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T. Toki · SciRah

Researcher profile · Semantic Scholar

T. Toki

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T. Toki — researcher profile on SciRah

h-index: 31
Works: 148
Citations: 3,621

Most-cited papers

The landscape of somatic mutations in Down syndrome–related myeloid disorders
K. Yoshida, T. Toki, Y. Okuno, Rika Kanezaki +29 more
2013Nature Genetics361 citations Open access
Semantic Scholar
Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages.
Nobuhiko Harada, Masaya Kanayama, Atsushi Maruyama, Aruto Yoshida +7 more
2011Archives of Biochemistry and Biophysics216 citations
Semantic Scholar
Loss of function mutations in RPL27 and RPS27 identified by whole‐exome sequencing in Diamond‐Blackfan anaemia
Ru-Nan Wang, K. Yoshida, T. Toki, Takafumi Sawada +29 more
2015British Journal of Haematology103 citations
Semantic Scholar
Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities.
K. Banno, Sayaka Omori, K. Hirata, Nobutoshi Nawa +16 more
2016Cell Reports86 citations Open access
Semantic Scholar
Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia.
Rika Kanezaki, T. Toki, K. Terui, Gang Xu +16 more
2010Blood79 citations
Semantic Scholar
Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia.
Madoka Kuramitsu, A. Sato-Otsubo, T. Morio, M. Takagi +21 more
2012Blood57 citations Open access
Semantic Scholar
De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome.
T. Toki, K. Yoshida, Ru-Nan Wang, Sou Nakamura +35 more
2018American Journal of Human Genetics47 citations Open access
Semantic Scholar
Preserved High Probability of Overall Survival with Significant Reduction of Chemotherapy for Myeloid Leukemia in Down Syndrome: A Nationwide Prospective Study in Japan
T. Taga, Tomoyuki Watanabe, D. Tomizawa, K. Kudo +17 more
2016Pediatric Blood & Cancer45 citations
Semantic Scholar
Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia
Y. Konno, T. Toki, S. Tandai, Gang Xu +16 more
2010Haematologica43 citations Open access
Semantic Scholar
Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia.
Takashi Yokoyama, T. Toki, Y. Aoki, Rika Kanezaki +7 more
2012Blood37 citations
Semantic Scholar
Molecular pathogenesis in Diamond–Blackfan anemia
E. Ito, Y. Konno, T. Toki, K. Terui
2010International journal of hematology35 citations
Semantic Scholar
Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia
F. Ikeda, K. Yoshida, T. Toki, Tamayo Uechi +22 more
2017Haematologica34 citations Open access
Semantic Scholar
Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies
Y. Kazuki, Y. Yakura, S. Abe, M. Osaki +12 more
2014Scientific Reports33 citations Open access
Semantic Scholar
Acute megakaryoblastic leukemia with acquired trisomy 21 and GATA1 mutations in phenotypically normal children
Rintaro Ono, D. Hasegawa, S. Hirabayashi, T. Kamiya +8 more
2015European Journal of Pediatrics25 citations
Semantic Scholar
Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome.
T. Toki, Rika Kanezaki, E. Kobayashi, H. Kaneko +12 more
2013Blood25 citations
Semantic Scholar
Landscape of driver mutations and their clinical effects on Down syndrome-related myeloid neoplasms.
Tomohiko Sato, Kenichi Yoshida, T. Toki, Rika Kanezaki +53 more
2024Blood23 citations
Semantic Scholar
Predictive factors for the development of leukemia in patients with transient abnormal myelopoiesis and Down syndrome
Genki Yamato, Takao Deguchi, K. Terui, T. Toki +19 more
2021Leukemia23 citations Open access
Semantic Scholar
Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome.
S. Saida, Kenichiro Watanabe, A. Sato-Otsubo, K. Terui +17 more
2013Blood22 citations Open access
Semantic Scholar
Reduced-intensity conditioning is effective for hematopoietic stem cell transplantation in young pediatric patients with Diamond–Blackfan anemia
Shun Koyamaishi, Takuya Kamio, Akie Kobayashi, Tomohiko Sato +28 more
2020Bone Marrow Transplantation21 citations
Semantic Scholar
The key role of stem cell factor/KIT signaling in the proliferation of blast cells from Down syndrome-related leukemia
T. Toki, Rika Kanezaki, S. Adachi, Hisanori Fujino +6 more
2009Leukemia20 citations Open access
Semantic Scholar
Diagnostic challenge of Diamond–Blackfan anemia in mothers and children by whole-exome sequencing
T. Ichimura, K. Yoshida, Y. Okuno, T. Yujiri +15 more
2017International journal of hematology19 citations
Semantic Scholar
Gene alterations involving the CRLF2‐JAK pathway and recurrent gene deletions in Down syndrome‐associated acute lymphoblastic leukemia in Japan
I. Hanada, K. Terui, F. Ikeda, T. Toki +20 more
2014Genes, Chromosomes and Cancer19 citations
Semantic Scholar
Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome
T. Taga, Shiro Tanaka, D. Hasegawa, K. Terui +18 more
2021Leukemia18 citations
Semantic Scholar
Integrated genetic and epigenetic analysis revealed heterogeneity of acute lymphoblastic leukemia in Down syndrome
Y. Kubota, K. Uryu, Tatsuya Ito, M. Seki +22 more
2019Cancer Science17 citations Open access
Semantic Scholar
Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly
Haruka Matsumori, Kenji Watanabe, H. Tachiwana, Tomoko Fujita +15 more
2022Life Science Alliance16 citations Open access
Semantic Scholar
Resistance of t(17;19)‐acute lymphoblastic leukemia cell lines to multiagents in induction therapy
Atsushi Watanabe, T. Inukai, K. Kagami, Masako Abe +25 more
2019Cancer Medicine15 citations Open access
Semantic Scholar
Effective response to azacitidine in a child with a second relapse of myeloid leukemia associated with Down syndrome after bone marrow transplantation
Suguru Uemura, Takeshi Mori, C. Nagano, Satoru Takafuji +5 more
2018Pediatric Blood & Cancer13 citations
Semantic Scholar
Prospective Study of 168 Infants with Transient Abnormal Myelopoiesis with Down Syndrome: Japan Pediatric Leukemia/Lymphoma Study Group, TAM-10 Study
H. Muramatsu, Tomoyuki Watanabe, D. Hasegawa, Myoung-ja Park +13 more
201513 citations
Semantic Scholar
Exposure to a MRI‐type high‐strength static magnetic field stimulates megakaryocytic/erythroid hematopoiesis in CD34+ cells from human placental and umbilical cord blood
S. Monzen, Kenji Takahashi, T. Toki, E. Ito +3 more
2009Bioelectromagnetics12 citations
Semantic Scholar
Highly sensitive detection of GATA1 mutations in patients with myeloid leukemia associated with Down syndrome by combining Sanger and targeted next generation sequencing
K. Terui, T. Toki, T. Taga, S. Iwamoto +12 more
2020Genes, Chromosomes and Cancer11 citations
Semantic Scholar
BRAF V600E-positive cells as molecular markers of bone marrow disease in pediatric Langerhans cell histiocytosis
K. Kudo, T. Toki, Rika Kanezaki, Tatsuhiko Tanaka +31 more
2022Haematologica10 citations Open access
Semantic Scholar
Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation
Yoko Nishinaka-Arai, A. Niwa, Shiori Matsuo, Y. Kazuki +9 more
2020Haematologica10 citations Open access
Semantic Scholar
Erythrocyte glutathione is a novel biomarker of Diamond-Blackfan anemia.
T. Utsugisawa, T. Uchiyama, T. Toki, H. Ogura +8 more
2016Blood Cells, Molecules & Diseases10 citations
Semantic Scholar
Clinical, cytogenetic, and molecular analyses of 17 neonates with transient abnormal myelopoiesis and nonconstitutional trisomy 21
Kentaro Yuzawa, K. Terui, T. Toki, Rika Kanezaki +9 more
2020Pediatric Blood & Cancer9 citations
Semantic Scholar
MYH7 mutation identified by next-generation sequencing in three infant siblings with bi-ventricular noncompaction presenting with restrictive hemodynamics: A report of three siblings with a severe phenotype and poor prognosis.
Fumitake Miura, J. Shimada, Yosuke Kitagawa, K. Otani +6 more
2019Journal of Cardiology Cases9 citations Open access
Semantic Scholar
Selective KIT inhibitor KI-328 and HSP90 inhibitor show different potency against the type of KIT mutations recurrently identified in acute myeloid leukemia
A. Tsujimura, H. Kiyoi, Y. Shiotsu, Y. Ishikawa +5 more
2010International journal of hematology9 citations
Semantic Scholar
Atypical erythroblastosis in a patient with Diamond–Blackfan anemia who developed del(20q) myelodysplasia
Motoshi Sonoda, M. Ishimura, Y. Ichimiya, Eiko Terashi +8 more
2018International journal of hematology6 citations
Semantic Scholar
Transient myeloproliferative disorder with partial trisomy 21
Takahide Takahashi, A. Inoue, J. Yoshimoto, Kiichiro Kanamitsu +8 more
2015Pediatric Blood & Cancer6 citations
Semantic Scholar
[Transient myeloproliferative disorder in Down syndrome].
E. Ito, T. Toki
2012Nihon rinsho. Japanese journal of clinical medicine6 citations
Semantic Scholar
A novel mutation of ribosomal protein S10 gene in a Japanese patient with diamond-Blackfan anemia.
M. Yazaki, M. Kamei, Yasuhiko Ito, Y. Konno +3 more
2012Journal of pediatric hematology/oncology5 citations
Semantic Scholar
Anti-leukemic effect of azacitidine, a DNA methyltransferase inhibitor, on cell lines of myeloid leukemia associated with Down syndrome.
Tatsuhiko Tanaka, Ko Kudo, Rika Kanezaki, Kentaro Yuzawa +7 more
2024Experimental Hematology4 citations
Semantic Scholar
Childhood acute myeloid leukemia with 5q deletion and HNRNPH1-MLLT10 fusion: the first case report
K. Kudo, Y. Kubota, T. Toki, Rika Kanezaki +13 more
2022Blood Advances4 citations Open access
Semantic Scholar
Correction to: Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome
T. Taga, Shiro Tanaka, D. Hasegawa, K. Terui +18 more
2021Leukemia3 citations Open access
Semantic Scholar
Usefulness of functional splicing analysis to confirm precise disease pathogenesis in Diamond-Blackfan anemia caused by intronic variants in RPS19
Satoru Takafuji, Takeshi Mori, Noriyuki Nishimura, Nobuyuki Yamamoto +10 more
2021Pediatric Hematology & Oncology3 citations Open access
Semantic Scholar
Enzymatic Changes in Red Blood Cells of Diamond-Blackfan Anemia
T. Utsugisawa, T. Uchiyama, T. Toki, Keiko Shimojima-Yamamoto +3 more
20213 citations
Semantic Scholar
A Case of Congenital Leukemia With MYB-GATA1 Fusion Gene in a Female Patient
Shuichi Ozono, S. Yano, Saori Oishi, Miho Mitsuo +4 more
2021Journal of pediatric hematology/oncology3 citations
Semantic Scholar
Outcome of colorectal cancer in Diamond–Blackfan syndrome with a ribosomal protein S19 mutation
K. Kimura, K. Shimazu, T. Toki, Momoko Misawa +9 more
2020Clinical Journal of Gastroenterology3 citations
Semantic Scholar
Clinical Features of Pediatric Acute Myeloid Leukemia with TP53 and CDKN2A/2B copy Number Alterations
Yusuke Hara, T. Taki, Genki Yamato, K. Yoshida +20 more
2019Blood3 citations Open access
Semantic Scholar
Two siblings with familial neuroblastoma with distinct clinical phenotypes harboring an ALK germline mutation
K. Kudo, H. Ueno, Tomohiko Sato, Kaori Kubo +11 more
2018Genes, Chromosomes and Cancer3 citations
Semantic Scholar
[Molecular mechanisms underlying the pathology of Diamond-Blackfan anemia].
T. Toki, E. Ito
2015[Rinsho ketsueki] The Japanese journal of clinical hematology3 citations
Semantic Scholar

Frequent co-authors

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E. Ito×45
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E. Ito — researcher profile on SciRah
K. Terui×31
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K. Terui — researcher profile on SciRah
Rika Kanezaki×17
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Rika Kanezaki — researcher profile on SciRah
S. Adachi×15
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S. Adachi — researcher profile on SciRah

×12

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K. Yoshida — researcher profile on SciRah

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S. Ogawa — researcher profile on SciRah

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S. Kojima — researcher profile on SciRah

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Y. Hayashi — researcher profile on SciRah

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S. Ohga — researcher profile on SciRah

Takuya Kamio×10

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Takuya Kamio — researcher profile on SciRah

Y. Shiraishi×9

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Y. Shiraishi — researcher profile on SciRah

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Ru-Nan Wang — researcher profile on SciRah