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T. Herbert · SciRah

Researcher profile · Semantic Scholar

T. Herbert

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T. Herbert — researcher profile on SciRah

h-index: 26
Works: 42
Citations: 2,301

Most-cited papers

The Extracellular Signal-regulated Kinase Pathway Regulates the Phosphorylation of 4E-BP1 at Multiple Sites*
T. Herbert, Andrew R. Tee, C. Proud
2002Journal of Biological Chemistry198 citations Open access
Semantic Scholar
Evidence for Rapamycin Toxicity in Pancreatic β-Cells and a Review of the Underlying Molecular Mechanisms
A. Barlow, M. Nicholson, T. Herbert
2013Diabetes193 citations Open access
Semantic Scholar
Identification of a protein linked to the genomic and subgenomic mRNAs of feline calicivirus and its role in translation.
T. Herbert, I. Brierley, T. D. Brown
1997Journal of General Virology172 citations Open access
Semantic Scholar
cAMP-dependent Protein Kinase and Ca2+Influx through L-type Voltage-gated Calcium Channels Mediate Raf-independent Activation of Extracellular Regulated Kinase in Response to Glucagon-like Peptide-1 in Pancreatic β-Cells*
E. Gomez, C. Pritchard, T. Herbert
2002Journal of Biological Chemistry152 citations Open access
Semantic Scholar
Distinct Signalling Pathways Mediate Insulin and Phorbol Ester-stimulated Eukaryotic Initiation Factor 4F Assembly and Protein Synthesis in HEK 293 Cells*
T. Herbert, Gordon R. Kilhams, I. Batty, C. Proud
2000Journal of Biological Chemistry110 citations Open access
Semantic Scholar
Cooperativity between the Preproinsulin mRNA Untranslated Regions Is Necessary for Glucose-stimulated Translation*
B. Wicksteed, T. Herbert, C. Alárcon, M. K. Lingohr +2 more
2001Journal of Biological Chemistry102 citations Open access
Semantic Scholar
Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of rapamycin signalling to protein synthesis in L6 muscle cells.
K. Evans, Z. Nasim, Jeremy R. Brown, H. Butler +5 more
2007Journal of the American Society of Nephrology98 citations Open access
Semantic Scholar
Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E.
T. Herbert, R. Fåhraeus, A. Prescott, D. Lane +1 more
2000Current Biology92 citations Open access
Semantic Scholar
Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)
A. Barlow, Jianling Xie, C. E. Moore, S. C. Campbell +3 more
2012Diabetologia79 citations Open access
Semantic Scholar
The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes
Jianling Xie, T. Herbert
2011Cellular and Molecular Life Sciences70 citations Open access
Semantic Scholar
A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?
T. Herbert, D. Laybutt
2016Diabetes69 citations Open access
Semantic Scholar
PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells
C. E. Moore, Omotola Omikorede, E. Gomez, G. Willars +1 more
2010Molecular Endocrinology69 citations Open access
Semantic Scholar
Role of Unfolded Protein Response Dysregulation in Oxidative Injury of Retinal Pigment Epithelial Cells
Chen Chen, M. Cano, J. Wang, Jingming Li +5 more
2014Antioxidants and Redox Signaling67 citations Open access
Semantic Scholar
cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity
Jianling Xie, G. A. Ponuwei, C. E. Moore, G. Willars +2 more
2011Cellular Signalling66 citations Open access
Semantic Scholar
Inhibition of SNAT2 by metabolic acidosis enhances proteolysis in skeletal muscle.
K. Evans, Z. Nasim, Jeremy R. Brown, Emma L. Clapp +4 more
2008Journal of the American Society of Nephrology66 citations Open access
Semantic Scholar
A decrease in cellular energy status stimulates PERK-dependent eIF2α phosphorylation and regulates protein synthesis in pancreatic β-cells
E. Gomez, Michael L. Powell, A. Bevington, T. Herbert
200865 citations Open access
Semantic Scholar
Glucose-stimulated Protein Synthesis in Pancreatic β-Cells Parallels an Increase in the Availability of the Translational Ternary Complex (eIF2-GTP·Met-tRNAi) and the Dephosphorylation of eIF2α*
E. Gomez, Michael L. Powell, Isabel C. Greenman, T. Herbert
2004Journal of Biological Chemistry62 citations Open access
Semantic Scholar
Identification of cAMP-dependent kinase as a third in vivo ribosomal protein S6 kinase in pancreatic beta-cells.
C. E. Moore, Jianling Xie, E. Gomez, T. Herbert
2009Journal of Molecular Biology56 citations Open access
Semantic Scholar
System-L amino acid transporters play a key role in pancreatic β-cell signalling and function.
Qiu-Ping Cheng, V. Beltran, Stanley M. H. Chan, Jeremy R. Brown +2 more
2016Journal of Molecular Endocrinology52 citations Open access
Semantic Scholar
A decrease in cellular energy status stimulates PERK-dependent eIF2alpha phosphorylation and regulates protein synthesis in pancreatic beta-cells.
E. Gomez, Michael L. Powell, A. Bevington, T. Herbert
2008Biochemical Journal40 citations
Semantic Scholar
Angiotensin II Causes &bgr;‐Cell Dysfunction Through an ER Stress‐Induced Proinflammatory Response
Stanley M. H. Chan, Yeh-Siang Lau, Alyson A. Miller, Jacqueline Ku +4 more
2017Endocrinology35 citations Open access
Semantic Scholar
Endoplasmic reticulum stress up‐regulates Nedd4‐2 to induce autophagy
Hao Wang, Ruo-Qiong Sun, D. Camera, Xiao-Yi Zeng +5 more
2016The FASEB Journal33 citations Open access
Semantic Scholar
Endoplasmic reticulum stress and cell death in mTORC1‐overactive cells is induced by nelfinavir and enhanced by chloroquine
Charlotte E. Johnson, David K. Hunt, M. Wiltshire, T. Herbert +4 more
2015Molecular Oncology33 citations Open access
Semantic Scholar
Distinct glucose-dependent stress responses revealed by translational profiling in pancreatic β-cells
Isabel C. Greenman, E. Gomez, C. E. Moore, T. Herbert
2007Journal of Endocrinology30 citations Open access
Semantic Scholar
Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1.
Jianling Xie, Norhan M. El Sayed, Cheng Qi, Xuechan Zhao +2 more
2014Journal of Molecular Endocrinology28 citations Open access
Semantic Scholar
Evidence That Ca2+ within the Microdomain of the L-Type Voltage Gated Ca2+ Channel Activates ERK in MIN6 Cells in Response to Glucagon-Like Peptide-1
Joanne L. Selway, R. Rigatti, N. M. Storey, Jing Lu +2 more
2012PLoS ONE27 citations Open access
Semantic Scholar
21 Regulation of Translation Elongation and the Cotranslational Protein Targeting Pathway
T. Herbert, C. Proud
200726 citations
Semantic Scholar
The selective recruitment of mRNA to the ER and an increase in initiation are important for glucose-stimulated proinsulin synthesis in pancreatic beta-cells.
Isabel C. Greenman, E. Gomez, C. E. Moore, T. Herbert
2005Biochemical Journal25 citations Open access
Semantic Scholar
3′,4′-dihydroxyflavonol ameliorates endoplasmic reticulum stress-induced apoptosis and endothelial dysfunction in mice
Yeh-Siang Lau, M. Mustafa, K. Choy, Stanley M. H. Chan +3 more
2018Scientific Reports24 citations Open access
Semantic Scholar
ER stress in rodent islets of Langerhans is concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes
Omotola Omikorede, C. Qi, T. Gorman, P. Chapman +3 more
2013Nutrition & Diabetes24 citations Open access
Semantic Scholar
PERK in the life and death of the pancreatic beta-cell.
T. Herbert
2007Biochemical Society Transactions22 citations
Semantic Scholar
The inositol-requiring enzyme 1 (IRE1α) RNAse inhibitor, 4µ8C, is also a potent cellular antioxidant.
Stanley M. H. Chan, M. Lowe, Ashton Bernard, Alyson A. Miller +1 more
2018Biochemical Journal21 citations Open access
Semantic Scholar
Vitamin C protects against hypoxia, inflammation, and ER stress in primary human preadipocytes and adipocytes.
Xiao-Qin Luo, C. Ng, Jing-Jing He, Meng-Liu Yang +3 more
2022Molecular and Cellular Endocrinology20 citations
Semantic Scholar
The role of de novo protein synthesis and SIRT1 in ER stress-induced Atf4 and Chop mRNA expression in mammalian cells.
Stanley M. H. Chan, Xuechan Zhao, Abdulsalam Elfowiris, Cherubina Ratnam +1 more
2017Biochimie19 citations Open access
Semantic Scholar
Molecular mechanisms of muscarinic acetylcholine receptor–stimulated increase in cytosolic free Ca2+ concentration and ERK1/2 activation in the MIN6 pancreatic β-cell line
Joanne L. Selway, C. E. Moore, R. Mistry, R. A. John Challiss +1 more
2011Acta Diabetologica17 citations Open access
Semantic Scholar
Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21
E. Jo, Songpei Li, Qingning Liang, Xin-Mei Zhang +5 more
2017PLoS ONE16 citations Open access
Semantic Scholar
Malaria Susceptibility—It's Not All in the Genes
Isabel C. Greenman, E. Gomez, C. E. Moore, T. Herbert
2005PLoS Medicine15 citations Open access
Semantic Scholar
1 Identification of cAMP-dependent kinase as a third in vivo ribosomal protein S 6 kinase in pancreatic β-cells
C. E. Moore, Jianling Xie, E. Gomez, T. Herbert
20096 citations
Semantic Scholar
Dexamethasone acutely suppresses the anabolic SNAT2/SLC38A2 amino acid transporter protein in L6‐G8C5 rat skeletal muscle cells
Safia S. I. Blbas, E. Watson, H. Butler, Jeremy R. Brown +4 more
2020FASEB bioAdvances2 citations Open access
Semantic Scholar
'The global identification of glucose-regulated RNA binding proteins (RBPs) in pancreatic β-cells reveals a link between insulin secretion and gene expression.'
T. Herbert, R. Wardman
20190 citations
Semantic Scholar
Investigation of the Molecular Mechanisms Leading to Protein Translation Inhibition in Response to Endoplasmic Reticulum Stress
Abdulsalam Elfowiris, T. Herbert
2018AL-MUKHTAR JOURNAL OF SCIENCES0 citations Open access
Semantic Scholar
Glucagon‐like peptide‐1 signals to PKB and mTORC1 via the activation of the insulin‐like growth factor receptor (IGF1R) in islets of Langerhans
N. Mostafa, C. E. Moore, T. Herbert
20120 citations
Semantic Scholar

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C. E. Moore×11
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E. Gomez×10
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A. Bevington×6
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Jianling Xie×6
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Jianling Xie — researcher profile on SciRah

Stanley M. H. Chan

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Stanley M. H. Chan — researcher profile on SciRah

Jeremy R. Brown×4

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Jeremy R. Brown — researcher profile on SciRah

Isabel C. Greenman×4

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Isabel C. Greenman — researcher profile on SciRah

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C. Proud — researcher profile on SciRah

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G. Willars — researcher profile on SciRah

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Michael L. Powell — researcher profile on SciRah

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Ji-Ming Ye — researcher profile on SciRah

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A. Barlow — researcher profile on SciRah