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M. F. Gulen · SciRah

Researcher profile · Semantic Scholar

M. F. Gulen

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M. F. Gulen — researcher profile on SciRah

h-index: 29
Works: 46
Citations: 7,533

Most-cited papers

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
Selene Glück, B. Guey, M. F. Gulen, K. Wolter +6 more
2017Nature Cell Biology1,097 citations Open access
Semantic Scholar
Targeting STING with covalent small-molecule inhibitors
S. M. Haag, M. F. Gulen, L. Reymond, Antoine Gibelin +7 more
2018Nature1,085 citations Open access
Semantic Scholar
cGAS–STING drives ageing-related inflammation and neurodegeneration
M. F. Gulen, Natasha Samson, Alexander Keller, Marius Schwabenland +9 more
2023Nature927 citations Open access
Semantic Scholar
The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease
You-Cun Qian, Cai-Ni Liu, J. Hartupee, C. Z. Altuntas +14 more
2007Nature Immunology641 citations
Semantic Scholar
The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
J. Di Domizio, M. F. Gulen, F. Saidoune, Vivek V. Thacker +13 more
2022Nature485 citations Open access
Semantic Scholar
Signalling strength determines proapoptotic functions of STING
M. F. Gulen, U. Koch, S. M. Haag, Fabian Schuler +4 more
2017Nature Communications466 citations Open access
Semantic Scholar
Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.
R. Wassermann, M. F. Gulen, C. Sala, Sonia Garcia Perin +7 more
2015Cell Host and Microbe392 citations Open access
Semantic Scholar
The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.
Hui Xiao, M. F. Gulen, J. Qin, Jianhong Yao +12 more
2007Immunity342 citations Open access
Semantic Scholar
Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis
Zi-Zhen Kang, C. Z. Altuntas, M. F. Gulen, Cai-Ni Liu +9 more
2010Immunity304 citations Open access
Semantic Scholar
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation
M. F. Gulen, Zi-Zhen Kang, K. Bulek, You-Zhong Wan +13 more
2010Immunity208 citations Open access
Semantic Scholar
IKKi is required for interleukin 17-dependent signaling associated with neutrophilia and pulmonary inflammation
K. Bulek, Cai-Ni Liu, S. Swaidani, Liwen Wang +13 more
2011Nature Immunology192 citations Open access
Semantic Scholar
The essential role of SIGIRR/TIR8 in regulation of Th2 immune response
K. Bulek, S. Swaidani, J. Qin, Yi Lu +7 more
2009Journal of Immunology173 citations Open access
Semantic Scholar
T cell-intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis
B. Martin, Chen-Hui Wang, Cun-Jin Zhang, Zi-Zhen Kang +20 more
2016Nature Immunology156 citations Open access
Semantic Scholar
Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFκB Activation Pathways Bifurcate at IL-1 Receptor-associated Kinase Modification*
Jianhong Yao, Tae Whan Kim, J. Qin, Zheng-Fan Jiang +11 more
2007Journal of Biological Chemistry116 citations Open access
Semantic Scholar
IKKα negatively regulates ASC-dependent inflammasome activation
B. Martin, Chen-Hui Wang, J. Willette-Brown, T. Herjan +16 more
2014Nature Communications110 citations Open access
Semantic Scholar
SIGIRR, a Negative Regulator of TLR/IL-1R Signalling Promotes Microbiota Dependent Resistance to Colonization by Enteric Bacterial Pathogens
H. P. Sham, E. Yu, M. F. Gulen, G. Bhinder +9 more
2013PLoS Pathogens85 citations Open access
Semantic Scholar
Cutting Edge: TNF Receptor-Associated Factor 4 Restricts IL-17–Mediated Pathology and Signaling Processes
J. Zepp, Cai-Ni Liu, Wen Qian, Ling Wu +3 more
2012Journal of Immunology79 citations Open access
Semantic Scholar
Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates Interleukin-1-induced Th17 cell maintenance
M. F. Gulen, K. Bulek, Hui Xiao, Min-Jia Yu +14 more
2012Immunity75 citations Open access
Semantic Scholar
Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin−c-Kit+ innate cell population
Zi-Zhen Kang, S. Swaidani, Weiguo Yin, Chen-Hui Wang +8 more
2012Immunity73 citations Open access
Semantic Scholar
IL-17-induced Act1-mediated signaling is critical for cuprizone-induced demyelination
Zi-Zhen Kang, Li-Ping Liu, Roo Spangler, C. Spear +6 more
2012Journal of Neuroscience72 citations Open access
Semantic Scholar
Loss of single immunoglobulin interlukin-1 receptor-related molecule leads to enhanced colonic polyposis in Apcmin mice
Hui Xiao, Weiguo Yin, Mohammed A. S. Khan, M. F. Gulen +5 more
2010Gastroenterology61 citations Open access
Semantic Scholar
IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease
Sucai Dong, J. Saha, Jing-Yong Zhao, N. Brooks +8 more
200956 citations
Semantic Scholar
Protective role of macrophage-derived ceruloplasmin in inflammatory bowel disease
Bakytzhan Bakhautdin, M. Febbraio, E. Goksoy, C. de la Motte +5 more
2012Gut55 citations Open access
Semantic Scholar
A CC′ Loop Decoy Peptide Blocks the Interaction Between Act1 and IL-17RA to Attenuate IL-17- and IL-25-Induced Inflammation
Cai-Ni Liu, S. Swaidani, Wen Qian, Zi-Zhen Kang +12 more
2011Science Signaling53 citations Open access
Semantic Scholar
Autoimmunity to Uroplakin II Causes Cystitis in Mice: A Novel Model of Interstitial Cystitis
C. Z. Altuntas, F. Daneshgari, Ç. Şakalar, E. Goksoy +5 more
2011European Urology53 citations Open access
Semantic Scholar
T cell-derived Act1 is necessary for IL-25-mediated Th2 responses and allergic airway inflammation
S. Swaidani, K. Bulek, Zi-Zhen Kang, M. F. Gulen +5 more
2011Journal of Immunology45 citations Open access
Semantic Scholar
Human Colon Tumors Express a Dominant-negative Form of SIGIRR That Promotes Inflammation and Colitis-associated Colon Cancer in Mice
Jun-Jie Zhao, K. Bulek, M. F. Gulen, J. Zepp +10 more
2015Gastroenterology39 citations Open access
Semantic Scholar
EspL is essential for virulence and stabilizes EspE, EspF and EspH levels in Mycobacterium tuberculosis
C. Sala, N. Odermatt, Paloma Soler-Arnedo, M. F. Gulen +3 more
2018PLoS Pathogens34 citations Open access
Semantic Scholar
Bladder Dysfunction in Mice with Experimental Autoimmune Encephalomyelitis
C. Z. Altuntas, F. Daneshgari, Gui-Ming Liu, Adebola C. Fabiyi +7 more
2008Journal of Neuroimmunology32 citations Open access
Semantic Scholar
Interleukin-1 Receptor-Associated Kinase-2 (IRAK2) Is a Critical Mediator of Endoplasmic Reticulum (ER) Stress Signaling
Samir Benosman, Palaniyandi Ravanan, R. G. Correa, Y. Hou +10 more
2013PLoS ONE28 citations Open access
Semantic Scholar
m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner
M. Balzarolo, Sander Engels, Anja J. de Jong, Katka Franke +6 more
2019bioRxiv13 citations Open access
Semantic Scholar
IRAK4 kinase Activity is Required for Th17 Differentiation and Th17-mediated Disease
Kirk Staschke, Sucai Dong, J. Saha, Jing-Yong Zhao +10 more
2009Journal of Immunology4 citations Open access
Semantic Scholar
Inside Job: Viruses Transfer cGAMP between Cells.
M. F. Gulen, A. Ablasser
2015Cell Host and Microbe3 citations Open access
Semantic Scholar
296: IL-17-signaling in LGR5-positive stem cells promotes colon tumorigenesis
J. Zepp, Cai-Ni Liu, M. F. Gulen, Jun-Jie Zhao +3 more
20131 citations
Semantic Scholar
SS1-2 SIGIRR protein suppresses Th17 cell proliferation via negative regulation of the Interleukin-1 receptor pathway and inhibition of mTOR kinase activation
M. F. Gulen, Zi-Zhen Kang, K. Bulek, You-Zhong Wan +13 more
20101 citations
Semantic Scholar
Abstract 2928: Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress.
R. Palaniyandi, Samir Benosman, Y. Hou, R. G. Correa +7 more
20130 citations
Semantic Scholar
SIGIRR limits colitic and epithelial homeostatic responses, but promotes microbiota dependent colonization resistance to enteric bacterial pathogens (P3067)
H. P. Sham, E. Yu, M. F. Gulen, Justin M. Chan +8 more
2013Journal of Immunology0 citations
Semantic Scholar
TRAF4 restricts IL-17-mediated pathology and signaling processes
J. Zepp, Cai-Ni Liu, Wen Qian, Ling Wu +3 more
2012Journal of Immunology0 citations Open access
Semantic Scholar
Toll-Like Receptors are critical in controlling colonic inflammation and cancer
Hui Xiao, Weiguo Yin, Mohammed A. S. Khan, M. F. Gulen +2 more
2011BMC Proceedings0 citations Open access
Semantic Scholar
CNS Autoimmune Inflammation: RICK Must NOD!
Zi-Zhen Kang, M. F. Gulen, Xiao-Xia Li
2011Immunity0 citations Open access
Semantic Scholar
CS10-3. IKKi is required for interleukin 17-dependent signaling associated with neutrophilia and pulmonary inflammation
K. Bulek, Cai-Ni Liu, S. Swaidani, Liwen Wang +13 more
20110 citations
Semantic Scholar
The Role of Sigirr in Innate and Adaptive Immunity
M. F. Gulen
20100 citations
Semantic Scholar
649 IMMUNIZATION WITH SELF UROPLAKIN II CAUSES AUTOIMMUNE CYSTITIS; NOVEL MURINE EXPERIMENTAL AUTOIMMUNE CYSTITIS MODEL
C. Z. Altuntas, L. Byrne, Ç. Şakalar, M. F. Gulen +5 more
20100 citations
Semantic Scholar
PS1-34 Act 1 in central nervous system is critical for autoimmune encephalomyelitis
Zi-Zhen Kang, C. Z. Altuntas, M. F. Gulen, Cai-Ni Liu +9 more
20100 citations
Semantic Scholar
Inflammatory cytokines and anti-microbial responses (WS-068) Chairpersons: Yasunobu Yoshikai, Xiaoxia Li
J. D. Burke, N. Sonenburg, L. Platanias, E. Fish +34 more
20100 citations
Semantic Scholar
Regulation of Th2 Immune Response Receptor-Related Molecule/Toll IL-1R8 in The Essential Role of Single Ig IL-1
Xiao-Xia Li, Kastelein, M. Aronica, M. Kosz-Vnenchak +8 more
20090 citations
Semantic Scholar

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