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N. Sakai · SciRah

Researcher profile · Semantic Scholar

N. Sakai

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N. Sakai — researcher profile on SciRah

h-index: 16
Works: 65
Citations: 2,315

Most-cited papers

Basal forebrain circuit for sleep-wake control
Min Xu, Shinjae Chung, Si-Yu Zhang, Peng Zhong +7 more
2015Nature Neuroscience482 citations Open access
Semantic Scholar
Maturation and circuit integration of transplanted human cortical organoids
Omer Revah, Felicity Gore, Kevin W. Kelley, Jimena Andersen +18 more
2022Nature423 citations Open access
Semantic Scholar
Muscleblind-Like 2 Mediated Alternative Splicing in the Developing Brain and Dysregulation in Myotonic Dystrophy
Konstantinos Charizanis, Kuang-Yung Lee, Ranjan Batra, Marianne Goodwin +22 more
2012Neuron334 citations Open access
Semantic Scholar
Neuronal Defects in a Human Cellular Model of 22q11.2 Deletion Syndrome
Themasap A. Khan, Omer Revah, A. Gordon, Se-Jin Yoon +23 more
2020Nature Medicine176 citations Open access
Semantic Scholar
A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait
Luo-Ying Zhang, Arisa Hirano, Pei-Ken Hsu, Christopher R. Jones +12 more
2016Proceedings of the National Academy of Sciences of the United States of America159 citations Open access
Semantic Scholar
Greatly Increased Numbers of Histamine Cells in Human Narcolepsy with Cataplexy
J. John, Thomas C. Thannickal, R. McGregor, Lalini Ramanathan +7 more
2013Annals of Neurology119 citations Open access
Semantic Scholar
Antisense oligonucleotide therapeutic approach for Timothy syndrome
Xiao-Yu Chen, Fikri Birey, Min-Yin Li, Omer Revah +12 more
2024Nature112 citations Open access
Semantic Scholar
The Sleep-Promoting and Hypothermic Effects of Glycine are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus
Nobuhiro Kawai, N. Sakai, M. Okuro, Sachie Karakawa +5 more
2015Neuropsychopharmacology67 citations Open access
Semantic Scholar
Strain differences in diazepam metabolism at its three metabolic sites in sprague-dawley, brown norway, dark agouti, and wistar strain rats.
K. Saito, N. Sakai, Hyung-sub Kim, M. Ishizuka +2 more
2004Drug Metabolism And Disposition48 citations
Semantic Scholar
A New Conversion Method for Recovering Valuable Chemicals from Oil Palm Shell Wastes Utilizing Liquid-Phase Oxidation with H2O2 under Mild Conditions
K. Mae, I. Hasegawa, N. Sakai, K. Miura
200042 citations
Semantic Scholar
Allosteric Chirality Amplification in Zinc Bilinone Dimer
T. Mizutani, N. Sakai, S. Yagi, T. Takagishi +2 more
200041 citations
Semantic Scholar
BMAL1 loss in oligodendroglia contributes to abnormal myelination and sleep
D. Rojo, Louisa Dal Cengio, Anna Badner, Samuel H. Kim +18 more
2023Neuron39 citations Open access
Semantic Scholar
HPLC analysis of CSF hypocretin-1 in type 1 and 2 narcolepsy
N. Sakai, Mari Matsumura, Ling Lin, E. Mignot +1 more
2019Scientific Reports37 citations Open access
Semantic Scholar
An overview of hypocretin based therapy in narcolepsy
S. Takenoshita, N. Sakai, Y. Chiba, Mari Matsumura +2 more
2018Expert Opinion on Investigational Drugs31 citations
Semantic Scholar
Familial narcolepsy in the Lipizzaner horse: a report of three fillies born to the same sire
E. Ludvikova, S. Nishino, N. Sakai, P. Jahn
2012Veterinary Quarterly18 citations Open access
Semantic Scholar
Impact of rat P450 genetic polymorphism on diazepam metabolism
N. Sakai, M. Ishizuka
2009Expert Opinion on Drug Metabolism & Toxicology16 citations
Semantic Scholar
Intraperitoneal injection of ginkgolide B, a major active compound of Ginkgo biloba, dose-dependently increases the amount of wake and decreases non-rapid eye movement sleep in C57BL/6 mice.
S. Nishimon, Mai Yamaguchi, Hisae Muraki, N. Sakai +1 more
2020Neuroscience Letters15 citations
Semantic Scholar
Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome
Tatsunori Takahashi, N. Sakai, T. Iwasaki, T. Doyle +2 more
2020Scientific Reports14 citations Open access
Semantic Scholar
A rare genetic variant in the cleavage site of prepro-orexin is associated with idiopathic hypersomnia
T. Miyagawa, Susumu Tanaka, Mihoko Shimada, N. Sakai +40 more
2022npj Genomic Medicine13 citations Open access
Semantic Scholar
Polymorphism in diazepam metabolism in Wistar rats.
K. Saito, Hyung-sub Kim, N. Sakai, M. Ishizuka +2 more
2004Journal of Pharmacy and Science13 citations
Semantic Scholar
Helical chirality control in zinc bilinone dimers
S. Yagi, Ryuhei Yamada, T. Takagishi, N. Sakai +4 more
199913 citations
Semantic Scholar
Wake-promoting effects of ONO-4127Na, a prostaglandin DP1 receptor antagonist, in hypocretin/orexin deficient narcoleptic mice.
Y. Sagawa, M. Sato, N. Sakai, S. Chikahisa +4 more
2016Neuropharmacology12 citations
Semantic Scholar
Intracranial mast cells contribute to the control of social behavior in male mice.
Daisuke Tanioka, S. Chikahisa, Noriyuki Shimizu, T. Shiuchi +3 more
2021Behavioural Brain Research11 citations
Semantic Scholar
Noninvasive detection of sleep/wake changes and cataplexy-like behaviors in orexin/ataxin-3 transgenic narcoleptic mice across the disease onset
M. Sato, Y. Sagawa, N. Hirai, S. Sato +6 more
2014Experimental Neurology10 citations Open access
Semantic Scholar
Comparison of Solriamfetol and Modafinil on Arousal and Anxiety-Related Behaviors in Narcoleptic Mice
N. Sakai, S. Nishino
2022Neurotherapeutics9 citations Open access
Semantic Scholar
Chronic Powder Diet After Weaning Induces Sleep, Behavioral, Neuroanatomical, and Neurophysiological Changes in Mice
Emiko Anegawa, Nozomu Kotorii, Yuji Ishimaru, M. Okuro +2 more
2015PLoS ONE8 citations Open access
Semantic Scholar
Genetic Basis of Inter- and Intrastrain Differences in Diazepam p-Hydroxylation in Rats
N. Sakai, K. Saito, K. Sakamoto, M. Ishizuka +1 more
2009Drug Metabolism And Disposition8 citations
Semantic Scholar
IMPORTANCE OF CYP2D3 IN POLYMORPHISM OF DIAZEPAM P-HYDROXYLATION IN RATS
N. Sakai, K. Saito, Hyung-sub Kim, A. Kazusaka +3 more
2005Drug Metabolism And Disposition8 citations
Semantic Scholar
Brain Mast Cells in Sleep and Behavioral Regulation.
S. Nishino, N. Sakai, Naoya Nishino, T. Ono
2022Current topics in behavioral neurosciences5 citations
Semantic Scholar
Sake yeast induces the sleep-promoting effects under the stress-induced acute insomnia in mice
S. Nishimon, N. Sakai, S. Nishino
2021Scientific Reports5 citations Open access
Semantic Scholar
regulation: its binding is reduced in Dark Agouti rats
N. Sakai, K. Sakamoto, S. Fujita, M. Ishizuka
20095 citations
Semantic Scholar
Diazepam metabolism in the kidneys of male and female rats of various strains.
Hyung-sub Kim, N. Sakai, K. Saito, S. Fujita +1 more
2010Journal of Veterinary Medical Science4 citations Open access
Semantic Scholar
Eurycoma longifolia (Tongkat Ali) enhances wakefulness during active periods but facilitates sleep during resting periods in C57BL/6 mice
T. Ono, Naoya Nishino, Y. Iwai, Y. Iwai +3 more
2023European Journal of Neuroscience3 citations
Semantic Scholar
Stimulants in Excessive Daytime Sleepiness
N. Sakai, S. Chikahisa, S. Nishino
20103 citations
Semantic Scholar
Probability estimation of narcolepsy type 1 in DTA mice using unlabeled EEG and EMG data
Laura Rose, A. N. Zahid, Louise Piilgaard, Christine Egebjerg +23 more
2025SLEEP Advances2 citations Open access
Semantic Scholar
BMAL1 loss in oligodendroglial lineage cells dysregulates myelination and sleep
D. Rojo, Anna Badner, Louisa Dal Cengio, Samuel H. Kim +14 more
2022bioRxiv2 citations Open access
Semantic Scholar
Altered responses of end‐expiratory lung volume and upper airway patency to body posture in diet‐induced obese mice
Tatsunori Takahashi, N. Sakai, S. Nishino
2021Physiological Reports2 citations Open access
Semantic Scholar
Sleep and the glymphatic system
N. Sakai, S. Nishino
2021Reference Module in Neuroscience and Biobehavioral Psychology2 citations
Semantic Scholar
Advances in pharmaceutical treatment options for narcolepsy
Tatsunori Takahashi, N. Sakai, Mari Matsumura, Chen-Yu Li +2 more
2018Expert Opinion on Orphan Drugs2 citations
Semantic Scholar
Estimate of the Nose Current of Air at the Time of Apnea or Hypopnea by Throat Sound Analysis
N. Sakai, M. Matsumura
20132 citations Open access
Semantic Scholar
Poster Session II: October 1 (12pm) ‐ October 2
Y. Mori, S. Miyata, T. Katayama, M. Tohyama +13 more
20122 citations
Semantic Scholar
Human neuromodulatory assembloids to study serotonin signaling and disease
Sabina Kanton, Xiang-Ling Meng, Chun-Yang Dong, Fikri Birey +9 more
2026bioRxiv1 citations Open access
Semantic Scholar
0322 PLASMA AMINO ACID CHANGES IN PATIENTS WITH INSOMNIA AND SLEEP DISORDERS BREATHING
S. Takenoshita, N. Sakai, Ling Lin, M. Einen +3 more
20171 citations
Semantic Scholar
Modulations of Ventral Tegmental Area (VTA) Dopaminergic Neurons by Hypocretins/Orexins: Implications in Vigilance and Behavioral Control
S. Nishino, N. Sakai
20161 citations
Semantic Scholar
Antibiotic furazolidone induces CYP1A but not CYP2E1 subfamily in rat liver.
N. Sasaki, N. Sakai, Y. Ikenaka, Tomomi Kamiya +4 more
2008Journal of Veterinary Medical Science1 citations Open access
Semantic Scholar
A rare genetic variant in the cleavage site of prepro-orexin confers susceptibility to idiopathic hypersomnia
T. Miyagawa, S. Tanaka, M. Shimada, N. Sakai +40 more
2026Sleep Medicine0 citations Open access
Semantic Scholar
Sleep-wake and circadian behavior in brain-specific sirtuin 1 knockout mice and effects of nicotinamide mononucleotide supplementation
N. Sakai, R. Yoshimoto, Daisuke Yamaguchi, S. Nishino
2026Scientific Reports0 citations Open access
Semantic Scholar
Author Correction: Maturation and circuit integration of transplanted human cortical organoids
Omer Revah, Felicity Gore, Kevin W. Kelley, Jimena Andersen +18 more
2026Nature0 citations Open access
Semantic Scholar
[Sleep and Cerebrospinal Fluid].
N. Sakai
2025Brain and nerve = Shinkei kenkyu no shinpo0 citations
Semantic Scholar
Eurycoma longifolia (Tongkat Ali) supplementation enhances sleep and wake consolidation in wild-type, but not in narcoleptic mice
N. Sakai, K. Komi, Naoya Nishino, Yutaka Kuroki +1 more
2024SLEEP Advances0 citations Open access
Semantic Scholar

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S. Nishino×27
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S. Nishino — researcher profile on SciRah
M. Ishizuka×8
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M. Ishizuka — researcher profile on SciRah
S. Nishino×7
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S. Nishino — researcher profile on SciRah
S. Fujita×7
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S. Pașca — researcher profile on SciRah

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K. Saito — researcher profile on SciRah

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Min-Yin Li — researcher profile on SciRah

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Fikri Birey — researcher profile on SciRah

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M. Okuro — researcher profile on SciRah

Hyung-sub Kim×4

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Hyung-sub Kim — researcher profile on SciRah

Xiao-Yu Chen×3

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Xiao-Yu Chen — researcher profile on SciRah