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G. de Sousa · SciRah

Researcher profile · Semantic Scholar

G. de Sousa

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G. de Sousa — researcher profile on SciRah

h-index: 32
Works: 86
Citations: 2,676

Most-cited papers

Is CYP1A1 induction always related to AHR signaling pathway?
C. Delescluse, G. Lemaire, G. de Sousa, R. Rahmani
2000Toxicology153 citations
Semantic Scholar
A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides.
G. Lemaire, G. de Sousa, R. Rahmani
2004Biochemical Pharmacology151 citations
Semantic Scholar
In vivo distribution and metabolisation of 14C-imidacloprid in different compartments of Apis mellifera L.
S. Suchail, G. de Sousa, R. Rahmani, Luc P. Belzunces
2004Pest Management Science140 citations Open access
Semantic Scholar
Cadmium-induced apoptosis through the mitochondrial pathway in rainbow trout hepatocytes: involvement of oxidative stress.
C. R. Faverney, N. Orsini, G. de Sousa, R. Rahmani
2004Aquatic Toxicology128 citations
Semantic Scholar
Thawed human hepatocytes in primary culture.
M. Dou, G. de Sousa, B. Lacarelle, M. Placidi +4 more
1992Cryobiology90 citations
Semantic Scholar
Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes.
N. Zucchini, G. de Sousa, B. Bailly-maitre, J. Gugenheim +3 more
2005Biochimica et Biophysica Acta89 citations Open access
Semantic Scholar
Microcystin-LR causes the collapse of actin filaments in primary human hepatocytes.
T. Batista, G. de Sousa, J. Šuput, R. Rahmani +1 more
2003Aquatic Toxicology85 citations
Semantic Scholar
Carbaryl induces CYP1A1 gene expression in HepG2 and HaCaT cells but is not a ligand of the human hepatic Ah receptor.
N. Ledirac, C. Delescluse, G. de Sousa, M. Pralavorio +4 more
1997Toxicology and Applied Pharmacology79 citations
Semantic Scholar
Comparative study of bisphenol A and its analogue bisphenol S on human hepatic cells: a focus on their potential involvement in nonalcoholic fatty liver disease.
L. Peyre, P. Rouimi, G. de Sousa, C. Héliès-Toussaint +4 more
2014Food and Chemical Toxicology76 citations
Semantic Scholar
Dexamethasone inhibits spontaneous apoptosis in primary cultures of human and rat hepatocytes via Bcl-2 and Bcl-xL induction
B. Bailly-maitre, G. de Sousa, K. Boulukos, J. Gugenheim +1 more
2001Cell Death and Differentiation76 citations
Semantic Scholar
Adverse Outcome Pathway-Driven Analysis of Liver Steatosis in Vitro: A Case Study with Cyproconazole.
C. Luckert, A. Braeuning, G. de Sousa, S. Durinck +15 more
2018Chemical Research in Toxicology69 citations Open access
Semantic Scholar
Spontaneous apoptosis in primary cultures of human and rat hepatocytes: molecular mechanisms and regulation by dexamethasone
B. Bailly-Maitre, G. de Sousa, N. Zucchini, J. Gugenheim +2 more
2002Cell Death and Differentiation60 citations
Semantic Scholar
Comparative effects of rifabutin and rifampicin on cytochromes P450 and UDP-glucuronosyl-transferases expression in fresh and cryopreserved human hepatocytes.
B. Reinach, G. de Sousa, P. Dostert, R. Ings +2 more
1999Chemico-Biological Interactions60 citations
Semantic Scholar
Tissue-specific expression and methylation of the human CYP2E1 gene.
F. Botto, E. Sérée, Said El Khyari, G. de Sousa +6 more
1994Biochemical Pharmacology60 citations
Semantic Scholar
An adverse outcome pathway-based approach to assess steatotic mixture effects of hepatotoxic pesticides in vitro.
D. Lichtenstein, C. Luckert, Jimmy Alarcan, G. de Sousa +16 more
2020Food and Chemical Toxicology59 citations Open access
Semantic Scholar
Role of cytochrome P450 3A in the metabolism of mefloquine in human and animal hepatocytes.
Frank Fontaine, G. de Sousa, Philip C. Burcham, P. Duchêne +1 more
2000Life Science59 citations
Semantic Scholar
A multicentre study of acute in vitro cytotoxicity in rat liver cells.
Alain Fautrel, Christophe Chesné, André Guillouzo, G. de Sousa +18 more
1991Toxicology in Vitro55 citations
Semantic Scholar
Antioxidant properties of tea blunt ROS-dependent lipogenesis: beneficial effect on hepatic steatosis in a high fat-high sucrose diet NAFLD obese rat model.
Laura Braud, S. Battault, G. Meyer, A. Nascimento +7 more
2017Journal of Nutritional Biochemistry54 citations Open access
Semantic Scholar
The PERICLES research program: an integrated approach to characterize the combined effects of mixtures of pesticide residues to which the French population is exposed.
A. Crépet, F. Héraud, C. Béchaux, M. Gouze +15 more
2013Toxicology51 citations
Semantic Scholar
Cytotoxic effects and induction of cytochromes P450 1A1/2 by insecticides, in hepatic or epidermal cells: binding capability to the Ah receptor.
C. Delescluse, N. Ledirac, G. de Sousa, M. Pralavorio +2 more
1998Toxicology Letters50 citations
Semantic Scholar
Cytochrome 1A1 induction by primaquine in human hepatocytes and HepG2 cells: absence of binding to the aryl hydrocarbon receptor.
Frank Fontaine, Chantal Delescluse, G. de Sousa, Pierre Lesca +1 more
1999Biochemical Pharmacology49 citations
Semantic Scholar
Lindane and cell death: at the crossroads between apoptosis, necrosis and autophagy.
N. Zucchini-Pascal, G. de Sousa, R. Rahmani
2009Toxicology48 citations
Semantic Scholar
Comparison of genistein metabolism in rats and humans using liver microsomes and hepatocytes.
J. Bursztyka, E. Perdu, J. Tulliez, L. Debrauwer +6 more
2008Food and Chemical Toxicology44 citations
Semantic Scholar
Disposition and metabolism of the angiogenic moderator O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) in human hepatocytes and tissue microsomes.
L. Placidi, E. Cretton-scott, G. de Sousa, R. Rahmani +2 more
1995Cancer Research41 citations
Semantic Scholar
Cellular impact of combinations of endosulfan, atrazine, and chlorpyrifos on human primary hepatocytes and HepaRG cells after short and chronic exposures
A. Nawaz, Andrej Razpotnik, P. Rouimi, G. de Sousa +2 more
2014Cell Biology and Toxicology39 citations
Semantic Scholar
Impacts of low doses of pesticide mixtures on liver cell defence systems.
P. Rouimi, N. Zucchini-Pascal, Gwendoline Dupont, Andrej Razpotnik +3 more
2012Toxicology in Vitro39 citations Open access
Semantic Scholar
Interspecies variability in mitoxantrone metabolism using primary cultures of hepatocytes isolated from rat, rabbit and humans.
B. Richard, G. Fabre, G. de Sousa, I. Fabre +2 more
1991Biochemical Pharmacology37 citations
Semantic Scholar
Modulation of CYP3A4 activity alters the cytotoxicity of lipophilic phycotoxins in human hepatic HepaRG cells.
P. Ferron, K. Hogeveen, G. de Sousa, R. Rahmani +3 more
2016Toxicology in Vitro36 citations
Semantic Scholar
In vitro glucuronidation of 3'-azido-3'-deoxythymidine by human liver. Role of UDP-glucuronosyltransferase 2 form.
J. F. Rajaonarison, B. Lacarelle, G. de Sousa, J. Catalin +1 more
1991Drug Metabolism And Disposition36 citations
Semantic Scholar
Comparative metabolism of 3'-azido-3'-deoxythymidine in cultured hepatocytes from rats, dogs, monkeys, and humans.
F. Nicolas, G. de Sousa, Pascal Thomas, M. Placidi +2 more
1995Drug Metabolism And Disposition34 citations
Semantic Scholar
Freshly isolated or cryopreserved human hepatocytes in primary culture: Influence of drug metabolism on hepatotoxicity.
G. de Sousa, M. Dou, D. Barbe, Bruno Lacarelle +2 more
1991Toxicology in Vitro33 citations
Semantic Scholar
Effects of endosulfan on hepatoma cell adhesion: Epithelial-mesenchymal transition and anoikis resistance.
L. Peyre, N. Zucchini-Pascal, G. de Sousa, R. Rahmani
2012Toxicology32 citations Open access
Semantic Scholar
Spot 14 protein interacts and co-operates with chicken ovalbumin upstream promoter-transcription factor 1 in the transcription of the L-type pyruvate kinase gene through a specificity protein 1 (Sp1) binding site.
Emmanuel Compe, G. de Sousa, Kamel François, R. Roche +4 more
2001Biochemical Journal32 citations Open access
Semantic Scholar
Comparative study of CYP1A1 induction by 3-methylcholanthrene in various human hepatic and epidermal cell types.
C. Delescluse, N. Ledirac, G. de Sousa, M. Pralavorio +3 more
1997Toxicology in Vitro32 citations
Semantic Scholar
Increase of cytochrome P-450 1A and glutathione transferase transcripts in cultured hepatocytes from dogs, monkeys, and humans after cryopreservation
G. de Sousa, S. Langouët, F. Nicolas, G. Lorenzon +3 more
1996Cell Biology and Toxicology31 citations
Semantic Scholar
Organochlorine pesticides induce epithelial to mesenchymal transition of human primary cultured hepatocytes.
N. Zucchini-Pascal, L. Peyre, G. de Sousa, R. Rahmani
2012Food and Chemical Toxicology28 citations
Semantic Scholar
Insecticide cytotoxicity and CYP1A1/2 induction in primary human and rat hepatocyte cultures.
G. de Sousa, Frank Fontaine, M. Pralavorio, D. Botta-Fridlund +2 more
1997Toxicology in Vitro28 citations
Semantic Scholar
A multi-laboratory evaluation of cryopreserved monkey hepatocyte functions for use in pharmaco-toxicology.
G. de Sousa, F. Nicolas, M. Placidi, R. Rahmani +13 more
1999Chemico-Biological Interactions26 citations
Semantic Scholar
Effects of macrolide antibiotics on CYP3A expression in human and rat hepatocytes: interspecies differences in response to troleandomycin.
N. Ledirac, G. de Sousa, Franck Fontaine, Constantin Agouridas +3 more
2000Drug Metabolism And Disposition25 citations
Semantic Scholar
Acitretin biotransformation into etretinate: role of ethanol on in vitro hepatic metabolism.
J. Laugier, G. de Sousa, H. Bun, J. Geiger +2 more
1994Dermatology25 citations
Semantic Scholar
Development of a liquid chromatography/atmospheric pressure photo-ionization high-resolution mass spectrometry analytical method for the simultaneous determination of polybrominated diphenyl ethers and their metabolites: application to BDE-47 metabolism in human hepatocytes.
C. Marteau, S. Chevolleau, I. Jouanin, E. Perdu +6 more
2012Rapid Communications in Mass Spectrometry22 citations Open access
Semantic Scholar
In vitro human metabolism of permethrin isomers alone or as a mixture and the formation of the major metabolites in cryopreserved primary hepatocytes.
Marie-Emilie Willemin, A. Kadar, G. de Sousa, E. Leclerc +2 more
2015Toxicology in Vitro20 citations
Semantic Scholar
Tissue-specific induction and inactivation of cytochrome P450 catalysing lauric acid hydroxylation in the sea bass, Dicentrarchus labrax.
C. Sabourault, G. de Sousa, M. Amichot, A. Cuany +5 more
1999Comparative Biochemistry and Physiology Part B Comparative Biochemistry20 citations
Semantic Scholar
Effect of Brewing Duration on the Antioxidant and Hepatoprotective Abilities of Tea Phenolic and Alkaloid Compounds in a t-BHP Oxidative Stress-Induced Rat Hepatocyte Model
Laura Braud, L. Peyre, G. de Sousa, M. Armand +2 more
2015Molecules19 citations Open access
Semantic Scholar
A concentration addition model to assess activation of the pregnane X receptor (PXR) by pesticide mixtures found in the French diet.
G. de Sousa, A. Nawaz, J. Cravedi, R. Rahmani
2014Toxicological Sciences17 citations Open access
Semantic Scholar
Bis(hydroxyphenyl)methane—bisphenol F—metabolism by the HepG2 human hepatoma cell line and cryopreserved human hepatocytes
Coralie Dumont, E. Perdu, G. de Sousa, L. Debrauwer +3 more
2011Drug and chemical toxicology (New York, N.Y. 1978)17 citations
Semantic Scholar
Peritoneal implantation of cryopreserved encapsulated porcine hepatocytes in rats without immunosuppression: viability and function.
Elizabeth H. Baldini, R. Cursio, G. de Sousa, A. Margara +7 more
2008Transplantation Proceedings17 citations
Semantic Scholar
Anti-apoptotic pro-survival effect of clotrimazole in a normothermic ischemia reperfusion injury animal model.
A. Iannelli, G. de Sousa, N. Zucchini, M. Saint-Paul +2 more
2011Journal of Surgical Research16 citations
Semantic Scholar
Pregnane X receptor activation protects rat hepatocytes against deoxycholic acid‐induced apoptosis
N. Zucchini-Pascal, G. de Sousa, Jérôme Pizzol, R. Rahmani
2010Liver international (Print)15 citations
Semantic Scholar
Molecular investigation of the effects of lindane in rat hepatocytes: microarray and mechanistic studies.
N. Zucchini-Pascal, G. de Sousa, Jérôme Pizzol, R. Rahmani
2011Food and Chemical Toxicology14 citations
Semantic Scholar

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R. Rahmani×27
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R. Rahmani — researcher profile on SciRah
R. Rahmani×12
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R. Rahmani — researcher profile on SciRah
R. Rahmani×11
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R. Rahmani — researcher profile on SciRah
N. Zucchini-Pascal×9
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N. Zucchini-Pascal — researcher profile on SciRah

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M. Placidi — researcher profile on SciRah

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C. Delescluse×4

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C. Delescluse — researcher profile on SciRah

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N. Ledirac — researcher profile on SciRah

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M. Pralavorio — researcher profile on SciRah

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L. Peyre — researcher profile on SciRah

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G. Lemaire — researcher profile on SciRah

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N. Zucchini — researcher profile on SciRah