11 citations Open access
Semantic Scholar
Anti-BCMA-CAR NK Cells Expressing Soluble TRAIL: Promising Therapeutic Approach for Multiple Myeloma in Combination with Bortezomib and γ-Secretase Inhibitors
Benjamin Motais, Sandra Charvátová, M. Hrdinka, R. Hájek +1 more
2022Blood9 citations Open access
Semantic Scholar
The Transmembrane Region Is Responsible for Targeting of Adaptor Protein LAX into “Heavy Rafts”
M. Hrdinka, P. Otáhal, V. Hořejší
2012PLoS ONE6 citations Open access
Semantic Scholar
Normal Development and Function of T Cells in Proline Rich 7 (Prr7) Deficient Mice
M. Hrdinka, Kritika Sudan, S. Just, A. Drobek +7 more
2016PLoS ONE5 citations Open access
Semantic Scholar
Abstract 5469: Preclinical safety and efficacy of SOT109, an antibody-drug conjugate targeting cadherin 17 (CDH17) for the treatment of colorectal and other gastrointestinal tract tumors
Nataliia Kalynovska, Diana Hudecz, M. Hrdinka, I. Procházková +10 more
2025Cancer Research4 citations
Semantic Scholar
Deubiquitinase BAP1 is crucial for surface expression of T cell receptor (TCR) complex, T cell-B cell conjugate formation, and T cell activation.
Dhwani Radhakrishnan, Jana Kotulová, L. Hofmanová, Anjana Anilkumar Sithara +11 more
2024Journal of Leukocyte Biology4 citations Open access
Semantic Scholar
Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis
Z. Chyra, T. Ševčíková, Petr Vojta, Janka Puterová +30 more
2020Haematologica4 citations Open access
Semantic Scholar
Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine
M. Zátopková, T. Ševčíková, V. Fanfani, Z. Chyra +22 more
2021Blood Advances3 citations Open access
Semantic Scholar
LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane.
Peter Draber, Ondřej Štěpánek, M. Hrdinka, A. Drobek +6 more
2013Journal of Biological Chemistry3 citations Open access
Semantic Scholar
BRCA1 and BRCA2 as prognostic markers in oral squamous cell carcinoma: a minireview
D. Gedeonová, Claretta Bianchi, J. Štembírek, M. Hrdinka +5 more
2025Frontiers in Oncology2 citations Open access
Semantic Scholar
Identification of Deubiquitinase OTUD1 As a Novel Player in Resistance of Multiple Myeloma to Bortezomib
A. Vdovin, T. Jelínek, M. Hrdinka, J. Bago +3 more
2019Blood1 citations Open access
Semantic Scholar
Conservative Retention of Pre‐Existing Dental Implants Contralateral to Adjuvant Radiotherapy for Maxillary Oral Squamous Cell Carcinoma: A 4‐Year Follow‐Up Case Report
D. Gedeonová, M. J. Fatyga, M. Hrdinka, J. Štembírek +3 more
2026Case Reports in Dentistry0 citations Open access
Semantic Scholar
P-344 Multiomics profiling of extramedullary multiple myeloma tumors and their microenvironment
T. Jelínek, D. Žihala, T. Ševčíková, Anjana Anilkumar Sithara +16 more
2023Clinical Lymphoma, Myeloma & Leukemia0 citations
Semantic Scholar
P805: EXTRAMEDULLARY MULTIPLE MYELOMA: MOLECULAR PATHOGENESIS AND NOVEL THERAPEUTIC TARGETS
D. Žihala, Tomáš Jelínek, T. Ševčíková, Anjana Anilkumar Sithara +15 more
2023HemaSphere0 citations Open access
Semantic Scholar
PB2397: TRANSCRIPTOME ANALYSIS OF DIFFUSE LARGE B-CELL LYMPHOMA CELLS EXPRESSING MYD88 L265P REVEALS CD44, LGALS3, NFKBIZ AND BATF AS DOWNSTREAM TARGETS OF ONCOGENIC NF-ΚB SIGNALING.
M. Turi, Anjana Anilkumar Sithara, L. Hofmanová, D. Žihala +11 more
2023HemaSphere0 citations Open access
Semantic Scholar
Cell competition for cancer treatment with Urine Progenitor Cells
J. Bago, Dhwani Radhakrishnan, M. Hrdinka, T. Cichoń +5 more
2023bioRxiv0 citations Open access
Semantic Scholar
P-001: RNA-sequencing reveals transcriptomic similarity of AL amyloidosis and MGUS aberrant plasma cells along with several potential ALA target candidate genes
Z. Chyra, T. Ševčíková, A. Anilkumar, Petr Vojta +11 more
2022Clinical Lymphoma, Myeloma & Leukemia0 citations
Semantic Scholar
Identification of Novel Regulatory Pathway for Immunoglobulin Production Provides Rational Treatment for Bortezomib-Resistant Multiple Myeloma Patients
A. Vdovin, M. Durech, T. Jelínek, T. Ševčíková +11 more
2020Blood0 citations
Semantic Scholar
PB2098 IDENTIFICATION OF NOVEL REGULATORS OF PLASMA CELLS MIGRATION IN MULTIPLE MYELOMA PATIENTS
A. Vdovin, T. Jelínek, M. Hrdinka, T. Ševčíková +2 more
2019HemaSphere0 citations Open access
Semantic Scholar
CYLD Limits Lys 63-and M et 1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling Graphical
M. Hrdinka, Berthe Katrine Fiil, M. Zucca, Derek M Leske +7 more
20160 citations
Semantic Scholar
The role of membrane microdomains and transmembrane adaptor proteins PRR7 and SCIMP in the regulation of immunoreceptor signaling
M. Hrdinka
20120 citations
Semantic Scholar
Regulation of heme degradation in association with multiple sclerosis
L. Králik, E. Krasulová, M. Hrdinka, L. Pospisilova +3 more
20080 citations
Semantic Scholar
Molecular pathology of heme biosynthesis. Porphobilinogen deaminase (PBGD): Novel mutations in Czech and Slovak patients with acute intermittent porphyria (AIP)
M. Hrdinka, D. Ulbrichová, E. Flachsova, J. Zeman +1 more
20060 citations
Semantic Scholar
HUMAN X-LINKED SIDEROBLASTIC ANAEMIA ( XLSA ) CAUSING MUTATIONS EXPLAINED BY THE CRYSTAL STRUCTURE OF 5-AMINOLEVULINATE SYNTHASE FROM RHODOBACTER CAPSULATUS
M. Hrdinka, E. Flachsova, I. Mikula, M. Bodnárová +7 more
20050 citations
Semantic Scholar

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R. Hájek×18
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T. Ševčíková×17
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T. Jelínek — researcher profile on SciRah

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M. Gyrd-Hansen×6

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Anjana Anilkumar Sithara×6