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U. Bierbach · SciRah

Researcher profile · Semantic Scholar

U. Bierbach

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U. Bierbach — researcher profile on SciRah

h-index: 32
Works: 94
Citations: 2,575

Most-cited papers

Design, synthesis, and biological activity of a novel non-cisplatin-type platinum-acridine pharmacophore.
Elizabeth T. Martins, H. Baruah, Jaroslaw Kramarczyk, G. Saluta +3 more
2001Journal of Medicinal Chemistry110 citations
Semantic Scholar
A Non-Cross-Linking Platinum–Acridine Agent with Potent Activity in Non-Small Cell Lung Cancer
Zhidong Ma, J. Choudhury, M. Wright, C. Day +3 more
2008Journal of Medicinal Chemistry98 citations Open access
Semantic Scholar
Platinum-intercalator conjugates: from DNA-targeted cisplatin derivatives to adenine binding complexes as potential modulators of gene regulation.
H. Baruah, Colin G. Barry, U. Bierbach
2004Current Topics in Medicinal Chemistry97 citations
Semantic Scholar
Synthesis, Structure, Biological Activity, and DNA Binding of Platinum(II) Complexes of the Type trans-[PtCl(2)(NH(3))L] (L = Planar Nitrogen Base). Effect of L and Cis/Trans Isomerism on Sequence Specificity and Unwinding Properties Observed in Globally Platinated DNA.
U. Bierbach, Y. Qu, T. Hambley, J. Peroutka +3 more
1999Inorganic Chemistry88 citations
Semantic Scholar
Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development
D. Pandya, Nikunj B. Bhatt, Hong Yuan, Cynthia S. Day +4 more
2016Chemical Science78 citations Open access
Semantic Scholar
Solution structural study of a DNA duplex containing the guanine-N7 adduct formed by a cytotoxic platinum-acridine hybrid agent.
H. Baruah, M. Wright, U. Bierbach
2005Biochemistry76 citations
Semantic Scholar
Using Fluorescent Post-Labeling to Probe the Subcellular Localization of DNA-Targeted Platinum
Song Ding, Xin Qiao, J. Suryadi, Glen S Marrs +2 more
2013Angewandte Chemie70 citations Open access
Semantic Scholar
Mechanism of action of non-cisplatin type DNA-targeted platinum anticancer agents: DNA interactions of novel acridinylthioureas and their platinum conjugates.
H. Baruah, Christopher L. Rector, S. Monnier, U. Bierbach
2002Biochemical Pharmacology70 citations
Semantic Scholar
Modification of Platinum(II) Antitumor Complexes with Sulfur Ligands. 1. Synthesis, Structure, and Spectroscopic Properties of Cationic Complexes of the Types [PtCl(diamine)(L)]NO3 and [{PtCl(diamine)}2(L-L)](NO3)2 (L = Monofunctional Thiourea Derivative; L-L = Bifunctional Thiourea Derivative)
U. Bierbach, T. Hambley, N. Farrell
199870 citations
Semantic Scholar
DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)].
A. Žákovská, O. Novakova, Z. Balcarová, U. Bierbach +2 more
1998European Journal of Biochemistry68 citations Open access
Semantic Scholar
DNA metalating-intercalating hybrid agents for the treatment of chemoresistant cancers.
J. Suryadi, U. Bierbach
2012Chemistry67 citations
Semantic Scholar
The Cell’s Nucleolus: an Emerging Target for Chemotherapeutic Intervention
A. Pickard, U. Bierbach
2013ChemMedChem50 citations Open access
Semantic Scholar
Duplex-promoted platination of adenine-N3 in the minor groove of DNA: challenging a longstanding bioinorganic paradigm.
Colin G. Barry, C. Day, U. Bierbach
2005Journal of the American Chemical Society46 citations
Semantic Scholar
Unprecedented monofunctional metalation of adenine nucleobase in guanine- and thymine-containing dinucleotide sequences by a cytotoxic platinum-acridine hybrid agent.
Colin G. Barry, H. Baruah, U. Bierbach
2003Journal of the American Chemical Society46 citations
Semantic Scholar
Redesigning the DNA-Targeted Chromophore in Platinum–Acridine Anticancer Agents: A Structure–Activity Relationship Study
A. Pickard, Fang Liu, T. Bartenstein, Laura G. Haines +3 more
2014Chemistry45 citations Open access
Semantic Scholar
Structure–activity relationships in platinum–acridinylthiourea conjugates: effect of the thiourea nonleaving group on drug stability, nucleobase affinity, and in vitro cytotoxicity
Margaret C. Ackley, Colin G. Barry, A. M. Mounce, M. Farmer +6 more
2004JBIC Journal of Biological Inorganic Chemistry43 citations
Semantic Scholar
Gold(I) Analogues of a Platinum–Acridine Antitumor Agent are only Moderately Cytotoxic but Show Potent Activity Against Mycobacterium Tuberculosis
Lauren C. Eiter, N. Hall, C. Day, G. Saluta +2 more
2009Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Effect of the diamine nonleaving group in platinum-acridinylthiourea conjugates on DNA damage and cytotoxicity.
Rajsekhar Guddneppanavar, J. Choudhury, Alexander R Kheradi, Bartlett D Steen +4 more
2007Journal of Medicinal Chemistry42 citations
Semantic Scholar
Using a Build-and-Click Approach for Producing Structural and Functional Diversity in DNA-Targeted Hybrid Anticancer Agents
Song Ding, Xin Qiao, G. Kucera, U. Bierbach
2012Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
Replacement of a Thiourea-S with an Amidine-NH Donor Group in a Platinum–Acridine Antitumor Compound Reduces the Metal's Reactivity with Cysteine Sulfur
Zhidong Ma, Lu Rao, U. Bierbach
2009Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
Unusual intercalation of acridin-9-ylthiourea into the 5'-GA/TC DNA base step from the minor groove: implications for the covalent DNA adduct profile of a novel platinum-intercalator conjugate.
H. Baruah, U. Bierbach
2003Nucleic Acids Research40 citations Open access
Semantic Scholar
Investigating the cellular fate of a DNA-targeted platinum-based anticancer agent by orthogonal double-click chemistry
Xin Qiao, Song Ding, Fang Liu, G. Kucera +1 more
2014JBIC Journal of Biological Inorganic Chemistry39 citations Open access
Semantic Scholar
Synthesis, Aqueous Reactivity, and Biological Evaluation of Carboxylic Acid Ester-Functionalized Platinum–Acridine Hybrid Anticancer Agents
Leigh A Graham, J. Suryadi, Tiffany K. West, G. Kucera +1 more
2012Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
Inhibition of DNA Synthesis by a Platinum–Acridine Hybrid Agent Leads to Potent Cell Kill in Non-Small Cell Lung Cancer
Christopher L Smyre, G. Saluta, T. Kute, G. Kucera +1 more
2011ACS Medicinal Chemistry Letters39 citations Open access
Semantic Scholar
Synthesis, biological activity, and DNA-damage profile of platinum-threading intercalator conjugates designed to target adenine.
Rajsekhar Guddneppanavar, G. Saluta, G. Kucera, U. Bierbach
2006Journal of Medicinal Chemistry39 citations
Semantic Scholar
Kinetically favored platination of adenine in the g-rich human telomeric repeat.
Lu Rao, U. Bierbach
2007Journal of the American Chemical Society37 citations Open access
Semantic Scholar
Adenine-N3 in the DNA minor groove - an emerging target for platinum containing anticancer pharmacophores.
Rajsekhar Guddneppanavar, U. Bierbach
2007Anti-Cancer Agents in Medicinal Chemistry37 citations
Semantic Scholar
Comparative chemogenomics to examine the mechanism of action of DNA-targeted platinum-acridine anticancer agents
Kahlin Cheung-Ong, Kyung Song, Zhidong Ma, Daniel Shabtai +7 more
2012ACS Chemical Biology36 citations Open access
Semantic Scholar
Replacement of a Thiourea with an Amidine Group in a Monofunctional Platinum–acridine Antitumor Agent. Effect on DNA Interactions, DNA Adduct Recognition and Repair
Hana Kostrhunová, J. Malina, A. Pickard, J. Štěpánková +6 more
2011Molecular Pharmaceutics33 citations Open access
Semantic Scholar
Inversion of the cis geometry requirement for cytotoxicity in structurally novel platinum(II) complexes containing the bidentate N,O-donor pyridin-2-yl-acetate.
U. Bierbach, M. Sabat, Nicholas P. Farrell
2000Inorganic Chemistry33 citations
Semantic Scholar
Oxidative Addition of the Dithiobis(formamidinium) Cation to Platinum(II) Chloro Am(m)ine Compounds: Studies on Structure, Spectroscopic Properties, Reactivity, and Cytotoxicity of a New Class of Platinum(IV) Complexes Exhibiting S-Thiourea Coordination.
U. Bierbach, T. Hambley, John D. Roberts, N. Farrell
1996Inorganic Chemistry33 citations
Semantic Scholar
Characterization of the bisintercalative DNA binding mode of a bifunctional platinum–acridine agent
J. Choudhury, U. Bierbach
2005Nucleic Acids Research32 citations Open access
Semantic Scholar
Cellular Recognition and Repair of Monofunctional–Intercalative Platinum–DNA Adducts
Fang Liu, J. Suryadi, U. Bierbach
2015Chemical Research in Toxicology31 citations Open access
Semantic Scholar
Metal-intercalator-mediated self-association and one-dimensional aggregation in the structure of the excised major DNA adduct of a platinum-acridine agent.
H. Baruah, C. Day, M. Wright, U. Bierbach
2004Journal of the American Chemical Society31 citations
Semantic Scholar
Modulation of the chemical and biological properties of trans platinum complexes: monofunctional platinum complexes containing one nucleobase as potential antiviral chemotypes
D. Sartori, B. Miller, U. Bierbach, N. Farrell
2000JBIC Journal of Biological Inorganic Chemistry31 citations
Semantic Scholar
Modulation of Nucleotide Binding of trans Platinum(II) Complexes by Planar Ligands. A Combined Proton NMR and Molecular Mechanics Study.
U. Bierbach, N. Farrell
1997Inorganic Chemistry31 citations
Semantic Scholar
Synthesis, Reactivity, and Biological Activity of Gold(I) Complexes Modified with Thiourea-Functionalized Tyrosine Kinase Inhibitors
Mu Yang, A. Pickard, Xin Qiao, Matthew J Gueble +3 more
2015Inorganic Chemistry29 citations Open access
Semantic Scholar
Unique base-step recognition by a platinum-acridinylthiourea conjugate leads to a DNA damage profile complementary to that of the anticancer drug cisplatin.
Michael E. Budiman, R. Alexander, U. Bierbach
2004Biochemistry29 citations
Semantic Scholar
Modification of Platinum(II) Antitumor Complexes with Sulfur Ligands. 2. Reactivity and Nucleotide Binding Properties of Cationic Complexes of the Types [PtCl(diamine)(L)]NO3 and [{PtCl(diamine)}2(L-L)](NO3)2 (L = Monofunctional Thiourea Derivative; L-L = Bifunctional Thiourea Derivative) in Relatio
U. Bierbach, John D. Roberts, N. Farrell
199829 citations
Semantic Scholar
Interactions of a Platinum-Modified Perylene Derivative with the Human Telomeric G-Quadruplex
Lu Rao, Joshua D. Dworkin, W. E. Nell, U. Bierbach
2011Journal of Physical Chemistry B27 citations Open access
Semantic Scholar
Analysis of the DNA damage produced by a platinum–acridine antitumor agent and its effects in NCI-H460 lung cancer cells
Xin Qiao, Alexandra E Zeitany, M. Wright, A. Essader +3 more
2012Metallomics26 citations Open access
Semantic Scholar
Rates of intercalator-driven platination of DNA determined by a restriction enzyme cleavage inhibition assay
J. Choudhury, Lu Rao, U. Bierbach
2010JBIC Journal of Biological Inorganic Chemistry25 citations Open access
Semantic Scholar
Design of Enzymatically Cleavable Prodrugs of a Potent Platinum-Containing Anticancer Agent
Song Ding, A. Pickard, G. Kucera, U. Bierbach
2014Chemistry24 citations Open access
Semantic Scholar
A non-crosslinking platinum-acridine hybrid agent shows enhanced cytotoxicity compared to clinical BCNU and cisplatin in glioblastoma cells.
S. Hess, Joel G. Anderson, U. Bierbach
2005Bioorganic & Medicinal Chemistry Letters24 citations
Semantic Scholar
Biophysical characterization and molecular modeling of the coordinative-intercalative DNA monoadduct of a platinum-acridinylthiourea agent in a site-specifically modified dodecamer
H. Baruah, U. Bierbach
2004JBIC Journal of Biological Inorganic Chemistry24 citations
Semantic Scholar
Large-Pore Functionalized Mesoporous Silica Nanoparticles as Drug Delivery Vector for a Highly Cytotoxic Hybrid Platinum–Acridine Anticancer Agent
Ye Zheng, Cale D. Fahrenholtz, C. L. Hackett, Song Ding +6 more
2017Chemistry23 citations
Semantic Scholar
Unusual Reactivity of a Potent Platinum–Acridine Hybrid Antitumor Agent
Leigh A Graham, G. Wilson, Tiffany K. West, C. Day +2 more
2011ACS Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Platinum-acridinylthiourea conjugates show cell line-specific cytotoxic enhancement in H460 lung carcinoma cells compared to cisplatin
S. Hess, A. M. Mounce, Russel C. Sequeira, Todd M. Augustus +2 more
2005Cancer Chemotherapy and Pharmacology22 citations
Semantic Scholar
DNA minor groove adducts formed by a platinum-acridine conjugate inhibit association of tata-binding protein with its cognate sequence.
Michael E. Budiman, U. Bierbach, R. Alexander
2005Biochemistry20 citations
Semantic Scholar
Structural and reactivity studies on the ternary system guanine/methionine/trans-[PtCl2(NH3)L] (L=NH3, quinoline): implications for the mechanism of action of nonclassical trans-platinum antitumor complexes
U. Bierbach, Nicholas P. Farrell
1998JBIC Journal of Biological Inorganic Chemistry20 citations
Semantic Scholar

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G. Kucera×15
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G. Kucera — researcher profile on SciRah
C. Day×10
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H. Baruah×8
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H. Baruah — researcher profile on SciRah
N. Farrell×7
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G. Saluta — researcher profile on SciRah

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M. Wright — researcher profile on SciRah

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Song Ding — researcher profile on SciRah

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Xin Qiao — researcher profile on SciRah

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A. Pickard — researcher profile on SciRah

J. Choudhury×4

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J. Choudhury — researcher profile on SciRah

Colin G. Barry×4

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Colin G. Barry — researcher profile on SciRah

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J. Suryadi — researcher profile on SciRah