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Elspeth M Beauchamp · SciRah

Researcher profile · Semantic Scholar

Elspeth M Beauchamp

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Elspeth M Beauchamp — researcher profile on SciRah

h-index: 18
Works: 53
Citations: 1,721

Most-cited papers

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway.
Elspeth M Beauchamp, Lymor Ringer, G. Bulut, Kamal P. Sajwan +9 more
2011Journal of Clinical Investigation327 citations Open access
Semantic Scholar
GLI1 Is a Direct Transcriptional Target of EWS-FLI1 Oncoprotein*
Elspeth M Beauchamp, G. Bulut, O. Abaan, Kevin Chen +6 more
2009Journal of Biological Chemistry165 citations Open access
Semantic Scholar
The evolution of the TOR pathway and its role in cancer
Elspeth M Beauchamp, L. Platanias
2013Oncogene153 citations Open access
Semantic Scholar
Wnt signaling promotes proliferation and stemness regulation of spermatogonial stem/progenitor cells.
N. Golestaneh, Elspeth M Beauchamp, S. Fallen, M. Kokkinaki +2 more
2009Reproduction139 citations Open access
Semantic Scholar
Autophagy is a survival mechanism of acute myeloid leukemia precursors during dual mTORC2/mTORC1 targeting
J. Altman, Amy Szilard, Dennis J. Goussetis, A. Sassano +7 more
2014Clinical Cancer Research111 citations Open access
Semantic Scholar
Wnt-3a and Dickkopf-1 Stimulate Neurite Outgrowth in Ewing Tumor Cells via a Frizzled3- and c-Jun N-Terminal Kinase-Dependent Mechanism
Y. Endo, Elspeth M Beauchamp, David Woods, W. G. Taylor +3 more
2008Molecular and Cellular Biology106 citations Open access
Semantic Scholar
YK-4-279 Inhibits ERG and ETV1 Mediated Prostate Cancer Cell Invasion
Said Rahim, Elspeth M Beauchamp, Ya-Li Kong, Milton L. Brown +2 more
2011PLoS ONE105 citations Open access
Semantic Scholar
Central Role of ULK1 in Type I Interferon Signaling
Diana Saleiro, Swarna Mehrotra, B. Kroczynska, Elspeth M Beauchamp +15 more
2015Cell Reports68 citations Open access
Semantic Scholar
Human Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells
A. Sassano, E. Mavrommatis, A. Arslan, B. Kroczynska +7 more
2015Molecular and Cellular Biology62 citations Open access
Semantic Scholar
Beta-Catenin Accelerates Human Papilloma Virus Type-16 Mediated Cervical Carcinogenesis in Transgenic Mice
G. Bulut, S. Fallen, Elspeth M Beauchamp, Lauren E. Drebing +7 more
2011PLoS ONE60 citations Open access
Semantic Scholar
Merestinib blocks Mnk kinase activity in acute myeloid leukemia progenitors and exhibits antileukemic effects in vitro and in vivo.
E. Kosciuczuk, Diana Saleiro, B. Kroczynska, Elspeth M Beauchamp +6 more
2016Blood42 citations Open access
Semantic Scholar
Identification and targeting of novel CDK9 complexes in acute myeloid leukemia.
Elspeth M Beauchamp, S. Abedin, Sara G Radecki, Mariafausta Fischietti +13 more
2019Blood37 citations Open access
Semantic Scholar
Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells
F. Eckerdt, Elspeth M Beauchamp, J. Bell, Asneha Iqbal +5 more
2014OncoTarget37 citations Open access
Semantic Scholar
Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation
J. Bell, F. Eckerdt, Harshil Dhruv, D. Finlay +17 more
2017Molecular Cancer Research32 citations Open access
Semantic Scholar
A new era for an ancient drug: arsenic trioxide and Hedgehog signaling.
Elspeth M Beauchamp, A. Üren
2012Vitamins and hormones32 citations
Semantic Scholar
Pharmacological mTOR targeting enhances the antineoplastic effects of selective PI3Kα inhibition in medulloblastoma
F. Eckerdt, Jessica Clymer, J. Bell, Elspeth M Beauchamp +3 more
2019Scientific Reports31 citations Open access
Semantic Scholar
Cancer Biology and Signal Transduction Direct Binding of Arsenic Trioxide to Ampk and Generation of Inhibitory Effects on Acute Myeloid Leukemia Precursors
Elspeth M Beauchamp, E. Kosciuczuk, Ruth Serrano, Dhaval M. Nanavati +5 more
25 citations
Semantic Scholar
Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110α subunit of PI3 kinase
M. Colamonici, Gavin T Blyth, Diana Saleiro, Amy Szilard +5 more
2015OncoTarget20 citations Open access
Semantic Scholar
Schlafen 5 as a Novel Therapeutic Target in Pancreatic Ductal Adenocarcinoma
Mariafausta Fischietti, F. Eckerdt, Gavin T Blyth, A. Arslan +14 more
2021Oncogene18 citations Open access
Semantic Scholar
Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms
Diana Saleiro, Jeremy Q. Wen, E. Kosciuczuk, F. Eckerdt +15 more
2022Nature Communications17 citations Open access
Semantic Scholar
Resveratrol enhances the suppressive effects of arsenic trioxide on primitive leukemic progenitors
E. J. Wu, Dennis J. Goussetis, Elspeth M Beauchamp, E. Kosciuczuk +3 more
2014Cancer Biology & Therapy16 citations Open access
Semantic Scholar
Potent Antineoplastic Effects of Combined PI3Kα-MNK Inhibition in Medulloblastoma
F. Eckerdt, J. Bell, Elspeth M Beauchamp, Jessica Clymer +9 more
2019Molecular Cancer Research14 citations Open access
Semantic Scholar
SLFN11 negatively regulates non-canonical NFkB signaling to promote glioblastoma progression.
Mariafausta Fischietti, F. Eckerdt, Ricardo E. Perez, Jamie N. Guillen Magaña +10 more
2022Cancer Research Communications12 citations Open access
Semantic Scholar
OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia
B. Eisfelder, C. Saygin, Joseph Wynne, Margaret W Colton +7 more
2021Blood Cancer Journal12 citations Open access
Semantic Scholar
Inhibitory effects of SEL201 in acute myeloid leukemia
E. Kosciuczuk, Aroop K. Kar, Gavin T Blyth, Mariafausta Fischietti +10 more
2019OncoTarget12 citations Open access
Semantic Scholar
Wnt-3 a and Dickkopf-1 Stimulate Neurite Outgrowth in Ewing Tumor Cells via a Frizzled 3-and c-Jun N-Terminal Kinase-Dependent Mechanism
R. G. Taylor, J. Toretsky, A. Üren, Jeffrey S. Yoshimi Endo +3 more
200812 citations
Semantic Scholar
Pre-clinical evidence of PIM kinase inhibitor activity in BCR-ABL1 unmutated and mutated Philadelphia chromosome-positive (Ph+) leukemias
D. A. Curi, Elspeth M Beauchamp, Gavin T Blyth, A. Arslan +4 more
2015OncoTarget11 citations Open access
Semantic Scholar
Inhibitory effects of Tomivosertib in acute myeloid leukemia
M. Suárez, Gavin T Blyth, A. Mina, E. Kosciuczuk +7 more
2021OncoTarget9 citations Open access
Semantic Scholar
Discovery of novel Mnk inhibitors using mutation-based induced-fit virtual high-throughput screening
R. Mishra, Matthew R. Clutter, Gavin T Blyth, E. Kosciuczuk +4 more
2019Chemical Biology and Drug Design9 citations Open access
Semantic Scholar
Discovery of potent and selective MNK kinase inhibitors for the treatment of leukemia
Purav P. Vagadia, Javier Izquierdo-Ferrer, Candice Mazewski, Gavin T Blyth +9 more
2025Journal of Medicinal Chemistry8 citations Open access
Semantic Scholar
Targeting CHAF1B Enhances IFN Activity against Myeloproliferative Neoplasm Cells
Diana Saleiro, E. Kosciuczuk, Mariafausta Fischietti, Ricardo E. Perez +10 more
2023Cancer Research Communications8 citations Open access
Semantic Scholar
BH3 mimetics and multi-kinase inhibition in AML.
Elspeth M Beauchamp, L. Platanias
2012Blood7 citations
Semantic Scholar
Targeting SLFN11-regulated pathways restores chemotherapy sensitivity in AML
Sara H. Small, Ricardo E. Perez, Elspeth M Beauchamp, Aneta Baran +6 more
2024Blood neoplasia2 citations Open access
Semantic Scholar
Overcoming treatment challenges in imatinib-resistant chronic myelogenous leukemia
D. A. Curi, Elspeth M Beauchamp, L. Platanias
2015Leukemia and Lymphoma2 citations
Semantic Scholar
Regulatory Effects of Arsenic on Cellular Signaling Pathways: Biological Effects and Therapeutic Implications
Elspeth M Beauchamp, Ruth Serrano, L. Platanias
20142 citations
Semantic Scholar
Direct binding of arsenic trioxide to AMPK and generation of inhibitory effects on acute myeloid leukemia precursors
Elspeth M Beauchamp, E. Kosciuczuk, Ruth Serrano, Dhaval M. Nanavati +5 more
2014Molecular Cancer Therapeutics1 citations Open access
Semantic Scholar
Abstract 3409: Arsenic trioxide inhibits Ewing sarcoma growth by blocking Hedgehog/GLI pathway
Elspeth M Beauchamp, Olga C. Rodriguez, C. Albanese, J. Toretsky +1 more
20101 citations
Semantic Scholar
Multi-omics analysis reveals LARP1 as a key integrator of translation and metabolism in AML
Dominik A. Nahotko, Brian J. Lee, Emely Lopez Fajardo, Aneta Baran +9 more
2026Oncogenesis0 citations Open access
Semantic Scholar
Schlafen 5 is an intracellular immune checkpoint and controls IFN responses in pancreatic ductal adenocarcinoma
Mariafausta Fischietti, M. Zannikou, Elspeth M Beauchamp, Diana Saleiro +13 more
2026JCI Insight0 citations Open access
Semantic Scholar
Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia
Jamie N. Guillen Magaña, M. Zannikou, Aneta Baran, Sara H. Small +8 more
2025Cancer Research Communications0 citations
Semantic Scholar
Development of a SIN1 targeting inhibitor as a novel therapeutic approach for the treatment of malignancies
Elspeth M Beauchamp, Atul Jain, Matthew R. Clutter, Dominik A. Nahotko +21 more
2025Molecular Cancer Therapeutics0 citations Open access
Semantic Scholar
Loss of function mouse models reveal a novel regulatory function for ULK1 in myeloproliferative neoplasms
Diana Saleiro, Jeremy Q. Wen, M. Zannikou, Brian J. Lee +21 more
2025Molecular and Cellular Biology0 citations
Semantic Scholar
LARP1 Regulates Leukemogenesis of AML By Altering Cell Metabolism and mRNA Translation
Dominik A. Nahotko, Aneta Baran, Mariafausta Fischietti, Sara H. Small +2 more
2024Blood0 citations
Semantic Scholar
Modulating Schlafen 12 Activity Using Velcrins in Acute Myeloid Leukemia Cells
Jamie Nelly Guillen Magana, Leonidas C. Platanias, M. Zannikou, Sara H. Small +3 more
2024Blood0 citations
Semantic Scholar
Abstract A39: Role of LARP1 in the leukemogenesis of Acute Myeloid Leukemia
D. A. Nahotko, Aneta Baran, Mariafausta Fischietti, Elspeth M Beauchamp +1 more
2023Blood Cancer Discovery0 citations
Semantic Scholar
PB1791: SLFN11 REGULATES MULTIPLE PATHWAYS THAT ARE IMPORTANT FOR TREATMENT RESPONSE IN AML
S. Small, Elspeth M Beauchamp, Mariafausta Fischietti, Ricardo E. Perez +1 more
2023HemaSphere0 citations Open access
Semantic Scholar
SLFN11 Is a Potential Biomarker and Modulator of Treatment Response in AML
S. Small, Mariafausta Fischietti, Elspeth M Beauchamp, Ricardo E. Perez +1 more
2022Blood0 citations Open access
Semantic Scholar
Differential Response of Glioma Stem Cells to Arsenic 1 Trioxide Therapy is Regulated by MNK 1 and mRNA 2 Translation
J. Bell, F. Eckerdt, Harshil Dhruv, D. Finlay +18 more
20170 citations
Semantic Scholar
Abstract 4328: Beta-catenin accelerates human papillomavirus type16 -E7 mediated cervical carcinogenesis in transgenic mice
G. Bulut, S. Fallen, Elspeth M Beauchamp, Lauren E. Drebing +7 more
20110 citations
Semantic Scholar
Abstract 663: YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion
Said Rahim, Elspeth M Beauchamp, Ya-Li Kong, Milton L. Brown +2 more
20110 citations
Semantic Scholar

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