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W. Wels · SciRah

Researcher profile · Semantic Scholar

W. Wels

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W. Wels — researcher profile on SciRah

h-index: 59
Works: 218
Citations: 13K

Most-cited papers

Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma.
N. Ahmed, V. Brawley, M. Hegde, C. Robertson +22 more
2015Journal of Clinical Oncology931 citations Open access
Semantic Scholar
HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma
N. Ahmed, V. Brawley, M. Hegde, K. Bielamowicz +29 more
2017JAMA Oncology805 citations Open access
Semantic Scholar
TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy
Z. Grada, M. Hegde, T. Byrd, D. Shaffer +11 more
2013Molecular Therapy: Nucleic Acids443 citations Open access
Semantic Scholar
ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma.
Congcong Zhang, Michael C. Burger, Lukas Jennewein, S. Genssler +8 more
2016Journal of the National Cancer Institute378 citations
Semantic Scholar
Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape.
M. Hegde, M. Mukherjee, Z. Grada, A. Pignata +17 more
2019Journal of Clinical Investigation367 citations Open access
Semantic Scholar
Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor.
Kurt Schönfeld, C. Sahm, Congcong Zhang, S. Naundorf +18 more
2015Molecular Therapy343 citations Open access
Semantic Scholar
Amendment history : Expression of Concern ( July 2019 ) Tandem CAR T cells targeting HER 2 and IL 13 R a 2 mitigate tumor antigen escape
M. Hegde, M. Mukherjee, Z. Grada, A. Pignata +17 more
2019315 citations
Semantic Scholar
3D model for CAR‐mediated cytotoxicity using patient‐derived colorectal cancer organoids
Theresa Schnalzger, Marnix H. P. Groot, Congcong Zhang, M. H. Mosa +5 more
2019EMBO Journal310 citations Open access
Semantic Scholar
NK-92: an ‘off-the-shelf therapeutic’ for adoptive natural killer cell-based cancer immunotherapy
G. Suck, M. Odendahl, P. Nowakowska, C. Seidl +3 more
2016Cancer Immunology and Immunotherapy302 citations Open access
Semantic Scholar
Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Cancer Cells and Induction of Protective Antitumor Immunity
Congcong Zhang, P. Oberoi, S. Oelsner, A. Waldmann +3 more
2017Frontiers in Immunology285 citations Open access
Semantic Scholar
Advantages and applications of CAR-expressing natural killer cells
W. Glienke, R. Esser, C. Priesner, J. D. Suerth +6 more
2015Frontiers in Pharmacology227 citations Open access
Semantic Scholar
CD19‐CAR engineered NK‐92 cells are sufficient to overcome NK cell resistance in B‐cell malignancies
A. Romanski, C. Uherek, G. Bug, E. Seifried +4 more
2016Journal of Cellular and Molecular Medicine206 citations Open access
Semantic Scholar
In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome
Anett Pfeiffer, F. Thalheimer, S. Hartmann, Annika M. Frank +8 more
2018EMBO Molecular Medicine199 citations Open access
Semantic Scholar
CAR-Engineered NK Cells for the Treatment of Glioblastoma: Turning Innate Effectors Into Precision Tools for Cancer Immunotherapy
Michael C. Burger, Congcong Zhang, P. Harter, A. Romanski +5 more
2019Frontiers in Immunology193 citations Open access
Semantic Scholar
Focused Ultrasound Delivers Targeted Immune Cells to Metastatic Brain Tumors
R. Alkins, Alison Burgess, M. Ganguly, G. Francia +3 more
2013Cancer Research190 citations Open access
Semantic Scholar
Retargeting NK-92 cells by means of CD19- and CD20-specific chimeric antigen receptors compares favorably with antibody-dependent cellular cytotoxicity
L. Boissel, Monica Betancur-Boissel, Weiquan Lu, D. Krause +3 more
2013Oncoimmunology180 citations Open access
Semantic Scholar
Continuously expanding CAR NK-92 cells display selective cytotoxicity against B-cell leukemia and lymphoma.
S. Oelsner, M. Friede, Congcong Zhang, J. Wagner +7 more
2017Cytotherapy170 citations Open access
Semantic Scholar
Dual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances antitumor activity and survival
S. Genssler, Michael C. Burger, Congcong Zhang, S. Oelsner +4 more
2016Oncoimmunology169 citations Open access
Semantic Scholar
Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma
M. Hegde, Sujith K. Joseph, F. Pashankar, C. Derenzo +21 more
2020Nature Communications159 citations Open access
Semantic Scholar
TEM8/ANTXR1-specific CAR T cells as a targeted therapy for triple-negative breast cancer
T. Byrd, Kristen Fousek, A. Pignata, C. Szot +21 more
2017Cancer Research136 citations Open access
Semantic Scholar
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis
Paul K. Ziegler, J. Bollrath, Charles Pallangyo, T. Matsutani +24 more
2018Cell127 citations Open access
Semantic Scholar
Intracranial injection of natural killer cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastoma
Michael C. Burger, M. Forster, A. Romanski, F. Strassheimer +31 more
2023Neuro-Oncology124 citations Open access
Semantic Scholar
Clinical grade manufacturing of genetically modified, CAR-expressing NK-92 cells for the treatment of ErbB2-positive malignancies
P. Nowakowska, A. Romanski, Nicole Miller, M. Odendahl +5 more
2017Cancer Immunology and Immunotherapy107 citations Open access
Semantic Scholar
Autologous HER2-specific CAR T-cells after lymphodepletion for advanced sarcoma – A Phase I trial
M. Hegde, Shoba A. Navai, C. Derenzo, Sujith K. Joseph +33 more
2024Nature Cancer102 citations Open access
Semantic Scholar
High Cytotoxic Efficiency of Lentivirally and Alpharetrovirally Engineered CD19-Specific Chimeric Antigen Receptor Natural Killer Cells Against Acute Lymphoblastic Leukemia
Stephan Müller, Tobias Bexte, Veronika Gebel, F. Kalensee +7 more
2020Frontiers in Immunology101 citations Open access
Semantic Scholar
A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma
J. Wagner, V. Pfannenstiel, A. Waldmann, J. Bergs +8 more
2017Frontiers in Immunology96 citations Open access
Semantic Scholar
Genetically engineered CAR NK cells display selective cytotoxicity against FLT3‐positive B‐ALL and inhibit in vivo leukemia growth
S. Oelsner, A. Waldmann, Arne Billmeier, J. Röder +9 more
2019International Journal of Cancer82 citations Open access
Semantic Scholar
“UniCAR”-modified off-the-shelf NK-92 cells for targeting of GD2-expressing tumour cells
N. Mitwasi, A. Feldmann, C. Arndt, S. Koristka +20 more
2020Scientific Reports81 citations Open access
Semantic Scholar
Exclusive Transduction of Human CD4+ T Cells upon Systemic Delivery of CD4-Targeted Lentiviral Vectors
Qi Zhou, K. Uhlig, Anke Muth, J. Kimpel +11 more
2015Journal of Immunology77 citations Open access
Semantic Scholar
Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape.
M. Hegde, M. Mukherjee, Z. Grada, A. Pignata +17 more
2021Journal of Clinical Investigation60 citations Open access
Semantic Scholar
Autologous HER2 CMV bispecific CAR T cells are safe and demonstrate clinical benefit for glioblastoma in a Phase I trial.
N. Ahmed, V. Brawley, M. Hegde, K. Bielamowicz +21 more
2015Journal of Immunotherapy for Cancer59 citations Open access
Semantic Scholar
Vaccination Directed against the Human Endogenous Retrovirus-K Envelope Protein Inhibits Tumor Growth in a Murine Model System
Benjamin Kraus, K. Fischer, S. Büchner, W. Wels +3 more
2013PLoS ONE54 citations Open access
Semantic Scholar
Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity
Congcong Zhang, J. Röder, Anne Scherer, Malena Bodden +6 more
2021Journal for ImmunoTherapy of Cancer53 citations Open access
Semantic Scholar
Disialoganglioside-specific human natural killer cells are effective against drug-resistant neuroblastoma
D. Seidel, Anastasia Shibina, N. Siebert, W. Wels +3 more
2015Cancer Immunology and Immunotherapy41 citations
Semantic Scholar
Generation and characterization of ErbB2-CAR-engineered cytokine-induced killer cells for the treatment of high-risk soft tissue sarcoma in children
M. Merker, Verena Pfirrmann, S. Oelsner, S. Fulda +4 more
2017OncoTarget40 citations Open access
Semantic Scholar
CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation
J. Eitler, W. Rackwitz, N. Wotschel, Venugopal Gudipati +15 more
2024Journal for ImmunoTherapy of Cancer39 citations Open access
Semantic Scholar
Expansion of HER2-CAR T cells after lymphodepletion and clinical responses in patients with advanced sarcoma.
M. Hegde, C. Derenzo, Hui-Min Zhang, Melinda Mata +16 more
201737 citations
Semantic Scholar
ERBB2-CAR-Engineered Cytokine-Induced Killer Cells Exhibit Both CAR-Mediated and Innate Immunity Against High-Risk Rhabdomyosarcoma
M. Merker, J. Wagner, H. Kreyenberg, C. Heim +8 more
2020Frontiers in Immunology35 citations Open access
Semantic Scholar
EGFR-Targeted Granzyme B Expressed in NK Cells Enhances Natural Cytotoxicity and Mediates Specific Killing of Tumor Cells
P. Oberoi, R. Jabulowsky, Hayat Bähr-Mahmud, W. Wels
2013PLoS ONE32 citations Open access
Semantic Scholar
Inability of granule polarization by NK cells defines tumor resistance and can be overcome by CAR or ADCC mediated targeting
J. Eitler, N. Wotschel, Nicole Miller, L. Boissel +3 more
2021Journal for ImmunoTherapy of Cancer31 citations Open access
Semantic Scholar
Directed Differentiation of Mobilized Hematopoietic Stem and Progenitor Cells into Functional NK Cells with Enhanced Antitumor Activity
P. Oberoi, Kathrina Kamenjarin, Jose Francisco Villena Ossa, B. Uherek +2 more
2020Cells30 citations Open access
Semantic Scholar
Arming NK cells with enhanced antitumor activity
P. Oberoi, W. Wels
2013Oncoimmunology23 citations Open access
Semantic Scholar
Cytomegalovirus-specific cytokine-induced killer cells: concurrent targeting of leukemia and cytomegalovirus.
Verena Pfirrmann, S. Oelsner, E. Rettinger, S. Huenecke +7 more
2015Cytotherapy22 citations
Semantic Scholar
Immunomagnetic selection or irradiation eliminates alloreactive cells but also reduces anti-tumor potential of cytokine-induced killer cells: implications for unmanipulated cytokine-induced killer cell infusion.
E. Rettinger, H. Kreyenberg, M. Merker, S. Kuçi +7 more
2014Cytotherapy22 citations
Semantic Scholar
CD33 Delineates Two Functionally Distinct NK Cell Populations Divergent in Cytokine Production and Antibody-Mediated Cellular Cytotoxicity
Maryam Hejazi, Congcong Zhang, S. Bennstein, V. Balz +19 more
2022Frontiers in Immunology18 citations Open access
Semantic Scholar
Dual Targeting of Glioblastoma Cells with Bispecific Killer Cell Engagers Directed to EGFR and ErbB2 (HER2) Facilitates Effective Elimination by NKG2D-CAR-Engineered NK Cells
A. Kiefer, M. Prüfer, J. Röder, Jordi Pfeifer Serrahima +4 more
2024Cells17 citations Open access
Semantic Scholar
Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer
Nivedha Murali Shankar, Paola Ortiz-Montero, A. Kurzyukova, W. Rackwitz +5 more
2023bioRxiv17 citations Open access
Semantic Scholar
Arming cytotoxic lymphocytes for cancer immunotherapy by means of the NKG2D/NKG2D-ligand system
M. Lazarova, W. Wels, A. Steinle
2020Expert Opinion on Biological Therapy16 citations
Semantic Scholar
Clinical translation and regulatory aspects of CAR/TCR-based adoptive cell therapies—the German Cancer Consortium approach
A. Krackhardt, B. Anliker, M. Hildebrandt, M. Bachmann +8 more
2018Cancer Immunology and Immunotherapy16 citations Open access
Semantic Scholar
ErbB2 (HER2)-CAR-NK-92 cells for enhanced immunotherapy of metastatic fusion-driven alveolar rhabdomyosarcoma
C. Heim, L. Moser, H. Kreyenberg, H. Bonig +12 more
2023Frontiers in Immunology15 citations Open access
Semantic Scholar

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