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K. Legge · SciRah

Researcher profile · Semantic Scholar

K. Legge

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K. Legge — researcher profile on SciRah

h-index: 32
Works: 138
Citations: 4,113

Most-cited papers

Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice.
Jin-Cun Zhao, Jing-Xian Zhao, K. Legge, S. Perlman
2011Journal of Clinical Investigation265 citations Open access
Semantic Scholar
Innate immune control and regulation of influenza virus infections
J. McGill, Jonathan W. Heusel, K. Legge
2009Journal of Leukocyte Biology190 citations Open access
Semantic Scholar
IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection
J. McGill, N. van Rooijen, K. Legge
2010Journal of Experimental Medicine149 citations Open access
Semantic Scholar
Influenza A Viral Replication Is Blocked by Inhibition of the Inositol-requiring Enzyme 1 (IRE1) Stress Pathway*
Ihab H. Hassan, Michael S. Zhang, Linda S. Powers, Jian Q. Shao +4 more
2011Journal of Biological Chemistry142 citations Open access
Semantic Scholar
Elevated mitochondrial superoxide disrupts normal T-cell development to impair adaptive immune responses to an influenza challenge
A. Case, J. McGill, L. Tygrett, T. Shirasawa +4 more
2010Free Radical Biology & Medicine111 citations Open access
Semantic Scholar
Neurohormonal Modulation of the Innate Immune System is Pro-inflammatory in the Pre-hypertensive Spontaneously Hypertensive Rat, a Genetic Model of Essential Hypertension
S. Harwani, M. Chapleau, K. Legge, Z. Ballas +1 more
2012Circulation Research109 citations Open access
Semantic Scholar
Pulmonary Infection with Influenza A Virus Induces Site-Specific Germinal Center and T Follicular Helper Cell Responses
Alexander W. Boyden, K. Legge, T. Waldschmidt
2012PLoS ONE88 citations Open access
Semantic Scholar
Cutting Edge: Contribution of Lung-Resident T Cell Proliferation to the Overall Magnitude of the Antigen-Specific CD8 T Cell Response in the Lungs following Murine Influenza Virus Infection1
J. McGill, K. Legge
2009Journal of Immunology88 citations Open access
Semantic Scholar
Natural Killer Cell Recruitment to the Lung During Influenza A Virus Infection Is Dependent on CXCR3, CCR5, and Virus Exposure Dose
Lindsey E. Carlin, Emily A. Hemann, Zeb R. Zacharias, Jonathan W. Heusel +1 more
2018Frontiers in Immunology85 citations Open access
Semantic Scholar
Protective CD8 T cell mediated immunity against influenza A virus infection following influenza virus-like particle vaccination
Emily A. Hemann, Sang-Moo Kang, K. Legge
2013Journal of Immunology75 citations Open access
Semantic Scholar
Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment
Tyler K. Ulland, Nidhi Jain, Emma E. Hornick, Eric I. Elliott +13 more
2016Nature Communications73 citations Open access
Semantic Scholar
T regulatory cells participate in the control of germinal centre reactions
Carla-Maria Alexander, Lorraine T. Tygrett, Alexander W. Boyden, Kristy L. Wolniak +2 more
2011Immunology72 citations Open access
Semantic Scholar
Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells
R. Langlois, K. Legge
2010Journal of Immunology64 citations Open access
Semantic Scholar
Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly
N. Pham, L. Pewe, Courtney J. Fleenor, R. Langlois +3 more
2010Proceedings of the National Academy of Sciences of the United States of America64 citations Open access
Semantic Scholar
Lymphopenia associated with highly virulent H5N1 virus infection due to plasmacytoid dendritic cell mediated apoptosis of T cells
K. Boonnak, Leatrice N. Vogel, F. Feldmann, H. Feldmann +2 more
2014Journal of Immunology63 citations Open access
Semantic Scholar
Cutting Edge: Eosinophils Do Not Contribute to Respiratory Syncytial Virus Vaccine-Enhanced Disease1
Elaine M. Castilow, K. Legge, S. Varga
2008Journal of Immunology61 citations Open access
Semantic Scholar
Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections
J. McGill, D. Meyerholz, Michelle R Edsen-Moore, B. Young +5 more
2009Journal of Immunology59 citations Open access
Semantic Scholar
Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T-Cell Responses in vivo
Robert K Strother, Derek B. Danahy, Dmitri I. Kotov, T. Kucaba +4 more
2016Journal of Immunology58 citations Open access
Semantic Scholar
Polyanhydride Nanovaccine Induces Robust Pulmonary B and T Cell Immunity and Confers Protection Against Homologous and Heterologous Influenza A Virus Infections
Zeb R. Zacharias, K. Ross, Emma E. Hornick, Jonathan T. Goodman +3 more
2018Frontiers in Immunology50 citations Open access
Semantic Scholar
Chronic ethanol induces inhibition of antigen‐specific CD8+ but not CD4+ immunodominant T cell responses following Listeria monocytogenes inoculation
Prajwal Gurung, B. Young, Ruth A. Coleman, Susan C. Wiechert +5 more
2008Journal of Leukocyte Biology48 citations Open access
Semantic Scholar
The magnitude of the T cell response to a clinically-significant dose of influenza virus is regulated by TRAIL
Erik L. Brincks, Prajwal Gurung, R. Langlois, Emily A. Hemann +2 more
2011Journal of Immunology46 citations Open access
Semantic Scholar
This information is current as InfectionsSeverity of Murine Influenza Virus Chronic Alcohol Consumption Increases the
D. Meyerholz, Michelle R Edsen-Moore, J. McGill, Ruth A. Coleman +2 more
200846 citations
Semantic Scholar
Influenza A Virus Vaccination: Immunity, Protection, and Recent Advances Toward A Universal Vaccine
Christopher E. Lopez, K. Legge
2020Vaccines44 citations Open access
Semantic Scholar
Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T cell proliferation
Ji Fan, Michelle R Edsen-Moore, L. Turner, R. Cook +3 more
2010Alcoholism: Clinical and Experimental Research40 citations Open access
Semantic Scholar
Nlrp12 mediates adverse neutrophil recruitment during influenza virus infection
Emma E. Hornick, Balaji Banoth, Ann M. Miller, Zeb R. Zacharias +7 more
2017Journal of Immunology32 citations Open access
Semantic Scholar
Influenza-induced expression of functional TNF-related apoptosis-inducing ligand (TRAIL) on human PBMC
Erik L. Brincks, T. Kucaba, K. Legge, Thomas S. Griffith
2008Human Immunology31 citations Open access
Semantic Scholar
Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity
Angela D. Pack, Patrick V. Schwartzhoff, Zeb R. Zacharias, Daniel Fernandez-Ruiz +5 more
2021Cell Reports29 citations Open access
Semantic Scholar
Diet-induced obesity does not impact the generation and maintenance of primary memory CD8 T cells
Shaniya H. Khan, Emily A. Hemann, K. Legge, L. Norian +1 more
2014Journal of Immunology27 citations Open access
Semantic Scholar
Dendritic cell NLRC4 regulates influenza A virus-specific CD4 T cell responses through FasL expression.
Emma E. Hornick, J. Dagvadorj, Zeb R. Zacharias, Ann M. Miller +6 more
2019Journal of Clinical Investigation25 citations Open access
Semantic Scholar
Kinetics and Phenotype of the CD4 T Cell Response to Influenza Virus Infections
Emma E. Hornick, Zeb R. Zacharias, K. Legge
2019Frontiers in Immunology22 citations Open access
Semantic Scholar
Plasmacytoid Dendritic Cells Require Direct Infection To Sustain the Pulmonary Influenza A Virus-Specific CD8 T Cell Response
Emily A. Hemann, Louisa E. Sjaastad, R. Langlois, K. Legge
2015Journal of Virology21 citations Open access
Semantic Scholar
Chronic ethanol exposure selectively inhibits the influenza-specific CD8 T cell response during influenza A virus infection
Emily A. Hemann, J. McGill, K. Legge
2014Alcoholism: Clinical and Experimental Research15 citations Open access
Semantic Scholar
Oseltamivir treatment prevents the increased influenza virus disease severity and lethality occurring in chronic ethanol consuming mice
R. Langlois, D. Meyerholz, Ruth A. Coleman, R. Cook +2 more
2010Alcoholism: Clinical and Experimental Research15 citations Open access
Semantic Scholar
Prefusion F-based polyanhydride nanovaccine induces both humoral and cell-mediated immunity resulting in long-lasting protection against respiratory syncytial virus
Laura M. Stephens, K. Ross, Kody A. Waldstein, K. Legge +3 more
2021Journal of Immunology13 citations Open access
Semantic Scholar
Primary and long-term B-cell responses in the upper airway and lung after influenza A virus infection
Alexander W. Boyden, Allison M. Frickman, K. Legge, T. Waldschmidt
2014Immunologic research12 citations
Semantic Scholar
Immunomodulatory Effects of Subacute Inhalation Exposure to Copper Oxide Nanoparticles in House Dust Mite-Induced Asthma
Sudartip Areecheewakul, A. Adamcakova-Dodd, Zeb R. Zacharias, X. Jing +6 more
2023ACS Nano11 citations Open access
Semantic Scholar
Antigen Exposure History Defines CD8 T Cell Dynamics and Protection during Localized Pulmonary Infections
Natalija Van Braeckel-Budimir, Matthew D Martin, Stacey M. Hartwig, K. Legge +2 more
2017Frontiers in Immunology11 citations Open access
Semantic Scholar
Quantification of the Frequency and Multiplicity of Infection of Respiratory- and Lymph Node–Resident Dendritic Cells During Influenza Virus Infection
Rebecca VanOosten Anderson, J. McGill, K. Legge
2010PLoS ONE11 citations Open access
Semantic Scholar
Vaccine technologies against avian influenza: current approaches and new directions.
K. Ross, L. Huntimer, J. V. Vela Ramirez, Justin R. Adams +8 more
2014Journal of Biomedical Nanotechnology9 citations
Semantic Scholar
Chronic ethanol consumption reduces existing CD8 T cell memory and is associated with lesions in protection against secondary influenza A virus infections
Zeb R. Zacharias, K. Legge
2019Journal of Immunology8 citations Open access
Semantic Scholar
Contribution of lung-resident T cell proliferation to the overall magnitude of the antigen-specific CD8 T cell response in the lungs following murine influenza virus infection
J. McGill, K. Legge
2009Journal of Immunology8 citations Open access
Semantic Scholar
Polyanhydride nanovaccine against H3N2 influenza A virus generates mucosal resident and systemic immunity promoting protection
Christopher E. Lopez, Zeb R. Zacharias, K. Ross, Balaji Narasimhan +2 more
2024npj Vaccines7 citations Open access
Semantic Scholar
Myelin-reactive CD8+ T cells influence conventional dendritic cell subsets towards a mature and regulatory phenotype in experimental autoimmune encephalomyelitis
Mohit A Upadhye, Connor R Wilhelm, Kai J Rogers, Chakrapani Vemulawada +4 more
2025Journal of Neuroinflammation4 citations Open access
Semantic Scholar
Peripheral regulation of T cells by dendritic cells during infection
Emily A. Hemann, K. Legge
2014Immunologic research4 citations
Semantic Scholar
CD40 Signaling in Mice Elicits a Broad Antiviral Response Early during Acute Infection with RNA Viruses
Kai J. Rogers, P. T. Richards, Zeb R. Zacharias, L. Stunz +5 more
2023Viruses3 citations Open access
Semantic Scholar
Polyanhydride-based RSV prefusion F nanoparticle vaccine establishes lasting protection mediated by humoral and cellular immune responses
Laura M. Stephens, K. Ross, Stacey M. Hartwig, J. McLellan +3 more
2020Journal of Immunology3 citations
Semantic Scholar
Alcohol and the Adaptive Immune Response in the Airway: Dendritic Cell and Lymphocyte Impairments
K. Legge, T. Waldschmidt
20142 citations
Semantic Scholar
Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced disease
Elaine M. Castilow, K. Legge, S. Varga
2008Journal of Immunology2 citations Open access
Semantic Scholar
Isoflavone Rich Diet Ameliorates Experimental Autoimmune Encephalomyelitis (EAE) through Modulation of Gut Bacteria Depleted in Multiple Sclerosis Patients
Samantha N. Freedman, S. Shahi, K. Zarei, Arnav Gupta +4 more
2020Journal of Immunology1 citations
Semantic Scholar
Linking diet, gut microbiota and autoimmunity: A phytoestrogen diet alters the gut microbiota and influences Experimental Autoimmune Encephalomyelitis (EAE)
Samantha N. Freedman, S. Shahi, K. Zarei, Arnav Gupta +4 more
2019Journal of Immunology1 citations
Semantic Scholar

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J. McGill×9
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Emma E. Hornick×5

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Alexander W. Boyden×4

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