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C. Esmon · SciRah

Researcher profile · Semantic Scholar

C. Esmon

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C. Esmon — researcher profile on SciRah

h-index: 122
Works: 530
Citations: 51K

Most-cited papers

Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice.
B. McDonald, R. Davis, S. Kim, Mandy Tse +3 more
2017Blood624 citations Open access
Semantic Scholar
Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial.
J. Vincent, B. François, I. Zabolotskikh, M. Daga +22 more
2019Journal of the American Medical Association (JAMA)292 citations Open access
Semantic Scholar
A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation*
J. Vincent, M. Ramesh, David Ernest, S. LaRosa +25 more
2013Critical Care Medicine274 citations
Semantic Scholar
Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children.
C. Moxon, S. Wassmer, D. Milner, N. Chisala +9 more
2013Blood214 citations Open access
Semantic Scholar
Endothelial cell protein C receptor: a multiliganded and multifunctional receptor.
L. Rao, C. Esmon, U. Pendurthi
2014Blood197 citations Open access
Semantic Scholar
Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition.
Sumra Nazir, I. Gadi, M. M. Al-Dabet, Ahmed Elwakiel +13 more
2017Blood154 citations Open access
Semantic Scholar
Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner
J. Borissoff, J. Otten, S. Heeneman, P. Leenders +13 more
2013PLoS ONE145 citations Open access
Semantic Scholar
PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells
S. Gur-Cohen, T. Itkin, S. Chakrabarty, C. Graf +13 more
2015Nature Medicine137 citations Open access
Semantic Scholar
Targeting factor Xa and thrombin: impact on coagulation and beyond
C. Esmon
2013Thrombosis and Haemostasis131 citations
Semantic Scholar
Lipid presentation by the protein C receptor links coagulation with autoimmunity
Nadine Mueller-Calleja, Anne Hollerbach, J. Royce, Svenja Ritter +20 more
2021Science108 citations Open access
Semantic Scholar
Histones induce phosphatidylserine exposure and a procoagulant phenotype in human red blood cells
F. Semeraro, C. T. Ammollo, N. Esmon, C. Esmon
2014Journal of Thrombosis and Haemostasis87 citations Open access
Semantic Scholar
The Role of Extracellular Histones in Influenza Virus Pathogenesis.
Harshini K. Ashar, N. Mueller, Jennifer M. Rudd, T. Snider +11 more
2018American Journal of Pathology83 citations Open access
Semantic Scholar
Molecular circuits in thrombosis and inflammation
C. Esmon
2013Thrombosis and Haemostasis83 citations
Semantic Scholar
Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis.
Yutian Chen, Q. Pu, Yongyuan Ma, Hua Zhang +9 more
2020Cell Metabolism82 citations Open access
Semantic Scholar
Activated Protein C Ameliorates Renal Ischemia-Reperfusion Injury by Restricting Y-Box Binding Protein-1 Ubiquitination.
Wei Dong, Hong-Jie Wang, K. Shahzad, F. Bock +15 more
2015Journal of the American Society of Nephrology79 citations Open access
Semantic Scholar
Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice.
M. Lopez-Ramirez, Angela Pham, R. Girard, T. Wyseure +11 more
2019Blood77 citations Open access
Semantic Scholar
Endothelial Protein C Receptor Function in Murine and Human Breast Cancer Development
F. Schaffner, N. Yokota, Tatiana Carneiro-Lobo, Maki Kitano +5 more
2013PLoS ONE69 citations Open access
Semantic Scholar
Protein C and acute inflammation: a clinical and biological perspective.
Sarah C. Christiaans, B. Wagener, C. Esmon, J. Pittet
2013American Journal of Physiology - Lung cellular and Molecular Physiology69 citations
Semantic Scholar
Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1.
Vijay Kondreddy, Jue Wang, S. Keshava, C. Esmon +2 more
2018Blood53 citations Open access
Semantic Scholar
Roles of coagulation and fibrinolysis in angiotensin II enhanced microvascular thrombosis
Elena Y. Senchenkova, J. Russell, C. Esmon, D. N. Granger
2014Microcirculation50 citations Open access
Semantic Scholar
Evidence for the important role of inflammation in xenotransplantation
Juan Li, H. Hara, Yi Wang, C. Esmon +2 more
2019Journal of Inflammation49 citations Open access
Semantic Scholar
Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions
J. Ogbechi, M. Ruf, Belinda S Hall, K. Bodman-Smith +7 more
2015PLoS Pathogens48 citations Open access
Semantic Scholar
Vascular Immunotargeting to Endothelial Determinant ICAM-1 Enables Optimal Partnering of Recombinant scFv-Thrombomodulin Fusion with Endogenous Cofactor
C. Greineder, A. Chacko, S. Zaytsev, Blaine Zern +6 more
2013PLoS ONE43 citations Open access
Semantic Scholar
Plasmodium falciparum adhesion domains linked to severe malaria differ in blockade of endothelial protein C receptor
Sowmya Sampath, A. J. Brazier, Marion Avril, M. Bernabeu +6 more
2015Cellular Microbiology41 citations Open access
Semantic Scholar
AN INVESTIGATION OF EXTRACELLULAR HISTONES IN PIG-TO-BABOON ORGAN XENOTRANSPLANTATION
Tao Li, Whayoung Lee, H. Hara, C. Long +7 more
2017Transplantation40 citations Open access
Semantic Scholar
Factor VIIa induces extracellular vesicles from the endothelium: A potential mechanism for its hemostatic effect.
K. Das, S. Keshava, S. Ansari, Vijay Kondreddy +4 more
2021Blood39 citations Open access
Semantic Scholar
Activated protein C reverses epigenetically sustained p66Shc expression in plaque-associated macrophages in diabetes
K. Shahzad, I. Gadi, Sumra Nazir, M. M. Al-Dabet +12 more
2018Communications Biology36 citations Open access
Semantic Scholar
Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently
I. Gadi, Sameen Fatima, Ahmed Elwakiel, Sumra Nazir +16 more
2020Circulation Research35 citations Open access
Semantic Scholar
Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo
J. Sundaram, S. Keshava, R. Gopalakrishnan, C. Esmon +2 more
2014Journal of Thrombosis and Haemostasis35 citations Open access
Semantic Scholar
ICAM-1-targeted thrombomodulin mitigates tissue factor-driven inflammatory thrombosis in a human endothelialized microfluidic model.
C. Greineder, Ian H Johnston, C. Villa, K. Gollomp +4 more
2017Blood Advances34 citations Open access
Semantic Scholar
Challenges and priorities for research: a report from the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on thrombosis in pediatric cardiology and congenital heart disease.
Brian W. McCrindle, Jennifer S. Li, C. Manlhiot, J. Tweddell +19 more
2014Circulation34 citations Open access
Semantic Scholar
Inhibition of endogenous activated protein C attenuates experimental autoimmune encephalomyelitis by inducing myeloid-derived suppressor cells
Leah M. Alabanza, N. Esmon, C. Esmon, Margaret S. Bynoe
2013Journal of Immunology34 citations Open access
Semantic Scholar
Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin like function
T. Madhusudhan, Hong-Jie Wang, Sanchita P. Ghosh, Wei Dong +17 more
2017Blood32 citations Open access
Semantic Scholar
Structural and Functional Studies of γ-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium
K. Vadivel, S. Agah, A. S. Messer, D. Cascio +5 more
2013Journal of Molecular Biology32 citations Open access
Semantic Scholar
Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia‐reperfusion injury
Ronald Carnemolla, C. Villa, C. Greineder, S. Zaitsev +7 more
2017The FASEB Journal29 citations Open access
Semantic Scholar
Fondaparinux pentasaccharide reduces sepsis coagulopathy and promotes survival in the baboon model of E. coli sepsis
R. Keshari, R. Silasi, N. Popescu, C. Georgescu +5 more
2019Journal of Thrombosis and Haemostasis28 citations Open access
Semantic Scholar
Regulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signaling
S. Gur-Cohen, O. Kollet, C. Graf, C. Esmon +2 more
2016Annals of the New York Academy of Sciences28 citations Open access
Semantic Scholar
Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis.
M. Starr, Hitoshi Takahashi, D. Okamura, Brittany A. Zwischenberger +6 more
2015American Journal of Physiology. Heart and Circulatory Physiology26 citations Open access
Semantic Scholar
Dual targeting of therapeutics to endothelial cells: collaborative enhancement of delivery and effect
C. Greineder, Jacob B. Brenza, Ronald Carnemolla, S. Zaitsev +6 more
2015The FASEB Journal25 citations Open access
Semantic Scholar
Activated Protein C has a Regulatory Role in Factor VIII Function.
Amelia R. Wilhelm, Nicole A Parsons, B. Samelson-Jones, R. Davidson +3 more
2021Blood23 citations Open access
Semantic Scholar
Podocyte Integrin-β 3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy.
T. Madhusudhan, Sanchita P. Ghosh, Hong-Jie Wang, Wei Dong +20 more
2020Journal of the American Society of Nephrology22 citations Open access
Semantic Scholar
EPCR deficiency or function-blocking antibody protects against joint bleeding-induced pathology in hemophilia mice.
J. Magisetty, U. Pendurthi, C. Esmon, L. Rao
2020Blood22 citations Open access
Semantic Scholar
Factor VIIa interaction with EPCR modulates the hemostatic effect of rFVIIa in hemophilia therapy: Mode of its action
S. Keshava, J. Sundaram, Anuradha Rajulapati, C. Esmon +2 more
2017Blood Advances22 citations Open access
Semantic Scholar
Thrombosis in Pediatric Cardiology and Congenital Heart Disease Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on Challenges and Priorities for Research: A Report From the National Heart, Lung, and
R. Portman, M. Rose, J. Strony, J. Kaltman +17 more
201422 citations
Semantic Scholar
Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging
Di Ren, Julia Fedorova, Kayla Davitt, L. Tran +5 more
2021Circulation Research21 citations Open access
Semantic Scholar
Rab GTPases Regulate Endothelial Cell Protein C Receptor-Mediated Endocytosis and Trafficking of Factor VIIa
R. Nayak, S. Keshava, C. Esmon, U. Pendurthi +1 more
2013PLoS ONE21 citations Open access
Semantic Scholar
Thrombin spatial distribution determines Protein C activation during hemostasis and thrombosis.
T. Marar, Chelsea N. Matzko, Jie Wu, C. Esmon +4 more
2021Blood19 citations Open access
Semantic Scholar
Overexpression of the Endothelial Protein C Receptor Is Detrimental during Pneumonia-Derived Gram-negative Sepsis (Melioidosis)
L. Kager, M. Schouten, W. Wiersinga, J. D. de Boer +8 more
2013PLoS Neglected Tropical Diseases19 citations Open access
Semantic Scholar
A critical role of endothelial cell protein C receptor in the intestinal homeostasis in experimental colitis
Vijay Kondreddy, S. Keshava, C. Esmon, U. Pendurthi +1 more
2020Scientific Reports18 citations Open access
Semantic Scholar
Platelet Endothelial Cell Adhesion Molecule Targeted Oxidant-Resistant Mutant Thrombomodulin Fusion Protein with Enhanced Potency In Vitro and In Vivo
Ronald Carnemolla, C. Greineder, A. Chacko, Kruti Patel +4 more
2013Journal of Pharmacology and Experimental Therapeutics16 citations Open access
Semantic Scholar

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