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M. Hirai · SciRah

Researcher profile · Semantic Scholar

M. Hirai

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M. Hirai — researcher profile on SciRah

h-index: 15
Works: 37
Citations: 542

Most-cited papers

A Noninvasive System for Monitoring Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors with Plasma DNA
Tomomi Nakamura, N. Sueoka-Aragane, K. Iwanaga, A. Sato +8 more
2011Journal of Thoracic Oncology77 citations Open access
Semantic Scholar
Application of a Highly Sensitive Detection System for Epidermal Growth Factor Receptor Mutations in Plasma DNA
Tomomi Nakamura, N. Sueoka-Aragane, K. Iwanaga, A. Sato +7 more
2012Journal of Thoracic Oncology74 citations Open access
Semantic Scholar
PIK3CA mutation profiling in patients with breast cancer, using a highly sensitive detection system
Tatsusnori Shimoi, A. Hamada, M. Yamagishi, M. Hirai +12 more
2018Cancer Science41 citations Open access
Semantic Scholar
Investigation of appropriate pre-analytical procedure for circulating free DNA from liquid biopsy
A. Sato, Chiho Nakashima, Tomonori Abe, Junichi Kato +6 more
2018OncoTarget37 citations Open access
Semantic Scholar
Mechanisms of acquired resistance to afatinib clarified with liquid biopsy
Tomomi Nakamura, Chiho Nakashima, K. Komiya, Kazuki Kitera +3 more
2018PLoS ONE36 citations Open access
Semantic Scholar
Early detection of pancreatic cancer by comprehensive serum miRNA sequencing with automated machine learning
Munenori Kawai, A. Fukuda, Ryo Otomo, Shunsuke Obata +37 more
2024British Journal of Cancer32 citations Open access
Semantic Scholar
Cloning and expression of a brain-specific putative UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase gene.
Naosuke Nakamura, Shinya Toba, M. Hirai, S. Morishita +4 more
2005Biological and Pharmaceutical Bulletin29 citations Open access
Semantic Scholar
Automated DNA extraction using cellulose magnetic beads can improve EGFR point mutation detection with liquid biopsy by efficiently recovering short and long DNA fragments
Chiho Nakashima, A. Sato, Tomonori Abe, Junichi Kato +6 more
2018OncoTarget28 citations Open access
Semantic Scholar
Fully automated and super-rapid system for the detection of JAK2V617F mutation.
R. Tanaka, J. Kuroda, W. Stevenson, E. Ashihara +13 more
2008Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis28 citations
Semantic Scholar
Development of a Novel, Fully-Automated Genotyping System: Principle and Applications
Shun-ichi Suzuki, Mariko Komori, M. Hirai, N. Ureshino +1 more
2012Italian National Conference on Sensors27 citations Open access
Semantic Scholar
Single nucleotide polymorphism genotyping of CYP2C19 using a new automated system.
Naoko Matsumoto, F. Kakihara, S. Kimura, Yukari Kurebayashi +3 more
2007Analytical Biochemistry19 citations
Semantic Scholar
Localization of low-abundant cancer cells in a sharply expanded microfluidic step-channel using dielectrophoresis
S. Kim, Hiroshi Ito, M. Kozuka, M. Hirai +1 more
201718 citations
Semantic Scholar
A novel detection strategy for living circulating tumor cells using 5-aminolevulinic acid.
S. Matsusaka, M. Kozuka, H. Takagi, Hiroshi Ito +3 more
2014Cancer Letters17 citations
Semantic Scholar
Clinical Significance of Circulating Tumor Cell Induced Epithelial-Mesenchymal Transition in Patients with Metastatic Colorectal Cancer by Single-Cell RNA-Sequencing
M. Kozuka, F. Battaglin, P. Jayachandran, Jing-Yuan Wang +6 more
2021Cancers16 citations Open access
Semantic Scholar
Cancer marker-free enrichment and direct mutation detection in rare cancer cells by combining multi-property isolation and microfluidic concentration.
S. Kim, Hiroshi Ito, M. Kozuka, H. Takagi +2 more
2019Lab on a Chip15 citations
Semantic Scholar
Comprehensive circulating microRNA profile as a supersensitive biomarker for early-stage lung cancer screening
Masayasu Inagaki, Makoto Uchiyama, Kanae Yoshikawa-Kawabe, M. Ito +16 more
2023Journal of Cancer Research and Clinical Oncology12 citations Open access
Semantic Scholar
Analysis of the Circulating Tumor Cell Capture Ability of a Slit Filter-Based Method in Comparison to a Selection-Free Method in Multiple Cancer Types
H. Takagi, Liang Dong, M. Kuczler, Kara A. Lombardo +3 more
2020International Journal of Molecular Sciences12 citations Open access
Semantic Scholar
A novel approach to detect KRAS/BRAF mutation for colon cancer: Highly sensitive simultaneous detection of mutations and simple pre-treatment without DNA extraction
Shun-ichi Suzuki, S. Matsusaka, M. Hirai, Harumi Shibata +3 more
2015International Journal of Oncology6 citations Open access
Semantic Scholar
An automated rapid detection system using the quenching probe method for detecting interleukin 28B and inosine triphosphatase single nucleotide polymorphisms in chronic hepatitis C
Hirokazu Takahashi, Toshihiko Mizuta, Satoshi Oeda, Hiroshi Isoda +10 more
2013Journal of Viral Hepatitis6 citations Open access
Semantic Scholar
Simultaneous detection of JAK2, CALR, and MPL mutations and quantitation of JAK2 V617F allele burden in myeloproliferative neoplasms using the quenching probe‐Tm method in i‐densy IS‐5320
Kunihito Arai, M. Sakaguchi, Shunsuke Yui, T. Kitano +15 more
2022International Journal of Laboratory Hematology3 citations
Semantic Scholar
Detection of KRAS Mutations in Plasma DNA Using a fully Automated Rapid Detection System in Colorectal Cancer Patients
Kazuhisa Hosoya, S. Matsusaka, T. Kashiwada, Koichi Suzuki +8 more
2017Pathology and Oncology Research3 citations Open access
Semantic Scholar
A Multi-institutional Study to Diagnose the Risk of Lymph Node Metastasis Using a CRP Genetic Polymorphism Test Kit in pT1, cN0 Thoracic Esophageal Squamous Cell Carcinoma
S. Motoyama, M. Hosaka, T. Kamei, Masaki Ueno +16 more
2022Anticancer Research2 citations
Semantic Scholar
Plasma T790M and HGF as potential predictive markers for EGFR-TKI re-challenge.
Tomomi Nakamura, Naomi Watanabe, A. Sato, K. Komiya +6 more
2017Oncology Letters2 citations Open access
Semantic Scholar
Single cell RNA-sequence analysis to identify transcriptomic differences associated with treatment outcome and ethnicity in circulating tumor cells (CTCs) from patients (pts) with metastatic colorectal cancer (mCRC).
F. Battaglin, Yonatan Amzaleg, M. Kozuka, P. Jayachandran +9 more
2021Journal of Clinical Oncology1 citations
Semantic Scholar
Automated and rapid system for detection of ALK rearrangement genes in non-small cell lung cancer based on a Quenching Probe method
M. Yamagishi, K. Tsuta, T. Shimoi, Y. Tanabe +7 more
20161 citations Open access
Semantic Scholar
Abstract 2089: Fully automated SNP detection from whole blood and mutation detection from plasma-free DNA
Mariko Komori, Tomomi Nakamura, N. Sueoka-Aragane, K. Iwanaga +10 more
20121 citations
Semantic Scholar
Multicenter development and validation of a serum microRNA–based diagnostic model for breast cancer and its association with tumor burden and biological aggressiveness: an observational case-control study
A. Yamaguchi, Kana Kawanishi, Kei Ishii, Yukiko Fukui +15 more
2026Breast Cancer Research0 citations Open access
Semantic Scholar
Comparison of Comprehensive Serum miRNA Sequencing and Apolipoprotein A2 Isoforms for Early Detection of Pancreatic Cancer
H. Kashima, Munenori Kawai, Kei Iimori, M. Nagao +22 more
2026Cancers0 citations Open access
Semantic Scholar
Abstract 2751: Automatic DNA extraction system can improve theEGFRpoint mutation detection rate of liquid biopsy
Chiho Nakashima, A. Sato, Tomonori Abe, Tomomi Nakamura +6 more
20170 citations
Semantic Scholar
Abstract 3782: Genetic analysis using a novel high-purity enrichment system for circulating tumor cells independent of epithelial cell antigen
H. Takagi, M. Kozuka, Hiroshi Ito, S. Kim +2 more
20170 citations
Semantic Scholar
Genetic testing by a novel high-purity concentration system for circulating tumor cells independent of epithelial markers
H. Ito, H. Takagi, M. Kozuka, S. Kim +2 more
20160 citations Open access
Semantic Scholar
Abstract 4117: A non-invasive system for monitoring resistance to EGFR tyrosine kinase inhibitors with plasma DNA in lung cancer patients
N. Aragane, Tomomi Nakamura, K. Iwanaga, A. Sato +8 more
20110 citations
Semantic Scholar
Automated and Rapid Detection of BCR-ABL Kinase Domain Mutations in IM Resistant Patients with Ph+ Leukemias.
R. Tanaka, S. Kimura, Toshiya Hosomi, M. Hirai +10 more
20090 citations
Semantic Scholar
Detection of the V617F Mutation of JAK2 Using a Novel Fully Automated SNP Super-Rapid Detector.
R. Tanaka, J. Kuroda, E. Ashihara, T. Ishikawa +6 more
20070 citations
Semantic Scholar
Method and apparatus for concentrating and purifying nucleic acid
M. Hirai, Jun Murakami, Satoshi Hashiguchi, K. Inose
20030 citations
Semantic Scholar
Multiple Pathways of Repair for 7,8-Dihydro-8-oxoguanine:C, A, G Mispairs in Escherichia coli
M. Hirai, Qiu-Mei Zhang, Y. Matsumoto, Kazao Yamamoto +1 more
19990 citations
Semantic Scholar
Molecular Mechanisms for Transcriptional Regulation of Escherichia coli Endonuclease VIII gene (nei)
M. Hirai, Qiu-Mei Zhang, Kazuo Yamamoto, S. Yonei
19980 citations
Semantic Scholar

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S. Kimura×15
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Tomomi Nakamura×9
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Tomomi Nakamura — researcher profile on SciRah
A. Sato×9
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K. Komiya×9
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N. Sueoka-Aragane

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E. Sueoka — researcher profile on SciRah

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M. Kozuka — researcher profile on SciRah

Tomonori Abe×6

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Toshiya Hosomi×6

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S. Matsusaka×5

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H. Takagi — researcher profile on SciRah