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L. Wiebe · SciRah

Researcher profile · Semantic Scholar

L. Wiebe

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L. Wiebe — researcher profile on SciRah

h-index: 28
Works: 271
Citations: 3,511

Most-cited papers

Hypoxia-specific tumor imaging with 18F-fluoroazomycin arabinoside.
M. Piert, H. Machulla, M. Picchio, G. Reischl +7 more
2005Journal of Nuclear Medicine331 citations
Semantic Scholar
[18F]Fluoroazomycinarabinofuranoside (18FAZA) and [18F]Fluoromisonidazole (18FMISO): a comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors.
D. Sorger, M. Patt, Piyush Kumar, L. Wiebe +6 more
2003Nuclear Medicine and Biology223 citations
Semantic Scholar
Initial results of hypoxia imaging using 1-α-d-(5-deoxy-5-[18F]-fluoroarabinofuranosyl)-2-nitroimidazole (18F-FAZA)
E. Postema, A. B. McEwan, T. Riauka, Piyush Kumar +3 more
2009European Journal of Nuclear Medicine and Molecular Imaging167 citations
Semantic Scholar
Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development.
Yan Li, Guifang Huang, J. Diakur, L. Wiebe
2008Current Drug Delivery120 citations
Semantic Scholar
Electrophysiological characterization of a recombinant human Na+‐coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes
Kyla M. Smith, Amy M. L. Ng, Sylvia Y. M. Yao, Kathy A. Labedz +7 more
2004Journal of Physiology93 citations
Semantic Scholar
Asialoglycoprotein receptor-targeted superparamagnetic iron oxide nanoparticles.
Guifang Huang, J. Diakur, Zheng-He Xu, L. Wiebe
2008International journal of pharmaceutics64 citations
Semantic Scholar
Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.
S. Moharram, Ai-Hua Zhou, L. Wiebe, E. Knaus
2004Journal of Medicinal Chemistry49 citations
Semantic Scholar
5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.
W. Cristofoli, L. Wiebe, E. De Clercq, G. Andrei +3 more
2007Journal of Medicinal Chemistry45 citations
Semantic Scholar
Design, synthesis, and preliminary biological evaluation of 6-O-glucose-azomycin adducts for diagnosis and therapy of hypoxic tumors.
Piyush Kumar, G. Shustov, Hong Liang, V. Khlebnikov +4 more
2012Journal of Medicinal Chemistry36 citations
Semantic Scholar
Synthesis of hypoxia imaging agent 1-(5-deoxy-5-fluoro-α-D-arabinofuranosyl)-2-nitroimidazole using microfluidic technology.
Vincent R Bouvet, M. Wuest, L. Wiebe, F. Wuest
2011Nuclear Medicine and Biology35 citations
Semantic Scholar
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
E. Naimi, Ai-Hua Zhou, P. Khalili, L. Wiebe +3 more
2003Journal of Medicinal Chemistry32 citations
Semantic Scholar
The chemistry and radiochemistry of hypoxia-specific, radiohalogenated nitroaromatic imaging probes.
Piyush Kumar, Veena Bacchu, L. Wiebe
2015Seminars in nuclear medicine30 citations
Semantic Scholar
Cellular mechanism of action of 2-nitroimidazoles as hypoxia-selective therapeutic agents
Faisal Bin Rashed, Diana Diaz-Dussan, F. Mashayekhi, Dawn Macdonald +11 more
2022Redox Biology29 citations Open access
Semantic Scholar
Cytotoxicity and cellular uptake of pyrimidine nucleosides for imaging herpes simplex type-1 thymidine kinase (HSV-1 TK) expression in mammalian cells.
K. Morin, W. Duan, Li-Huan Xu, Ai-Hua Zhou +4 more
2004Nuclear Medicine and Biology19 citations
Semantic Scholar
Molecular Imaging and Treatment of Malignant Gliomas Following Adenoviral Transfer of the Herpes Simplex Virus-Thymidine Kinase Gene and the Somatostatin Receptor Subtype 2 Gene
S. Verwijnen, P. A. S. Sillevis Smith, R. Hoeben, M. Rabelink +5 more
2004Cancer Biotherapy and Radiopharmaceuticals19 citations
Semantic Scholar
Detecting functional changes with [18F]FAZA in a renal cell carcinoma mouse model following sunitinib therapy
D. Chapman, H. Jans, Ivy Ma, J. Mercer +3 more
2014EJNMMI Research17 citations Open access
Semantic Scholar
Comparative Evaluation of Therapeutic Radiopharmaceuticals
L. Wiebe
2008Journal of Nuclear Medicine17 citations Open access
Semantic Scholar
PET radiopharmaceuticals for metabolic imaging in oncology
L. Wiebe
200417 citations
Semantic Scholar
Confocal laser scanning microscopy (CLSM) based evidence for cell permeation by mono-4-(N-6-deoxy-6-amino-β-cyclodextrin)-7-nitrobenzofuran (NBD-β-CyD).
Hai Wei, Weizhong Zheng, J. Diakur, L. Wiebe
2011International journal of pharmaceutics15 citations
Semantic Scholar
Synthesis and Hypoxia Selective Radiosensitization Potential of β-2-FAZA and β-3-FAZL: Fluorinated Azomycin β-Nucleosides
Piyush Kumar, S. Emami, Z. Kresolek, J. Yang +2 more
200913 citations
Semantic Scholar
Bifunctional Metal - Nitroimidazole Complexes for Hypoxia Theranosis in Cancer
Carolynne L. Ricardo, Piyush Kumar, L. Wiebe
201512 citations Open access
Semantic Scholar
Radioiodination of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene (dRFIB), a putative thymidine mimic nucleoside for cell proliferation studies.
A. Stahlschmidt, H. Machulla, G. Reischl, E. Knaus +1 more
2008Applied Radiation and Isotopes12 citations
Semantic Scholar
[131I]Iodoazomycin arabinoside for low-dose-rate isotope radiotherapy: radiolabeling, stability, long-term whole-body clearance and radiation dosimetry estimates in mice.
Piyush Kumar, S. McQuarrie, Aihya Zhou, A. B. McEwan +1 more
2005Nuclear Medicine and Biology12 citations
Semantic Scholar
Applications of nucleoside-based molecular probes for the in vivo assessment of tumour biochemistry using positron emission tomography (PET)
L. Wiebe
200711 citations Open access
Semantic Scholar
Meta-[123I]iodobenzylguanidine is selectively radiotoxic to neuroblastoma cells at concentrations that spare cells of haematopoietic lineage
Ying He, B. Das, S. Baruchel, Piyush Kumar +2 more
2004Nuclear medicine communications11 citations
Semantic Scholar
NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS
Ashraf Al-Madhoun, S. Eriksson, Zhi-Xian Wang, E. Naimi +2 more
200410 citations
Semantic Scholar
Synthesis of 1-β- D -(5-Deoxy-5-iodoarabinofuranosyl)-2-nitroimidazole (β-IAZA): A Novel Marker of Tissue Hypoxia
Piyush Kumar, K. Ohkura, D. Beiki, L. Wiebe +1 more
200310 citations Open access
Semantic Scholar
Positron Emission Tomography (PET) and Pharmacokinetics: Classical Blood Sampling Versus Image-Derived Analysis of [18F]FAZA and [18F]FDG in a Murine Tumor Bearing Model.
H. Jans, Xiao-hong Yang, D. Brocks, Piyush Kumar +2 more
2018Journal of Pharmacy & Pharmaceutical Sciences9 citations Open access
Semantic Scholar
Synthesis and Biological Evaluation of Iodoglucoazomycin (I‐GAZ), an Azomycin–Glucose Adduct with Putative Applications in Diagnostic Imaging and Radiotherapy of Hypoxic Tumors
Piyush Kumar, Hassan R H Elsaidi, Bohdarianna Zorniak, E. Laurens +4 more
2016ChemMedChem9 citations Open access
Semantic Scholar
In Vitro and In Vivo Evaluation of [18F]F-GAZ, a Novel Oxygen-Mimetic Azomycin-Glucose Conjugate, for Imaging Hypoxic Tumor
M. Wuest, Piyush Kumar, Monica Z. Wang, Jennifer Yang +2 more
2012Cancer Biotherapy and Radiopharmaceuticals8 citations
Semantic Scholar
Synthesis, radiofluorination, and hypoxia-selective studies of FRAZ: A configurational and positional analogue of the clinical hypoxia marker, [18F]-FAZA.
Piyush Kumar, E. Naimi, A. McEwan, L. Wiebe
2010Bioorganic & Medicinal Chemistry8 citations
Semantic Scholar
NEW [11C]PHOSGENE BASED SYNTHESIS OF 11C]PYRIMIDINES FOR POSITRON EMISSION TOMOGRAPHY
K. Seki, K. Nishijima, Kimihito Sanoki, Y. Kuge +5 more
20097 citations Open access
Semantic Scholar
Development of an Economical, Single Step Synthesis of FAZA, a Clinical Hypoxia Marker, and Potential Synthons to Prepare its Positional Analogs
P. Kumar, S. Emami, A. McEwan, L. Wiebe
20096 citations
Semantic Scholar
18F‐FESB: synthesis and automated radiofluorination of a novel 18F‐labeled pet tracer for β‐amyloid plaques
Piyush Kumar, Weizhong Zheng, S. McQuarrie, J. Jhamandas +1 more
20056 citations
Semantic Scholar
CycloSaligenyl Pronucleotides of 5-Iodo and 5-Trifluoromethyl-1-(2-deoxy-β-D-ribofuranosyl)-2,4-difluorobenzene Mimics of Thymidine: Synthesis and Evaluation of this Pronucleotide Monophosphate Delivery System for Compounds with Potential Anticancer Activity
Wei-Yang Sun, Ai-Hua Zhou, L. Wiebe, E. Knaus
2003Nucleosides, Nucleotides & Nucleic Acids6 citations
Semantic Scholar
Microwave-assisted radiosynthesis of the hypoxia marker 1-α-D-(5- deoxy-5-[18F]fluoroarabinofuranosyl)-2-nitroimidazole ([18F]FAZA).
Piyush Kumar, Raymond E. Ortlieb, Arjun K. Gupta, L. Wiebe
2014Current Radiopharmaceuticals5 citations
Semantic Scholar
Labelling of Small Biomolecules Using Novel Technetium-99m Cores
L. Wiebe
2008Journal of Nuclear Medicine5 citations Open access
Semantic Scholar
A novel and efficient synthesis of [2-11C]5-fluorouracil for prognosis of cancer chemotherapy.
K. Seki, K. Nishijima, Y. Kuge, N. Tamaki +2 more
2007Journal of Pharmacy & Pharmaceutical Sciences5 citations
Semantic Scholar
Synthesis and Antiviral Activity of Novel Fluorinated 2′,3′‐Dideoxynucleosides
Piyush Kumar, K. Ohkura, J. Balzarini, E. De Clercq +2 more
2004Nucleosides, Nucleotides & Nucleic Acids5 citations
Semantic Scholar
Influence of 2-Nitroimidazoles in the Response of FaDu Cells to Ionizing Radiation and Hypoxia/Reoxygenation Stress
Faisal Bin Rashed, Wisdom Deebeke Kate, M. Fanta, L. Wiebe +2 more
2023Antioxidants4 citations Open access
Semantic Scholar
Putative electron-affinic radiosensitizers and markers of hypoxic tissue: Synthesis and preliminary in vitro biological characterization of C3-amino-substituted benzotriazine dioxides (BTDOs).
Hassan R H Elsaidi, Xiao-hong Yang, F. Ahmadi, M. Weinfeld +2 more
2019European journal of medicinal chemistry4 citations
Semantic Scholar
A Water-Soluble Fenbendazole (FBZ) Formulation for Treating Pinworm Infections in Laboratory Animals
Jang-Ha Ryu, J. Diakur, S. Kelly, J. Russell +1 more
20134 citations
Semantic Scholar
Review: Technegas - 99mTc-Metal Core Graphite Nanoparticles for Pulmonary Ventilation Imaging
L. Wiebe, W. Burch, D. Abrams
20104 citations
Semantic Scholar
Synthesis and hypoxia selective radiosensitization potential of beta-2-FAZA and beta-3-FAZL: fluorinated azomycin beta-nucleosides.
P. Kumar, S. Emami, Z. Kresolek, J. Yang +2 more
2009Medicinal chemistry4 citations
Semantic Scholar
Synthesis, transportability and hypoxiaselective binding of 1-beta-D-(5-Deoxy-5-fluororibofuranosyl)-2-nitroimidazole (beta-5-FAZR), a configurational isomer of the clinical hypoxia marker, FAZA.
S. Emami, Piyush Kumar, Jennifer Yang, Zbigniew Kresolic +4 more
2007Journal of Pharmacy & Pharmaceutical Sciences4 citations
Semantic Scholar
Biochemical and pharmacokinetic evaluation of a novel pyrimidine nucleoside nitric oxide donor as a potential anticancer/antiviral agent.
P. Khalili, E. Naimi, Wei-Yang Sun, E. Knaus +1 more
2003European Journal of Pharmaceutical Sciences4 citations
Semantic Scholar
Dose‐dependent pharmacokinetics of 1‐(2‐Deoxy‐β‐D‐ ribofuranosyl)‐2,4‐difluoro‐5‐iodobenzene: A potential mimic of 5‐iodo‐2′‐deoxyuridine
P. Khalili, E. Naimi, Wei-Yang Sun, E. Knaus +1 more
2003Biopharmaceutics & drug disposition4 citations
Semantic Scholar
Development of [131I]I-EOE-TPZ and [131I]I-EOE-TPZMO: Novel Tirapazamine (TPZ)-Based Radioiodinated Pharmaceuticals for Application in Theranostic Management of Hypoxia
Hassan R H Elsaidi, F. Ahmadi, L. Wiebe, Piyush Kumar
2019Pharmaceuticals3 citations Open access
Semantic Scholar
Pharmacokinetics and Scintigraphic Imaging of the Hypoxia-Imaging Agent [123I]IAZA in Healthy Adults Following Exercise-Based Cardiac Stress
D. Stypinski, S. McQuarrie, A. McEwan, L. Wiebe
2018Pharmaceutics3 citations Open access
Semantic Scholar
Synthesis of dialkylaminoaryl phosphonate bioisosteres of tyrosine and tyramine: a novel application of allene phosphonate chemistry for the synthesis of false substrates of tyrosinase
Dean A. Mazzuca, C. Angelov, L. Wiebe
20153 citations Open access
Semantic Scholar

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Piyush Kumar×22
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Piyush Kumar — researcher profile on SciRah
E. Knaus×10
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E. Knaus — researcher profile on SciRah
A. McEwan×8
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A. McEwan — researcher profile on SciRah
E. Naimi×5
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E. Naimi — researcher profile on SciRah

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J. Diakur — researcher profile on SciRah

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Ai-Hua Zhou — researcher profile on SciRah

Xiao-hong Yang×4

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Xiao-hong Yang — researcher profile on SciRah

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M. Wuest — researcher profile on SciRah

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S. Emami — researcher profile on SciRah

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K. Ohkura — researcher profile on SciRah

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K. Seki — researcher profile on SciRah

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E. De Clercq — researcher profile on SciRah