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M. Carr · SciRah

Researcher profile · Semantic Scholar

M. Carr

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M. Carr — researcher profile on SciRah

h-index: 14
Works: 23
Citations: 618

Most-cited papers

Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.
Niamh M. O'Boyle, M. Carr, L. Greene, Orla Bergin +5 more
2010Journal of Medicinal Chemistry111 citations Open access
Semantic Scholar
Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects.
M. Carr, L. Greene, Andrew J. S. Knox, David G. Lloyd +2 more
2010European journal of medicinal chemistry67 citations
Semantic Scholar
Synthesis and toxicity towards normal and cancer cell lines of benzimidazolequinones containing fused aromatic rings and 2-aromatic ring substituents.
Eoin Moriarty, M. Carr, Sarah Bonham, M. P. Carty +1 more
2010European journal of medicinal chemistry59 citations
Semantic Scholar
“True” Antiandrogens—Selective Non-Ligand-Binding Pocket Disruptors of Androgen Receptor–Coactivator Interactions: Novel Tools for Prostate Cancer
L. Caboni, G. Kinsella, F. Blanco, D. Fayne +5 more
2012Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand.
Niamh M. O'Boyle, J. Pollock, M. Carr, Andrew J. S. Knox +5 more
2014Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators.
I. Barrett, M. Meegan, Rosario B. Hughes, M. Carr +5 more
2008Bioorganic & Medicinal Chemistry46 citations Open access
Semantic Scholar
Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe.
Niamh M. O'Boyle, M. Carr, L. Greene, N. Keely +5 more
2011European journal of medicinal chemistry39 citations Open access
Semantic Scholar
Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity.
Niamh M. O'Boyle, I. Barrett, L. Greene, M. Carr +6 more
2017Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
The Vascular Targeting Agent Combretastatin-A4 and a Novel cis-Restricted β-Lactam Analogue, CA-432, Induce Apoptosis in Human Chronic Myeloid Leukemia Cells and Ex Vivo Patient Samples Including Those Displaying Multidrug Resistance
L. Greene, Seema M. Nathwani, Sandra A. Bright, D. Fayne +14 more
2010Journal of Pharmacology and Experimental Therapeutics27 citations
Semantic Scholar
The influence of the aziridinyl substituent of benzimidazoles and benzimidazolequinones on toxicity towards normal and Fanconi anaemia cells.
Karen Fahey, Liz O'Donovan, M. Carr, M. P. Carty +1 more
2010European journal of medicinal chemistry27 citations
Semantic Scholar
Novel cis-restricted β-lactam combretastatin A-4 analogues display anti-vascular and anti-metastatic properties in vitro.
Seema M. Nathwani, L. Hughes, L. Greene, M. Carr +4 more
2013Oncology Report20 citations Open access
Semantic Scholar
Combretastatin (CA)-4 and its novel analogue CA-432 impair T-cell migration through the Rho/ROCK signalling pathway.
J. Pollock, N. Verma, Niamh M. O'Boyle, M. Carr +2 more
2014Biochemical Pharmacology19 citations
Semantic Scholar
β-Lactam type molecular scaffolds for antiproliferative activity: Synthesis and cytotoxic effects in breast cancer cells
M. Meegan, M. Carr, Andrew J. S. Knox, D. Zisterer +1 more
200817 citations Open access
Semantic Scholar
Design, Synthesis and Biochemical Evaluation of Novel Selective Estrogen Receptor Ligand Conjugates Incorporating an Endoxifen-Combretastatin Hybrid Scaffold
N. Keely, M. Carr, B. Yassin, Gloria Ana +3 more
2016Biomedicines16 citations Open access
Semantic Scholar
Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects
I. Barrett, M. Carr, Niamh M. O'Boyle, L. Greene +4 more
2010Journal of Enzyme Inhibition and Medicinal Chemistry14 citations Open access
Semantic Scholar
Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening.
M. Carr, Andrew J. S. Knox, D. K. Nevin, Niamh M. O'Boyle +7 more
2019Bioorganic & Medicinal Chemistry11 citations Open access
Semantic Scholar
BubR1 is required for the mitotic block induced by combretastatin-A4 and a novel cis-restricted ß-lactam analogue in human cancer cells.
L. Greene, M. Carr, N. Keeley, M. Lawler +2 more
2011International Journal of Molecular Medicine8 citations Open access
Semantic Scholar
Development of the β-lactam type molecular scaffold for selective estrogen receptor α modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells
M. Carr, Andrew J. S. Knox, David G. Lloyd, D. Zisterer +1 more
2016Journal of Enzyme Inhibition and Medicinal Chemistry6 citations Open access
Semantic Scholar
Beta-lactam type molecular scaffolds for antiproliferative activity: synthesis and cytotoxic effects in breast cancer cells.
M. Meegan, M. Carr, Andrew J. S. Knox, D. Zisterer +1 more
2008Journal of Enzyme Inhibition and Medicinal Chemistry3 citations
Semantic Scholar
Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-360
G. Hall, R. Cowan, M. Carr
20210 citations
Semantic Scholar
Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-300
G. Hall, R. Cowan, M. Carr
20210 citations
Semantic Scholar
Androgen Receptor Ligands - Europe WO2013076275 A1
G. Kinsella, L. Caboni, D. Fayne, F. Blanco +5 more
20130 citations
Semantic Scholar
Development of the beta-lactam structure as a scaffold for biologically active compounds
M. Carr
20070 citations
Semantic Scholar

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M. Meegan×18
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D. Zisterer×16
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David G. Lloyd×13
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Niamh M. O'Boyle×9
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Andrew J. S. Knox

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Seema M. Nathwani×4

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Seema M. Nathwani — researcher profile on SciRah

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D. Fayne — researcher profile on SciRah

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N. Keely — researcher profile on SciRah

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L. Caboni — researcher profile on SciRah

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