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S. Poli · SciRah

Researcher profile · Semantic Scholar

S. Poli

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S. Poli — researcher profile on SciRah

h-index: 29
Works: 70
Citations: 2,361

Most-cited papers

A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.
F. Jenck, J. Wichmann, F. Dautzenberg, J. Moreau +9 more
2000Proceedings of the National Academy of Sciences of the United States of America287 citations Open access
Semantic Scholar
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.
D. Schwab, H. Fischer, A. Tabatabaei, S. Poli +1 more
2003Journal of Medicinal Chemistry204 citations Open access
Semantic Scholar
Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist.
C. Riemer, E. Borroni, B. Levet-Trafit, James R. Martin +3 more
2003Journal of Medicinal Chemistry192 citations Open access
Semantic Scholar
A Phase 2A Trial of the Novel mGluR5‐Negative Allosteric Modulator Dipraglurant for Levodopa‐Induced Dyskinesia in Parkinson's Disease
F. Tison, C. Keywood, Mark Wakefield, F. Durif +9 more
2016Movement Disorders125 citations
Semantic Scholar
ADX71743, a Potent and Selective Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7: In Vitro and In Vivo Characterization
M. Kalinichev, M. Rouillier, Françoise Girard, I. Royer-Urios +10 more
2013Journal of Pharmacology and Experimental Therapeutics98 citations
Semantic Scholar
A Potent and Selective Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator Improves Movement in Rodent Models of Parkinson's Disease
E. Le Poul, C. Boléa, Françoise Girard, S. Poli +13 more
2012Journal of Pharmacology and Experimental Therapeutics97 citations
Semantic Scholar
Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.
S. Parmentier-Batteur, P. Hutson, Karsten Menzel, Jason M. Uslaner +19 more
2014Neuropharmacology93 citations
Semantic Scholar
Characterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression
B. Campo, M. Kalinichev, N. Lambeng, M. El Yacoubi +10 more
2011Journal of neurogenetics80 citations
Semantic Scholar
The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model
E. Bézard, Elsa Y. Pioli, Qin Li, Françoise Girard +5 more
2014Movement Disorders70 citations
Semantic Scholar
Characterization of the Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 ADX88178 in Rodent Models of Neuropsychiatric Disorders
M. Kalinichev, E. Le Poul, C. Boléa, Françoise Girard +12 more
2014Journal of Pharmacology and Experimental Therapeutics68 citations Open access
Semantic Scholar
Regio- and diastereo-selective synthesis of dimeric lignans using oxidative coupling
F. Chioccara, S. Poli, B. Rindone, T. Pilati +6 more
199366 citations Open access
Semantic Scholar
The chloroperoxidase-catalyzed oxidation of phenols. Mechanism, selectivity, and characterization of enzyme-substrate complexes.
L. Casella, Michele Gullotti, C. Selvaggini, S. Poli +2 more
1994Biochemistry63 citations
Semantic Scholar
A negative allosteric modulator demonstrates biased antagonism of the follicle stimulating hormone receptor
J. Dias, Béatrice Bonnet, Barbara A. Weaver, J. Watts +5 more
2010Molecular and Cellular Endocrinology54 citations Open access
Semantic Scholar
Mechanism of enantioselective oxygenation of sulfides catalyzed by chloroperoxidase and horseradish peroxidase. Spectral studies and characterization of enzyme-substrate complexes.
L. Casella, M. Gullotti, Raffaella Ghezzi, S. Poli +3 more
1992Biochemistry54 citations
Semantic Scholar
Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
J. Cid, G. Tresadern, G. Duvey, Robert Lütjens +19 more
2014Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
mGluR5 negative allosteric modulators overview: a medicinal chemistry approach towards a series of novel therapeutic agents.
J. Rocher, Béatrice Bonnet, C. Boléa, Robert Lütjens +6 more
2011Current Topics in Medicinal Chemistry50 citations
Semantic Scholar
Reduction of excessive alcohol drinking by a novel GABAB receptor positive allosteric modulator ADX71441 in mice
Lara S. Hwa, M. Kalinichev, H. Haddouk, S. Poli +1 more
2013Psychopharmacology41 citations Open access
Semantic Scholar
Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists.
T. Hoffmann, M. Bös, H. Stadler, P. Schnider +7 more
2006Bioorganic & Medicinal Chemistry Letters39 citations Open access
Semantic Scholar
Profiling of FSHR negative allosteric modulators on LH/CGR reveals biased antagonism with implications in steroidogenesis.
M. Ayoub, Romain Yvinec, G. Jégot, J. Dias +4 more
2016Molecular and Cellular Endocrinology38 citations Open access
Semantic Scholar
Inhibition of Follicle-Stimulating Hormone‐Induced Preovulatory Follicles in Rats Treated with a Nonsteroidal Negative Allosteric Modulator of Follicle-Stimulating Hormone Receptor1
J. Dias, B. Campo, Barbara A. Weaver, J. Watts +5 more
2014Biology of Reproduction36 citations Open access
Semantic Scholar
Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.
J. Cid, G. Duvey, G. Tresadern, V. Nhem +19 more
2012Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
Negative allosteric modulation of mGlu5 receptor rescues striatal D2 dopamine receptor dysfunction in rodent models of DYT1 dystonia.
G. Sciamanna, Giulia Ponterio, Annalisa Tassone, Marta Maltese +6 more
2014Neuropharmacology34 citations
Semantic Scholar
Oxidation of catechols and catecholamines by horseradish peroxidase and lactoperoxidase: ESR spin stabilization approach combined with optical methods
R. Ferrari, E. Laurenti, L. Casella, S. Poli
199333 citations
Semantic Scholar
Spectroscopic and binding studies on the stereoselective interaction of tyrosine with horseradish peroxidase and lactoperoxidase.
L. Casella, M. Gullotti, S. Poli, M. Bonfà +2 more
1991Biochemical Journal33 citations Open access
Semantic Scholar
Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells
C. Volpi, G. Mondanelli, M. T. Pallotta, C. Vacca +22 more
2015Neuropharmacology32 citations Open access
Semantic Scholar
An aminomethylpyrimidine DPP-IV inhibitor with improved properties.
J. Peters, D. Hunziker, H. Fischer, M. Kansy +9 more
2004Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage
Marta Motolese, F. Mastroiacovo, M. Cannella, D. Bucci +8 more
2015Molecular Brain29 citations Open access
Semantic Scholar
ADX71441, a novel, potent and selective positive allosteric modulator of the GABAB receptor, shows efficacy in rodent models of overactive bladder
Mikhail Kalinichev, S. Palea, Hasnaà Haddouk, I. Royer-Urios +5 more
2014British Journal of Pharmacology29 citations Open access
Semantic Scholar
Novel hexahydrospiro[piperidine-4,1'-pyrrolo[3,4-c]pyrroles]: highly selective small-molecule nociceptin/orphanin FQ receptor agonists.
S. Kolczewski, G. Adam, A. Cesura, F. Jenck +7 more
2003Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
The drug candidate, ADX71441, is a novel, potent and selective positive allosteric modulator of the GABAB receptor with a potential for treatment of anxiety, pain and spasticity
M. Kalinichev, Françoise Girard, H. Haddouk, M. Rouillier +5 more
2017Neuropharmacology25 citations
Semantic Scholar
Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.
J. Cid, G. Duvey, P. Cluzeau, V. Nhem +26 more
2010ACS Chemical Neuroscience24 citations Open access
Semantic Scholar
Endogenous Proteins Controlling Amyloid β-Peptide Polymerization
B. Bohrmann, L. Tjernberg, P. Kuner, S. Poli +6 more
1999Journal of Biological Chemistry22 citations Open access
Semantic Scholar
New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones.
A. Trabanco, G. Duvey, J. Cid, G. Macdonald +17 more
2011Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Amorphous solid dispersion successfully improved oral exposure of ADX71943 in support of toxicology studies
Mohamad Haitham Ayad, Béatrice Bonnet, J. Quinton, Steven Leigh +1 more
2013Drug Development and Industrial Pharmacy17 citations
Semantic Scholar
Safety, tolerability, pharmacokinetics and pharmacokinetic‐pharmacodynamic modelling of the novel H4 receptor inhibitor SENS‐111 using a modified caloric test in healthy subjects
F. Venail, P. Attali, E. Wersinger, R. Gomeni +2 more
2018British Journal of Clinical Pharmacology16 citations Open access
Semantic Scholar
Regio- and Diastereoselective Synthesis of Dimeric Lignans Using Oxidative Coupling.
F. Chioccara, S. Poli, B. Rindone, T. Pilati +3 more
199314 citations
Semantic Scholar
Effect of the Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulator Dipraglurant on Motor and Non-Motor Symptoms of Parkinson’s Disease
M. Epping-Jordan, Françoise Girard, Anne-Sophie Bessis, V. Mutel +10 more
2023Cells13 citations Open access
Semantic Scholar
Discovery of potent, balanced and orally active dual NK1/NK3 receptor ligands.
J. Peters, T. Hoffmann, P. Schnider, H. Stadler +7 more
2010Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
ADX71943 and ADX71441, novel positive allosteric modulators of the GABAB receptor with distinct central/peripheral profiles, show efficacy in the monosodium iodoacetate model of chronic osteoarthritis pain in the rat
M. Kalinichev, T. Donovan-Rodríguez, Françoise Girard, H. Haddouk +6 more
2017European Journal of Pharmacology11 citations
Semantic Scholar
The Effects of SENS-111, A New H4R Antagonist, On Vertigo Induced by Caloric Test in Healthy Volunteers (HV) is Related to Plasma Concentrations.
P. Attali, Roberto Gomeni, Eric Wersinger, S. Poli +1 more
2016Clinical Therapeutics11 citations
Semantic Scholar
Inhibition of Follicle-Stimulating Hormone Induced Preovulatory Follicles in Rats Treated with a Nonsteroidal Negative Allosteric Modulator of Follicle-Stimulating Hormone Receptor 1 Running Title: FSHR Negative Allosteric Modulator
J. Dias, B. Campo, Barbara A. Weaver, J. Watts +5 more
201311 citations
Semantic Scholar
First-in-Human Study in Healthy Subjects with the Noncytotoxic Monoclonal Antibody OSE-127, a Strict Antagonist of IL-7Rα.
N. Poirier, I. Baccelli, L. Belarif, R. Abes +14 more
2023Journal of Immunology10 citations
Semantic Scholar
Analgesic effect of ADX71441, a positive allosteric modulator (PAM) of GABAB receptor in a rat model of bladder pain
Pradeep Kannampalli, S. Poli, C. Boléa, J. Sengupta
2017Neuropharmacology9 citations
Semantic Scholar
New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2). Identification and synthesis of N-propyl-5-substituted isoquinolones
A. Trabanco, G. Duvey, J. Cid, G. Macdonald +17 more
20118 citations
Semantic Scholar
Purification, characterization and catalytic activity of anionic zucchini peroxidase
L. Casella, M. Gullotti, S. Poli, R. Ferrari +2 more
1993Biometals7 citations
Semantic Scholar
A novel series of metabotropic glutamate receptor 5 negative allosteric modulators based on a 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine core.
G. Duvey, B. Perry, E. Le Poul, S. Poli +7 more
2013Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
HAEM-PROTEIN INTERACTIONS. THE BINDING OF HAEM COMPLEXES TO SERUM ALBUMIN
L. Casella, M. Gullotti, S. Poli, L. De Gioia
19936 citations
Semantic Scholar
Electron paramagnetic resonance studies on VO(IV)-D-aspartic acid and VO(IV)-D-aspartic acid α-benzylester complexes
R. Ferrari, E. Laurenti, S. Poli, L. Casella
19926 citations
Semantic Scholar
SENS-401 Effectively Reduces Severe Acoustic Trauma-Induced Hearing Loss in Male Rats With Twice Daily Administration Delayed up to 96 hours.
Mathieu Petremann, Charlotte Romanet, A. Broussy, C. T. van Ba +2 more
2019Otology and Neurotology5 citations
Semantic Scholar
mGluR2 Activators and mGluR5 Blockers Advancing in the Clinic for Major CNS Disorders
Sylvain Celanire, G. Duvey, S. Poli, J. Rocher
20125 citations
Semantic Scholar

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