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M. Ruzek · SciRah

Researcher profile · Semantic Scholar

M. Ruzek

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M. Ruzek — researcher profile on SciRah

h-index: 21
Works: 53
Citations: 2,140

Most-cited papers

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation
A. Hooftman, Stefano Angiari, Svenja S. Hester, Sarah E. Corcoran +10 more
2020Cell Metabolism572 citations Open access
Semantic Scholar
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages.
M. Runtsch, Stefano Angiari, A. Hooftman, Ridhima Wadhwa +21 more
2022Cell Metabolism312 citations Open access
Semantic Scholar
Characterization of Early Cytokine Responses and an Interleukin (IL)-6–dependent Pathway of Endogenous Glucocorticoid Induction during Murine Cytomegalovirus Infection
M. Ruzek, Andrew H. Miller, S. Opal, B. Pearce +1 more
1997Journal of Experimental Medicine219 citations Open access
Semantic Scholar
A modified model of graft-versus-host-induced systemic sclerosis (scleroderma) exhibits all major aspects of the human disease.
M. Ruzek, Sharda S. Jha, S. Ledbetter, S. Richards +1 more
2004Arthritis & Rheumatism123 citations
Semantic Scholar
Replication of Murine Cytomegalovirus in Differentiated Macrophages as a Determinant of Viral Pathogenesis
Laura K. Hanson, J. S. Slater, Z. Karabekian, H. W. Virgin +6 more
1999Journal of Virology110 citations Open access
Semantic Scholar
Allogeneic mesenchymal stem cells do not protect NZB × NZW F1 mice from developing lupus disease
M. Youd, C. Blickarz, L. Woodworth, T. Touzjian +6 more
2010Clinical and Experimental Immunology101 citations Open access
Semantic Scholar
Pharmacology of AMD3465: a small molecule antagonist of the chemokine receptor CXCR4.
V. Bodart, V. Anastassov, M. Darkes, Stefan R Idzan +13 more
2009Biochemical Pharmacology58 citations
Semantic Scholar
Human endothelial precursor cells express tumor endothelial marker 1/endosialin/CD248
R. Bagley, Cécile Rouleau, T. S. St Martin, P. Boutin +9 more
2008Molecular Cancer Therapeutics58 citations
Semantic Scholar
Minimal Effects on Immune Parameters Following Chronic Anti-TGF-β Monoclonal Antibody Administration to Normal Mice
M. Ruzek, M. Hawes, B. Pratt, J. McPherson +3 more
2003Immunopharmacology and immunotoxicology52 citations
Semantic Scholar
A NOVEL CLINICALLY RELEVANT APPROACH TO TIP THE BALANCE TOWARDS REGULATION IN STRINGENT TRANSPLANT MODEL
F. D’Addio, Xueli Yuan, A. Habicht, John M. Williams +6 more
2010Transplantation48 citations Open access
Semantic Scholar
Characterization of in vitro antimurine thymocyte globulin-induced regulatory T cells that inhibit graft-versus-host disease in vivo.
M. Ruzek, J. Waire, D. Hopkins, Gina Lacorcia +9 more
2008Blood48 citations
Semantic Scholar
In Vivo Characterization of Rabbit Anti-Mouse Thymocyte Globulin: A Surrogate for Rabbit Anti-Human Thymocyte Globulin
M. Ruzek, K. Neff, Michael Luong, Karen A. Smith +5 more
2009Transplantation44 citations Open access
Semantic Scholar
Anti-thymocyte globulin (ATG) prevents autoimmune encephalomyelitis by expanding myelin antigen-specific Foxp3+ regulatory T cells.
Denise T Chung, T. Korn, J. Richard, M. Ruzek +4 more
2007International Immunology42 citations
Semantic Scholar
Adenoviral vectors stimulate murine natural killer cell responses and demonstrate antitumor activities in the absence of transgene expression.
M. Ruzek, B. Kavanagh, A. Scaria, S. Richards +1 more
2002Molecular Therapy42 citations Open access
Semantic Scholar
Safety, Tolerability, and Pharmacodynamics of ABT‐122, a Tumor Necrosis Factor– and Interleukin‐17–Targeted Dual Variable Domain Immunoglobulin, in Patients With Rheumatoid Arthritis
R. Fleischmann, F. Wagner, A. Kivitz, H. Mansikka +7 more
2017Arthritis & Rheumatology35 citations Open access
Semantic Scholar
Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma.
J. Karman, J. Tedstone, Nathan K Gumlaw, Yunxiang Zhu +7 more
2010International Immunology31 citations
Semantic Scholar
Modeling the Clinical Phenotype of BTK Inhibition in the Mature Murine Immune System
Micah J. Benson, Varenka Rodriguez, D. von Schack, S. Keegan +12 more
2014Journal of Immunology29 citations
Semantic Scholar
Homeostatic role of transforming growth factor-beta in the oral cavity and esophagus of mice and its expression by mast cells in these tissues.
A. Vitsky, J. Waire, R. Pawliuk, Arden Bond +12 more
2009American Journal of Pathology28 citations Open access
Semantic Scholar
Synovial Inflammatory Pathways Characterize Anti‐TNF–Responsive Rheumatoid Arthritis Patients
Jing Wang, D. Conlon, F. Rivellese, A. Nerviani +8 more
2022Arthritis & Rheumatology27 citations
Semantic Scholar
Potential predictive biomarkers of adalimumab response in patients with hidradenitis suppurativa *
Y. Cao, F. Hong, D. Conlon, L. Sidur +5 more
2021British Journal of Dermatology23 citations
Semantic Scholar
Transient Low-Dose Methotrexate Induces Tolerance to Murine Anti-Thymocyte Globulin and Together They Promote Long-Term Allograft Survival
Alexandra M. Joseph, K. Neff, J. Richard, Lan Gao +7 more
2012Journal of Immunology21 citations Open access
Semantic Scholar
Murine Antithymocyte Globulin T-Cell Depletion Is Mediated Predominantly by Macrophages, but the Fas/FasL Pathway Selectively Targets Regulatory T Cells
K. Neff, S. Richards, John M. Williams, R. Garman +1 more
2011Transplantation17 citations Open access
Semantic Scholar
Adalimumab Induces a Wound Healing Profile in Patients with Hidradenitis Suppurativa by Regulating Macrophage Differentiation and Matrix Metalloproteinase Expression.
Yonghao Cao, B. Harvey, F. Hong, M. Ruzek +3 more
2021Journal of Investigative Dermatology14 citations Open access
Semantic Scholar
A first‐in‐human study of the novel immunology antibody–drug conjugate, ABBV‐3373, in healthy participants
Ronilda R. D'Cunha, H. Küpper, D. Arikan, Weihan Zhao +4 more
2023British Journal of Clinical Pharmacology13 citations Open access
Semantic Scholar
FRI0164 Safety, Tolerability, And Functional Activity of ABT-122, A Dual TNF- and IL-17A–Targeted DVD-IG™, Following Single-Dose Administration in Healthy Subjects
H. Mansikka, M. Ruzek, M. Hugunin, A. Ivanov +14 more
201513 citations
Semantic Scholar
Ultrasound imaging accurately detects skin thickening in a mouse scleroderma model.
J. Tedstone, S. Richards, R. Garman, M. Ruzek
2008Ultrasound in Medicine and Biology10 citations
Semantic Scholar
Generation of antigen-specific cytotoxic T lymphocytes and regulation of cytokine production takes place in the absence of CD3ζ
J. She, M. Ruzek, P. Velupillai, I. D. de Aos +5 more
199910 citations
Semantic Scholar
Dual Blockade of Interleukin-1β and Interleukin-17A Reduces Murine Arthritis Pathogenesis but Also Leads to Spontaneous Skin Infections in Nonhuman Primates
M. Ruzek, Lili Huang, Ting-Ting Zhang, S. Bryant +4 more
2018Journal of Pharmacology and Experimental Therapeutics9 citations Open access
Semantic Scholar
POS0365 ANTI-TNF GLUCOCORTICOID RECEPTOR MODULATOR ANTIBODY DRUG CONJUGATE FOR THE TREATMENT OF AUTOIMMUNE DISEASES
B. Stoffel, M. McPherson, A. Hernandez, C. Goess +10 more
20217 citations
Semantic Scholar
Plasma IgE levels, activation marker expression, and cytokine production in non-atopic individuals.
Anila Prabhu, M. Ruzek, D. Kamat, Ambika Mathur
1997Annals of Allergy, Asthma & Immunology6 citations
Semantic Scholar
FRI0188 Safety, Tolerability, and Pharmacodynamics of ABT-122, A Dual TNF- and IL-17–Targeted Dual Variable Domain (DVD)-IG™ in Patients with Rheumatoid Arthritis
R. Fleischmann, F. Wagner, Alan J. Kivitz, H. Mansikka +5 more
20164 citations
Semantic Scholar
FRI0176 ABT-122, A Novel Dual Variable Domain (DVD)-IG™, Targeting TNF and IL-17, Inhibits Peripheral Blood Mononuclear Cell Production of GM-CSF and Decreases Lymphocyte Expression of CXCR4 in Healthy Subjects
M. Ruzek, D. Conlon, H. Mansikka, R. Padley +1 more
20154 citations
Semantic Scholar
Selected Mechanistic Studies and Future Directions for Thymoglobulin
M. Ruzek, J. Dzuris, Lan Gao, R. Bigelow +4 more
20074 citations Open access
Semantic Scholar
Decreased production of IL-2 and IFN-gamma by stimulated splenocytes from mice bearing plasma cell tumors is associated with alteration of DNA-binding factors.
M. Ruzek, D. O'Brien, Ambika Mathur
1996International Immunology4 citations
Semantic Scholar
Plasma cell tumors decrease CD23 mRNA expression in vivo in murine splenic B cells
M. Ruzek, A. Mathur
19954 citations
Semantic Scholar
Biomarkers for the clinical development of antiviral therapies
T. Ng, P. Dorr, Preethi Krishnan, D. Cohen +5 more
2021Cytometry. Part B, Clinical cytometry3 citations Open access
Semantic Scholar
Transplantation Immunotherapy with Antithymocyte Globulin (ATG)
J. Dzuris, C. Bloy, M. Ruzek, John M. Williams
20122 citations
Semantic Scholar
Anti-Murine Thymocyte Globulin Prevents Acute Graft-Versus-Host Disease and Induces Foxp3+ T Cells in Target Organs.
M. Ruzek, J. Waire, W. Weber, John M. Williams +2 more
20072 citations
Semantic Scholar
POS1025 COMBINATION OF BULK AND SINGLE CELL RNASEQ ANALYSES TO REVEAL MECHANISMS OF ABT-317 (JAK INHIBITOR) ON SYNOVIAL FIBROBLASTS
Y. Son, D. Korenfeld, B. Harvey, J. Wang +4 more
2023Annals of the Rheumatic Diseases1 citations Open access
Semantic Scholar
In vitro and in vivo recovery of IFN-γ, but not IL-2, production by IL-12 in mice with plasma ceIL tumors
M. Ruzek, A. Mathur
19961 citations Open access
Semantic Scholar
Clinical Connections
M. Ruzek
2022Arthritis & Rheumatology0 citations
Semantic Scholar
A Higher Induction Dosing Regimen of Adalimumab Does Not Enhance Modulation of Downstream Blood Molecular Markers in Patients With Moderately to Severely Active Crohn’s Disease or Ulcerative Colitis
M. Ferrante, V. Pivorunas, J. Butler, N. Mahi +15 more
20210 citations
Semantic Scholar
S809 A Higher Induction Dosing Regimen of Adalimumab Does Not Enhance Modulation of Downstream Blood Molecular Markers in Patients With Moderately to Severely Active Crohn’s Disease or Ulcerative Colitis
M. Ferrante, V. Pivorunas, J. Butler, N. Mahi +13 more
2021American Journal of Gastroenterology0 citations
Semantic Scholar
Length Safety , Tolerability , and Pharmacodynamics of ABT-122 , a TNF-and IL-17 – Targeted Dual Variable Domain Immunoglobulin , in Patients With RA Running Title : ABT-122 safety and pharmacodynamics
R. Fleischmann, F. Wagner, A. Kivitz, H. Mansikka +7 more
20170 citations
Semantic Scholar
A Bruton’s Tyrosine Kinase inhibitor prevents antigen-driven B cell activation, germinal center persistence and memory B cell re-activation in vivo (109.10)
Varenka Rodriguez, J. Springer, M. Schnute, K. Dunussi-joannopoulos +3 more
2012Journal of Immunology0 citations
Semantic Scholar
Long-Term Allograft Survival Globulin and Together They Promote Tolerance to Murine Anti-Thymocyte Transient Low-Dose Methotrexate Induces
M. Ruzek, R. Garman, John M. Williams, S. Richards +7 more
20120 citations
Semantic Scholar
A Bruton's Tyrosine Kinase inhibitor prevents antigen-driven B cell activation, germinal center persistence and memory B cell re-activation in vivo
Varenka Rodriguez, J. Springer, M. Schnute, K. Dunussi-joannopoulos +3 more
20120 citations
Semantic Scholar
Effects of Rabbit Anti-Mouse Thymocyte Globulin Treatment in a Splenocyte-Induced Model of Aplastic Anemia
M. Ruzek, K. Phillips, S. Richards, K. Mamlouk +2 more
20100 citations
Semantic Scholar
Differential Susceptibility of T Cell Subsets to Depletion by Murine ATG is Dependent on Both Effector Mechanism and Effector Cell Type
K. Neff, John M. Williams, S. Richard, R. Garman +1 more
20100 citations
Semantic Scholar
F.99. In Vivo Effects of Rabbit Anti-Murine Thymocyte Globulin in Normal Mice
K. Neff, Michael Luong, Karen A. Smith, S. Richards +4 more
20080 citations
Semantic Scholar

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